Digital Commons Network^™

Examining The Role Of The Unfolded Protein Response In Depression, Matthew Timberlake

All ETDs from UAB

Depression is the leading cause of disability worldwide and impacts nearly 350 million people with a disproportionate representation in women with a 1:1.7 ratio of occurrence compared to men. This disorder is characterized by shifts in mood to include feelings of hopelessness, sadness, and lethargy as well as changes in diet, motivation, and sleep patterns. Further, over 50% of patients who struggle with depression also have suicidal ideation and as many as 10% of those commit suicide. At present, treatment plans include behavioral therapy (often) in conjunction with antidepressant medications which act on monoamines and their circuits in the central …

Discovering The Genetic Architecture Underlying Exercise Response Using Drosophila Melanogaster, Louis P. Watanabe

All ETDs from UAB

The growth of modern jobs, technology, and transportation has coincided with increased sedentary behavior in many developed nations. In the United States, this increase has contributed partially to rising rates of obesity, leading to more than 78 million obese individuals. The annual medical costs associated with obesity are thought to range from 147 to 210 billion dollars. The initial treatment recommendations for individuals with obesity are increased exercise and changes in diet. Despite the strong narrative pushing exercise as a health benefit, individual responses can vary widely, and little is known regarding the genetic networks modulating exercise response. In order …

Examining Web-Based Lifestyle Interventions For Cancer Survivors, Victoria Williams

All ETDs from UAB

Diet, physical activity, and body weight status are important modifiable risk factors for many health outcomes among cancer survivors, including cancer recurrence. Face-to-face, print, and mailed lifestyle interventions have been used to promote behavior change in cancer survivors successfully. However, such approaches are costly and have limited reach. Web-based lifestyle interventions represent a promising solution to this public health concern. Therefore, this project involved first reviewing and identifying gaps in the existing literature in this area and then developing and pilot testing a web-based lifestyle intervention for cancer survivors. For this three-part dissertation, study 1 was a narrative review of …

Genetic And Epigenetic Underpinnings Of End-Stage Human Heart Failure, Mark Emile Pepin

All ETDs from UAB

Heart failure (HF) is the clinical endpoint of numerous diseases that negatively impact the heart’s capacity to pump and/or fill with blood. A variety of genetic and environmental factors have been identified as critical determinants of HF susceptibility; however, these factors cannot independently explain the phenotypic diversity of human HF. Instead, a complex interplay has been theorized to exist between genetics and the environment, although the molecular underpinnings of this synergy remain poorly understood. Of the possible mechanisms, epigenetic influences are uniquely capable of explaining how acute stressors of the cardiac microenvironment trigger the stable – yet reversible – reprogramming …

Meat: A Novel, Sergey Belyaev, Boris Pilnyak, Ronald D. Leblanc

Faculty Publications

An English-language translation of a Russian novel that appeared in the Soviet thick journal "Novyi Mir" in three installments during February, March, and April of 1936.

Designing And Implementing Inclusive Community-Based Health Promotion Intiatives, Cassandra Herman

All ETDs from UAB

Background: People with disabilities (PWDs) have poorer health outcomes, yet are they are underserved by public health initiatives. PWDs face numerous barriers to participation in community-based health programs despite mounting evidence about these barriers along with recommendations and guidelines to become more inclusive of disability. Policy, system, and environmental (PSE) changes that are inclusive of PWDs can help create access to health promotion programs for PWDs. Systematically implementing inclusive PSE changes using implementation science principles can support effective and sustainable changes are implemented for each unique community context. The purpose of this dissertation is to explore the experiences of public …

Effectiveness Of Cardiopulmonary Rehabilitation On The Functional Capacity Of Cardiac Patients One-Year Post Rehab, Danish Gulamani

