Digital Commons Network^™

A Case Study Of The Patient Wait Experience In An Emergency Department With Therapy Dogs, Colleen A. Dell, James Stempien, Lindsey Broberg, Alicia Husband, Lacey Jurke, Betty Rohr, Jane Smith, Joseph Rubin, Susan Tupper, Donna Goodridge, Cathie Fornssler, Logan Fele-Slaferek

Patient Experience Journal

The quality of patient healthcare is a growing concern in Canada’s hospital emergency departments (ED) due to increasing wait times and associated adverse outcomes. A developing body of literature indicates that therapy dogs can positively impact the patient experience. In 2016, members of our team partnered with the Royal University Hospital (RUH) in Saskatchewan to become the first ED in Canada to integrate a visiting therapy dog to positively impact the patient wait experience. The aim of this preliminary case study was to examine if and how this unique initiative impacted patients’ feelings during their ED wait. A brief questionnaire …

One Patient's Experiences And Expectations In The Healthcare System: Complicated And Critical Illness With Rare Diagnosis Described By His Advocate, Jennifer Cademartori

Patient Experience Journal

The health care business serves as a profession in the art of human illness. But unlike other businesses there is the human side, the patient experience. These patients are the “customers” receiving the care, but they, unlike customers at a retail store, are vulnerable and scared and must trust their lives in the hands of people they don’t know. The paradigm must change to reflect how the health care business is handled from the eyes of the person receiving the care from the first office visit, through the inpatient stay, to follow up visits. Patient focused training on all levels …

Perioperative Antimicrobial Prophylaxis In Vascular Surgery: A Quality Assessment And Improvement Project, Brian Torres

Dissertations

Introduction: Prophylactic antimicrobial selection and administration for the prevention of surgical site infections in vascular surgery is a recommended best practice. Non-adherence to published guidelines on the selection and administration of antimicrobials has been observed and may lead to reduced efficacy of antimicrobial prophylaxis.

Methods: An observational, descriptive design was used to study clinician knowledge and behavior and included a retrospective patient record review and provider knowledge survey. A clinical education intervention targeting providers responsible for the selection and administration of antimicrobial prophylaxis was conducted. A repeat patient record review and knowledge survey was completed following the education intervention.

Results: …

$17 Million Grant Will Explore Immune Cells In Inaccessible Tissues Of The Human Body, Jeff Hansen

Browse All News

No abstract provided.

Responding To Opioid Use Disorder: Identifying The Therapeutic Commitment Of Maine Nurse Practitioners, Jordan S. Porter

DNP Projects

Background: Buprenorphine, an underutilized pharmacotherapy, can play a key role in closing the substantial opioid use disorder (OUD) treatment gap in the United States. Although 2016 US legislation authorized trained nurse practitioners (NPs) to obtain the Drug Enforcement Agency waiver to prescribe buprenorphine for OUD, many NPs do not have the waiver, and a large proportion of waivered NPs do not prescribe to capacity. Purpose: To identify the therapeutic commitment of Maine NPs to OUD as well as understand why Maine NPs do not adopt and utilize buprenorphine for the treatment of OUD. Review of Evidence: Commitment …

Week Of April 22, 2019, New York Medical College

InTouch

• NYMed Talks Highlights Success Through Diversity
• Lectureship Honors the Late Gabor Kaley, Ph.D.

