Digital Commons Network^™

Animal Research For Alzheimer Disease: Failures Of Science And Ethics, John J. Pippin, Sarah E. Cavanaugh, Francesca Pistollato

Biomedicine and Animal Models in Research Collection

This chapter addresses the epidemiology and current understanding of AD as a scientific and societal challenge, reviews the uses and results of animal research in basic science and drug development, and discusses risk factors and funding. Important follow-up topics, including current and in-development, human-relevant approaches for replacement of the failed animal research paradigm, deserve comparable treatment and hence are not addressed here. The reader is referred to the list of recommended readings at the end of the chapter for further discussion of these topics.

The Changing Paradigm In Preclinical Toxicology: In Vitro And In Silico Methods In Liver Toxicity Evaluations, Fozia Noor

Application of Alternative Methods Collection

In vitro methods, based on human primary cells, cell lines, and genetically modified reporter cell lines, have greatly expanded the scope of in vitro toxicology. Other significant progress in the area of human-induced pluripotent stem cells (hiPSCs) (Asgari et al., 2010; Schwartz et al., 2014; Shinde et al., 2016; Shtrichman, Germanguz and Itskovitz-Eldor, 2013) is allowing the application of patient and disease-specific hiPSCs (Ghodsizadeh et al., 2010; McCracken et al., 2014; Siller et al., 2013). Moreover, the tools of precise genome editing with engineered nucleases, such as the zinc finger nucleases (zfns), the transcription activator-like effecter nucleases (talens) and, more …

The Potential Of Organ On Chip Technology For Replacing Animal Testing, Malcolm Wilkinson

Human Clinical Trials Collection

The term organ on a chip is used to describe the latest stage of development of in vitro cell culture technology. Figure 26.1 shows its steady development since the 1960s. Each step forward has improved our ability to model human-clinical response to new drugs or therapies and has enabled safety risk assessment of existing cosmetics, personal care products, or other chemicals in the environment. Scientific evidence that the predictive power of in vitro tests is superior to the use of animals will trigger a major shift in the way that medical research, in many areas, is carried out. In this …

Recent Developments In Alternatives To Animal Testing, Katy Taylor

Application of Alternative Methods Collection

Methods that replace techniques that use live animals, or methods of testing substances without live animal use, are known as alternatives, replacements or non-animal methods. Some prefer the term advanced technologies given the fact that they often rely on more sophisticated technology and are more human- relevant than the animal test they replace (see Langley et al., 2015). There have been efforts to replace animal tests since the 1960s. Significant progress initially came in replacing animals used to diagnose human disease; to produce biological drugs (such as vaccines); and to safety test batches of these drugs as they were produced. …

When Is An Alternative Not An Alternative? Supporting Progress For Absolute Replacement Of Animals In Science, Craig Redmond

Humane Science Movement Collection

This chapter addresses some of the areas in which animals are still used within “alternatives”-based research and calls on animal welfare and in vitro organizations to lead the debate and encourage absolute replacement of animal use in research. Without this, progress to end animal research will always remain limited, despite the paradigm shift seen in recent decades.

Research And Testing Without Animals: Where Are We Now And Where Are We Heading?, Thomas Hartung

Humane Science Movement Collection

Experiments involving non-human animals (hereinafter referred to as animals) were the predominant technology in the life sciences from the 1920s to the 1970s. Increasingly, animal-based procedures have been complemented and superseded by other approaches; yet, they still have an enormous reputation as an apparent definitive answer to many scientific and, especially, regulatory questions. They have been questioned first for ethical reasons: Can we justify making animals suffer for scientific inquiry? Simply said, people have different views on this question, but the general public views animal experimentation more and more critically. The animal research community has sought a compromise between those …

Ethics, Efficacy, And Decision-Making In Animal Research, Lawrence A. Hansen, Kori Ann Kosberg

Morality and Ethics of Animal Experimentation Collection

Few would disagree with the ethical contention that if cruelty to animals is not wrong, then nothing is wrong. In fact, it is not only wrong, but in most states in the us, it is a crime, a felony no less. And yet, intentionally inflicting pain and suffering upon animals, which meets Webster’s definition of cruelty, is routinely countenanced when vivisection (from the Latin vivi, to be alive, and secare, to cut) is performed under license for biomedical research. Deciding to embrace, or reject, or limit animal research demands our best ethical judgment; and it is complicated by factual disputes …

Elevated Sensitivity To Tactile Stimuli In Stereotypic Horses, Sabrina Briefer Freymond, Déborah Bardou, Sandrine Beuret, Iris Bachmann, Klaus Zuberbühler, Elodie Briefer

