Digital Commons Network^™

Related Peripheral Blood Stem Cell Donors Experience More Severe Symptoms And Less Complete Recovery At One Year Compared To Unrelated Donors, M. A. Pulsipher, B. R. Logan, D. M. Kiefer, P. Chitphakdithai, M. L. Riches, D. Rizzo, P. Anderlini, R. Bayer, I. Sahdev, B. E. Shaw, +51 Additional Authors

Journal Articles

No abstract provided.

Cost-Effective Surveillance For Infectious Diseases Through Specimen Pooling And Multiplex Assays, Christopher Bilder, Joshua Tebbs, Christopher Mcmahan

Department of Statistics: Faculty Publications

To develop specimen pooling algorithms that reduce the number of tests needed to test individuals for infectious diseases with multiplex assays.

Rigorous Analysis Of An Edge-Based Network Disease Model, Sabrina Mai

Honors Undergraduate Theses

Edge-based network disease models, in comparison to classic compartmental epidemiological models, better capture social factors affecting disease spread such as contact duration and social heterogeneity. We reason that there should exist infinitely many equilibria rather than only an endemic equilibrium and a disease-free equilibrium for the edge-based network disease model commonly used in the literature, as there do not exist any changes in demographic in the model. We modify the commonly used network model by relaxing some assumed conditions and factor in a dependency on initial conditions. We find that this modification still accounts for realistic dynamics of disease spread …

Baystate Health Sciences Library Newsletter - Winter 2019, Maria Roman

Library Newsletters

Health Sciences Newsletter - Winter 2019

Even Obligate Symbioses Show Signs Of Ecological Contingency: Impacts Of Symbiosis For An Invasive Stinkbug Are Mediated By Host Plant Context, Janelle Couret, Lynn Huynh-Griuffin, Ivan Antolic-Soban, Tarik Salam Acevedo-Gonzalez, Nicole M. Gerardo

Biological Sciences Faculty Publications

Many species interactions are dependent on environmental context, yet the benefits of obligate, mutualistic microbial symbioses to their hosts are typically assumed to be universal across environments. We directly tested this assumption, focusing on the symbiosis between the sap‐feeding insect Megacopta cribraria and its primary bacterial symbiont Candidatus Ishikawaella capsulata. We assessed host development time, survival, and body size in the presence and absence of the symbiont on two alternative host plants and in the insects' new invasive range. We found that association with the symbiont was critical for host survival to adulthood when reared on either host plant, with …

Antagonism Of Quorum Sensing Phenotypes By Analogs Of The Marine Bacterial Secondary Metabolite 3-Methyl-N-(2′-Phenylethyl)-Butyramide, Susan M. Meschwitz, Margaret E. Teasdale, Ann Mozzer, Nicole Martin, Jiayuan Liu, Stephanie Forschner-Dancause, David C. Rowley

Biomedical and Pharmaceutical Sciences Faculty Publications

Quorum sensing (QS) antagonists have been proposed as novel therapeutic agents to combat bacterial infections. We previously reported that the secondary metabolite 3-methyl-N-(2′-phenylethyl)-butyramide, produced by a marine bacterium identified as Halobacillus salinus, inhibits QS controlled phenotypes in multiple Gram-negative reporter strains. Here we report that N-phenethyl hexanamide, a structurally-related compound produced by the marine bacterium Vibrio neptunius, similarly demonstrates QS inhibitory properties. To more fully explore structure–activity relationships within this new class of QS inhibitors, a panel of twenty analogs was synthesized and biologically evaluated. Several compounds were identified with increased attenuation of QS-regulated phenotypes, most notably N-(4-fluorophenyl)-3-phenylpropanamide against the …

Neurogenesis In Neurodegenerative Diseases: Role Of Mfg-E8, Cletus Cheyuo, Monowar Aziz, Ping Wang

