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Articles 20401 - 20430 of 29632
Full-Text Articles in Entire DC Network
Modeling Human Cancer-Induced Cachexia, Erin E. Talbert, Maria C. Cuitin˜ O, Katherine J. Ladner, Priyani V. Rajasekerea, Melissa Siebert, Reena Shakya, Gustavo W. Leone, Michael C. Ostrowski, Brain Paleo, Noah Weisleder, Peter J. Reiser, Amy Webb, Cynthia D. Timmers, Daniel S. Eiferman, David C. Evans, Mary E. Dilhoff, Carl R. Schmidt
Modeling Human Cancer-Induced Cachexia, Erin E. Talbert, Maria C. Cuitin˜ O, Katherine J. Ladner, Priyani V. Rajasekerea, Melissa Siebert, Reena Shakya, Gustavo W. Leone, Michael C. Ostrowski, Brain Paleo, Noah Weisleder, Peter J. Reiser, Amy Webb, Cynthia D. Timmers, Daniel S. Eiferman, David C. Evans, Mary E. Dilhoff, Carl R. Schmidt
Faculty & Staff Scholarship
Talbert et al. developed an inducible mouse model of cachexia caused by pancreatic cancer. This model exhibits features of the human condition, including the progressive depletion of muscle and adipose tissue associated with tumor progression.
Biologically Inspired Design Of Context-Aware Smart Products, Ang Liu, Ivan Teo, Diandi Chen, Stephen Lu, Thorsten Wuest, Zhinan Zhang, Fei Tao
Biologically Inspired Design Of Context-Aware Smart Products, Ang Liu, Ivan Teo, Diandi Chen, Stephen Lu, Thorsten Wuest, Zhinan Zhang, Fei Tao
Faculty & Staff Scholarship
The rapid development of information and communication technologies (ICTs) and cyber–physical sys-tems (CPSs) has paved the way for the increasing popularity of smart products. Context-awareness isan important facet of product smartness. Unlike artifacts, various bio-systems are naturally characterizedby their extraordinary context-awareness. Biologically inspired design (BID) is one of the most commonlyemployed design strategies. However, few studies have examined the BID of context-aware smart prod-ucts to date. This paper presents a structured design framework to support the BID of context-awaresmart products. The meaning of context-awareness is defined from the perspective of product design.The framework is developed based on the theoretical foundations …
The Role Of Sirt1 In Skeletal Muscle Function And Repair Of Older Mice, Mathew J. Myers, Danielle L. Sheperd, Andrya J. Durr, David S. Stanton, Junaith S. Mohamed, John M. Hollander, Stephen E. Alway
The Role Of Sirt1 In Skeletal Muscle Function And Repair Of Older Mice, Mathew J. Myers, Danielle L. Sheperd, Andrya J. Durr, David S. Stanton, Junaith S. Mohamed, John M. Hollander, Stephen E. Alway
Faculty & Staff Scholarship
Background Sirtuin 1 (SIRT1) is a NAD+ sensitive deacetylase that has been linked to longevity and has been suggested to confer beneficial effects that counter aging-associated deterioration. Muscle repair is dependent upon satellite cell function, which is reported to be reduced with aging; however, it is not known if this is linked to an aging-suppression of SIRT1. This study tested the hypothesis that Sirtuin 1 (SIRT1) overexpression would increase the extent of muscle repair and muscle function in older mice. Methods We examined satellite cell dependent repair in tibialis anterior, gastrocnemius, and soleus muscles of 13 young wild-type mice (20–30 …
A New Transgenic Reporter Line Reveals Wnt-Dependent Snai2 Re-Expression And Cranial Neural Crest Differentiation In Xenopus, Jiejing Li, Mark Perfetto, Christopher Materna, Rebecca Li, Hong Thi Tran, Kris Vleminckx, Melinda K. Duncan, Shuo Wei
A New Transgenic Reporter Line Reveals Wnt-Dependent Snai2 Re-Expression And Cranial Neural Crest Differentiation In Xenopus, Jiejing Li, Mark Perfetto, Christopher Materna, Rebecca Li, Hong Thi Tran, Kris Vleminckx, Melinda K. Duncan, Shuo Wei
Faculty & Staff Scholarship
During vertebrate embryogenesis, the cranial neural crest (CNC) forms at the neural plate border and subsequently migrates and diferentiates into many types of cells. The transcription factor Snai2, which is induced by canonical Wnt signaling to be expressed in the early CNC, is pivotal for CNC induction and migration in Xenopus. However, snai2 expression is silenced during CNC migration, and its roles at later developmental stages remain unclear. We generated a transgenic X. tropicalis line that expresses enhanced green fuorescent protein (eGFP) driven by the snai2 promoter/enhancer, and observed eGFP expression not only in the pre-migratory and migrating CNC, but …
