Digital Commons Network^™

Enabling Global Clinical Collaborations On Identifiable Patient Data: The Minerva Initiative., Christoffer Nellåker, Fowzan S Alkuraya, Gareth Baynam, Raphael A Bernier, Francois P J Bernier, Vanessa Boulanger, Michael Brudno, Han G Brunner, Jill Clayton-Smith, Benjamin Cogné, Hugh J S Dawkins, Bert B A Devries, Sofia Douzgou, Tracy Dudding-Byth, Evan E Eichler, Michael Ferlaino, Karen Fieggen, Helen V Firth, David R Fitzpatrick, Dylan Gration, Tudor Groza, Melissa Haendel, Nina Hallowell, Ada Hamosh, Jayne Hehir-Kwa, Marc-Phillip Hitz, Mark Hughes, Usha Kini, Tjitske Kleefstra, R Frank Kooy, Peter Krawitz, Sébastien Küry, Melissa Lees, Gholson J Lyon, Stanislas Lyonnet, Julien L Marcadier, Stephen Meyn, Veronika Moslerová, Juan M Politei, Cathryn C Poulton, F Lucy Raymond, Margot R F Reijnders, Peter N Robinson, Corrado Romano, Catherine M Rose, David C G Sainsbury, Lyn Schofield, Vernon R Sutton, Marek Turnovec, Anke Van Dijck, Hilde Van Esch, Andrew O M Wilkie

Faculty Research 2019

The clinical utility of computational phenotyping for both genetic and rare diseases is increasingly appreciated; however, its true potential is yet to be fully realized. Alongside the growing clinical and research availability of sequencing technologies, precise deep and scalable phenotyping is required to serve unmet need in genetic and rare diseases. To improve the lives of individuals affected with rare diseases through deep phenotyping, global big data interrogation is necessary to aid our understanding of disease biology, assist diagnosis, and develop targeted treatment strategies. This includes the application of cutting-edge machine learning methods to image data. As with most digital …

Nh Veterinary Diagnostic Lab Identifies First Ever Reported Case Of A Virus In Chimney Swifts, Erika Mantz

Media Relations

No abstract provided.

Addressing Non-Communicable Disease In Rural Nigeria Through Dietary Assessment, Tamara Dochelle Otey

International Nursing Research Congress (INRC)

Non-communicable diseases (NCDs) are major problems in Nigeria. For management and prevention of NCDs, dietary modifications must occur and coincide with the culture. We obtained 24hr diet recall and favorite recipe with methods of cooking from participants to gain knowledge of their current diet to develop cultural dietary modifications.

Minimally-Invasive Methods Of Examining Biological Changes In Response To Chronic Stress: A Scoping Review, Rebecca Elizabeth Salomon, Ashley Vaughan, Kelly R. Tan, Keely Muscatell

International Nursing Research Congress (INRC)

Nurse researchers are increasingly interested in the biological effects of chronic stress. Using minimally invasive methods to collect biological indicators may improve research access to vulnerable populations. This review maps the indicators being measured through minimally invasive methods to investigate a variety of biological changes in response to chronic stress.

Nh Veterinary Diagnostic Lab Identifies Virus In Chimney Swifts, Lori Tyler Gula

UNH Today Archive

No abstract provided.

Type X Strains Of Toxoplasma Gondii Are Virulent For Southern Sea Otters (Enhydra Lutris Nereis) And Present In Felids From Nearby Watersheds, Karen Shapiro, Elizabeth Vanwormer, Andrea Packham, Erin Dodd, Patricia A. Conrad, Melissa Miller

School of Veterinary and Biomedical Sciences: Faculty Publications

Why some Toxoplasma gondii-infected southern sea otters (Enhydra lutris nereis) develop fatal toxoplasmosis while others have incidental or mild chronic infections has long puzzled the scientific community. We assessed robust datasets on T. gondii molecular characterization in relation to detailed necropsy and histopathology results to evaluate whether parasite genotype influences pathological outcomes in sea otters that stranded along the central California coast. Genotypes isolated from sea otters were also compared with T. gondii strains circulating in felids from nearby coastal regions to assess land-to-sea parasite transmission. The predominant T. gondii genotypes isolated from 135 necropsied sea otters were atypical Type …

