Digital Commons Network^™

Evidence For The Role Of Mindfulness In Cancer: Benefits And Techniques., R. Mehta, K. Sharma, L. Potters, A. G. Wernicke, B. Parashar

Journal Articles

Mindfulness is being used increasingly in various aspects of cancer management. Benefits of mindfulness practices are being observed to manage the adverse effects of treatment, symptoms from cancer progression, and the cost-effectiveness compared to conventional contemporary management strategies. In this review article, we present clinical trial data showing the benefits of mindfulness in various aspects of cancer management as well as techniques that have been commonly used in this practice.

A Model-Based Method For Assessment Of Salivary Gland And Planning Target Volume Dosimetry In Volumetric-Modulated Arc Therapy Planning On Head-And-Neck Cancer., H. Zhang, Y. Cao, J. Antone, A. C. Riegel, M. Ghaly, L. Potters, A. Jamshidi

Journal Articles

This study examined the relationship of achievable mean dose and percent volumetric overlap of salivary gland with the planning target volume (PTV) in volumetric-modulated arc therapy (VMAT) plan in radiotherapy for a patient with head-and-neck cancer. The aim was to develop a model to predict the viability of planning objectives for both PTV coverage and organs-at-risk (OAR) sparing based on overlap volumes between PTVs and OARs, before the planning process. Forty patients with head-and-neck cancer were selected for this retrospective plan analysis. The patients were treated using 6 MV photons with 2-arc VMAT plan in prescriptions with simultaneous integrated boost …

Long-Term Safety Of Single-Agent Ibrutinib In Patients With Chronic Lymphocytic Leukemia In 3 Pivotal Studies, S. E. Coutre, J. C. Byrd, P. Hillmen, J. C. Barrientos, P. M. Barr, S. Devereux, T. Robak, T. J. Kipps, A. Schuh, S. M. O’Brien, +9 Additional Authors

Journal Articles

© 2019 by The American Society of Hematology Ibrutinib, a first-in-class once-daily oral Bruton tyrosine kinase inhibitor indicated for chronic lymphocytic leukemia (CLL), is continued until progressive disease or unacceptable toxicity. We conducted an integrated safety analysis of single-agent ibrutinib from randomized phase 3 studies PCYC-1112 (RESONATE, n 5 195) and PCYC-1115/1116 (RESONATE-2, n 5 135), and examined longer-term safety separately in the phase 1b/2 PCYC-1102/1103 study (n 5 94, 420 mg/d). In the integrated analysis (ibrutinib treatment up to 43 months), the most common adverse events (AEs) were primarily grade 1/2; diarrhea (n 5 173, 52% any-grade; n 5 …

Defining Inflammatory Cell States In Rheumatoid Arthritis Joint Synovial Tissues By Integrating Single-Cell Transcriptomics And Mass Cytometry, F. Zhang, K. Wei, K. Slowikowski, C. Y. Fonseka, A. Rao, Kelly, S. M. Goodman, D. Tabechian, P. K. Gregersen, S. Raychaudhuri, +55 Additional Authors

Journal Articles

© 2019, The Author(s), under exclusive licence to Springer Nature America, Inc. To define the cell populations that drive joint inflammation in rheumatoid arthritis (RA), we applied single-cell RNA sequencing (scRNA-seq), mass cytometry, bulk RNA sequencing (RNA-seq) and flow cytometry to T cells, B cells, monocytes, and fibroblasts from 51 samples of synovial tissue from patients with RA or osteoarthritis (OA). Utilizing an integrated strategy based on canonical correlation analysis of 5,265 scRNA-seq profiles, we identified 18 unique cell populations. Combining mass cytometry and transcriptomics revealed cell states expanded in RA synovia: THY1(CD90) + HLA-DRA hi sublining fibroblasts, IL1B + …

Erratum: Distinct Hla Associations With Rheumatoid Arthritis Subsets Defined By Serological Subphenotype (The American Journal Of Human Genetics (2019) 105(3) (616–624), (S0002929719303052), (10.1016/J.Ajhg.2019.08.002)), C. Terao, B. Brynedal, Z. Chen, X. Jiang, Westerlind, Hansson, P. J. Jakobsson, K. Lundberg, P. K. Gregersen, S. Raychaudhuri, +10 Additional Authors

Journal Articles

© 2019 The Author(s) (The American Journal of Human Genetics 105, 616–624; September 5, 2019) In the originally published version of this article, the first author, Chikashi Tereo, had footnotes indicating affiliations with the first seven institutions. The correct affiliations are the first six plus footnote 17, indicating equal contribution. This error has been corrected here and online, and the authors and copyeditor express their regret for the mistake.