Characterization And Localization Of Cyclin B3 Transcript In Both Oocyte And Spermatocyte Of The Rainbow Trout (Oncorhynchus Mykiss), Wenzhi Guan, Liangjie Qiu, Bo Zhang, Jianbo Yao, Qing Xiao, Gaofeng Qiu
Characterization And Localization Of Cyclin B3 Transcript In Both Oocyte And Spermatocyte Of The Rainbow Trout (Oncorhynchus Mykiss), Wenzhi Guan, Liangjie Qiu, Bo Zhang, Jianbo Yao, Qing Xiao, Gaofeng Qiu
Faculty & Staff Scholarship
B-type cyclins are regulatory subunits with distinct roles in the cell cycle. To date, at least three subtypes of B-type cyclins (B1, B2, and B3) have been identified in vertebrates. Previously, we reported the characterization and expression profiles of cyclin B1 and B2 during gametogenesis in the rainbow trout (Oncorhynchus mykiss). In this paper, we isolated another subtype of cyclin B, cyclin B3 (CB3), from a cDNA library of the rainbow trout oocyte. The full-length CB3 cDNA (2,093 bp) has an open reading frame (1,248 bp) that encodes a protein of 416 amino acid residues. The CB3 transcript …
Fib-Sem Three-Dimensional Tomography For Characterization Of Carbon-Based Materials, Nan Nan, Jingxin Wang
Fib-Sem Three-Dimensional Tomography For Characterization Of Carbon-Based Materials, Nan Nan, Jingxin Wang
Faculty & Staff Scholarship
A review on the recent advances of the three-dimensional (3D) characterization of carbon-based materials was conducted by focused ion beam-scanning electron microscope (FIB-SEM) tomography. Current studies and further potential applications of the FIB-SEM 3D tomography technique for carbon-based materials were discussed. The goal of this paper is to highlight the advances of FIB-SEM 3D reconstruction to reveal the high and accurate resolution of internal structures of carbon-based materials and provide suggestions for the adoption and improvement of the FIB-SEM tomography system for a broad carbon-based research to achieve the best examination performances and enhance the development of innovative carbon-based materials.
A Praxis Briefing: Mental Health On The Campus: Defining Challenges And Opportunities, Stephen Beers, Connie Horton, Brad A. Lau, Nathan Greer, C. Skip Trudeau, Kim Stave, Brenda Roth
A Praxis Briefing: Mental Health On The Campus: Defining Challenges And Opportunities, Stephen Beers, Connie Horton, Brad A. Lau, Nathan Greer, C. Skip Trudeau, Kim Stave, Brenda Roth
Growth: The Journal of the Association for Christians in Student Development
No abstract provided.
I Am, Because We Are: Intersubjectivity And The Ethics Of Care In Student-Teacher Relationships, Sanjana Kothary
I Am, Because We Are: Intersubjectivity And The Ethics Of Care In Student-Teacher Relationships, Sanjana Kothary
Student Library Research Awards
100/200-level Award recipient for 2019. Project completed for course EDUC 215. Supporting faculty: Deepa Vasudevan
Characterizing Sid2p Kinase Recruitment To The Contractile Ring During Cell Division In Schizosaccharomyces Pombe, Emma M. Magee
Characterizing Sid2p Kinase Recruitment To The Contractile Ring During Cell Division In Schizosaccharomyces Pombe, Emma M. Magee
Honors Thesis Collection
No abstract provided.
The Impact Of Stereotypical Cues On Women’S College Students’ Sense Of Belonging In Computer Science, Jessica Abramson
The Impact Of Stereotypical Cues On Women’S College Students’ Sense Of Belonging In Computer Science, Jessica Abramson
Honors Thesis Collection
No abstract provided.
Characterization Of Hybrid Antimicrobial Peptides, Ju Young Kwag
Characterization Of Hybrid Antimicrobial Peptides, Ju Young Kwag
Honors Thesis Collection
No abstract provided.
Determining The Function Of The Imprinted, Brain Enriched Mir-379/410 Mirna Cluster In In Vitro Derived Neurons, Hannah Jacobs, Phillip A. Sharp, Amanda Whipple
Determining The Function Of The Imprinted, Brain Enriched Mir-379/410 Mirna Cluster In In Vitro Derived Neurons, Hannah Jacobs, Phillip A. Sharp, Amanda Whipple
Honors Thesis Collection
No abstract provided.