Exploration Of The Formation And Mechanism Of Vbnc State Of Salmonella Enterica Serovar Typhimurium During Hydrogen Peroxide Disinfection, Nie Xinying, Liao Hongmei, Liu Yuanfa

Food and Machinery

In order to determine the effective bactericidal concentration of hydrogen peroxide, Salmonella enterica serovar Typhimurium was used as a target microorganism to explore the effect of hydrogen peroxide on activity and culturability of it in tap water and its viable but non-culturable (VBNC) state by means of molecular biology. The results showed that lower hydrogen peroxide concentration (0～15 mmol/L) could kill some S. Typhimurium, which could be completely sterilized with 1 mol/L hydrogen peroxide. It was also found that 4.08 lg(CFU/mL) S. Typhimurium could be induced into a VBNC state as exposure to 15 mmol/L hydrogen peroxide. The morphology and …

Abstract Book (Pdf), Lsu Health School Of Medicine

Summer Research Internship Program

No abstract provided.

Provider Attitudes And Practice Patterns For Direct-Acting Antiviral Therapy For Patients With Hepatocellular Carcinoma, Nicole E. Rich, Ju-Dong Yang, Ponni V. Perumalswami, Naim Alkhouri, Whitney Jackson, Neehar D. Parikh, Neil Mehta, Reena Salgia, Andres Duarte-Rojo, Laura Kulik, Mina Rakoski, Adnan Said, Omobonike Oloruntoba, George N. Ioannou, Maarouf A. Hoteit, Andrew M. Moon, Amol S. Rangnekar, Sheila L. Eswaran, Elizabeth Zheng, Janice H. Jou, James Hanje, Anjana Pillai, Ruben Hernaez, Robert Wong, Steven Scaglione, Hrishikesh Samant, Devika Kapuria, Shaun Chandna, Russell Rosenblatt, Veeral Ajmera, Catherine Frenette, Sanjaya K. Satapathy, Parvez Mantry, Prasun Jalal, Binu V John, Oren K Fix, Michael Leise, Christina C Lindenmeyer, Avegail Flores, Nayan Patel, Z Gordon Jiang, Nyan Latt, Renumathy Dhanasekaran, Mobolaji Odewole, Sofia Kagan, Jorge A Marrero, Amit G Singal

Gastroenterology Articles

BACKGROUND & AIMS: Direct-acting antivirals (DAAs) are effective against hepatitis C virus and sustained virologic response is associated with reduced incidence of hepatocellular carcinoma (HCC). However, there is controversy over the use of DAAs in patients with active or treated HCC and uncertainty about optimal management of these patients. We aimed to characterize attitudes and practice patterns of hepatology practitioners in the United States regarding the use of DAAs in patients with HCC.

METHODS: We conducted a survey of hepatology providers at 47 tertiary care centers in 25 states. Surveys were sent to 476 providers and we received 279 responses …

Pre-Exposure Prophylaxis (Prep) Protocol For The Urgent Care Setting, Jack J. Mayeux, Yeow Chye Ng

International Nursing Research Congress (INRC)

Pre-exposure prophylaxis (PrEP) is an excellent HIV prevention medication. While PrEP use has increased, the urgent care has been reluctant and slow to embrace this prevention method due to a lack of guidance. This presentation presents a PrEP initiation protocol specific to the urgent care setting.

Improving Care In Nursing Homes: A Mixed-Methods Interdisciplinary Study, Patricia W. Stone

International Nursing Research Congress (INRC)

In the US, there are almost 16,000 nursing homes across the country with approximately 1.5 million elderly residents living in them at any one time. Unfortunately, care is often suboptimal in these settings. An overview of a national mixed methods, interdisciplinary study aimed at identifying best practices will be presented.

