Digital Commons Network^™

Stochastic Partial Differential Equation Sis Epidemic Models: Modeling And Analysis, Nhu N. Nguyen, George Yin

Communications on Stochastic Analysis

No abstract provided.

Risk Factors For Mortality Of Patients With Ceftriaxone Resistant E. Coli Bacteremia Receiving Carbapenem Versus Beta Lactam/Beta Lactamase Inhibitor Therapy, Nosheen Nasir, Sara Ahmed, , Samrah Razi, Safia Awan, Syed Faisal Mahmood

Section of Internal Medicine

Objective: Extended spectrum β-lactamases (ESBL) producing Enterobacteriaceae predominantly E. coli and K. pneumoniae bacteremia have limited treatment options and high mortality. The objective was to determine the risk factors for in-hospital mortality particularly treatment with carbapenem versus beta lactam/beta lactamase combination (BL/BLI) in patients with ceftriaxone resistant E. coli bacteremia. A retrospective cohort study was conducted at the Aga Khan University, Karachi, Pakistan. Adult patients with sepsis and monomicrobial ceftriaxone resistant E. coli bacteremia were enrolled. Factors associated with mortality in patients were determined using logistic regression analysis.

Results: Mortality rate was 37% in those empirically treated with carbapenem …

Isolation And Identification Of Candida Albicans In Different Clinical Samples, Taghreed Khudhur Mohammed, Khalil Molod Wahab, Mohammed Abed Jawad

Al-Nisour Journal for Medical Sciences

The prevalence of candidacies caused by Candida albicans has increased years ago. The samples (Vaginal swabs; urethral swabs; urine; and ear swabs) were cultured on Sabourauds Dextrose Agar and CHROM agar™Candida to detect Candida albicans in patients clinically suffered from candidiasis. Six hundred and five clinical samples were collected from patients whose ages ranged from (20 – 69) years. All Candida albicans isolates were identified by using microscopic examination in wet smear and stained smear; in addition to germ tube test and API Candida. The highest rate of Candida albicans infections were 73.3% in pregnant women in age group (20 …

Investigation Of Antimicrobial Activities Of Lactuca Sativa (L.) Extracts Against Clinical Pathogens, Shahbaa M. Al-Khazraji, Emad M. Rasheed

Al-Nisour Journal for Medical Sciences

The present study describes the antimicrobial activity of 3 extracts of Lactuca sativa Linn. (Lettuce), collected from the local markets in Baghdad. Successive petroleum ether, methanol and ethyl acetate+water extracts of Lactuca sativa leaves were tested (in vitro) for their antimicrobial activities by agar-well diffusion assay. All extracts displayed varied levels of antibacterial or antifungal activity. The petroleum ether extract exhibited antibacterial effect against all of the tested bacteria and the diameter of zones varied between 14-20 mm. The petroleum ether extract of Lactuca sativa leaves presented a good activity against Escherichia coli, Staphylococcus aureus and Yersinia enterocolitica, 20 mm, …

Vitamin D Status And Risk Of Incident Tuberculosis Disease: A Nested Case-Control Study, Systematic Review, And Individual-Participant Data Meta-Analysis, Omowunmi Aibana, Chuan-Chin Huang, Said Aboud, Alberto Arnedo-Pena, Mercedes C. Becerra, Juan B. Bellido-Blasco, Ramesh Bhosale, Roger Calderon, Silvia Chiang, Jerome Galea

Social Work Faculty Publications

Background: Few studies have evaluated the association between preexisting vitamin D deficiency and incident tuberculosis (TB). We assessed the impact of baseline vitamins D levels on TB disease risk.

Methods and findings: We assessed the association between baseline vitamin D and incident TB in a prospective cohort of 6,751 HIV-negative household contacts of TB patients enrolled between September 1, 2009, and August 29, 2012, in Lima, Peru. We screened for TB disease at 2, 6, and 12 months after enrollment. We defined cases as household contacts who developed TB disease at least 15 days after enrollment of the index patient. …

Atep 546.50: General Medical Assessment, Melanie L. Mcgrath

University of Montana Course Syllabi, 2016-2020

No abstract provided.