Personality Collection

Although stereotypic behaviors are a common problem in captive animals, why certain individuals are more prone to develop them remains elusive. In horses, individuals show considerable differences in how they perceive and react to external events, suggesting that this may partially account for the emergence of stereotypies in this species. In this study, we focused on crib-biting, the most common stereotypy displayed by horses. We compared how established crib-biters (“CB” = 19) and normal controls (“C” = 18) differed in response to a standard “personality” assessment test battery, i.e., reactivity to humans, tactile sensitivity, social reactivity, locomotor activity, and curiosity …

Ethical And Scientific Pitfalls Concerning Laboratory Research With Non-Human Primates, And Possible Solutions, Constança Carvalho, Augusta Gaspar, Andrew Knight, Luís Vicente

Morality and Ethics of Animal Experimentation Collection

Basic and applied laboratory research, whenever intrusive or invasive, presents substantial ethical challenges for ethical committees, be it with human beings or with non-human animals. In this paper we discuss the use of non-human primates (NHPs), mostly as animal models, in laboratory based research. We examine the two ethical frameworks that support current legislation and guidelines: deontology and utilitarianism. While human based research is regulated under deontological principles, guidelines for laboratory animal research rely on utilitarianism. We argue that the utilitarian framework is inadequate for this purpose: on the one hand, it is almost impossible to accurately predict the benefits …

Just Preservation, A. Treves, F. J. Santiago-Ávila, W. S. Lynn

Anthropogenics and Population Decline Collection

We are failing to protect the biosphere. Novel views of conservation, preservation, and sustainability are surfacing in the wake of consensus about our failures to prevent extinction or slow climate change. We argue that the interests and well-being of non-humans, youth, and future generations of both human and non-human beings (futurity) have too long been ignored in consensus-based, anthropocentric conservation. Consensus-based stakeholder-driven processes disadvantage those absent or without a voice and allow current adult humans and narrow, exploitative interests to dominate decisions about the use of nature over its preservation for futurity of all life. We propose that authentically non-anthropocentric …

Protecting Biodiversity In British Columbia: Recommendations For Developing Species At Risk Legislation, Alana R. Westwood, Sarah P. Otto, Arne Mooers, Chris Darimont, Karen E. Hodges, Chris Johnson, Brian M. Starzomski, Cole Burton, Kai M. A. Chan, Marco Festa-Bianchet, Shaun Fluker, Sumeet Gulati, Aerin L. Jacob, Dan Kraus, Tara G. Martin, Wendy J. Palen, John D. Reynolds, Jeannette Whitton

Threatened and Endangered Animal Populations Collection

British Columbia has the greatest biological diversity of any province or territory in Canada. Yet increasing numbers of species in British Columbia are threatened with extinction. The current patchwork of provincial laws and regulations has not effectively prevented species declines. Recently, the Provincial Government has committed to enacting an endangered species law. Drawing upon our scientific and legal expertise, we offer recommendations for key features of endangered species legislation that build upon strengths and avoid weaknesses observed elsewhere. We recommend striking an independent Oversight Committee to provide recommendations about listing species, organize Recovery Teams, and monitor the efficacy of actions …

A Second Order Bdf Numerical Scheme With Variable Steps For The Cahn-Hilliard Equation, Wenbin Chen, Xiaoming Wang, Yue Yan, Zhuying Zhang

Mathematics and Statistics Faculty Research & Creative Works

We present and analyze a second order in time variable step BDF2 numerical scheme for the Cahn-Hilliard equation. the construction relies on a second order backward difference, convex-splitting technique and viscous regularizing at the discrete level. We show that the scheme is unconditionally stable and uniquely solvable. in addition, under mild restriction on the ratio of adjacent time-steps, an optimal second order in time convergence rate is established. the proof involves a novel generalized discrete Gronwall-type inequality. as far as we know, this is the first rigorous proof of second order convergence for a variable step BDF2 scheme, even in …

Development Of Entomopathogenic Fungi As Biopesticides For The Management Of Cowpea Aphid, Aphis Craccivora Koch, Allan Ndua Mweke

All PhD Dissertations

Cowpea (Vigna unguiculata L. Walp) is an important African indigenous vegetable in the tropics where it is considered as a key source of nutrients and income for small-holder farmers.The crop is drought tolerant and does well in poor soils because of its ability to fix atmospheric nitrogen. Cowpea is commonly used in soil fertility management and provides livestock fodder. However, the exploitation of the full potential of this crop is constrained by abiotic and biotic factors that lead to low yields in Africa. Among the biotic factor's cowpea aphid (Aphis craccivora Koch) is a major limiting factor in cowpea production …