Networking In The Dark: Social Capital And Online Networks For Less Privileged College Applicants, Debra Rowcroft
Networking In The Dark: Social Capital And Online Networks For Less Privileged College Applicants, Debra Rowcroft
Honors Thesis Collection
This project analyzes the different ways less privileged students apply to college, the tools they use to prepare for admissions, and the information they receive from their networks about higher education. Building from Bourdieu’s theories on capital and field, this study highlights how students from non-dominant backgrounds have to adapt and overcome to succeed in an admissions system designed to reward the cultural capital available to students from educated families. I conducted 18 in depth, semi structured interviews with high school students and recent graduates to uncover the motivations and behaviors in their college choice process. Information in their immediate …
Vinod And The Patels: The Puzzle Of Indian-American Partisanship, Ananya Hariharan
Vinod And The Patels: The Puzzle Of Indian-American Partisanship, Ananya Hariharan
Honors Thesis Collection
This project investigates Indian American partisanship. Why, despite several large cleavages like religion and income, do most Indian Americans identify with a single party? Building on a long tradition of studying partisanship, I posit that Indian-Americans share a group consciousness borne out of experiences of racial discrimination. This group consciousness drives Indian-Americans to identify as Democrats. First, I present several theories of party identification and evaluate their explanatory power, both theoretically and when applied to other groups, such as Jewish Americans and Asian-Americans. I then present an original theory of party identification in the Indian-American community. Next, I explore the …
Investigating The Role Of N-Methyl-D-Aspartate Receptor Subunit Exchange In Visual Recognition Memory, Ying Li
Honors Thesis Collection
Visual memory is a complex neurophysiological process wherein visual inputs are transduced and encoded within networks of synapsing neurons. At the core of this system are neurotransmitters and postsynaptic receptors, including N-methyl-D-aspartate (NMDA) receptors, which are necessary for visual memory in mice. Interestingly, with age there is a predictable, visual experience-dependent replacement of NMDA receptor subunit NR2B by a second subunit, NR2A. Both subunits have been implicated in regulating potentiation in the murine primary visual cortex (V1) in response to visual stimulus in other forms of plasticity, such as ocular dominance. The goal of this project was to characterize NMDA …
Quantifying Air-Sea Gas Exchange At High Wind Speeds Using Noble Gas Measurements: Insights From The Sustain Wind-Wave Tank, Lumi Kinjo
Honors Thesis Collection
Gas exchange at high wind speed is not well understood—few studies have been conducted at wind speeds above 15 m s-1, and significant disagreement exists between gas exchange models at high wind speeds. In particular, the flux due to bubbles is not explicitly included in many gas exchange models, despite the fact that bubble-mediated gas exchange becomes increasingly important at higher wind speeds. The goal of my thesis project is to quantify air-sea gas exchange under high wind speeds and to examine the relationship between noble gas measurements, bubble spectra, wave-type, and water temperature. Noble gases serve as excellent tracers …
Too Many Men On The Ice: Intersections Of Gender, Race, And Sexuality In The Nhl, Anne Coyne
Too Many Men On The Ice: Intersections Of Gender, Race, And Sexuality In The Nhl, Anne Coyne
Honors Thesis Collection
No abstract provided.
The Scientist And American Cinema: Trends And Case Studies, Ciara Wardlow
The Scientist And American Cinema: Trends And Case Studies, Ciara Wardlow
Honors Thesis Collection
This thesis explores historical trends in the depiction of scientists in popular film from 1931 to present, emphasizing how both scientific developments and current events influence the characterization of movie scientists and how these popular depictions of scientists can, in turn, have real-world influence. In addition to giving a historical overview of these trends, this thesis examines case studies looking specifically at the evolving relationship between space science and cinema, the representation of historical scientists in biographical films, and the evolution of scientist characters in two scientist-starring short stories, "Who Goes There?" and "The Fly," and their respective film adaptations …
Regioselective Synthesis Of N1-Pyrazoles Using Pyridine Electrophiles, Si Tong Bao
Regioselective Synthesis Of N1-Pyrazoles Using Pyridine Electrophiles, Si Tong Bao
Honors Thesis Collection
No abstract provided.