All ETDs from UAB

ABSTRACT Cardiac rehabilitation (CR) programs are designed to improve functional capacity, quality of life, reduce cardiovascular risk factors, and improve psychosocial well-being through lifestyle management strategies. While CR programs effectively reduce cardiovascular disease (CVD) risk factors and improve functional capacity at discharge, little is known regarding long-term lifestyle behavior changes and changes in functional capacity that occur following discharge. PURPOSE: Examine changes in 6-minute walk distance (6MWD) 11-15 months following discharge from CR to evaluate long-term changes in functional capacity. METHODS: Patients who completed 24-36 sessions and 6-minute walk tests [6MWT, intake, discharge, and post-discharge (11-15 months following discharge)] between …

The Weight Of Social Relationships: Social Network Analysis In An Adult Weight Loss Program, Alena Borgatti

All ETDs from UAB

Adult behavioral obesity interventions often show improved attendance and weight loss when delivered in a group, as opposed to individual, therapy format. However, research on the exact mechanisms through which group therapy confers additional weight loss is lacking. Pediatric obesity interventions have recently begun to utilize social network analysis (SNA) to identify structural ties that may improve adherence and weight loss; however, this research is limited and has yet to be replicated in an adult weight loss program. The current study is the first to evaluate social networks in an adult behavioral weight loss intervention. Four weight loss groups were …

Social Support And Self-Care Efficacy As Mediators Of Racial Disparities In Diabetes Health In Older Adults, Wesley Browning

All ETDs from UAB

Diabetes is a health problem that affects millions of Americans annually, and Black Americans have a higher prevalence with more complications than White Americans. A disparity exists between Black and White older adults living with diabetes in distress related to symptoms, treatment, and complications associated with the disease. Additionally, there are differences in levels of performing diabetes self-care behaviors between Blacks and Whites. One series of factors that may predict better diabetes self-care and diabetes distress in older adults are self-care efficacy and components of social support. This study used linear regression models to predict racial differences between Blacks and …

Associations Between Dietary Fat Intake And Waist Circumference, Phonchit Teng Soukhamneut

All ETDs from UAB

The objective of this study was to assess: 1) trends in dietary fat intake from 2003-2016 2) the association between type of dietary fat intake and waist circumference (WC), 3) the association between type of dietary fat intake and body shape, and 4) whether these associations vary by sex and race/ethnicity. This secondary data analysis included 27,057 adults aged 19 to 65 from the National Health and Examination Survey (NHANES) 2003-2016. For WC, participants were categorized into high-risk (men: WC ≥ 40 in; women: WC ≥ 35 in) and low-risk (men: WC < 40 in; women: WC < 35 in). Total fat intake was categorized as high (TOTFAT ≥ 35%) and low (TOTFAT< 35%). Saturated fat intake was categorized into high (SATFAT ≥ 10%) and low (SATFAT < 10%). Unsaturated fat intake was categorized into high (UNSATFAT ≥ 25%) and low (UNSATFAT < 25%). Logistic regression was performed to assess the associations between DFI and WC and DFI and body shape, controlling for age, BMI, and total caloric intake. NHW men with high TOTFAT were found to have 1.41 (OR: 1.41, 1.19 – 1.68) times the odds of having a high-risk WC compared to men with a diet low in TOTFAT, controlling for age, BMI, and total caloric intake. NHW men with a diet high in SATFAT were at increased odds of having a high-risk WC compared to men with a diet low in SATFAT, after controlling for covariates (OR: 1.49, 1.21 -1.84). NHW men with a diet high in UNSATFAT were at increased odds of having a high-risk WC compared to men with a diet low in UNSATFAT after controlling for covariates (OR: 1.375, 1.09 – 1.74). There were no significant associations found among NWB and MA men for any type of dietary fat intake. For women, no associations were found between type of dietary fat and WC by race/ethnicity. There were no associations between DFI and body shape by race/ethnicity groups and sex. Future studies are needed to further investigate the body shape cut-off points for increased risk associated with chronic disease.