Faculty & Staff Scholarship

Neurodegenerative diseases are devastating medical conditions with no effective treatments. Restoration of impaired neurogenesis represents a promising therapeutic strategy for neurodegenerative diseases. Milk fat globule-epidermal growth factor-factor VIII (MFG-E8) is a secretory glycoprotein that plays a wide range of cellular functions including phagocytosis of apoptotic cells, anti-inflammation, tissue regeneration, and homeostasis. The beneficial role of MFG-E8 has been shown in cerebral ischemia (stroke), neurodegenerative diseases such as Alzheimer’s disease and Parkinson’s disease, and traumatic brain injury. In stroke, MFG-E8 promotes neural stem cell proliferation and their migration toward the ischemic brain tissues. These novel functions of MFG-E8 are primarily mediated …

Mutualist-Provisioned Resources Impact Vector Competency, Rita V. M. Rio, Anna K. S. Jozwick, Amy F. Savage, Afsoon Sabet, Aurelien Vigneron, Yineng Wu, Serap Aksoy, Brian L. Weiss

Faculty & Staff Scholarship

ABSTRACT Many symbionts supplement their host’s diet with essential nutrients. However, whether these nutrients also enhance parasitism is unknown. In this study, we investigated whether folate (vitamin B9) production by the tsetse fly (Glossina spp.) essential mutualist, Wigglesworthia, aids auxotrophic African trypanosomes in completing their life cycle within this obligate vector. We show that the expression of Wigglesworthia folate biosynthesis genes changes with the progression of trypanosome infection within tsetse. The disruption of Wigglesworthia folate production caused a reduction in the percentage of flies that housed midgut (MG) trypanosome infections. However, decreased folate did not prevent MG trypanosomes from migrating …

Longitudinal Analysis Of Memory B And T Cell Responses To Dengue Virus In A 5-Year Prospective Cohort Study In Thailand, Luis A. Sánchez-Vargas, Sonia Kounlavouth, Madison L. Smith, Kathryn B. Anderson, Anon Srikiatkhachorn, Damon W. Ellison, Jeffrey R. Currier, Timothy P. Endy, Anuja Mathew, Alan L. Rothman

Cell and Molecular Biology Faculty Publications

Prior exposure to dengue virus (DENV) has a profound impact on the outcome of infection, which varies according to the interval between infections. Antibodies secreted by B cells and cytokines secreted by T cells are thought to contribute both to protective immunity against DENV and the pathogenesis of dengue disease. We analyzed peripheral blood mononuclear cells (PBMC) collected from Thai children over a 5-year prospective cohort study to define the dynamics of DENV-specific memory B and T cell responses and the impact of symptomatic or subclinical DENV infections. To measure B cell responses, PBMC were stimulated with IL-2 plus R848 …

Bacterial Community Dynamics In An Oyster Hatchery In Response To Probiotic Treatment, Rebecca J. Stevick, Saebom Sohn, Tejashree H. Modak, David R. Nelson, David C. Rowley, Karin Tammi, Roxanna Smolowitz, Kathryn Markey Lundgren, Anton F. Post, Marta Gomez-Chiarri

Cell and Molecular Biology Faculty Publications

Larval oysters in hatcheries are susceptible to diseases caused by bacterial pathogens, including Vibrio spp. Previous studies have shown that daily addition of the probiotic Bacillus pumilus RI06-95 to water in rearing tanks increases larval survival when challenged with the pathogen Vibrio coralliilyticus. We propose that the presence of probiotics causes shifts in bacterial community structure in rearing tanks, leading to a net decrease in the relative abundance of potential pathogens. During three trials spanning the 2012–2015 hatchery seasons, larvae, tank biofilm, and rearing water samples were collected from control and probiotic-treated tanks in an oyster hatchery over a …

Research At Nebraska, 2018-2019 Report, University Of Nebraska-Lincoln

Office of Research and Economic Development: Publications

This publication is a snapshot of the fiscal year’s activities. To read more stories about research and creativity at Nebraska, visit the online edition at https://research.unl.edu/annualreport/2019. Additional multimedia are available for many stories.

College Of Pharmacy 2019, Nova Southeastern University

Health Professions Divisions Course Catalogs and Course Descriptions

No abstract provided.

University Of Texas At Tyler Course Catalog, 2019 - 2020, University Of Texas At Tyler

Catalogs

No abstract provided.