Perceived Barriers Related To Testing, Management And Treatment Of Hcv Infection Among Physicians Prescribing Opioid Agonist Therapy: The C-Scope Study, Alain H. Litwin, Martine Drolet, Chizoba Nwankwo, Martha Torrens, Andrej Kastelic, Stephan Walcher, Lorenzo Somaini, Emily Mulvihill, Jochen Ertl, Jason Grebely

Project ECHO Bibliography

The aim of this analysis was to evaluate perceived barriers related to HCV testing, management and treatment among physicians practicing in clinics offering opioid agonist treatment (OAT). C-SCOPE was a study consisting of a self-administered survey among physicians practicing at clinics providing OAT in Australia, Canada, Europe and the United States between April and May 2017. A 5-point Likert scale (1 = not a barrier, 3 = moderate barrier, 5 = extreme barrier) was used to measure responses to perceived barriers for HCV testing, evaluation and treatment across the domains of the health system, clinic and patient. Among the 203 …

Patient And Provider Perspectives On Sexual History Taking During Gynecological Care: A Pilot Study In An Academic Family Medical Setting In New York City, Ashley M. Chastain

Dissertations and Theses

Background: In the United States (US), women face a number of serious issues concerning sexual health. Current surveillance data indicates that overall rates of bacterial sexually transmitted infections (STIs) are increasing rapidly. While rates of new diagnoses have decreased, the risks of acquiring HIV are still relatively high for some females, specifically Black/African-American women. In New York City (NYC), where this dissertation research was conducted, similar HIV/STI rates exist among females of reproductive age (aged 15-44). Among women in the US, there are also high estimated rates of other sexual health problems, such as sexual anxiety, sexual dysfunction, and intimate …

Primary Esophageal Tuberculosis Mimicking Esophageal Carcinoma On Computed Tomography: A Case Report., Muhammad Salman Khan, Muhammad Hassan Arif, Amir Humza Shohail, Waseem Ahmed Memon

Department of Radiology

BACKGROUND:
Tuberculosis (TB) has a rare extrapulmonary manifestation known as esophageal tuberculosis, accounting for 0.2% of total TB patients. Esophageal TB typically presents with dysphagia, with retrosternal pain or odynophagia, but generalized symptoms such as low-grade fever, decreased appetite, and weight loss are also observed. Esophageal carcinoma and Crohn's disease of the esophagus are important differential diagnoses with similar presentation.
CASE SUMMARY
: We present a case of a 25-year-old male, who presented with esophageal TB mimicking an esophageal carcinoma. Lab work-up, Mantoux test, and chest X-ray were normal. Barium-swallow examination showed moderate dilatation of distal esophagus with a nodular …

Comfort And Physical Classroom Design: Using Student Voice To Inform School Leadership, Ann M. Wagner

All Theses And Dissertations

This qualitative phenomenological study considered the comfort of students in the secondary physical classroom, seeking ways to meet the needs of 21st Century learners and to provide an equitable environment for all learners. A student survey was conducted on elements of the physical classroom space and interviews were conducted to further delve into student comfort in the classroom. As part of the interviews, students drew an ideal classroom space to further share their thoughts and ideas. Interviewees and respondents articulated the need for individual space in the classroom, for temperature control, and for the reduction of noise to optimize the …

Detection And Concentration Of Plasma Aflatoxin Is Associated With Detection Of Oncogenic Human Papillomavirus In Kenyan Women, Jianjun Zhang, Elkanah Omenge, Philip Tonui, Yan Tong, Titus Manai, Stephen Kiptoo, Kapten Muthoka, John Groopman, Joshua Smith, Erin Madeen

Obstetrics and Gynaecology, East Africa

Background: Cervical cancer is common in Kenyan women. Cofactors in addition to infection with oncogenic human papillomavirus (HPV) are likely to be important in causing cervical cancer, because only a small percentage of HPV-infected women will develop this malignancy. Kenyan women are exposed to dietary aflatoxin, a potent carcinogen and immunosuppressive agent, which may be such a cofactor.