Methods For The Establishment Of A Dss-Induced Ibd Model In Adult Zebrafish, Ningxiang Zeng

All ETDs from UAB

Inflammatory Bowel Disease (IBD) is a group of idiopathic chronic inflammatory intestinal conditions. To reveal its pathogenesis, several different animal models have been established. Although no single model captures the complexity of human IBD, each model provides valuable insights into one or another major aspect of disease, and together they have led to the establishment of a generally accepted understanding for human IBD pathogenesis. Recently, zebrafish have become an important platform for IBD research, and several murine IBD outcomes have been adapted to the zebrafish. Dextran Sulfate Sodium (DSS) -induced colitis, the most widely used murine IBD model, has never …

Exploring The Link Between Dietary Fiber, The Gut Microbiota And Estrogen Metabolism Among Women With Breast Cancer, Ayse G. Zengul

All ETDs from UAB

Breast cancer continues to be a very prevalent disease and impacts over 260,000 new patients per year in the United States. The gut microbiota composition may affect breast cancer risk by modulating various hormonal metabolites including endogenous estrogens. Dietary factors impact gut microbial ecology and influence the regulation of estrogen metabolism. Current evidence supports the potential role of dietary fiber in breast cancer prevention and its possible modulating influence on serum estrogen levels through the gut microbiota associated with β-glucuronidase activity. However, this mechanism is not clearly understood. In this study, we aimed to explore the associations between dietary fiber, …

The Mechanism Of Glucose-Induced Trib3 Expression In Myoblasts And Myotubes, Xiaobing Liu

All ETDs from UAB

Our previous data indicates that glucose-toxicity is dependent upon upregulation of TRIB3 expression in muscle. TRIB3 is a glucose-responsive gene and, as a pseudokinase, it blocks phosphorylation of AKT resulting in insulin resistance. The purpose of the current study was to identify the role of the differentiation process and the minimal functional sequence of TRIB3 promoter region in modulating glucose-induced TRIB3 gene expression in C2C12 myocytes. First, C2C12 myocytes were collected every 48 hours during the whole differentiation, totally 4 intervals. Before collection, cells were treated with either 5mmol glucose or 25mmol glucose for 24 hours. Under 5mmol glucose, the …

Synthesis Of Silver Nanoparticles Using A Modified Tollens’ Method In Conjunction With Phytochemicals And Assessment Of Their Antimicrobial Activity, Muna A. Abudalo, Ismaeel R. Al-Mheidat, Alham W. Al-Shurafat, Colleen Grinham, Vinka Oyanedel-Craver

Civil & Environmental Engineering Faculty Publications

Background: Silver nanoparticles (AgNPs) have attracted great attention due to their outstanding electrical, optical, magnetic, catalytic, and antimicrobial properties. However, there is a need for alternative production methods that use less toxic precursors and reduce their undesirable by-products. Phyto-extracts from the leaves of olive and rosemary plants can be used as reducing agents and (in conjunction with Tollens’ reagent) can even enhance AgNP antimicrobial activity.

Methods: Conditions for the proposed hybrid synthesis method were optimized for olive leaf extracts (OLEs) and rosemary leaf extracts (RLEs). The resultant AgNPs were characterized using UV–visible spectroscopy, an environmental scanning electron microscope, …

Subversive Science, Dov Fox

Penn State Law Review (2003 - Present)

This Article introduces the phenomenon of subversive science, reveals its operation in modern American society, and analyzes its implications for law and policy amidst calls to defund or repress controversial lines of inquiry. Existing debates center on whether cutting-edge science casts doubt on abstract ideals that animate our legal system, from racial equality to criminal responsibility. This focus misses the deeper and more practical danger that lies in how citizens misperceive and misapply these ideals in election and trial decisions. What makes certain science “subversive” is its power to shake the public’s faith in those democratic cornerstones.