Municipal Composting Programs In Massachusetts: What Works, Where, Why And How?, Kimberly Chia Yan Min
Municipal Composting Programs In Massachusetts: What Works, Where, Why And How?, Kimberly Chia Yan Min
Honors Thesis Collection
The disposal of municipal solid waste is a cause of concern in its potential for pollution and its contribution to greenhouse gas emissions, pushing municipalities to embrace greener waste management strategies. Within this context, composting has grown in importance in recent years, particularly as an organic waste management strategy. This includes implementing curbside compostable waste collection programs, operating food scrap drop-off sites, and distributing compost bins. Given that municipal composting seems to be the way forward for many municipalities, it is crucial to ensure that such schemes are environmentally just, economically equitable and socially accessible. My thesis examines within the …
Quantifying The Effects Of Cell Wall Synthases In Schizosaccharomyces Pombe Using Atomic Force Microscopy, Justine Hsu
Quantifying The Effects Of Cell Wall Synthases In Schizosaccharomyces Pombe Using Atomic Force Microscopy, Justine Hsu
Honors Thesis Collection
No abstract provided.
A Systematic Approach To Understanding Macromolecular Crowding Effects On Biomolecular Interactions: Insights From Theoretical, “Toy” Model Systems, Rachel Kim
Honors Thesis Collection
No abstract provided.
Perturbing Cell Fate Utilizing A Whole-Cell Mrna Transfection Approach, Siyan Liu
Perturbing Cell Fate Utilizing A Whole-Cell Mrna Transfection Approach, Siyan Liu
Honors Thesis Collection
No abstract provided.
The Induction And Reduction Of Epithelial To Mesenchymal Transition In A Co-Culture Model Of The Airway Epithelium, Emily Liao
Honors Thesis Collection
Fibrosis is an incurable feature underlying chronic lung and airway diseases including chronic obstructive pulmonary disease (COPD) and idiopathic pulmonary fibrosis (IPF) that causes partial or total occlusion of the airway with fibrous tissue. In addition to causing these diseases, fibrosis also limits the effectiveness of lung transplants as a long-term treatment for end-stage diseases by causing the complication bronchiolitis obliterans syndrome (BOS). In order to improve our understanding of airway fibrosis, we have developed and characterized an in vitro cell co-culture model composed of airway epithelial cells and blood vessel endothelial cells through which we can induce fibrotic development. …
Evolutionary Development Of The Mammalian Pre-Sternum, Zeynep Yozgyur
Evolutionary Development Of The Mammalian Pre-Sternum, Zeynep Yozgyur
Honors Thesis Collection
The mammalian sternum has undergone a reduction in relative size and complexity over evolutionary time. This transformation was highly variable across species, generating multiple, controversial interpretations. Some authors claim that the evolutionary reduction led to loss of presternal elements, while others believe that all, or some, presternal elements were fused into a structure ambiguously referred to as the “manubrium”, a term adopted from the post-interclavicular unit of pre-mammalian ancestors. Previous work on the Paramylodon harlani presternum revealed a composite presternum and identified three elements - mediocranial, mediocaudal and lateral - each with a different developmental origin and marginal articulation. This …
The Role Of Nitrification, And Nitrate And Oxygen Diffusion In Enhancing Dissimilatory Nitrate Reduction To Ammonium In Agricultural Soils., Andrea Sama
Honors Thesis Collection
No abstract provided.
The Phosphatidylinositol-4 Kinase Genes, Pppi4kα1 And Pppi4kα2, Of Physcomitrella Patens: Crispr-Cas9 Mutagenesis And Development Of Promoter::Reporter Lines For Spatial Expression Analysis, Zijing Li
Honors Thesis Collection
No abstract provided.
An Unbiased Variance Estimator Of A K-Sample U-Statistic With Application To Auc In Binary Classification, Alexandria Guo
An Unbiased Variance Estimator Of A K-Sample U-Statistic With Application To Auc In Binary Classification, Alexandria Guo
Honors Thesis Collection
Many questions in research can be rephrased as binary classification tasks, to find simple yes-or-no answers. For example, does a patient have a tumor? Should this email be classified as spam? For classifiers trained to answer these queries, area under the ROC (receiver operating characteristic) curve (AUC) is a popular metric for assessing the performance of a binary classification method, where a larger AUC score indicates an overall better binary classifier. However, due to sampling variation, the model with the largest AUC score for a given data set is not necessarily the optimal model. Thus, it is important to evaluate …
How Speech Can Constitute Discrimination: Using Philosophy Of Language To Analyze Hostile Work Environment Sexual Harassment, Kate Applegate
How Speech Can Constitute Discrimination: Using Philosophy Of Language To Analyze Hostile Work Environment Sexual Harassment, Kate Applegate
Honors Thesis Collection
No abstract provided.
Charicleia’S Dream: Interpreting The Heroine Of A Greek Romance, Isabelle Raposo
Charicleia’S Dream: Interpreting The Heroine Of A Greek Romance, Isabelle Raposo
Honors Thesis Collection
No abstract provided.