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Apopo Annual Report 2019, Apopo

Global CWD Repository

APOPO originated from the idea of its founder Bart Weetjens to trains rats for the detection of landmines. Now, over 20 years later, APOPO deploys rats to find landmines and tuberculosis in many affected countries, and continues innovating to use its African Giant Pouched Rats in the battle against other scourges.

APOPO trains these ‘HeroRATs’ using positive reinforcement – they receive tasty treats when they identify a target scent. HeroRATs are at the core of the organization and it’s reflected in the way they are protected and responsibly raised.

Our Training and Research center is based at the foothills of …

Ua3/8/5 President's Office-Meredith Colleges/Department File, Wku Archives

WKU Archives Collection Inventories

College and departmental files created by the President's Office during Thomas Meredith's tenure as president of WKU. This series is not completely processed.

The Spirit Of Methodism: Missionary Zeal And The Gift Of An Evangelist, Philip R. Meadows

The Asbury Journal

The church does not need more vital congregations, but rather a few vital Christians, whose vitality is not measured in terms of institutional effectiveness, but by missionary zeal. This zeal is a hungering and thirsting for just one thing: the glory of God and the salvation of souls. It cannot be manufactured, but can only be caught from those who have been gifted by the Spirit to continue the charism of their founder, and fanned into flame. Without this type of Christian, there is no movement, and there is no Methodism. John Welsey's most important legacy was not his doctrine …

Structural And Functional Determinants Of Rodent And Human Surfactant Protein A: A Synthesis Of Binding And Computational Data, Armen Nalian, Todd M. Umstead, Ching-Hui Yang, Patricia Silveyra, Neal J. Thomas, Joanna Floros, Francis X. Mccormack, Zissis C. Chroneos

Faculty Publications

Surfactant protein A (SP-A) provides surfactant stability, first line host defense, and lung homeostasis by binding surfactant phospholipids, pathogens, alveolar macrophages (AMs), and epithelial cells. Non-primates express one SP-A protein whereas humans express two: SP-A1 and SP-A2 with core intra- and inter-species differences in the collagen-like domain. Here, we used macrophages and solid phase binding assays to discern structural correlates of rat (r) and human (h) SP-A function. Binding assays using recombinant rSP-A expressed in insect cells showed that lack of proline hydroxylation, truncations of amino-terminal oligomerization domains, and site-directed serine (S) or alanine (A) mutagenesis of cysteine 6 (C6S), …

Inhibition Of Pseudomonas Aeruginosa Biofilm Formation With Surface Modified Polymeric Nanoparticles, Tyler R. Flockton, Logan Schnorbus, Agustin Araujo, Jill Adams, Maryjane Hammel, Lark Perez

College of Science & Mathematics Departmental Research

The gram-negative bacterial pathogen Pseudomonas aeruginosa represents a prominent clinical concern. Due to the observed high levels of antibiotic resistance, copious biofilm formation, and wide array of virulence factors produced by these bacteria, new treatment technologies are required. Here, we present the development of a series of P. aeruginosa LecA-targeted polymeric nanoparticles and demonstrate the anti-adhesion and biofilm inhibitory properties of these constructs.

A Case Of Letting The Cat Out Of The Bag - Why Trap-Neuter-Return Is Not An Ethical Solution For Stray Cat (Felis Catus) Management., Heather M. Crawford, Michael C. Calver, Patricia A. Fleming

Management - TNR

Trap-Neuter-Return (TNR) programs, in which stray cats are captured, neutered and returned to the environment are advocated as a humane, ethical alternative to euthanasia. We review the TNR literature in light of current debate over whether or not there should be further TNR trials in Australia. We revisit the problems arising from stray cats living in association with human habitation and estimate how many stray cats would have to be processed through a scientifically-guided TNR program to avoid high euthanasia rates. We also identify10 ethical and welfare challenges that have to be addressed: we consider the quality of life for …

How To Evaluate The Science Of Non-Human Animal Use In Biomedical Research And Testing: A Proposed Format For Debate, Ray Greek, Lisa A. Kramer