Development Of Semiochemical-Based Strategies For The Management Of Antestia Bug, Antestiopsis Thunbergii (Heteroptera: Pentatomidae), Teresiah Nyambura Njihia

All PhD Dissertations

Antestia bug Antestiopsis thunbergii (Gmelin) is a key insect pest of Arabica coffee associated with high losses in terms of quality, yield and export market of produce from the African region. Although the pest prefer feeding on unripe (mature) green berries than other coffee berry maturity stages or coffee parts, the cues that influence their host choice are unknown. In addition, A. thunbergii is gregarious in the field and produces a strong distinct smell while disturbed, which is characteristic of defence and alarm pheromones. However, little is known about the identity of the volatile chemical compounds that this pest produces …

Nitrogen Dynamics In Organic And Conventional Farming Systems In The Sub-Humid Highlands Of Central Kenya, Martha Wangu Musyoka

All PhD Dissertations

Nitrogen (N) deficit is one of the limiting factors to food security in most developing countries while the excessive use of N has resulted in environmental contamination. Timely N availability, at the right rate is crucial to improving crop yield and N use efficiency in farming systems. Therefore, understanding nitrogen dynamics under different farming systems is essential to improve N use and recovery efficiencies of crops and in addressing environmental impacts associated with increased use of inorganic and organic inputs. This study focused on N dynamics in conventional (Conv) and organic (Org) farming systems as practiced by small scale farmers …

Discrimination Of Hypotrigona Species (Apidae: Meliponinae) In Kenya Using Nest Architecture, Cephalic Secretions And Molecular Tools, Nelly Njeri Ndungu

All PhD Dissertations

Stingless bees are important pollinators contributing significantly to biodiversity and food security. Stingless bees produce honey that has high medicinal value that fetches higher prices compared to the honey produced by honey bees (Apis mellifera). However,identification and classification of Afrotropical stingless bees, which is key and important for their domestication, still remains ambiguous and solely reliant on the use of morphological features. In this study, an integrative taxonomy approach was applied to identify and differentiate three Hypotrigona species: Hypotrigona gribodoi, H.ruspolii and H. araujoi that are found in Kenya. Nesting sites, nest architecture,morphometrics, DNA barcoding and hemotaxonomy using whole head …

Management Of Spoladea Recurvalis (Lepidoptera: Crambidae) On Amaranths Using Biopesticides, S. O. Miller

All PhD Dissertations

Amaranths are African indigenous vegetables (AIVs) that are gaining popularity in several countries around the world due to their nutritional, medicinal and economic values. Insect pests are however a major challenge to optimum production of amaranths. The lepidopteran defoliator moth commonly known as Hawaiian beet webworm/amaranth leaf-webber, Spoladea recurvalis has been reported to be a major pest in amaranth fields, with the potential of causing complete defoliation under severe outbreaks. The most common management practice for S. recurvalis is the use of synthetic insecticides. However, resource-poor farmers cannot afford synthetic insecticides, application of insecticides poses health and environmental risks and …

The American Yawp, Joseph Locke, Ben Wright

Open Educational Resources Collection

The American Yawp constructs a coherent and accessible narrative from all the best of recent historical scholarship. Without losing sight of politics and power, it incorporates transnational perspectives, integrates diverse voices, recovers narratives of resistance, and explores the complex process of cultural creation. It looks for America in crowded slave cabins, bustling markets, congested tenements, and marbled halls. It navigates between maternity wards, prisons, streets, bars, and boardrooms. Whitman’s America, like ours, cut across the narrow boundaries that strangle many narratives. Balancing academic rigor with popular readability, The American Yawp offers a multi-layered, democratic alternative to the American past.

Umsl Bulletin 2019-2020, University Of Missouri-St. Louis

Bulletins

The University Bulletin/Course Catalog 2019-2020 Edition.

Annual Report Of The Officers Of The Town Of Groton, New Hampshire Year Ending December 31, 2018., Groton Town Representatives

Groton, NH Annual Reports

This is an annual report containing vital statistics for a town/city in the state of New Hampshire.

Crispr Has The Potential To Change The World, But First We Have To Give It A Chance, Sarah J. Schultz

Nova Law Review

No abstract provided.

