Digital Commons Network^™

Glycated Serum Protein Genetics And Pleiotropy With Cardiometabolic Risk Factors, Matthew P. Johnson, Ryan Keyho, Nicholas B. Blackburn, Sandra Laston, Satish Kumar, Juan M. Peralta, Suman S. Thapa, Bradford Towne, Janardan Subedi, John Blangero, Sarah Williams-Blangero

School of Medicine Publications

Measurements of fasting glucose (FG) or glycated hemoglobin A1c (HbA1c) are two clinically approved approaches commonly used to determine glycemia, both of which are influenced by genetic factors. Obtaining accurate measurements of FG or HbA1c is not without its challenges, though. Measuring glycated serum protein (GSP) offers an alternative approach for assessing glycemia. The aim of this study was to estimate the heritability of GSP and GSP expressed as a percentage of total serum albumin (%GA) using a variance component approach and localize genomic regions (QTLs) that harbor genes likely to influence GSP and %GA trait variation in a large …

Unnecessary Prescribing Of Antibiotics To Healthy/Asymptomatic School-Age Carriers Of Potentially Pathogenic Bacteria, Mirjana Kostić, Vladimir Bedeković, Biserka Bastijančić-Kokić, Tomislav Lauc

Saudi Medical Journal

Objectives: To re-draw attention to the unnecessary prescribing of antibiotics. Methods: We monitored nasopharyngeal colonization by 3 potentially pathogenic bacteria, Streptococcus pyogenes, Streptococcus pneumoniae, and Haemophilus influenzae type b in 81 children between the ages of 6 and 7 years who attended the same primary school. The children’s health status was also monitored, without using antimicrobial treatment for healthy/asymptomatic carriers. Nasopharyngeal swabs were collected on 6 occasions during autumn months, from mid-September to mid-December 2016. The children who fell ill during the study were treated at the Ear, Nose and Throat Clinic, Sisters of Mercy University Hospital Center, Zagreb, Croatia. …

Who Launches New Global Influenza Strategy

Saudi Medical Journal

No abstract provided.

Profil Of Implementation Of Post Exposure Prophylaxis Of Hepatitis B, Hepatitis C And Human Immunodeficiency Virus To Health Care Worker In Cipto Mangunkusomo Hospital 2014-2016, Dewi Mira Ratih, Evy Yunihastuti, Regina Lestari, Andri Andri Sulaiman, Ikhwan Rinaldi

Jurnal Penyakit Dalam Indonesia

Introduction. Health care workers (HCW) have a high risk of infectious substance exposure. Hepatitis B, hepatitis C, or human immunodeficiency virus (HIV) are some diseases transmitted by body fluid or body tissue. Cipto Mangunkusumo Hospital Jakarta has been implementing post-exposure prophylaxis (PEP)s towards HIV, hepatitis B, and hepatitis C. This study aimed to identify the implementation of post-exposure prophylaxis of HIV, Hepatitis B, and Hepatitis C among HCW in Cipto Mangunkusumo Hospital Jakarta. Methods. A cross-sectional study was conducted to exposed workers in Cipto Mangunkusumo Hospital Jakarta between 2014-2016 who had been recorded by report. Demographic data were collected through …

Analysis Of Anc Levels After Filgrastim Therapy In Acute Leukemia Children With Neutropenia, Reta Anggraeni Widya, Susanto Nugroho, Sri Winarsih, Yulistiani Yulistiani

Folia Medica Indonesiana

Cytotoxic chemotherapy suppresses the hematopoietic system, and the most serious hematologic toxicity is neutropenia. This can decrease a risk of infection that causes delays in treatment and reduction of dose intensity, which reduces therapeutic outcome. Filgrastim is used to increase neutrophils level whose therapeutic effect is unknown. The effectiveness of filgrastim is based on the ANC level pre- and post-therapy. This study aimed to analyze the use of filgrastim on ANC level changes in acute leukemia children with neutropenia, and to analyze the patient that achieve ANC level's targeted therapy = 1000 cell/mm3. A prospective observational study with a longitudinal …