Methods: Demographics, behavioral data, plasma, and cervical swabs were collected from 88 human immunodeficiency virus-uninfected Kenyan women without cervical dysplasia. Human papillomavirus detection was compared between women with or without plasma aflatoxin B1-lysine (AFB1-lys) and evaluated in relation to AFB1-lys concentration.

Results: …

An Interview With Nancy Armstrong, Coauthor Of The Imaginary Puritan: Literature, Intellectual Labor, And The Origins Of Personal Life, Megan Behrent

Publications and Research

Nancy Armstrong is Gilbert, Louis, and Edward Lehrman Professor of Trinity College, Duke University; editor of Novel: A Forum on Fiction; author of Desire and Domestic Fiction (1987), Fiction in the Age of Photography (1999), How Novels Think: The Limits of Individualism, 1719-1900 (2005); and with Leonard Tennenhouse, coauthor of The Imaginary Puritan (1992) and Novels in the Time of Democratic Writing (2017).

Megan Behrent is Assistant Professor of English at New York City College of Technology, CUNY. Her research focuses on literature and social movements and the intersection among race, gender, sexuality, and class in twentieth and …

America’S Favorite Antidote: Drug-Induced Homicide In The Age Of The Overdose Crisis, Leo Beletsky

Utah Law Review

Nearing the end of its second decade, the overdose crisis in the United States continues to claim tens of thousands of lives. Despite the rhetorical emphasis on a “public health” approach, criminal law and its enforcement continue to play a central role among policy responses to this crisis. A legacy of the 1980s War on Drugs, statutory provisions that implicate drug distributors in overdose fatalities are on the books in many U.S. jurisdictions and federally. This Article articulates an interdisciplinary critique of these “drug-induced homicide” laws at a time of their increased popularity, expanding scope, and aggressive prosecution. That these …

Information Resources For Animal Control And Wildlife Damage Management, Stephen M. Vantassel, Michael W. Fall, Serge Lariviére

Wildlife Damage Management Technical Series

A bumper sticker reads, “If you think education is expensive, you oughta try ignorance.” That statement could not be truer in regard to wildlife damage management. Being willing to learn is a critical attitude for everyone involved in wildlife damage management. Since wildlife damage management intersects so many other disciplines, no single person can be an expert in all of them. In addition, the arrival of an invasive species, changes in building practices (e.g., egress windows, ridge vents), or the implementation of new regulations can confound traditional practices and require new control methods. Thus, it is important to provide a …

Modeling The Impact Of Newcastle Disease Virus Vaccinations On Chicken Production Systems In Northeastern Madagascar, Akshaya Annapragada, Cortni Borgerson, Sarah Iams, M. Ando Ravelomanantsoa, Graham C. Crawford, Marika Helin, Evelin Jean Gasta Anjaranirina, Hervet J. Randriamady, Christopher D. Golden

Department of Anthropology Faculty Scholarship and Creative Works

Chickens are a key source of nutrition for rural Malagasy communities. Due to high endemic rates of Newcastle disease, it remains challenging to raise sustainable chicken flocks as a consistent food source. Here, we explore the impact of triannual Newcastle disease virus (NDV) vaccine interventions on the growth and herd immunity acquisition of Malagasy chicken flocks. Between 2011 and 2018 we collected longitudinal data to assess the population dynamics of chicken populations in remote Malagasy communities. In 2016, we launched a pilot campaign for vaccination in six rural communities to determine the impacts on chicken survivorship and productivity. We used …

Predicting Functional Responses In Agro-Ecosystems From Animal Movement Data To Improve Management Of Invasive Pests, Mark Q. Wilber, Sarah M. Chinn, James C. Beasley, Raoul K. Bourghton, Ryan K. Brooks, Stephen S. Ditchkoff, Justin W. Fischer, Steve B. Hartley, Lindsey K. Holmstrom, John C. Kilgo, Jesse S. Lewis, Ryan S. Miller, Nathan P. Snow, Kurt C. Vercauteren, Samantha M. Wisely, Colleen T. Webb, Kim M. Peen

