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Research And Creative Activity, July 1, 2018-June 30, 2019: Major Sponsored Programs And Faculty Awards For Research And Creative Activity, University Of Nebraska-Lincoln, Office Of Research And Economic Development, University Of Nebraska-Lincoln

Office of Research and Economic Development: Publications

Foreword by Bob Wilhelm, Vice Chancellor for Research and Economic Development:

This booklet highlights successes in research, scholarship and creative activity by University of Nebraska–Lincoln faculty during the fiscal year running July 1, 2018, to June 30, 2019.

It lists investigators, project titles and funding sources on major grants and sponsored awards received during the year; fellowships and other recognitions and honors bestowed on our faculty; books published by faculty; performances, exhibitions and other creative activity by our faculty; and patents and licensing agreements issued for products of Nebraska research.

2019 marks the university’s 150th anniversary, an exciting time to …

Perspectives Of Us Women Participating In A Candidate Prep Study: Adherence, Acceptability And Future Use Intentions, K Rivet Amico, Catalina Ramirez, Margaret R. Caplan, Brooke E E Montgomery, Jennifer Stewart, Sally Hodder, Shobha Swaminathan, Jing Wang, Noshima Y. Darden-Tabb, Marybeth Mccauley, Kenneth H. Mayer, Timothy Wilkin, Raphael J. Landovitz, Roy Gulick, Adaora A. Adimora

Faculty & Staff Scholarship

Introduction

Limited data exist on acceptability of candidate pre‐exposure prophylaxis (PrEP) regimens among US women. We evaluated PrEP experiences, attitudes and future use intentions among sexually active women who completed the US‐based HIV Prevention Trials Network 069/AIDS Clinical Trials Group 5305 study.

Methods

Women participated in the study between March 2013 and November 2015. We analysed computer‐assisted self‐interview (CASI) surveys among 130 women and conducted in‐depth interviews among a subset of 26 women from three sites. Interviews were conducted in mid/late‐2015.

Results

Most women (57%) reported very good/excellent PrEP adherence on CASI, although 21% acknowledged over‐reporting adherence at least some …

Language Of Music And Its Psychophysical Foundations, Marina Korsakova-Kreyn

Lander College for Women - The Anna Ruth and Mark Hasten School Publications and Research

Application of music in rehabilitation medicine requires an understanding of the mechanisms of music perception. This article discusses differences in character of the basic melodic elements and addresses some of the specifics of tonal space. Colloquially, music is called the language of emotion. Bearing in mind that high-level cognitive functioning in humans is inseparable from affective consciousness, investigating the mechanisms of emotional processing belongs to an important area of cognitive sciences. Studying music perception can help to advance methods of music therapy and to elucidate major aspects of human consciousness.

Professional Judgment In An Era Of Artificial Intelligence And Machine Learning, Frank A. Pasquale

Faculty Scholarship

Though artificial intelligence (AI) in healthcare and education now accomplishes diverse tasks, there are two features that tend to unite the information processing behind efforts to substitute it for professionals in these fields: reductionism and functionalism. True believers in substitutive automation tend to model work in human services by reducing the professional role to a set of behaviors initiated by some stimulus, which are intended to accomplish some predetermined goal, or maximize some measure of well-being. However, true professional judgment hinges on a way of knowing the world that is at odds with the epistemology of substitutive automation. Instead of …

Genetic Patient Reform In The United States: The Growing Problem With § 101, Abigail Carlson

Fordham Undergraduate Law Review

With revolutionary findings in the biomedical industry growing exponentially, patents are more crucial than ever in crediting researchers for their property. Many of these patents are of genetic material which have rattled the fabric of trademark law. This paper aims to assess § 101 of the Patent Act and where genetic patents fall under the existing clauses. While most genetically modified patents have been upheld in the courts, precedent has established that there has to exist a certain degree of modification to the material to maintain the patent. This is because genetic material falls under the exception of the laws …

Dewitt Wallace Library Annual Report 2018-2019, Teresa Fishel, Aaron Albertson, Jacquelyn F. Betsworth, Christina Buckles, Trisha Burr, Dave Collins, Angi Faiks, Beth Hillemann, Katy Gabrio, Ellen Holt-Werle, Connie Karlen, Virginia Moran, Louann Terveer, Michael Vieaux

Annual Report - DeWitt Wallace Library

Summary of Macalester's DeWitt Wallace Library activities for 2018-2019.