Correlation Between The Bacteriostatic And Bactericide Effect With Antibiofilm And Anticolony Spreading From Javanese Citronella Oil On Methicillin-Resistant Staphylococcus Aureus (Mrsa), Amaliyah Nurul Hidayah, Eddy Bagus Wasito, Kartuti Debora, Achmad Basori, Isnaeni Isnaeni, Budi Utomo

Folia Medica Indonesiana

Methicillin-resistant Staphylococcus aureus (MRSA) is a pathogenic bacterium that has been resistant to various types of antibiotics, so it is not easy to be treated with antibiotics and needs other solutions. Javanese citronella oil distilled from the Cymbopogon nardus plant is proven to function as an antibacterial agent (bacteriostatic and bactericidal), fungicide and repellent. This study aimed to prove that there is a positive correlation between bacteriostatic and bactericidal effects with antibiofilm and anticolony spreading from Javanese citronella oil on MRSA. The intended antibiofilm is a barrier to biofilm formation and eradication. Bacteriostatic and antibiofilm effects were tested using microtiter …

Assessment Of The Rapid Immunochromatographic Test As A Diagnostic Tool For Norovirus Related Diarrhea In Children, Reza Gunadi Ranuh, Alpha Fardah Athiyyah, Deanty Ayu Pa, Andy Darma, Dadik Raharjo, Toshiro Shirakawa, Subijanto Marto Sudarmo

Folia Medica Indonesiana

In developing countries, Norovirus is the second-leading cause of acute diarrhea, after rotavirus. The approved gold standard method for diagnosis of norovirus infection is RT-PCR. The rapid immunochromatographic test is a novel and expedient method for diagnosing norovirus that is relatively affordable. However, the use of the rapid immunochromatographic test remains controversial because of its accuracy. This study aimed to explore whether the rapid immunochromatographic test could be used for diagnosing norovirus-related diarrhea in children. Rapid immunochromatographic test (QuickNaviTM-Norovirus2) and RT-PCR on stool samples was used to diagnose norovirus. Stool samples were obtained from pediatric patients aged between 1 and …

Cytotoxic And Antimicrobial Activities Of The Constituents Of Ten Plant Species From Tanzania, Joan J. E. Munissi

Tanzania Journal of Science

This paper reports on the antimicrobial and cytotoxicity activities of crude extracts from the plant species Clemaptosis scabiosifolia (Ranunculaceae), Diospyros mafiensis (Ebenaceae), Dolichos kilimandscharicus (Leguminosae), Gnidia kraussiana (Thymelaeaceae), Hugonia castaneifolia (Linaceae), Neorautanenia mitis (Pappilionaceae), Tagetes minuta (Asteraceae), Uvaria acuminata (Annonaceae), Vernonia amygdalina (Asteraceae) and Zanha africana (Sapindaceae). All crude extracts were screened for their cytotoxicities in the brine shrimp lethality test (BST). Fractions and pure compounds from Hugonia castaneifolia, Diospyros mafiensis and Uvaria acuminata were tested for their cytotoxicity and antimicrobial activities against ten microorganisms, namely Candida albicans, Bacillus anthracis, Escherichia coli, Klebsiela pneumoniae, Proteus sp., Pseudomonas aeruginosa, Salmonella typhimurium, …

Prevalence Of Zoonotic Parasites In Stray Dogs In Rural Communities, Tanzania, Winifrida Kidima

Tanzania Journal of Science

The aim of this study was to identify and establish the baseline information on the prevalence of zoonotic parasites in stray dogs in Tanzania. A cross sectional study was conducted in Katavi, Arusha and Rukwa Regions in Tanzania. Intestinal parasites were analyzed from faecal samples collected from 364 dogs using modified sedimentation technique. Sixty-sixpercentage (66%) of the faecal samples were positive for gastrointestinal parasites while 7% had mixed infections, 27% were negative for the parasites. Higher proportions of the faecal samples were positive for gastrointestinal parasites in Arusha and Rukwa compared to Katavi (p< 0.0001). The prevalence of Ancylostomacaninum(49%) was higher compared to that of other parasites (p <0.0001). Prevalence of A. lumbricoideswas significantly higher compared to that of E. granulosusand S. stercoralis(p = 0.0046). There was a positive association between parasite positivity rates and collecting dog’s faecal samples near domestic animals (p < 0.00001). Parasite diversity was higher in stray dogs from Katavi and Arusha (p > 0.05). There was no association between …