Should Pre-Exposure Prophylaxis (Prep) Services Be Blamed For The Increased Rate Of Sexual Transmitted Infections?, Yeow Chye Ng, Jack J. Mayeux

International Nursing Research Congress (INRC)

Pre-exposure prophylaxis (PrEP) is a lifesaving HIV prevention medication. Critics have shared their concerns for oral PrEP as it may be promoting unprotected sex among PrEP users, and indirectly may cause a new surge of sexual transmitted infections (STIs). This study suggests that information is inconclusive at this time.

Telemedicine Counseling Intervention For Rural Hiv Patients With Comorbid Depression, Anxiety, And Substance Use Issues, Safiya George Dalmida

International Nursing Research Congress (INRC)

This presentation will discuss an intervention for PLWH with mental health and substance use issues, using: (1) peer education/support and (2) mental health and substance abuse group counseling via telemedicine/videoconferencing; among PLWH to support and improve medication adherence and retention in HIV care among PLWH.

A Retrospective Analysis Of Falls In Hospitalized Children, Deborah Spoerner

International Nursing Research Congress (INRC)

Pediatric fall risk assessment tools are intended to identify children at risk and provide specific interventions to reduce falls. Review of the literature reveals lack of consensus for fall risk factors, classifications, definitions, and accuracy of fall risk assessment tools.

Researchers Awarded $10 Million To Study Acute Flaccid Myelitis, Staff

Browse All News

No abstract provided.

Priority Mental, Neurological And Substance Use Disorders In Rural Kenya: Traditional Health Practitioners’ And Primary Health Care Workers’ Perspectives, Mary A. Bitta, Symon M. Kariuki, Joseph Gona, Amina Abubakar, Charles R. J. C. Newto

Institute for Human Development, East Africa

Background: Over 75% of people with mental neurological and substance use disorders (MNSD) live in low and middle-income countries with limited access to specialized care. The World Health Organization’s Mental Health Gap Action Program (mhGAP) aims to address the human resource gap but it requires contextualization.

Aim: We conducted a qualitative study in rural coastal Kenya to explore the local terms, perceived causes and management modalities of priority MNSD listed in the mhGAP, to inform implementation in this setting.

Methods: We conducted 8 focus group discussions with primary health care providers and traditional health practitioners and used the framework method …

Antimicrobials From An Epigenetics Based Fungal Metabolite Screening Program, Danielle H. Demers, Bill J. Baker, Ala Azhari, Renee M. Fleeman, Dennis E. Kyle, Lindsey Neil Shaw

USF Patents

Novel antimicrobial compounds against drug targets such as Eskape pathogens, Leishmania donovani, Mycobacterium tuberculosis, Clostridium difficile, Naegleria fowleri, and cancer are presented herein.

Protocol For A Process Evaluation Of A Cluster Randomized Controlled Trial Of The Learning Club Intervention For Women's Health, And Infant's Health And Development In Rural Vietnam, Jane Fisher, Trang Nguyen, Thach Duc Tran, Ha Tran, Tuan Tran, Stanley Luchters, David Hipgrave, Sarah Hanieh, Beverley-Ann Biggs

Population Health, East Africa

Background: Learning Clubs is a multi-component intervention to address the eight common risk factors for women’s health, and infant’s health and development in resource-constrained settings. We are testing in a cluster randomized controlled trial in rural Vietnam whether this intervention improves cognitive development in children when they are aged two. There are few comprehensive process evaluations of complex interventions to optimise early childhood development. The aim is to conduct a planned process evaluation of the Learning Clubs intervention in Vietnam.