United States Department of Agriculture Wildlife Services: Staff Publications

Functional responses describe how changing resource availability affects consumer resource use, thus providing a mechanistic approach to prediction of the invasibility and potential damage of invasive alien species (IAS). However, functional responses can be context dependent, varying with resource characteristics and availability, consumer attributes, and environmental variables. Identifying context dependencies can allow invasion and damage risk to be predicted across different ecoregions. Understanding how ecological factors shape the functional response in agro-ecosystems can improve predictions of hotspots of highest impact and inform strategies to mitigate damage across locations with varying crop types and availability. We linked heterogeneous movement data across …

Exploration Of The Inhibitory Properties Of The Nucleoside Antibiotic Salicyl-Ams And Analogues Targeting Siderophore Biosynthesis In Mycobacterium Tuberculosis, Glennon Bythrow

Dissertations, Theses, and Capstone Projects

Mycobacterium tuberculosis (Mtb) is a resilient, obligate bacterial pathogen responsible for pulmonary tuberculosis disease (TB), that has upheld a significant impact on global public health throughout history. The World Health Organization (WHO) approximates nearly 10 million new TB cases arose in 2017 alone, accounting for 1.6 million deaths. There has been a notable rise in TB cases produced by multidrug‑resistant (MDR) and extensively drug-resistant (XDR) strains of Mtb. This, along with the intrinsic resistance of Mtb to many standard drugs and poor patient compliance, is deeply impacting global control of TB. Among the several strategies currently in …

Multi-Scale Predictors Of Parasite Risk In Wild Male Savanna Baboons (Papio Cynocephalus), Bobby Habig, David A.W.A.M. Jansen, Mercy Y. Akinyi, Laurence R. Gesquiere, Susan C. Alberts, Elizabeth A. Archie

Publications and Research

Several factors are thought to shape male parasite risk in polygynous and polygynandrous mammals, including male-male competition, investment in potentially immunosuppressive hormones, and dispersal. Parasitism is also driven by processes occurring at larger scales, including host social groups and populations. To date, studies that test parasite-related costs of male behavior at all three scales—individual hosts, social groups, and the host population—remain rare. To fill this gap, we investigated multi-scale predictors of helminth parasitism in 97 male savanna baboons (Papio cynocephalus) living in the Amboseli ecosystem in Kenya over a 5-year span. Controlling for multi-scale processes, we found that many of …

A Study Protocol On Comparative Randomised Controlled Trial Of Homoeopathy -Vs- Allopathy In Acute Otitis Media And Its Recurrence In Children, Central Council For Research In Homoeopathy Ccrh

Indian Journal of Research in Homoeopathy

Background: Acute otitis media (AOM) is one of the most common acute infections in children, and injudicious prescription of antibiotics may lead to increase of antibiotic-resistant cases. Homoeopathic treatment may provide a safer and more effective treatment. Objective: Earlier, a pilot study conducted by the Central Council for Research in Homoeopathy (CCRH) on eighty patients at a single centre showed non-inferiority results. This study shall be undertaken to substantiate the earlier findings. Methods: This will be an open-label, non-inferiority, randomised controlled (parallel arm) trial to be conducted on children in the age group of 2–12 years, suffering from AOM. The …

Antibody Responses Against The Vaccine Antigens Ov-103 And Ov-Ral-2 Are Associated With Protective Immunity To Onchocerca Volvulus Infection In Both Mice And Humans., Parakkal Jovvian George, Jessica A. Hess, Sonia Jain, John B. Patton, Tingting Zhan, Nancy Tricoche, Bin Zhan, Maria Elena Bottazzi, Peter J. Hotez, David Abraham, Sara Lustigman

Department of Microbiology and Immunology Faculty Papers

BACKGROUND: The current strategy for the elimination of onchocerciasis is based on annual or bi-annual mass drug administration with ivermectin. However, due to several limiting factors there is a growing concern that elimination of onchocerciasis cannot be achieved solely through the current strategy. Additional tools are critically needed including a prophylactic vaccine. Presently Ov-103 and Ov-RAL-2 are the most promising vaccine candidates against an Onchocerca volvulus infection.