Citizen Science And The History Of Vaccination, Bailey Kemp

Undergraduate Research Symposium 2019

Vaccination has saved millions of lives by harnessing the power of the immune system to confer resistance to infectious disease. While modern “vaccination” is relatively new, “inoculation,” or the transferring of “virulent matter” from infected to uninfected person, has earlier origins. For instance, Lady Mary Wortley Montagu played a pioneering role in popularizing smallpox inoculation in 1720s England by inoculating her own children. Across the ocean, the Puritan minister Cotton Mather advocated for inoculation against the demands of other religious leaders who viewed inoculation as an assault on the will of God. Neither of these individuals were doctors, or even …

Ale Beer Containing Free And Immobilized Lactobacillus Brevis, A Potential Delivery System For Probiotics, Kriza Faye Albacite Calumba

LSU Master's Theses

Probiotic products can improve gastrointestinal health and probiotics in ale beer may be attractive to health-conscious consumers. However, the alcohol in beer may decrease probiotic viability. A powder produced from durian fruit (Durio zibethinus) rind, a by-product that is currently unutilized, contains large amounts of fiber which can be used to immobilize probiotics. The objective of this study was to produce ale beer with free Lactobacillus brevis (FLB) and immobilized cells (ILB) on durian rind powder (DRP) as a potential delivery system for probiotics. L. brevis was immobilized in DRP then the morphology of FLB and ILB was …

Role Of Avian Hosts In Spread And Maintenance Of Borrelia Spp. And Rickettsia Spp. In Ixodes Spp. Collected Off Birds In Southeastern Virginia, Alexandra Cumbie, Erin Heller, Anna Phan, Zach Bement, Eric Walters, Holly Gaff, Wayne Hynes

Graduate School Posters

The role that birds play in the maintenance and the movement of ticks and tick-borne pathogens is an important area of research. The home ranges of resident bird species, and the migratory nature of others, can influence vector-borne disease ecology in a region. Of particular interest is the interaction of birds, both resident and migratory, with Ixodes spp. which are the primary vector species of Borrelia burgdorferi, the causative agent of Lyme disease. This genus has also been associated with the detection of other tick-borne pathogens, including Rickettsia rickettsii. In this study, Ixodes spp. were removed from birds captured …

Inhibitory Effect Of Lactobacillus Bacteriocin Durancin Gl On L. Monocytogenes In Chilled Chicken, Wu Xueyou, Chen Zhengxing, Ju Xingrong

Food and Machinery

Lactobacillus bacteriocin is a kind of bacteriostatic protein or polypeptide produced by Lactobacillus. It has great application value in food preservation. In this study, Durancin GL, a Lactobacillus bacteriocin, was used to treat chilled chicken for storage. The antiseptic effect of Durancin GL on chilled chicken was investigated by sensory evaluation, quality analysis and inhibition of harmful microorganisms. The results show that treatment of chilled chicken with 200 AU/mL bacteriocin preservative solution can inhibit the growth of L. monocytogenes, slow down the increase of total volatile basic nitrogen (TVB-N) content and pH, and slow down the deterioration of meat quality. …

Synchrony Is More Than Its Top-Down And Climatic Parts: Interacting Moran Effects On Phytoplankton In British Seas, Lw Sheppard, Ej Defriez, Pc Reid, Dc Reuman

School of Biological and Marine Sciences

Large-scale spatial synchrony is ubiquitous in ecology. We examined 56 years of data representing chlorophyll density in 26 areas in British seas monitored by the Continuous Plankton Recorder survey. We used wavelet methods to disaggregate synchronous fluctuations by timescale and determine that drivers of synchrony include both biotic and abiotic variables. We tested these drivers for statistical significance by comparison with spatially synchronous surrogate data. Identification of causes of synchrony is distinct from, and goes beyond, determining drivers of local population dynamics. We generated timescale-specific models, accounting for 61% of long-timescale (> 4yrs) synchrony in a chlorophyll density index, but …