Methods: The evaluation will be conducted alongside the Learning Clubs trial using both qualitative and quantitative methods. Four domains will …

Nephromyces Represents A Diverse And Novel Lineage Of The Apicomplexa That Has Retained Apicoplasts, Sergio A. Munoz-Gomez, Keira Durnin, Laura Eme, Christopher Paight, Christopher E. Lane, Mary B. Saffo, Claudio H. Slamovits

Biological Sciences Faculty Publications

A most interesting exception within the parasitic Apicomplexa is Nephromyces, an extracellular, probably mutualistic, endosymbiont found living inside molgulid ascidian tunicates (i.e., sea squirts). Even though Nephromyces is now known to be an apicomplexan, many other questions about its nature remain unanswered. To gain further insights into the biology and evolutionary history of this unusual apicomplexan, we aimed to 1) find the precise phylogenetic position of Nephromyces within the Apicomplexa, 2) search for the apicoplast genome of Nephromyces, and 3) infer the major metabolic pathways in the apicoplast of Nephromyces. To do this, we sequenced a metagenome …

Nursing Partnership To Enhance Oncology Nurse Expertise And Capacity In Kampala, Uganda, Arlyce Jo Coumar, Kathleen K. Shannon Dorcy

International Nursing Research Congress (INRC)

Understanding international nursing collaboration is vital to enhance nurse workforce capacity and improving outcomes for cancer patients in Uganda. Does consideration of nurse role and working conditions through visit and survey guide curriculum and inquiry for improved patient outcomes and nursing expertise?

The Positive Deviance Approach For Preventing Healthcare Associated Infections Using Creative Solutions By Staff, Ricky Cohen, Anat Gesser-Edelsburg, Adva Mir Halavi

International Nursing Research Congress (INRC)

When ambiguity is at the heart of a demanding environment, in which the staff member is required to maneuver at a high speed between the tasks and to meet the standards of quality and safe care, the "Positive Deviance Approach" may be the strategy that provides creative solutions.

Contact Rates With Nesting Birds Before And After Invasive Snake Removal: Estimating The Effects Of Trap-Based Control, Amy A. Yackel Adams, Melia G. Nafus, Page E. Klug, Björn Lardner, M.J. Mazurek, Julie A. Savidge, Robert N. Reed

United States Department of Agriculture Wildlife Services: Staff Publications

Invasive predators are responsible for almost 60% of all vertebrate extinctions worldwide with the most vulnerable faunas occurring on islands. The brown treesnake (Boiga irregularis) is a notorious invasive predator that caused the extirpation or extinction of most native forest birds on Guam. The success of avian reintroduction efforts on Guam will depend on whether snake-control techniques sufficiently reduce contact rates between brown treesnakes and reintroduced birds. Mouse-lure traps can successfully reduce brown treesnake populations at local scales. Over a 22-week period both with and without active snake removal, we evaluated snake-trap contact rates for mouse- and bird-lure traps. Bird-lure …

Week Of July 22, 2019, New York Medical College

InTouch

• Inaugural Clinical Laboratory Sciences Class Arrives at NYMC
• Medical Students Receive POCUS Training
• NYMC Researchers Aim to Transform Treatment of Babesiosis
• The Latest Issue of Chironian is Now Online

Study Of Environmental Enteropathy And Malnutrition (Seem) In Pakistan: Protocols For Biopsy Based Biomarker Discovery And Validation, Najeeha Talat Iqbal, Sana Saeed, Kamran Sadiq, Marium N. Khan, Junaid Iqbal, Jennie Z. Ma, Fayaz Umrani, Sheraz Ahmed, Elizabeth A. Maier, Lee A. Denson, Shahida Qureshi, Syed Asad Ali

Department of Paediatrics and Child Health

Background:
Environmental Enteropathy (EE), characterized by alterations in intestinal structure, function, and immune activation, is believed to be an important contributor to childhood undernutrition and its associated morbidities, including stunting. Half of all global deaths in children < 5 years are attributable to under-nutrition, making the study of EE an area of critical priority.
Methods:
Community based intervention study, divided into two sub-studies, 1) Longitudinal analyses and 2) Biopsy studies for identification of EE features via omics analyses. Birth cohorts in Matiari, Pakistan established: moderately or severely malnourished (weight for height Z score (WHZ) < − 2) children, and well-nourished (WHZ > 0) children. Blood, urine, and fecal samples, for evaluation of potential biomarkers, will be collected at various time points from all participants (longitudinal …

Bjc Today

BJC Today

No abstract provided.