The Socio-Economic Impact Of The Disproportionate Occurrence Of Asthma In The State Of Mississippi: Should Reporting Be Mandated?, Lolita D. Gray, Jahniah Grimsley, Jabria Pearson

Journal of Health Ethics

The state of Mississippi continues to experience a disproportionate occurrence of asthma among its citizens and various associated socioeconomic impacts. The objective of this study seeks to gauge the perception of the participants in regards to this asthma disparity. Specifically, research questions seek responses to following: 1) Will mandated, systematic reporting of asthma occurrences among socioeconomically disadvantaged communities effectively address the asthma disparity and lead to a better quality of life? and 2) Will mandated, systematic reporting of asthma increase the socioeconomic impact among these communities? This cross-sectional study employs a case study methodology utilizing various research techniques, i.e. interviews, …

Route Of Administration For Antibiotics With High Oral Bioavailability, Michael J. Smith, Cary Thurm, Samir S. Shah, Sameer J. Patel, Matthew P. Kronman, Jeffrey S. Gerber, Joshua D. Courter, Brian R. Lee, Jason G. Newland, Adam L. Hersh

Open Access Publications

No abstract provided.

Clinical Characterization Of Host Response To Simian Hemorrhagic Fever Virus Infection In Permissive And Refractory Hosts: A Model For Determining Mechanisms Of Vhf Pathogenesis, Adam L. Bailey, Et Al

Open Access Publications

No abstract provided.

Comparing Screening And Treatment Of Bacterial Vaginosis And Pregnancy Outcomes, Stephanie Severson

Physician Assistant Scholarly Project Posters

• Evidence shows that bacterial vaginosis (BV) can lead to poor perinatal outcomes.

• The goal of this project is to answer the question of which pregnant patients should be screened for BV and does identification and treatment of BV during pregnancy improve perinatal outcomes.

• Due to variability in a multitude of factors, a generalized recommendation is difficult to make. Lack of recommendations are largely due to harm of treatment in those who were misdiagnosed.

• The development of polymerase chain reaction (PCR) has the capability to reduce misdiagnosis.

• Newer studies have shown benefit of early screening and …

Evaluating Shallow Mixing Protocols As Application Methods For Microbial Induced Calcite Precipitation Targeting Expansive Soil Treatment, Bhaskar C. S. Chittoori, Tasria Rahman, Malcolm Burbank, Arif Ali Baig Moghal

Civil Engineering Faculty Publications and Presentations

Expansive soils, also known as swell-shrink soils, undergo substantial volumetric changes due to moisture fluctuations from seasonal variations. These volumetric changes cause millions of dollars in damages annually. Microbial Induced Calcite Precipitation (MICP) is a promising soil improvement technique, which uses urease producing bacteria to precipitate calcium carbonate. In this study, a stabilization alternative for expansive soils was studied using MICP. Specifically, indigenous bacteria were stimulated by mixing enrichment and cementation solutions with expansive natural soils to precipitate calcium carbonate and make soil stronger and less expansive. This study examined three expansive soils with varying plasticity and mineralogical characteristics. Two …

Viral Sovereignty, Intellectual Property, And The Changing Global System For Sharing Pathogens For Infectious Disease Research, Sam Halabi

Annals of Health Law and Life Sciences

No abstract provided.

Table Of Contents, Annals Of Health Law

Annals of Health Law and Life Sciences

No abstract provided.

Foreword, Mary Hannosh

Annals of Health Law and Life Sciences

No abstract provided.

Successes And Failures Of Social Health Insurance Schemes In Africa - Nigeria Versus Ghana And Rwanda: A Comparative Analysis, Obiajulu Nnamuchi, Jirinwayo Jude Odinkonigbo, Uju Beatrice Obuka, Helen Agu

Annals of Health Law and Life Sciences

No abstract provided.