Theme: Diversity, Equity, Inclusion

Signals For The Future: New Ways To Tackle Nuclear Risk, Erika Gregory, Editor, Tim Maly, Editor, Center For Complexity

N Square Innovators Network

N Square is a hands-on alliance between staff, funders, and advisors working together to bring new ideas, people, and perspectives to nuclear arms control. At the heart of N Square is the Innovators Network, a vibrant community of cross-sector leaders prototyping and piloting breakthrough approaches including open intelligence platforms, movement-building tools, and innovative uses of technologies such as blockchain, AI, and machine learning to verify arms control agreements. Innovators Network fellows are visionary leaders who recognize the opportunities embedded within tough challenges. They're scientists, game designers, Hollywood screenwriters, global security gurus. They're inventors, branding specialists, diplomats, Gen-Y satellite imagery analysts, …

Recent Developments: In Re Adoption/Guardianship Of H.W, Harry Smoots

University of Baltimore Law Forum

No abstract provided.

The Impact Of Xanthine Oxidase (Xo) On Hemolytic Diseases, Heidi M. Schmidt, Eric E. Kelley, Adam C. Straub

Faculty & Staff Scholarship

Hemolytic diseases are associated with elevated levels of circulating free heme that can mediate endothelial dysfunction directly via redox reactions with biomolecules or indirectly by upregulating enzymatic sources of reactive species. A key enzymatic source of these reactive species is the purine catabolizing enzyme, xanthine oxidase(XO) as the oxidation of hypoxanthine to xanthine and subsequent oxidation of xanthine to uric acid generates superoxide (O2•-) and hydrogen peroxide (H2O2). While XO has been studied for over 120 years, much remains unknown regarding specific mechanistic roles for this enzyme in pathologic processes. This gap in knowledge stems from several interrelated issues …

Chronic Enteroviral Meningoencephalitis In A Patient On Rituximab For The Treatment Of Psoriatic Arthritis: A Case Report And Brief Literature Review, Roberto Tellez, Allison M. Lastinger, Jeffery P. Hogg

Faculty & Staff Scholarship

Enteroviruses are RNA viruses within the Picornaviridae family. Enteroviruses derive their name from the way they are typically transmitted via the intestinal tract. They commonly infect millions of people every year and often do not cause severe disease in immunocompetent patients with few exceptions. Aseptic meningitis is a classic manifestation and is usually self-limited, however, can lead to severe neurological complications in an immunocompromised individual. It has been well-described that patients with hypogammaglobulinemia are predisposed to developing chronic enteroviral meningoencephalitis [1]. This is the first reported case of enteroviral meningoencephalitis in a patient being treated for psoriatic arthritis with rituximab …

Long Non-Coding Rna Fam83h-As1 Is Regulated By Human Papillomavirus 16 E6 Independently Of P53 In Cervical Cancer Cells, Jaime A. Barr, Karen E. Hayes, Tayvia Brownmiler, Abby D. Harold, Rajaganapathi Jagannathan, Paul R. Lockman, Saleem Khan, Ivan Martinez

Faculty & Staff Scholarship

High-risk human papillomavirus (HPV) infection is one of the first events in the process of carcinogenesis in cervical and head and neck cancers. The expression of the viral oncoproteins E6 and E7 are essential in this process by inactivating the tumor suppressor proteins p53 and Rb, respectively, in addition to their interactions with other host proteins. Non-coding RNAs, such as long non-coding RNAs (lncRNAs) have been found to be dysregulated in several cancers, suggesting an important role in tumorigenesis. In order to identify host lncRNAs affected by HPV infection, we expressed the high-risk HPV-16 E6 oncoprotein in primary human keratinocytes …

Mckee Library Annual Report 2018-2019, Southern Adventist University

Annual Reports

The 2018-2019 Annual Report includes statistics on library usage, information on collaborative learning, updates on campus research day, and updates on KnowledgeExchange.