An Evaluation Of The Registration And Use Prospects For Four Candidate Toxicants For Controlling Invasive Mongooses (Herpestes Javanicus Auropunctatus), Emily W. Ruell, Chris N. Niebuhr, Robert T. Sugihara, Shane R. Siers

United States Department of Agriculture Wildlife Services: Staff Publications

The eradication or control of invasive small Indian mongooses from islands likely requires toxic baiting when removal by trapping proves insufficient. The one toxic bait currently registered for mongooses in the United States has relatively low palatability and efficacy for mongooses. Developing and registering a new pesticide can be very expensive, while funding for developing toxicants for mongooses is limited. Once registered, use of a toxic bait may be hindered by other factors, such as public opposition to an inhumane toxicant, poorer efficacy than expected, or if the toxic bait is difficult for applicators to apply or store. Therefore, we …

Applying Contemporary Management Principles To Implementing And Evaluating Value-Added Pharmacist Services., Shane P. Desselle, Leticia R Moczygemba, Antoinette B Coe, Karl Hess, David P Zgarrick

Faculty Publications & Research of the TUC College of Pharmacy

Value-added pharmacy services encompass traditional and emerging services provided by pharmacists to individual and entire populations of persons increasingly under the auspices of a public health mandate. The success of value-added pharmacy services is enhanced when they are carried out and assessed using appropriate theory-based paradigms. Many of the more important management theories for pharmacy services consider the "servicescape" of these services recognizing the uniqueness of each patient and service encounter that vary based upon health needs and myriad other factors. In addition, implementation science principles help ensure the financial viability and sustainability of these services. This commentary reviews some …

Conceptions Of Potency, Purity, And Synergy-By-Design: Toward Developing A Sowa Rigpa Medical Theory-Based Approach To Pharmaceutical Research, Tawni L. Tidwell, James H. Nettles

HIMALAYA, the Journal of the Association for Nepal and Himalayan Studies

Sowa Rigpa institutions and practitioners have growing interest in examining and legitimizing Sowa Rigpa formulas vis-à-vis pharmacological research methods, seeking scientific validation of what they view as ‘potency’ and ‘purity’ for their formulas. Likewise, the pharmacology researchers have demonstrated renewed interest in herbal medical traditions in mining for new drugs to address resistance, toxicity, and optimize what they view as ‘potency’ and ‘purity.’ However, differing conceptualizations emerge when the pharmacological drug discovery process is examined to determine what is being analyzed, how it is doing so, and what assumptions underlie such methods. Whether a formula is ‘active,’ ‘toxic’ or ‘effective’ …

Mixing It Up: The Impact Of Episodic Introgression On The Evolution Of High-Latitude Mesocarnivores, Jocelyn P. Colella

Biology ETDs

At high latitudes, climatic oscillations have triggered repeated episodes of organismal divergence by geographically isolating populations. For terrestrial species, extended isolation in glacial refugia – ice-free regions that enable terrestrial species persistence through glacial maxima – is hypothesized to stimulate allopatric divergence. Alternatively, upon glacial recession, divergent populations expanded from independent glacial refugia and often contacted other diverging populations. In the absence of reproductive isolating mechanisms, this biogeographic process may trigger hybridization and ultimately, gene flow between divergent taxa. My dissertation research aims to understand how these episodic periods of isolation and contact have impacted the evolution of high latitude …

Path Analysis Of Health Literacy And Retention In Care Among African Americans Living With Hiv, Ashley Anderson, Regine Haardoerfer, Marcia Holstad, Minh Nguyen, Drenna Waldrop-Valverde

International Nursing Research Congress (INRC)

Low health literacy and poor retention in HIV care may contribute to the morbidity and mortality of HIV among African Americans. Findings from this study suggest causal pathways between retention in care and health literacy among racially disparate HIV populations.