Consequences Of Pathogen Lists: Why Some Diseases May Continue To Plague Us, David Brett-Major, Trina Racine, Gary P. Kobinger

Journal Articles: Epidemiology

The current strategy used by many funding agencies for determining how money is spent on research to help prevent infectious disease outbreaks is based on pathogen-specific priority lists. Listing disease threats provides focus for business and research planning conducive to specific goals of developing a drug, or a vaccine, or other particular product. But, this singular type of focus has consequences. This perspective explores the consequences of lists, and describes how parallel programming independent of disease lists that address what we need to do to prevent and mitigate emerging disease risks may provide benefits out of reach of a singular …

Response 2019, Seattle Pacific University

Seattle Pacific Alumni Magazines

No abstract provided.

Rightsizing Open Access Journals Project - List Of Open Access Journals Added Or Updated In 2017 With The Effect On Usage Thru Mid-2019 (Data File), Barbara M. Pope

Faculty Submissions

Academic libraries have long had print journal collections to support the university’s discovery and research needs. However, they are also continually challenged with needs for relevant content, cost control, and space availability; some academic libraries have downsized their print journal collections as a result. Many academic libraries are replacing some print journal subscriptions with online subscriptions and supplementing with open access journals. Pittsburg State University’s (PSU) Axe Library faces the challenge of providing journal access in order to support the university’s needs and stay on budget. To that end, PSU drastically weeded its print journals in 2016 and later began …

Effect Of Abo Blood Group On Asymptomatic, Uncomplicated And Placental Plasmodium Falciparum Infection: Systematic Review And Meta-Analysis, Abraham Degarege, Merhawi T. Gebrezgi, Consuelo M. Beck-Sague, Mats Wahlgren, Luiz Carlos De Mattos, Purnima Madhivanan

Journal Articles: Epidemiology

BACKGROUND: Malaria clinical outcomes vary by erythrocyte characteristics, including ABO blood group, but the effect of ABO blood group on asymptomatic, uncomplicated and placental Plasmodium falciparum (P. falciparum) infection remains unclear. We explored effects of ABO blood group on asymptomatic, uncomplicated and placental falciparum infection in the published literature.

METHODS: A systematic review and meta-analysis was performed using the preferred reporting items for systematic reviews and meta-analyses guidelines. Articles in Pubmed, Embase, Web of Science, CINAHL and Cochrane Library published before February 04, 2017 were searched without restriction. Studies were included if they reported P. falciparum infection incidence or prevalence, …

Public Health And Personal Choice: The Ethics Of Vaccine Mandates And Parental Refusal In The United States, Rebecca Horan, Jonelle Depetro

2019 Awards for Excellence in Student Research and Creative Activity – Documents

In January 2019 The World Health Organization (WHO) released its list Ten threats to global health in 2019. For the first time ever, vaccine hesitancy, “the reluctance or refusal to vaccinate despite the availability of vaccine services” is officially on the list.1 Although great progress has been made in reducing or eradicating various diseases such as polio, measles, and whooping cough (pertussis), the number of parents refusing vaccination for their children is growing rapidly in what is now often referred to as the “anti-vaccination movement” ( or “anti-vax movement”). This is causing a threat to public health as …

252nd Annual Report Of The Selectmen And Other Town Officers Cornish, New Hampshire Year Ending December 31, 2018., Cornish Town Representatives

Cornish, NH Annual Reports

This is an annual report containing vital statistics for a town/city in the state of New Hampshire.

Disparities In The Use Of Prophylactic Treatments In Reproductive Health Between The Sexes: A Recommendation For The Use Of Hpv Vaccination Schemes Rather Than Surgical Interventions To Reduce Inequities And Threats To The Public’S Health

Florida A & M University Law Review

This Article will examine the unequal treatment of the sexes under the law with regard to prophylactic treatments against STDs. The second section of this Article will discuss the ethical and legal issues in the use of prophylactic treatments and the issues involving informed consent regarding their use. The third section of this Article will discuss the historic and current use of prophylactic surgeries on both sexes to prevent disease and the challenges that have been raised against such practices. The fourth section of this Article will discuss the use of the H.P.V. vaccinations in both sexes to reduce the …

Gattonrx Magazine - 2019, Bill Gatton College Of Pharmacy, East Tennessee State University

GattonRX Magazine

No abstract provided.