Emerging bodies of …

Patient Care In High-Level Containment Care Units: In A Resourced Setting, Angela M. Vasa, Kate C. Boulter, Jolene M. Horihan, David S. Cates, Craig A. Piquette, James N. Sullivan, Daniel W. Johnson, Angela L. Hewlett

Books and Book Chapters: Nebraska Medicine

Vasa, A., Boulter, K., Horihan, Cates, D., Piquette, C., Sullivan, J., Johnson, D, & Hewlett, A. (2019). Patient Care in High-Level Containment Care Units. In T. Cieslak, M. Kortepeter, C. Kratochvil, & J. Lawler (Eds.), Nebraska Isolation and Quarantine Manual (pp. 87-101). Lincoln, NE: University of Nebraska Press.

Multistate Outbreaks Of Foodborne Illness In The United States Associated With Fresh Produce From 2010 To 2017, Christina K Carstens, Joelle K Salazar, Charles Darkoh

Faculty, Staff and Student Publications

In the United States, the consumption of fresh fruits and vegetables has increased during recent years as consumers seek to make healthier lifestyle choices. However, the number of outbreaks associated with fresh produce that involve cases in more than one state (multistate) has increased concomitantly. As the distance along the farm-to-fork continuum has lengthened over time, there are also more opportunities for fresh produce contamination with bacterial pathogens before it reaches the consumer. This review provides an overview of the three bacterial pathogens (i.e., pathogenic

Afterlives Of Indigenous Archives, Ivy Schweitzer, Gordon Henry Jr

Dartmouth Scholarship

Afterlives of Indigenous Archives offers a compelling critique of Western archives and their use in the development of “digital humanities.” The essays collected here present the work of an international and interdisciplinary group of indigenous scholars; researchers in the field of indigenous studies and early American studies; and librarians, curators, activists, and storytellers. The contributors examine various digital projects and outline their relevance to the lives and interests of tribal people and communities, along with the transformative power that access to online materials affords. The authors aim to empower native people to re-envision the Western archive as a site of …

The Gendered Burdens Of Conviction And Collateral Consequences On Employment, Joni Hersch, Erin E. Meyers

Vanderbilt Law School Faculty Publications

Ex-offenders are subject to a wide range of employment restrictions that limit the ability of individuals with a criminal background to earn a living. This Article argues that women involved in the criminal justice system likely suffer a greater income-related burden from criminal conviction than do men. This disproportionate burden arises in occupations that women typically pursue, both through formal pathways, such as restrictions on occupational licensing, and through informal pathways, such as employers’ unwillingness to hire those with a criminal record. In addition, women have access to far fewer vocational programs while incarcerated. Further exacerbating this burden is that …

Factors Influencing Nurse Practitioners' Weight Management Practices In Primary Care, Suzanne Hyer

Electronic Theses and Dissertations

More American adults are overweight or obese than ever before. Nurse practitioners (NPs) play a critical and expanding role in primary care, which is an ideal setting for the assessment and management of weight loss. NPs can make a significant contribution to tackling the obesity crisis. The study presented here seeks to close the gap in data related to how NPs approach weight management with their primary care patients. This study focused on a comprehensive examination of the current practice patterns of NPs related to weight management, a theoretical concept analysis of weight bias among healthcare providers, along with the …

The Sustained Impact Of Prekindergarten Participation On Third Grade Academic Performance, Marissa Melin

Electronic Theses and Dissertations

In this study, the researcher investigated whether the impact of participating in a prekindergarten program on academic achievement persists through third grade. The study compared three groups of students: students who participated in voluntary prekindergarten, private prekindergarten, and students who did not participate in any prekindergarten program. Using a series of two-factor multivariate analyses of variance (MANOVAs), this investigation found no interaction effects among prekindergarten participation and race, gender, socioeconomic status, presence of a discipline referral, or chronic absenteeism on academic achievement in the third grade. However, there was a main effect for the type of prekindergarten program on academic …