Re-Personalising Work And Business: Bill Pollard And Servicemaster's Narrative Of Continuity Through Change, Gordon Preece

Pollard Research Fellowship Papers

This paper addresses the Re-Personalising of Work and Business by Bill Pollard, the long-serving CEO and Chair of the U.S. and global service industry giant ServiceMaster. It uses two frameworks to shed greater light on this story. The first framework is Michael Goldberg’s Narratival Ethics Audit, which explores the role of character/virtue reinforced through connections to story via rituals and traditions. The second framework is the Cambridge UK-based Relationship Foundation’s measure of relational proximity in terms of equality, continuity, multiplexity etc. The mega-theme running through these frameworks, as largely maintained and carried by Pollard and ServiceMaster, is that of the …

2018/2019 Robert E. Kennedy Library Annual Report, Robert E. Kennedy Library

Library Publications and Administrative Reports

We have named our annual report Inside 35, and we are introducing a new format that aims to illustrate the impact of our programs on the Cal Poly community and how a library experience can transform lives and define future careers. The library, through all it has to offer, inspires and celebrates every student’s experience of learning, discovery and personal growth.

Paradise Museum Of The Natural World, Emma Puryear

Studio Projects

Emma Puryear’s Museum of the Natural World seeks to create a familiar project, both aesthetically and content-wise, that reconnects residents with the natural world. Located between the East and West Villages, it will be a place for everyone in the community as a cultural center that seeks to promote responsible environmentalism. The project seeks also to revitalize Paradise Park by incorporating an outdoor eco-exhibit and community garden.

Long-Term Phytoremediating Abilities Of Dalbergia Sissoo Roxb. (Fabaceae), Saqib Ul Kalam, Fauzia Naushin, Fareed Ahmad Khan, Nishanta Rajakaruna

Biological Sciences

The boom of tanneries in north India has converted the river Ganga into a waste dumping stream. The tanneries discharge their heavy metal-rich effluents into the river. Tissues of two-year-old tree saplings of Dalbergia sissoo, soil sediments and river water samples were collected from three sites along the river Ganga at Jajmau, Kanpur. Site-1 was located 1 km upstream from the point of discharge of the effluents of the tanneries, Site-2 was close to the source point, and Site-3 was about 1 km downstream from the source point. Accumulation of Cu, Cr and Ni in leaves, bark, wood growth rings, …

Office Of The Vice Provost For Research Annual Report - 2019, Office Of The Vice Provost For Research, East Tennessee State University

Annual Reports

No abstract provided.

John Toland’S Pivotal Version Of Secularism At The Turn Of The Eighteenth Century, Edward Jayne

English Faculty Publications

John Toland’s Pivotal Version of Secularism at the Turn of the Eighteenth Century

John Toland (1669-1728) sustained a life-long confrontation with Christianity as well as with religion and orthodox belief in general. His unprecedented advance from Irish Catholicism to secularism and finally outright atheism played a central role in European philosophy despite its having been all but forgotten in later times. He left Ireland to attend Edinburgh University in Scotland followed by Leyden University in the Netherlands and finally a faculty position at Oxford University preceding his career as an independent author. By his early death he had published as …

Data Management Plan For Social-Ecological Dynamics Of Multi-Use Public Lands: The Role Of Recreational Shooting In Shaping Recreation Communities, Management Decisions, And Trophic Interactions, Michelle Armstrong, Jay D. Carlisle, Albertsons Library Research Data Management Team

Data Management and Sharing Plans

Data Management Plan for 2019 Dynamics of Integrated Socio-Environmental Systems (CNH2) Program Proposal

Study Of Synthesis Of Biodegradable Plastics From Alkaline Fermented Excessive Activated Sludge, Yaohui Liu, Chua Hong

Faculty of Science & Technology (THEi)

The environmental problems associated with plastics have become increasingly severe in recent years. Technologically and economically feasible solutions are in urgent need in order to ensure sustainable development in the plastic industry. Polyhydroxyalkanoates (PHAs) are a family of specialized polyesters of hydroxyalkanoates (HAs) and can be completely degraded in natural environment. They can be synthesized naturally or under artificially controlled processes. The barrier of limiting the application of PHAs is the high production cost. From years of study, PHAs are proofed to be able to be accumulated within the bacterial cells in activated sludge and the production yield had been …

Improving The Energy Efficiency Of Petrochemical Plant Operations: A Measurement And Verification Case Study Using A Balanced Wave Optimizer, Eve Man Hin Chan, Kar-Kit Chu, Hin-Fung Chow, Chi-Wing Tsang, Danny Chi Kuen Ho, Shuk-Kei Ho

Faculty of Science & Technology (THEi)

The Chinese petrochemical industry is facing pressure to meet strict targets of energy consumption and carbon emission reductions. Water pumps are the primary equipment used in most chemical and agrochemical industries sectors since water is commonly used for cooling and heating purposes, but these pumps also consume a large amount of energy. Other uses of water pumps in these industries include producing steam for heating, preparing reaction media or absorptive reagents, rinsing products, and distilling. As for the electrical components of the water pump systems, current technologies of variable frequency drives and superconducting transmission lines are unable to increase the …