Validation of Alternative Methods Collection

Over time, the interpretation of science has occasionally been corrupted by vested interest groups, be they financially motivated or ego driven. Scientific consensus and widespread public beliefs usually catch up with the evidence, but this can take a very long time and often costs lives. The use of non-human animals in biomedical research and testing is a scientific endeavor and, as such, can and should be evaluated in light of the best science currently available. But facts that have been accepted in all areas of science are routinely ignored or called into question by well-funded, vested interest groups, compromising the …

Wasted Money In United States Biomedical And Agricultural Animal Research, Jim Keen

Biomedicine and Animal Models in Research Collection

Biomedical and agricultural animal research uses millions of experimental animals and dozens of animal species each year by choice, precedent, or regulatory mandate in basic and applied life science research and toxicity testing of drugs, chemicals, and consumer products. Animal research is a large component of the international us$270 billion government-subsidized, biomedical industrial ecosystem (Chakma et al., 2014). In the United States (us) and presumably elsewhere, about half of these funds support animal research and testing (Institute of Medicine and National Research Council, 2012). Each year at least 115 million experimental animals (mostly mice and likely a significant underestimate) are …

Ethics, Efficacy, And Decision-Making In Animal Research, Lawrence A. Hansen, Kori Ann Kosberg

Morality and Ethics of Animal Experimentation Collection

Few would disagree with the ethical contention that if cruelty to animals is not wrong, then nothing is wrong. In fact, it is not only wrong, but in most states in the us, it is a crime, a felony no less. And yet, intentionally inflicting pain and suffering upon animals, which meets Webster’s definition of cruelty, is routinely countenanced when vivisection (from the Latin vivi, to be alive, and secare, to cut) is performed under license for biomedical research. Deciding to embrace, or reject, or limit animal research demands our best ethical judgment; and it is complicated by factual disputes …

Ethical And Scientific Pitfalls Concerning Laboratory Research With Non-Human Primates, And Possible Solutions, Constança Carvalho, Augusta Gaspar, Andrew Knight, Luís Vicente

Morality and Ethics of Animal Experimentation Collection

Basic and applied laboratory research, whenever intrusive or invasive, presents substantial ethical challenges for ethical committees, be it with human beings or with non-human animals. In this paper we discuss the use of non-human primates (NHPs), mostly as animal models, in laboratory based research. We examine the two ethical frameworks that support current legislation and guidelines: deontology and utilitarianism. While human based research is regulated under deontological principles, guidelines for laboratory animal research rely on utilitarianism. We argue that the utilitarian framework is inadequate for this purpose: on the one hand, it is almost impossible to accurately predict the benefits …

Study Of Synthesis Of Biodegradable Plastics From Alkaline Fermented Excessive Activated Sludge, Yaohui Liu, Chua Hong

Faculty of Science & Technology (THEi)

The environmental problems associated with plastics have become increasingly severe in recent years. Technologically and economically feasible solutions are in urgent need in order to ensure sustainable development in the plastic industry. Polyhydroxyalkanoates (PHAs) are a family of specialized polyesters of hydroxyalkanoates (HAs) and can be completely degraded in natural environment. They can be synthesized naturally or under artificially controlled processes. The barrier of limiting the application of PHAs is the high production cost. From years of study, PHAs are proofed to be able to be accumulated within the bacterial cells in activated sludge and the production yield had been …

Improving The Energy Efficiency Of Petrochemical Plant Operations: A Measurement And Verification Case Study Using A Balanced Wave Optimizer, Eve Man Hin Chan, Kar-Kit Chu, Hin-Fung Chow, Chi-Wing Tsang, Danny Chi Kuen Ho, Shuk-Kei Ho

Faculty of Science & Technology (THEi)

The Chinese petrochemical industry is facing pressure to meet strict targets of energy consumption and carbon emission reductions. Water pumps are the primary equipment used in most chemical and agrochemical industries sectors since water is commonly used for cooling and heating purposes, but these pumps also consume a large amount of energy. Other uses of water pumps in these industries include producing steam for heating, preparing reaction media or absorptive reagents, rinsing products, and distilling. As for the electrical components of the water pump systems, current technologies of variable frequency drives and superconducting transmission lines are unable to increase the …