Conduction Abnormalities After Transcatheter Aortic Valve Replacement, S. Kanjanauthai, K. Bhasin, L. Pirelli, C. A. Kliger

Journal Articles

© RADCLIFFE CARDIOLOGY 2019 Transcatheter aortic valve replacement (TAVR) has been established as a therapeutic option for patients with severe symptomatic aortic stenosis who are of intermediate or higher surgical risk. Several periprocedural complications are reduced with newer transcatheter heart valve generations; however, conduction abnormalities and the need for permanent pacemaker implantation have remained unchanged and are the most frequent TAVR complications. The close relationship of the atrioventricular node and left bundle branch to the subaortic region explains these potential conduction abnormalities. This article highlights conduction abnormalities after TAVR with a focus on basic conduction system anatomy in relation to …

The Evidence Of Human Exposure To Glyphosate: A Review, C. Gillezeau, M. Van Gerwen, R. M. Shaffer, I. Rana, L. Zhang, L. Sheppard, E. Taioli

Journal Articles

© 2019 The Author(s). Background: Despite the growing and widespread use of glyphosate, a broad-spectrum herbicide and desiccant, very few studies have evaluated the extent and amount of human exposure. Objective: We review documented levels of human exposure among workers in occupational settings and the general population. Methods: We conducted a review of scientific publications on glyphosate levels in humans; 19 studies were identified, of which five investigated occupational exposure to glyphosate, 11 documented the exposure in general populations, and three reported on both. Results: Eight studies reported urinary levels in 423 occupationally and para-occupationally exposed subjects; 14 studies reported …

Transfer Of Extracellular Vesicle-Associated-Rnas Induces Drug Resistance In Alk-Translocated Lung Adenocarcinoma, H. H. Kwok, Z. Ning, P. W. Chong, T. S. Wan, M. H. Ng, G. Y. Ho, M. S. Ip, D. C. Lam

Journal Articles

© 2019 by the authors. Licensee MDPI, Basel, Switzerland. Anaplastic lymphoma kinase (ALK) translocation is an actionable mutation in lung adenocarcinoma. Nonetheless tumour consists of heterogeneous cell subpopulations with diverse phenotypes and genotypes, and cancer cells can actively release extracellular vesicles (EVs) to modulate the phenotype of other cells in the tumour microenvironment. We hypothesized that EVs derived from a drug-resistant subpopulation of cells could induce drug resistance in recipient cells. We have established ALK-translocated lung adenocarcinoma cell lines and subclones. The subclones have been characterized and the expression of EV-RNAs determined by quantitative polymerase chain reaction. The effects of …

Anti-Inflammatory Effects Of Apocynin On Dextran Sulfate Sodium-Induced Mouse Colitis Model, Y. J. Hwang, S. J. Nam, W. Chun, S. I. Kim, S. C. Park, C. D. Kang, S. J. Lee

Journal Articles

© 2019 Hwang et al. This is an open access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited. Background and aim Various drugs have been developed for inflammatory bowel disease (IBD), but still there are limitations in the treatment due to the insufficient responses and significant adverse effects of immunosuppressant. Apocynin is an NADPH-oxidase inhibitor with established safety profiles. We aimed to investigate the protective efficacy of apocynin in IBD using chemicalinduced mouse colitis model. Method We induced experimental …

Imi – Defining And Classifying Myopia: A Proposed Set Of Standards For Clinical And Epidemiologic Studies, D. I. Flitcroft, M. He, J. B. Jonas, M. Jong, K. Naidoo, K. Ohno-Matsui, J. Rahi, S. Resnikoff, S. Vitale, L. Yannuzzi

Journal Articles

© 2019 The Authors. PURPOSE. We provide a standardized set of terminology, definitions, and thresholds of myopia and its main ocular complications. METHODS. Critical review of current terminology and choice of myopia thresholds was done to ensure that the proposed standards are appropriate for clinical research purposes, relevant to the underlying biology of myopia, acceptable to researchers in the field, and useful for developing health policy. RESULTS. We recommend that the many descriptive terms of myopia be consolidated into the following descriptive categories: myopia, secondary myopia, axial myopia, and refractive myopia. To provide a framework for research into myopia prevention, …

Choosing Core Outcomes For Use In Clinical Trials In Ophthalmology: Perspectives From Three Ophthalmology Outcomes Working Groups, I. J. Saldanha, J. T. Le, S. D. Solomon, M. X. Repka, E. K. Akpek, T. Li, N. Afshari, A. Ambrus, H. Perry, A. Wenick, +29 Additional Authors

Journal Articles

No abstract provided.

Safety And Efficacy Of Amniotic Cytokine Extract In The Treatment Of Dry Eye Disease., E. Yeu, D. F. Goldberg, F. S. Mah, K. A. Beckman, J. I. Luchs, J. D. Solomon, D. E. White, P. K. Gupta

Journal Articles

No abstract provided.