Bacteriological Diagnosis Of Febrile Neutropenia In Oncology Teaching Hospital, Azher S. Al-Zubaidy, Salam Salah Jumaah, Qasim Razaq Radhi

Iraqi Postgraduate Medical Journal

ABSTRACT: BACK GROUND: Fever may be the only indication of a severe infection, it occurs in about (10 -50%) of patients with solid malignancy during chemotherapy-induced neutropenia. OBJECTIVE: To determine the common pathogens causing febrile neutropenia and their susceptibility to antibiotics in patients with solid malignancies in oncology teaching hospital. PATIENTS AND METHODS: 50 patients with solid malignancy were enrolled in this cross sectional study. Blood culture and sensitivity test were investigated for them. Other sample cultures were investigated according to system involvement. RESULTS: Blood culture was positive in 18% of patients. Gram negative bacteria were predominant (81.81%). Among which …

Impact Of Intrinsic Physiological Factors In The Population Recovery Of Myotis Lucifugus (Little Brown Myotis) From White-Nose Syndrome, Caroline Burke, Caitlin Looney, Alissah Sillah, Christopher Richardson

Lesley University Community of Scholars Day

White-nose Syndrome (WNS) has decimated populations of hibernating bats in the US. In particular, Myotis lucifugus (little brown myotis) has been one of the most affected. We investigated the energetic cost of innate immune response and Pseudogymnoascus destructans (Pd) fungal activity on post-hibernating little brown myotis and the link with the recovery of local populations in New England from WNS. We captured bats at one of each of 4 colonies in Eastern Massachusetts and Southern New Hampshire, consecutively, every 14 days to minimize disturbance to the colony. Blood samples were collected from each bat. Respirometry trials were performed on each …

Efficacy Of Aqueous And Gaseous Chlorine Dioxide In Reducing Salmonella, E. Coli O157:H7, And Listeria Monocytogenes On Sweet Potatoes, Strawberries, And Blueberries, Phillip Luu

LSU Master's Theses

Chlorine dioxide, a stronger oxidizing agent, is effective against a broad spectrum of microorganisms. This study evaluated the efficacy of chlorine dioxide on reducing Salmonella, E. coli O157:H7, and Listeria monocytogenes on sweet potato (aqueous ClO₂), strawberries and blueberries (gaseous ClO₂). Sweet potatoes inoculated with multi-strain cocktails of each bacterial pathogen (10⁷ CFU/cm²) were treated with 5 ppm aqueous ClO₂ or water for 10, 20, and 30 minutes. Strawberries and blueberries spot inoculated with multi-strain cocktails of each bacterial pathogen (10⁷ CFU/g) were treated with gaseous ClO₂ sachets (63 mg/l for strawberry and 30 mg/l for blueberry) …

Open-Label Randomized Trial Of Early Clinical Outcomes Of Ceftaroline Fosamil Versus Vancomycin For The Treatment Of Acute Bacterial Skin And Skin Structure Infections At Risk Of Methicillin-Resistant Staphylococcus Aureus, Kimberly C. Claeys, Evan J. Zasowski, Trang D. Trinh, Anthony M. Casapao, Jason M. Pogue, Nitin Bhatia, Ryan P. Mynatt, Suprat S. Wilson, Crystal Arthur, Robert Welch, Robert Sherwin, Wasif Hafeez, Donald P. Levine, Keith S. Kaye, George Delgado, Christopher A. Giuliano, Robert Takla, Colleen Rieck, Leonard B. Johnson, Kyle P. Murray, James Gordon, Kate Reyes, Pamela Hartman, Susan L. Davis, Michael J. Rybak

Infectious Diseases Articles

INTRODUCTION: Acute bacterial skin and skin structure infections (ABSSSIs) remain among the most common infectious processes seen in the clinical setting. For patients with complicated ABSSSIs deemed to require intravenous antibiotics, vancomycin remains the mainstay therapy. Ceftaroline has been shown to be non-inferior to vancomycin and may result in faster resolution of signs of infection.