METHODOLOGY/PRINCIPAL FINDINGS: Protection induced by immunization of mice with the alum-adjuvanted Ov-103 or Ov-RAL-2 vaccines appeared to be antibody dependent since AID-/- mice that could not mount antigen-specific IgG antibody responses were not …

Knowledge Of Cytomegalic Inclusion Disease Among A Sample Of Pregnant Women In Baghdad City/Iraq, Ishraq Ahmed Chiad, Adel Amen Hama

Al-Nisour Journal for Medical Sciences

Background: Cytomegalovirus is a common virus that can cause disease in infant's whose mothers are infected with Cytomegalovirus during pregnancy. Objective: To determine knowledge of pregnant women regarding Cytomegalic inclusion disease. Subjects and methods: A cross sectional study was carried out in Baghdad City / Iraq, during the period started from the November 2017 to November 2018. Four primary health care centers randomly selected, and data were obtained by direct interview with the pregnant women by using detailed self- reporting questionnaire. Results: The demographic data was conducted on 360 pregnant women with the age group ranging from 16 to 46 …

Association Between The Infection By Cytomegalovirus (Cmv) With Acute And Chronic Toxoplasmosis Among Random Sample Of Aborted Women At Baghdad Province, Salah Mehdi Hassan, Amany M. Al-Kaysi, Amal Kamel

Al-Nisour Journal for Medical Sciences

This study was carried out during the periods from September 2017 to march 2018 in laboratories Department of different hospitals /Baghdad Teaching Hospital, and Abn-Abalady hospital in 70 women ages ranged from 20 year to 33 years .Bio-ELISA immuno-enzymatic assay was used for Cytomegalovirus Ab sera Immunoassay for the detection of Toxoplasma antibodies IgG and IgM also were carried out to all samples included.The results showed No significant differences between age group studied in pregnant and non-pregnant women in all sample studied and recoded that 25(46.3%) out of 34(63%) of pregnant women studied had Toxo-IgG antibodies and pregnant women who …

A Framework For Tribal Public Health Law, Aila Hoss

Nevada Law Journal

No abstract provided.

Role Of Dietary Flavonoid Compounds In Driving Patterns Of Microbial Community Assembly, Kerry L. Ivey, Andrew T. Chan, Jacques Izard, Aedin Cassidy, Geraint B. Rogers, Eric B. Rimm

Department of Food Science and Technology: Faculty Publications

Flavonoids are a group of polyphenolic dietary compounds found in many different plant-based foods. There is increasing evidence that higher flavonoid intake may be causally linked to a reduced risk of cardiovascular disease and other chronic diseases. The bioactivity and bioavailability of many dietary flavonoids can be influenced by gastrointestinal microbiome metabolism. However, the role that habitual flavonoid intake plays in shaping the human gut microbiome is poorly understood. We describe an application of an ecosystem-based analytic approach to nutritional, microbiome, and questionnaire data from a cohort of more than 240 generally healthy adult males to assess the role of …

Landscape Factors That Influence European Starling (Sturnus Vulgaris) Nest Box Occupancy At Nasa Plum Brook Station (Pbs), Erie County, Ohio, Usa, Morgan Pfeiffer, Thomas W. Seamans, Bruce N. Buckingham, Bradley F. Blackwell

United States Department of Agriculture Wildlife Services: Staff Publications

During the last decade at NASA Plum Brook Station (PBS), Erie County, Ohio, United States, there has been a nearly 50% decrease in European Starling (Sturnus vulgaris) occupancy (nests with ≥1 egg) of nest boxes designed to be used by starlings. Increased availability of natural cavities, from invertebrate pests, might have altered nest box occupation rates. It was hypothesized that starling nest box occupation rates would be a function of an index of potentially suitable tree cavities for nesting starlings, the semi-colonial nature of breeding starlings, and access to foraging areas (e.g., mowed lawns near buildings). Specifically, it was predicted …