Fc Receptor-Like 2 (Fcrl2) Is A Novel Marker Of Low-Risk Cll And Refines Prognostication Based On Ighv Mutation Status, L. K. Shea, K. Honjo, D. T. Redden, E. Tabengwa, Li, J. Li, M. Shakhmatov, N. Chiorazzi, R. S. Davis

Journal Articles

No abstract provided.

Clinically Significant Gains In Skillful Grasp Coordination By An Individual With Tetraplegia Using An Implanted Brain-Computer Interface With Forearm Transcutaneous Muscle Stimulation, M. Bockbrader, N. Annetta, D. Friedenberg, M. Schwemmer, Skomrock, Colachis, M. Zhang, C. Bouton, A. Rezai, W. J. Mysiw, +1 Additional Author

Journal Articles

© 2019 American Congress of Rehabilitation Medicine Objective: To demonstrate naturalistic motor control speed, coordinated grasp, and carryover from trained to novel objects by an individual with tetraplegia using a brain-computer interface (BCI)-controlled neuroprosthetic. Design: Phase I trial for an intracortical BCI integrated with forearm functional electrical stimulation (FES). Data reported span postimplant days 137 to 1478. Setting: Tertiary care outpatient rehabilitation center. Participant: A 27-year-old man with C5 class A (on the American Spinal Injury Association Impairment Scale) traumatic spinal cord injury Interventions: After array implantation in his left (dominant) motor cortex, the participant trained with BCI-FES to control …

Rnai Transfection Optimized In Primary Naïve B Cells For The Targeted Analysis Of Human Plasma Cell Differentiation, T. Shih, S. De, B. J. Barnes

Journal Articles

Upon antigen recognition, naïve B cells undergo rapid proliferation followed by differentiation to specialized antibody secreting cells (ASCs), called plasma cells. Increased circulating plasma cells are reported in patients with B cell-associated malignancies, chronic graft-vs.-host disease, and autoimmune disorders. Our aim was to optimize an RNAi-based method that efficiently and reproducibly knocks-down genes of interest in human primary peripheral B cells for the targeted analysis of ASC differentiation. The unique contributions of transcriptional diversity in species-specific regulatory networks and the mechanisms of gene function need to be approached directly in human B cells with tools to hone our basic inferences …

The Bin1 Rs744373 Snp Is Associated With Increased Tau-Pet Levels And Impaired Memory, N. Franzmeier, A. Rubinski, J. Neitzel, M. Ewers, W. Weiner, Aisen, R. Petersen, C. R. Jack, P. Davies, B. Ances, +90 Additional Authors

Journal Articles

© 2019, The Author(s). The single nucleotide polymorphism (SNP) rs744373 in the bridging integrator-1 gene (BIN1) is a risk factor for Alzheimer’s disease (AD). In the brain, BIN1 is involved in endocytosis and sustaining cytoskeleton integrity. Post-mortem and in vitro studies suggest that BIN1-associated AD risk is mediated by increased tau pathology but whether rs744373 is associated with increased tau pathology in vivo is unknown. Here we find in 89 older individuals without dementia, that BIN1 rs744373 risk-allele carriers show higher AV1451 tau-PET across brain regions corresponding to Braak stages II–VI. In contrast, the BIN1 rs744373 SNP was not associated …

Sequencing And Curation Strategies For Identifying Candidate Glioblastoma Treatments, M. O. Frank, T. Koyama, K. Rhrissorrakrai, N. Robine, F. Utro, A. Emde, B. Chen, J. Boockvar, A. Demopoulos, R. B. Darnell, +39 Additional Authors

Journal Articles

No abstract provided.

Deep Brain Stimulation: Current Challenges And Future Directions, A. M. Lozano, N. Lipsman, H. Bergman, P. Brown, S. Chabardes, J. W. Chang, K. Matthews, C. C. Mcintyre, M. Schulder, J. K. Krauss, +3 Additional Authors

Journal Articles

No abstract provided.