METHODS: Multicenter, prospective, open-label, randomized trial of ceftaroline versus vancomycin for the treatment of adult patients admitted for management of ABSSSIs from April 2012 to May 2016; 166 patients in the clinically evaluable (CE) group were needed to determine a 20% difference in primary outcome …

Topical Mining Of Malaria Using Social Media. A Text Mining Approach, James Boit, Omar El-Gayar

Annual Research Symposium

No abstract provided.

The Use Of Aerosolized Ribavirin In Respiratory Syncytial Virus Lower Respiratory Tract Infections In Adult Immunocompromised Patients: A Systematic Review, Lisa M. Avery, Charles Hoffmann, Karen M. Whalen

Pharmacy Faculty/Staff Publications

Introduction: Respiratory syncytial virus (RSV)–associated lower respiratory tract infection (LRTI) is a concern in immunocompromised patients. Aerosolized ribavirin (RBV AER) is used for treatment of RSV LRTI; however, adverse events and rising drug costs remain a challenge for patient management. The purpose of this systematic review is to summarize the efficacy and adverse event profile of RBV AER for the treatment of hospitalized RSV LRTI in immunocompromised adult patients. Methods: A Medline/PubMed, Embase, Google Scholar, Clinicaltrials.gov, and Cochrane Library database search was conducted from 1966 to January 2019 for the use of RBV AER. Search strategy: [(ribavirin OR ICN1229) AND …

Zika Virus-Specific Igy Results Are Therapeutic Following A Lethal Zika Virus Challenge Without Inducing Antibody-Dependent Enhancement, Kyle L. O'Donnell, Bernadette Meberg, James Schiltz, Matthew L. Nilles, David S. Bradley

Biomedical Sciences Faculty Publications

The Zika virus (ZIKV) is a newly emerged pathogen in the Western hemisphere. It was declared a global health emergency by the World Health Organization in 2016. There have been 223,477 confirmed cases, including 3720 congenital syndrome cases since 2015. ZIKV infection symptoms range from asymptomatic to Gullain–Barré syndrome and extensive neuropathology in infected fetuses. Passive and active vaccines have been unsuccessful in the protection from or the treatment of flaviviral infections due to antibody-dependent enhancement (ADE). ADE causes an increased viral load due to an increased monocyte opsonization by non-neutralizing, low-avidity antibodies from a previous dengue virus (DENV) infection …

Independent - Mar. 26, 2019, Robin Bridges

The Independent (1988-present)

No abstract provided.

Feral Swine Disease Surveillance – National Targets And Pilot Projects, Vienna R. Brown, Rachel M. Maison, Thomas Gidlewski

Wildlife Damage Management Conference

The National Feral Swine Damage Management Program (NFSP) in collaboration with the National Wildlife Disease Program (NWDP) and USDA APHIS Veterinary Services works to identify the diseases of national concern in feral swine. The current national disease surveillance program includes classical swine fever (CSF), swine brucellosis (SB), and pseudorabies (PRV). CSF is a foreign animal disease and feral swine samples collected and tested serve as part of Veterinary Services surveillance stream for this pathogen. Both SB and PRV have been eradicated from U.S. commercial swine operations; however, as they are endemic diseases in feral swine populations, monitoring of feral swine …

Week Of March 25, 2019, New York Medical College

InTouch

• Graduate Student Research Forum Displays a Broad Field of Research
• NYMC Hosts Fourth Annual HeLa Diversity and Inclusion Conference
• Center for Disaster Medicine Conducts Inaugural Tactical Emergency Casualty Course
• NYMC Welcomes AMSNY to Campus
• NYMC AMWA Chapter Hosts Annual Mentorship Dinner
• Alpha Omega Alpha Lecture Set for April 2

The Effect Of Phylogenetic Uncertainty And Imputation On Edge Scores, K. Bodie Weedop, Arne Ø. Mooers, Caroline M. Tucker, William D. Pearse

Biology Faculty Publications

Faced with the challenge of saving as much diversity as possible given financial and time constraints, conservation biologists are increasingly prioritizing species on the basis of their overall contribution to evolutionary diversity. Metrics such as EDGE (Evolutionary Distinct and Globally Endangered) have been used to set such evolutionarily based conservation priorities for a number of taxa, such as mammals, birds, corals, amphibians, and sharks. Each application of EDGE has required some form of correction to account for species whose positions within the tree of life are unknown. Perhaps the most advanced of these corrections is phylogenetic imputation, but to date …