Urban Complex Value Study Based On Management Practice Of China Central Place, Chao Fang

Dissertations and Theses Collection (Open Access)

In recent years in China, with the rapid development of China’s economy, the acceleration of urbanization, the extension of city size and the rapid growth of urban population, living conditions, traffic and environment in the cities are getting worse and worse. Under this background, urban complex integrating a series of functions like “living, business, office, tourism, culture and entertainment etc” has become popular with the urban administrators and developers in many cities. According to relevant statistics, by the end of 2015, there had been more than 2000 urban complexes (including the ones which have been completed, the ones which are …

Seasonal Variation In Acute Cholecystitis: An Analysis Of Cholecystectomies Spanning Three Decades, Muhammad Shoaib Khan, Noman Shahzad, Sumaiyya Arshad, Amir Hafeez Shariff

Department of Surgery Docs

BACKGROUND:
Seasonal variation in the occurrence of medical illnesses reflects the effect of the environment, provides insight into pathogenesis, and can assist health care administrators in allocating resources accordingly. Seasonal variation has been reported in various infectious and surgical diseases, but has been rarely studied in acute cholecystitis. Our objective was to study seasonal variation in acute cholecystitis at our institution.
METHODS:
We performed a retrospective analysis of patients who underwent cholecystectomy for acute cholecystitis from January 1988 to December 2018. Chi-square goodness-of-fit test was used to analyze seasonality of acute cholecystitis adjusting for variation in number of days between …

Improving The Youth Hiv Prevention And Care Cascades: Innovative Designs In The Adolescent Trials Network For Hiv/Aids Interventions, Sylvie Naar, Michael G Hudgens, Ron Brookmeyer, April Idalski Carcone, Jason Chapman, Shrabanti Chowdhury, Andrea Ciaranello, W Scott Comulada, Samiran Ghosh, Keith J Horvath, Ladrea Ingram, Sara Legrand, Cathy J Reback, Kit Simpson, Bonita Stanton, Tyrel Starks, Dallas Swendeman

Faculty, Staff and Student Publications

Dramatic decreases in HIV transmission are achievable with currently available biomedical and behavioral interventions, including antiretroviral therapy and pre-exposure prophylaxis. However, such decreases have not yet been realized among adolescents and young adults. The Adolescent Medicine Trials Network (ATN) for HIV/AIDS interventions is dedicated to research addressing the needs of youth at high risk for HIV acquisition as well as youth living with HIV. This article provides an overview of an array of efficient and effective designs across the translational spectrum that are utilized within the ATN. These designs maximize methodological rigor and real-world applicability of findings while minimizing resource …

Inspire : Vol 2, Issue 9, Department Of Medicine

INSPIRE – Department of Medicine Archives

Content

• Message From The Chair
• Women in Global Health (WGH) Pakistan Chapter
• Faculty Development Workshop Series
• Department of Medicine at National and International Forums Featured Faculty Profile Dr. Rabeea Azmat “ There is no shortcut to success!”
• What Are Academics Around the World Reading This Month?
• Publications

Morning Cortisol As An Alternative To Short Synecthan Test For The Diagnosis Of Primary Adrenal Insufficiency, Imran Ulhaq, Tauseef Ahmad, Adeel Khoja, Najmul Islam

Section of Diabetes, Endocrinology and Metabolism

Objective: To determine 7-9 am serum cortisol less than 5mcg/dl is an independent reliable confirmatory test for the diagnosis of primary adrenal insufficiency (PAI).

Methods: A total of 164 patients who visited the outpatient or inpatient department of Aga Khan University Hospital from June 2011 to June 2017 were included for the study. All those patients whose levels came out less than 5mcg/dl were recruited for the study and they all underwent SST. Other demographic and laboratory data were also recorded.

Results: The sensitivity of morning cortisol for diagnosis of PAI is 100% if levels are <1mcg/dl and decreases to 71.88% if levels are up to 5mcg/dl.

Conclusion: Morning cortisol is …