An Investigation Of The Appropriateness Of The English Language Learner Accountability Mark Established By The Every Student Succeeds Act Of 2015, Francisco Rivera

Electronic Theses and Dissertations

This quantitative study sought to disclose and describe differences in academic performance between English language learners (ELLs) and non-English language learners (non-ELLs) in grades sixth, seventh, and eighth during the two-year period of 2016 – 2018. A two-year period was utilized because of the two-year ELL accountability mark established by the Every Student Succeeds Act (ESSA) of 2015. The study used i-Ready diagnostic data, in both mathematics and reading, as the performance measures, and used ACCESS for ELLs (WIDA) tier scores (i.e., WIDA Tier A, WIDA Tier B, and WIDA Tier C) to identify the level of English language acquisition …

A Comparison Of Self-Service Technologies (Ssts) In The U.S. Restaurant Industry: An Evaluation Of Consumer Perceived Value, Satisfaction, And Behavioral Intentions, Motaz Zaitouni

Electronic Theses and Dissertations

Innovation in technology has been growing rapidly in recent years. Many restaurants have been utilizing different types of self-service technologies (SSTs) to enhance their operations and customer satisfaction. Despite, the rapid spread of SSTs in the restaurant industry, very limited empirical research has been conducted to evaluate the influence of SSTs type on customer dining experience. Therefore, the purpose of this dissertation was to examine the SSTs values that influence restaurant customers' satisfaction and their decision to continue to reuse SSTs. More specifically, this study utilized the Theory of Consumption Values (TCV) to examine consumers' perception of the SST values …

Promoting Physical Activity In Regional And Remote Cancer Survivors (Pparcs) Using Wearables And Health Coaching: Randomised Controlled Trial Protocol, Sarah J. Hardcastle, Dana Hince, Ruth Jimenez-Castuera, Terry Boyle, Vinicius Cavalheri, Greg Makin, Patrick Tan, Stuart Salfinger, Jason Tan, Ganendra Raj Mohan, Michael Levitt, Paul A. Cohen, Christobel Saunders, Cameron Platell

Health Sciences Papers and Journal Articles

Introduction: Physically active cancer survivors have substantially less cancer recurrence and improved survival compared with those who are inactive. However, the majority of survivors (70%–90%) are not meeting the physical activity (PA) guidelines. There are also significant geographic inequalities in cancer survival with poorer survival rates for the third of Australians who live in nonmetropolitan areas compared with those living in major cities. The primary objective of the trial is to increase moderate-to-vigorous PA (MVPA) among cancer survivors living in regional and remote Western Australia. Secondary objectives are to reduce sedentary behaviour and in conjunction with increased PA, improve quality …

Anticipating Aging And Prospecting Pension For Retirement Well-Being, Roberto E. Javier Jr., Mitzie Irene Conchada, Melvin Jabar

DLSU Business & Economics Review

Filipino young and middle-aged adults anticipate old age positively as it is a mark of achievement in human life but negatively apprehend living through their old age, given the high incidence of poverty among the elderly in the Philippines. The issues surrounding the insurance system, income security, and social pension in old age were all related to unfavorable views about living through the aging years. In-depth group interviews (IGIs) conducted across cities and municipalities in the countryside generated conceptions about aging and concerns about becoming old in a society with no strong social protection for its graying population. A qualitative …

Undergraduate Catalog, Georgia Southern University

Undergraduate & Graduate Catalogs

No abstract provided.