Lignin Valorizations With Ni Catalysts For Renewable Chemicals And Fuels Productions, Xiao Chen, Weixiang Guan, Chi-Wing Tsang, Haoquan Hu, Changhai Liang

Faculty of Science & Technology (THEi)

Energy and fuels derived from biomass pose lesser impact on the environmental carbon footprint than those derived from fossil fuels. In order for the biomass-to-energy and biomass-to-chemicals processes to play their important role in the loop of the circular economy, highly active, selective, and stable catalysts and the related efficient chemical processes are urgently needed. Lignin is the most thermal stable fraction of biomass and a particularly important resource for the production of chemicals and fuels. This mini review mainly focuses on lignin valorizations for renewable chemicals and fuels production and summarizes the recent interest in the lignin valorization over …

Glopid-R Report On Chikungunya, O'Nyong-Nyong And Mayaro Virus, Part I: Biological Diagnostics, Michael S. Diamond, Et Al

Open Access Publications

No abstract provided.

Phosphatidylcholine Synthesis Through Cholinephosphate Cytidylyltransferase Is Dispensable In Leishmania Major, Samrat Moitra, Mattie C. Pawlowic, Fong-Fu Hsu, Kai Zhang

Open Access Publications

No abstract provided.

Antibodies In The Diagnosis, Prognosis, And Prediction Of Psychotic Disorders., Thomas A Pollak, Jonathan P Rogers, Robert G Nagele, Mark Peakman, James M Stone, Anthony S David, Philip Mcguire

Rowan-Virtua School of Osteopathic Medicine Departmental Research

Blood-based biomarker discovery for psychotic disorders has yet to impact upon routine clinical practice. In physical disorders antibodies have established roles as diagnostic, prognostic and predictive (theranostic) biomarkers, particularly in disorders thought to have a substantial autoimmune or infective aetiology. Two approaches to antibody biomarker identification are distinguished: a "top-down" approach, in which antibodies to specific antigens are sought based on the known function of the antigen and its putative role in the disorder, and emerging "bottom-up" or "omics" approaches that are agnostic as to the significance of any one antigen, using high-throughput arrays to identify distinctive components of the …

Benefits Of Hpv Vaccination In Adolescent Males, Budd Theriot

Physician Assistant Scholarly Project Posters

HPV is the most common sexually transmitted infection in the United States, affecting approximately 75-80% of young adults at some point in their lives, and it is also known to be directly related to several forms of cancer including cervical, vaginal, penile, anal, oral, and oropharyngeal cancer. Vaccination against several high-risk strains of HPV first became available in the U.S. in June of 2006 and has been proven to be effective in creating antibodies against several strains of high-risk HPV, potentially decreasing and preventing more than 30,000 new cases of HPV related cancers each year. Despite this fact, HPV vaccination …

Parenteral Ascorbic Acid For Treatment Of Sepsis, Lindsey Hiatt

Physician Assistant Scholarly Project Posters

Sepsis kills nearly 1 million people each year in the United States and sepsis-related hospitalizations cost approximately $24 billion annually (Paoli, Reynolds, Sinha, Gitlin, & Crouser, 2018). Current treatment guidelines are limited to targeted antibiotics and hemodynamic support. While antibiotics are the definitive treatment to eradicate the infectious pathogen, there are currently no standard-of-care treatments that consistently and successfully attenuate the damage sustained to the body by its own inflammatory response to infection. Many different treatments have been trialed and failed to show improved outcomes. Vitamin C, or ascorbic acid, has long been associated with supporting immune function, and has …

No. 35: The Food Safety And Food Security Nexus In The Urbanizing Global South, Jodi Koberinski, Zhenzhong Si, Steffanie Scott

Hungry Cities Partnership

Socioeconomic and structural changes in the global food system, driven by rapid urbanization in the Global South, shape the nature and scale of food safety problems as well as the strategies designed to cope with them. These changes create new challenges for ensuring food security, given that food safety is an essential dimension of food security. By reviewing existing studies, this paper summarizes three key types of contaminant (microbiological, chemical, and physical) that compromise food safety. With analyses of three cases (avian flu, genetic modification contamination, and melamine-tainted milk) in the Global South, the paper explores how food safety is …

Avian Advice, January 2019, Dale Bumpers College Of Agricultural, Food, And Life Sciences (University Of Arkansas, Fayetteville). Center Of Excellence For Poultry Science, University Of Arkansas (System). Cooperative Extension Service

Avian Advice

No abstract provided.