An Effective Method For Acute Vagus Nerve Stimulation In Experimental Inflammation, A. S. Caravaca, A. L. Gallina, L. Tarnawski, K. J. Tracey, V. A. Pavlov, Y. A. Levine, P. S. Olofsson

Journal Articles

© 2019 Caravaca, Gallina, Tarnawski, Tracey, Pavlov, Levine and Olofsson. Neural reflexes regulate inflammation and electrical activation of the vagus nerve reduces inflammation in models of inflammatory disease. These discoveries have generated an increasing interest in targeted neurostimulation as treatment for chronic inflammatory diseases. Data from the first clinical trials that use vagus nerve stimulation (VNS) in treatment of rheumatoid arthritis and Crohn’s disease suggest that there is a therapeutic potential of electrical VNS in diseases characterized by excessive inflammation. Accordingly, there is an interest to further explore the molecular mechanisms and therapeutic potential of electrical VNS in a range …

Spectrotemporal Modulation Provides A Unifying Framework For Auditory Cortical Asymmetries, A. Flinker, W. K. Doyle, A. D. Mehta, O. Devinsky, D. Poeppel

Journal Articles

No abstract provided.

University Libraries Annual Report 2018-2019, Jennifer Hoyt (Ed.)

Libraries Reports and Documents

Annual Report of the Old Dominion University Libraries for 2018-2019. Contents define ways the Libraries engage:

1. Deal With at Length - Reorganization: Departments, Budgets, & Big Deals
2. To Begin and Carry On - Services, Instruction, Excellence, & Grand Spaces
3. A Crossroads Community - A Collaboration of Research, Exhibits, & Events
4. To Provide Occupation for Success - Publications, Presentations, & Representation
5. To Offer Opportunities for Engagement - Our Pledge to ODU Libraries & the ODU Community

Pacs Viewbook 2019-2020, Program In Audiology And Communication Sciences

PACS News

No abstract provided.

Physician Assistant Fort Meyers, Nova Southeastern University

Health Professions Divisions Course Catalogs and Course Descriptions

No abstract provided.

Occupational Therapy Fort Lauderdale 2019, Nova Southeastern University

Health Professions Divisions Course Catalogs and Course Descriptions

No abstract provided.

Construing Culture As Composition-Part 1: The Narrative Nature Of Truth, Lindy D. Backues

The Journal of Inductive Biblical Studies

No abstract provided.

Colorimetric Detection Of Aliphatic Alcohols In Β-Cyclodextrin Solutions, Anna Haynes, Priva Halpert, Mindy Levine

Chemistry Faculty Publications

The sensitive, selective, and practical detection of aliphatic alcohols is a continuing technical challenge with significant impact in public health research and environmental remediation efforts. Reported herein is the use of a β-cyclodextrin derivative to promote proximity-induced interactions between aliphatic alcohol analytes and a brightly colored organic dye, which resulted in highly analyte-specific color changes that enabled accurate alcohol identification. Linear discriminant analysis of the color changes enabled 100% differentiation of the colorimetric signals obtained from methanol, ethanol, and isopropanol in combination with BODIPY and Rhodamine dyes. The resulting solution-state detection system has significant broad-based applicability because it uses only …

Monitoring Biodiversity Using Aquatic Environmental Dna And Nanopore Sequencing, Jordan Callahan

SURE (Stonehill Undergraduate Research Experience)

This project aimed to detect wetland organismal diversity on the Stonehill College campus by sequencing free aquatic eDNA collected from water samples in the seasonal wetland behind O’Hara Hall and Shields Science Center. The Oxford Nanopore MinION DNA sequencer offered real-time data collection at a relatively low cost and demonstrated an “in-the-field” workflow. DNA was extracted from water samples collected using a pump-filter collection apparatus. Protocols for Nanopore sequencing were established and surveys plan to be conducted in order to measure standing plant diversity around the sampling locations. Plant reads from each sample yielded plants primarily from the Brassica, Callitriche, …

Sociosexuality, Testosterone, And Life History Status: Prospective Associations And Longitudinal Changes Among Men In Cebu, Philippines, Lee T. Gettler, Patty X. Kuo, Stacy Rosenbaum, Josephine L. Avila, Thomas W. Mcdade, Christopher W. Kuzawa

Department of Child, Youth, and Family Studies: Faculty Publications

Sociosexuality is defined as an individual's interest in uncommitted sexual activity and can be measured in terms of both psychological orientations and behavioral expression. In socio-ecological contexts in which adults monogamously partner and cooperate to raise children, individuals with unrestricted sociosexuality are likely to prioritize mating/competition over committed partnering and parenting. Given the importance of mother-father cooperation in the evolutionary past, humans may have the capacity to facultatively and opportunistically downregulate sociosexuality to focus on priorities related to invested partnering and parenting. To date, no prior studies have used longitudinal data to track within-individuals changes in sociosexuality as it relates …

Low Cost Solutions - Textbooks, Courses, Coursework, Yang Wu

Open Education Week 2019

No abstract provided.