Primary Follicular Lymphoma Of The Bladder Mimicking Inflammatory Condition: Case Report And Review Of The Literature, N. Haghi, X. Zhang, J. Kreshover

Journal Articles

© 2019 The Authors Primary lymphoma of the bladder is rare and may present with nonspecific symptoms and infection. Primary follicular lymphoma of the bladder is extremely rare with only a dozen reported cases. We present one case clinically mimicking an inflammatory process. A 79 year-old woman presents with recurrent urinary tract infections, urinary incontinence and frequency. Cystoscopic examination demonstrated a raised but flat lesion, suspicious for inflammatory lesion. Biopsy revealed a diagnosis of follicular lymphoma, grade 1–2. The presentation of primary follicular lymphoma of the bladder may be nonspecific, therefore it is important to consider this diagnosis in patients …

Homozygous Nlrp1 Gain-Of-Function Mutation In Siblings With A Syndromic Form Of Recurrent Respiratory Papillomatosis, S. B. Drutman, F. Haerynck, F. L. Zhong, D. Hum, N. J. Hernandez, S. Belkaya, F. Rapaport, S. J. De Jong, V. R. Bonagura, J. Laurent-Casanova, +13 Additional Authors

Journal Articles

© 2019 National Academy of Sciences. All rights reserved. Juvenile-onset recurrent respiratory papillomatosis (JRRP) is a rare and debilitating childhood disease that presents with recurrent growth of papillomas in the upper airway. Two common human papillomaviruses (HPVs), HPV-6 and -11, are implicated in most cases, but it is still not understood why only a small proportion of children develop JRRP following exposure to these common viruses. We report 2 siblings with a syndromic form of JRRP associated with mild dermatologic abnormalities. Whole-exome sequencing of the patients revealed a private homozygous mutation in NLRP1, encoding Nucleotide-Binding Domain Leucine-Rich Repeat Family Pyrin …

Interrogating The Genetic Determinants Of Tourette's Syndrome And Other Tic Disorders Through Genome-Wide Association Studies, D. Yu, J. H. Sul, F. Tsetsos, M. S. Nawaz, A. Y. Huang, I. Zelaya, C. Illmann, C. L. Budman, C. Budman, M. Woods, +119 Additional Authors

Journal Articles

No abstract provided.

Gene Expression Imputation Across Multiple Brain Regions Provides Insights Into Schizophrenia Risk, L. M. Huckins, A. Dobbyn, D. M. Ruderfer, G. Hoffman, W. Wang, A. F. Pardinas, V. M. Rajagopal, T. D. Als, A. K. Malhotra, P. F. Sullivan, +343 Additional Authors

Journal Articles

No abstract provided.

Sexual Dimorphism Of Gut Microbiota Dictates Therapeutics Efficacy Of Radiation Injuries, M. Cui, H. Xiao, Y. Li, S. Zhang, J. Dong, B. Wang, C. Zhu, M. Jiang, H. Wang, S. Fan, +2 Additional Authors

Journal Articles

© 2019 The Authors. Published by WILEY-VCH Verlag GmbH & Co. KGaA, Weinheim Accidental or iatrogenic ionizing radiation exposure precipitates acute and chronic radiation injuries. The traditional paradigm of mitigating radiotherapy-associated adverse side effects has ignored the gender-specific dimorphism of patients' divergent responses. Here, the effects of sexual dimorphism on curative efficiencies of therapeutic agents is examined in murine models of irradiation injury. Oral gavage of simvastatin ameliorates radiation-induced hematopoietic injury and gastrointestinal tract dysfunction in male mice, but adversely deteriorates these radiation syndromes in female animals. In a sharp contrast, feeding animals with high-fat diet (HFD) elicites explicitly contrary …

Physician Agreement On The Diagnosis Of Sepsis In The Intensive Care Unit: Estimation Of Concordance And Analysis Of Underlying Factors In A Multicenter Cohort, B. K. Lopansri, R. R. Miller, J. P. Burke, M. Levy, S. Opal, M. Narasimhan, A. Tsegaye, S. Hahn, P. Mayo, R. B. Brandon, +19 Additional Authors

Journal Articles

© 2019 The Author(s). Background: Differentiating sepsis from the systemic inflammatory response syndrome (SIRS) in critical care patients is challenging, especially before serious organ damage is evident, and with variable clinical presentations of patients and variable training and experience of attending physicians. Our objective was to describe and quantify physician agreement in diagnosing SIRS or sepsis in critical care patients as a function of available clinical information, infection site, and hospital setting. Methods: We conducted a post hoc analysis of previously collected data from a prospective, observational trial (N = 249 subjects) in intensive care units at seven US hospitals, …

Probabilistic Modeling Of Personalized Drug Combinations From Integrated Chemical Screen And Molecular Data In Sarcoma, N. E. Berlow, R. Rikhi, M. Geltzeiler, J. Abraham, M. N. Svalina, L. E. Davis, E. Wise, M. Mancini, R. G. Maki, C. Keller, +19 Additional Authors

Journal Articles

No abstract provided.