Genetic Diversity And Agronomic Performance Of Slovenian Landraces Of Proso Millet (Panicum Miliaceum L.), Marko Flajsman, Natasa Stajner, Darja Kocjan Acko

Turkish Journal of Botany

Proso millet (Panicum miliaceum L.) has many favored nutritional and agronomic traits, which makes it appropriate for cultivation and consumption all around the world. Genomic resources for proso millet are still very limited but the set of genomic data is improving. In this study, we genotyped six Slovenian landraces of proso millet (P. miliaceum L.) along with one Slovene autochthonous cultivar, Son?ek. The chosen set of 11 SSR markers showed that there is low overall heterozygosity (0.561) among Slovenian landraces of proso millet. However, we were able to determine distinct groups on the dendrogram for different landraces and the cultivar …

Natural And Anthropic Forest Fragments Have Distinct Ecological Behavior Due To Their Different Origin And Landscape Context, Cleber Souza, Polyanne Coelho, Paola Ferreira Santos, Gisele Cristina De Oliveira Menino, Jean Morel, Aline Moreira, Rubens Manoel Dos Santos

Turkish Journal of Botany

We tested the hypothesis that plant populations in natural fragments have distinct ecological behavior in relation to anthropic fragments. We selected the species Myrcia splendens (SW.) DC. in 2 forest fragments located in southeastern Brazil that present different origins and landscape contexts. The natural fragment originates from landscape relief variations and is inserted in a native grassland matrix, while the anthropic fragment originates from fragmentation due to area conversion and is inserted in an agricultural matrix. We established transects covering an area from one border to the other in each fragment, and we established subunits of 400 m2 within them. …

Spatiotemporal Distribution And Population Structure Of Clibanarius Symmetricus (Randall, 1840) (Crustacea, Diogenidae) In An Amazon Estuary, Ana Carolina Melo Rodrigues, Jussara Moretto Martinelli-Lemos

Turkish Journal of Zoology

Rocky outcrops in the intertidal zones of estuaries often contain a highly diverse microbenthic community which includes the hermit crab, Clibanarius symmetricus, an abundant species on the equatorial Amazon coast. However, the ecology of this anomuran is poorly understood. Given this, the present study investigated the spatiotemporal distribution and structure of the C. symmetricus populations that inhabit the rocky outcrops of the Marapanim estuary in northern Brazil. Samples were collected monthly over a yearly cycle covering both the dry and rainy seasons in the upper and lower midlittoral zones during low tide. The distribution and abundance of C. symmetricus were …

Application Of Multifactorial Discriminant Analysis In The Morphostructural Differentiation Of Wild And Cultured Populations Of Vieja Azul (Andinoacara Rivulatus), Johanna Caez, Ana Gonzalez, Martin A. Gonzalez, Elena Angon, Jorge M. Rodriguez, Francisco Peña, Cecilio Barba, Antón García

Turkish Journal of Zoology

To better determine the ecological variation (body shape and structure) of the Vieja Azul (Andinoacara rivulatus; syn.: Aequidens rivulatus) in northwest Ecuador (Los Ríos Province), 300 specimens of both sexes (150 male and 150 female) were collected from 3 different locations, one from a wild production system and two from fish farm populations in the Quevedo River. Twelve meristic, 26 traditional morphometric, and 32 truss measurements, among 25 anatomical landmarks, were determined. The body weight (BW), total length (TL), eye diameter (ED), dorsal fin ray length (DFRL), and body perimeter 3 (P3) showed significant differences (P < 0.05) between production systems, and sex had significant influence on preanal length (Pre-AL), P3, and body width 2 (LC2). Females showed higher mean values than males in all measurements, except for BW. The Fulton factor differed for both factors considered. The canonical discriminant analysis revealed a percentage of correct assignment of 64.42% for the dataset, 85% and 60.9% for cultured and wild females, and 62.1% and 56.3% for wild and cultured males, respectively, as well as morphometric variation between groups. Results could be attributed to environmental conditions (habitat, temperature, and food). The Mahalanobis test showed greater distances among females than among males. In conclusion, this study provides valuable morphological information on the shape and structure of Andinoacara rivulatus that can be used to characterize and quantify the changes that occur as a consequence of adaptation to a different habitat. The authors hope that the information obtained from the present study will be helpful for fisheries, biologists, and taxonomists.