A Mixed Method Multi-Country Assessment Of Barriers To Implementing Pediatric Inpatient Care Guidelines, Kirkby D. Tickell, Dorothy I. Mangale, Stephanie N. Tornberg-Belanger, Celine Bourdon, Johnstone Thitiri, Molline Timbwa, Jenala Njirammadzi, Wieger Voskuijl, Ali Faisal Saleem, Zaubina Kazi

Department of Paediatrics and Child Health

Introduction: Accelerating progress in reducing child deaths is needed in order to achieve the Sustainable Development Goal child mortality target. This will require a focus on vulnerable children-including young children, those who are undernourished or with acute illnesses requiring hospitalization. Improving adherence to inpatient guidelines may be an important strategy to reduce child mortality, including among the most vulnerable. The aim of our assessment of nine sub-Saharan African and South Asian hospitals was to determine adherence to pediatric inpatient care recommendations, in addition to capacity for and barriers to implementation of guideline-adherent care prior to commencing the Childhood Acute Illness …

Effects Of Dietary Sugars And Sugar Alcohols On Mortality And Thermal Tolerance In Culex Quinquefasciatus And Aedes Aegypti, Madeleine Chura

LSU Master's Theses

Aedes aegypti (L. 1762), the yellow fever mosquito, and Culex quinquefasciatus Say 1823, the southern house mosquito, are prevalent in tropical and subtropical areas worldwide and are responsible for the spread of a number of devastating diseases to humans and livestock. The development of new control methods, as well as continued study of mosquito biology, is vital for improving human health. This study aimed to examine the efficacy of sugar alcohols as a novel means for mosquito control, as well as how sugar alcohols and other factors are involved in thermal tolerance in mosquitoes.

No-choice tests with the sugar alcohols …

Barren Lands And Barren Bodies In Navajo Nation: Indian Women Warn About Uranium, Genetics, And Sterilization, Marie Bolton, Nancy C. Unger

History

Founded by Native American women in 1974, "Women of All Red Nations (WARN) insisted that the ongoing Indian public health crisis could not be properly understood exclusively within the context of the exploitation and pollution of the physical environment. It required as well an understanding of the larger context of Indian health issues evolving out of past and present cultural and political changes. This article focuses on selected health, threats affecting the Dine, or "the People," as Navajo Indians call themselves, living in Dine Bikeyah (Navajo Nation) during the mid to late 20^th century. Navajo history is marked by …

Dirt, Saliva And Leprosy: Anti-Inflammatory And Anti-Infectious Effects, Helieh S. Oz

Internal Medicine Faculty Publications

Ancient Egyptians smeared a mixture of dark soil on their eyelids and believed it protected eyes from unknown forces (illness). Recent studies have proven that the dark soil across the Nile River is rich in natural compounds including lead sulfide, which in low levels, promotes the production of nitric oxide (240-fold) by keratinocytes, with strong immune stimulatory and antimicrobial properties. Current investigations reveal anti-inflammatory and anti-infectious activities—including cytokines and chemokines—in saliva, as well as its friendly microbiota, which lines the surface of the oral cavity, its protection against inflammatory and infectious organisms in the stoma and other organs, such as …

Implementation Of Lgbt+ Health Education For Master’S Entry Nursing Students, Daniel R. Mead

College of Science and Health Theses and Dissertations

Background: There is a paucity of evidence linking Lesbian, Gay, Bisexual, and Transgender (LGBT+) health education with improvement in nursing students’ knowledge, attitudes, and comfort of LGBT+ health considerations.

Methods: In a pre- and post-test study design, a total of 77 master’s entry to nursing practice students completed the LGBT+ health educational module during the Community Health Nursing course.

Results: Statistically significant results were found between pre-test to post-test data for knowledge (p < .001, Cohen’s d 2.52), attitudes (p < .001, Cohen’s d 0.35), and comfort (p = .001, Cohen’s d 0.31) of LGBT+ health considerations.

Conclusion: The LGBT+ health education module …