Virginia Commonwealth University Commencement Program [2019], Virginia Commonwealth University

VCU Commencement Programs

No abstract provided.

The One Health Initiative: The Intersection Of Human, Animal, And Environmental Health, Mary Evelyn Pearsall

Senior Honors Projects, 2010-2019

The One Health concept is a global strategy for strengthening interdisciplinary collaborations among health care for humans, animals, and the environment. The purpose of this honors capstone project is to study the One Health Initiative and create a comprehensive thesis on what the initiative is and how it is relevant to different sectors of health. An overview of prevalent zoonotic diseases will be provided including how they are transmitted and their global relevance. Case studies on zoonotic diseases will be used in which the effectivity of a One Health approach can be analyzed. In addition, relevant sections on One Health …

Ms Environmental Biology Capstone Project, Jenna M. Slabe

Regis University Student Publications (comprehensive collection)

MS Environmental Biology Capstone Project

Suffolk Journal, Vol.83, No.10, 12/11/2019, Suffolk Journal

Suffolk Journal

No abstract provided.

Suffolk Journal, Vol.82, No.11, 2/06/2019, Suffolk Journal

Suffolk Journal

No abstract provided.

Suffolk Journal, Vol.83, No.9, 11/13/2019, Suffolk Journal

Suffolk Journal

No abstract provided.

Improving Hepatitis C Screenings In The 1945 To 1965 Birth Cohort In Outpatient Primary Care, Betina Muse Nakoda

Doctor of Nursing Practice (DNP) Final Clinical Projects, 2016-2019

Background: Hepatitis C virus (HCV) is a silent epidemic affecting a vulnerable patient population in our society. Among those considered high risk for having HCV are those individuals born between 1945 and 1965, termed the baby boomer population. Baby boomers are five times more likely to have and suffer mortality from HCV than any other patient population (CDC, 2018). HCV may not present with signs or symptoms until 20 to 30 years post contraction of the virus (CDC, 2018). In 2012, the Centers for Disease Control and Prevention (CDC) updated its recommendations for Hepatitis C screenings to include the baby …

Controlling Latent Tb Tuberculosis Infection In High-Burden Countries: A Neglected Strategy To End Tb, Gavin J. Churchyard, Susan Swindells

Journal Articles: Infectious Diseases

In a Perspective, Gavin Churchyard and Sue Swindells discuss the importance of strategies to target latent tuberculosis infection in high risk populations and thus disrupt a reservoir for new infections in high burden countries.

Implementing A Discharge Navigator Reducing 30-Day Readmissions For Heart Failure And Sepsis Populations, Karen Weeks

Doctor of Nursing Practice (DNP) Final Clinical Projects, 2016-2019

A national focus for healthcare reform is preventing hospital readmissions. Thirty-day unplanned hospital readmissions impact patient outcomes and are costly to the healthcare system. This project explored the impact between the discharge navigator and 30-day unplanned readmissions for heart failure and sepsis populations in a 238-bed community hospital located in central Virginia. The primary aim of this discharge navigator project was to reduce 30-day readmissions for the heart failure and sepsis populations to meet the goals of the top quartile for like hospitals and the evaluation of cost avoidance for these readmissions. Heart failure and sepsis populations are high risks …

Graduate Medical Education Annual Report 2018-2019, Children's Mercy Hospital

GME Annual Reports

Annual report of the Children's Mercy Hospital Graduate Medical Education department, including pediatric residency, internal medicine/pediatrics residency, fellowship programs, medical students, continuing medical education, and library services.