A Phase 1 And Randomized Controlled Phase 2 Trial Of The Safety And Efficacy Of The Combination Of Gemcitabine And Docetaxel With Ontuxizumab (Morab-004) In Metastatic Soft-Tissue Sarcomas, R. L. Jones, S. P. Chawla, S. Attia, P. Schoffski, H. Gelderblom, B. Chmielowski, A. Le Cesne, B. A. Van Tine, J. C. Trent, R. G. Maki, +7 Additional Authors

Journal Articles

No abstract provided.

Developmental Subtypes Assessed By Dna Methylation-Iplex Forecast The Natural History Of Chronic Lymphocytic Leukemia, B. Giacopelli, Q. Zhao, A. S. Ruppert, A. Agyeman, C. Weigel, Y. Z. Wu, M. M. Gerber, K. G. Rabe, K. R. Rai, C. C. Oakes, +16 Additional Authors

Journal Articles

© 2019 by The American Society of Hematology Alterations in global DNA methylation patterns are a major hallmark of cancer and represent attractive biomarkers for personalized risk stratification. Chronic lymphocytic leukemia (CLL) risk stratification studies typically focus on time to first treatment (TTFT), time to progression (TTP) after treatment, and overall survival (OS). Whereas TTFT risk stratification remains similar over time, TTP and OS have changed dramatically with the introduction of targeted therapies, such as the Bruton tyrosine kinase inhibitor ibrutinib. We have shown that genome-wide DNA methylation patterns in CLL are strongly associated with phenotypic differentiation and patient outcomes. …

Electroconvulsive Therapy Modulates Resting-State Eeg Oscillatory Pattern And Phase Synchronization In Nodes Of The Default Mode Network In Patients With Depressive Disorder, A. Takamiya, J. Hirano, B. Yamagata, S. Takei, T. Kishimoto, M. Mimura

Journal Articles

© 2019 Takamiya, Hirano, Yamagata, Takei, Kishimoto and Mimura. Introduction: Electroconvulsive therapy (ECT) has antidepressant effects, but it also has possible cognitive side effects. The effects of ECT on neuronal oscillatory pattern and phase synchronization, and the relationship between clinical response or cognitive change and electroencephalogram (EEG) measurements remain elusive. Methods: Individuals with unipolar depressive disorder receiving bilateral ECT were recruited. Five minutes of resting, eyes-closed, 19-lead EEG recordings were obtained before and after a course of ECT. Non-overlapping 60 artifact-free epocs of 2-s duration were used for the analyses. We used exact low resolution electromagnetic tomography (eLORETA) to compute …

Improvement Of Psychiatrists’ Clinical Knowledge Of The Treatment Guidelines For Schizophrenia And Major Depressive Disorders Using The ‘Effectiveness Of Guidelines For Dissemination And Education In Psychiatric Treatment (Eguide)’ Project: A Nationwide Dissemination, Education, And Evaluation Study, Y. Takaesu, K. Watanabe, S. Numata, M. Iwata, N. Kudo, S. Oishi, T. Takizawa, K. Nemoto, T. Kishimoto, R. Hashimoto, +38 Additional Authors

Journal Articles

© 2019 The Authors. Psychiatry and Clinical Neurosciences published by John Wiley & Sons Australia, Ltd on behalf of Japanese Society of Psychiatry and Neurology Aim: Although treatment guidelines for pharmacological therapy for schizophrenia and major depressive disorder have been issued by the Japanese Societies of Neuropsychopharmacology and Mood Disorders, these guidelines have not been well applied by psychiatrists throughout the nation. To address this issue, we developed the ‘Effectiveness of Guidelines for Dissemination and Education in Psychiatric Treatment (EGUIDE)’ integrated education programs for psychiatrists to disseminate the clinical guidelines. Additionally, we conducted a systematic efficacy evaluation of the programs. …