Ada News Convention Daily - 2019 Day 3, American Dental Association, Publishing Division

ADA News

The ADA News Daily (also called the ADA News Convention Daily) is a special edition of the ADA News published each day during American Dental Association Annual Sessions.

'Elle T'Aime Trop, Et Moi, Pas Assez': Jacques Feyder's Melodramatic Mise En Scène Of Female Desire In Pension Mimosas (1935), Barry Nevin

Articles

Extract

Melodrama ‘à la française’: Feyder and French cinema of the 1930s

By the end of 1934, Jacques Feyder had led a distinguished career in French silent cinema, had directed a critically acclaimed adaptation of Émile Zola’s Thérèse Raquin (1928) in Berlin, had returned from a three-year contract in Hollywood, had brought Le Grand Jeu to the screen (the greatest box-office success of the 1933–34 season), and appeared to be virtually unstoppable as he proceeded to direct his next film, Pension Mimosas. The film was described by one critic as ‘sans aucun doute l’une des œuvres les plus attendues …

Macalester Today Winter 2019, Macalester College

Macalester Today

No abstract provided.

Revegetation Using Cushion Plants After Recreational Trampling On A Colorado Fourteener, Catherine Kleier, Rachel Kreb, Mike Kintgen

Celebration of Scholarship and Research

Are cushion plants strong candidates for alpine trail revegetation? The authors present their findings.

Morphology And Evolution Of The Luminous Roughy Bioluminescent Organ (Teleostei: Trachichthyidae), Michael J. Ghedotti, Hannah Dekay, W. Leo Smith, Matthew P. Davis

Celebration of Scholarship and Research

INTRODUCTION

Bioluminescent organs in fishes that produce ventral camouflage against a background of downwelling light are very common, yet their anatomy often is poorly understood (Hastings, 1971; Young & Roper, 1976). Camouflage via ventral bioluminescence has evolved at least seven times within a wide range of teleosts (Haddock et al., 2010; Davis et al., 2014, 2016) and they vary greatly in the anatomical structures that form them (Haygood et al., 1994; Chakrabarty et al., 2011; Ghedotti et al., 2015, 2018).

The luminous roughies (genus Aulotrachichthys) have a light organ in the region of the anus that houses lumiescent bacteria in …

Temperature Affects Hatching Success Of Cocoons In The Invasive Asian Earthworm Amynthas Agrestis From The Southern Appalachians, James H. Blackmon, Melanie K. Taylor, Roberto Carrera-Martínez, Bruce A. Snyder, Mac A. Callaham

Faculty and Staff Works

Invasive Asian earthworms are increasingly common in the eastern USA where they are a major cause of terrestrial ecosystem disturbance. Among these, Amynthas agrestis (Crazy Worm, Alabama Jumper, and other common names) has been shown to alter above- and belowground food webs. Life-history traits of these earthworms are largely unknown, particularly in their invaded range. Here, we sought to answer questions about temperature effects on hatching success for cocoons of this species, using specimens collected from the southern Appalachian Mountains. We conducted 2 experiments investigating the effects of incubation temperature and the effect of varying the duration of cold temperature …

The Chloroplast And Mitochondrial Genomes Of The Green Algae Pediastrum Duplex Isolated From Central Georgia (Usa), Grayson C.R. Proulex, Blia Lor, Kalina M. Manoylov, A. Bruce Cahoon

Faculty and Staff Works

A Pediastrum duplex (Chlorophyta) strain was isolated from a freshwater system in Milledgeville, Georgia and its chloroplast and mitochondrial genomes sequenced. The chloroplast genome was 199,241 bp with 136 genes and the mitochondrial 40,756 bp with 40 genes, both were circular. Comparison of the ‘Milledgeville’ plastome to other P. duplex isolates revealed a nearly identical sequence identity to archived genes and genomic fragments from the strain UTEX1364 which was isolated from Lake Machovo in 1962. These sequences provide chloroplast and mitochondrial genomes from a wild P. duplex isolate and provide more organelle genomes for a genus with cryptic phylogenetic relationships.

Demystifying Nationwide Injunctions, Alan M. Trammell

Scholarly Articles

The phenomenon of nationwide injunctions—when a single district court judge completely prevents the government from enforcing a statute, regulation, or policy—has spawned a vigorous debate. A tentative consensus has emerged that an injunction should benefit only the actual plaintiffs to a lawsuit and should not apply to persons who were not parties. These critics root their arguments in various constitutional and structural constraints on federal courts, including due process, judicial hierarchy, and inherent limits on “judicial power.” Demystifying Nationwide Injunctions shows why these arguments fail.

This Article offers one of the few defenses of nationwide injunctions and is grounded in …