Self-Efficacy And Stem Career Interest In Black And Latino Middle School Students: A Study On The Next Generation Science Standards, Whitney Mccormick

LMU Theses and Dissertations

With only 11% of the current Science, Technology, Engineering, and Math (STEM) workforce being Black and Latino men and women, there is a crisis of underrepresented individuals in STEM fields. The construction of the Next Generation Science Standards (NGSS), and the mantra “all standards, all students,” represents an attempt to increase access to science for more students, and increase their self-efficacy about STEM subjects, as low self-efficacy is cited as one of the main causes of disinterest in STEM subjects. This study examined the relationship between students’ self-efficacy in STEM fields and their career interests, specifically in a population of …

The Perception Of Physical Activity And Social Support For Physical Activity Among Native Hawaiians 55 Years And Older, Verna Hanashiro

Dissertations

The benefits of physical activity on healthy aging and longevity have repeatedly been identified. Despite these known benefits, sedentary living is a serious and pervasive health problem among older adults throughout the United States, including the Native Hawaiian older adult population in Hawaii. Previous research has identified social support as a major facilitator for participation in physical activity.

The purpose of this study was to examine the perception of physical activity and social support for physical activity among Native Hawaiians 55 years of age and older.

Dress (Drug Rash, Eosinophilia, And Systemic Symptoms) Syndrome And Leflunomide: A Case Report, Reema M. Vaze Md, Anam Malik Md

Department of Medicine

No abstract provided.

Research Publications On Medical Microbiology In Pakistan During The Period 2013-2017, Ikram Ul Haq, Gulnaz Elahi, Iqra Dana

Library Philosophy and Practice (e-journal)

Aim: Research publications have been increasing all around the world in every field of knowledge including medical microbiology. The attempt has been made in this paper to describe the growth of medical microbiology research in Pakistan published from 2013 to 2017.

Methodology: Publications on medical microbiology with authorship to Pakistan indexed in the PubMed database were searched. The bibliographical citations of retrieved data were downloaded to examine the year-wise growth, authorship patterns, subject-wise distributions, institutional and country affiliation of the principal author. Microsoft Excel spreadsheet was used for data analysis.

Results: Three hundred and thirty-three documents with an average of …

Targeting Primary Cilia Immune Receptor Proteins For The Treatment Of Polycystic Kidney Disease Mechanisms, Nedaa Alomari

Pharmaceutical Sciences (MS) Theses

Background: Primary cilia are cellular organelles project from the cell surface of mammalian cell and play important roles in vertebrate development, organogenesis, health, and others genetic diseases. Primary cilium functions as a mechano-sensor and chemo-sensor. Defect in primary cilia causes the progression of polycystic kidney disease (PKD) which further leads to the inflammatory responses. We, therefore, investigated the role of Toll-like receptors 4 and 9 (TLR) in primary cilia towards PKD.

Purpose: The main purpose of the proposed study is to identify and target the immune reactive proteins i.e. TLRs in the primary cilia. By targeting those primary cilia immune …

A Translational Approach To Enzyme-Mediated Retinal Lipofuscin Removal For Atrophic Age-Related Macular Degeneration And Stargardt's Disease, Kelsey James Moody

Open Access Dissertations

Despite significant resource expenditures and decades of focused research, chronic age-associated diseases have not been met with improvements in patient outcomes that reflect the successes against infectious disease over the last century. This observation calls into question contention approaches to drug discovery for diseases of aging, and more importantly, their molecular targets. Herein, the strategies for engineered negligible senescence (SENS) framework for drug discovery -- an approach to treating aging broadly based on damage mitigation -- is presented. A translational program for age-related macular degeneration is detailed as illustration of this approach. Collectively, this work validates the academic and commercial …

Proceedings, Msvscc 2019, Old Dominion University, Department Of Modeling, Simulation & Visualization Engineering, Old Dominion University, Virginia Modeling, Analysis And Simulation Center

Modeling, Simulation and Visualization Student Capstone Conference

Old Dominion University Department of Modeling, Simulation & Visualization Engineering (MSVE) and the Virginia Modeling, Analysis and Simulation Center (VMASC) held the 13th annual Modeling, Simulation & Visualization (MSV) Student Capstone Conference on April 18, 2019.

The Conference featured student research and student projects that are central to MSV. Also participating in the conference were faculty members who volunteered their time to impart direct support to their students’ research, facilitated the various conference tracks, served as judges for each of the tracks, and provided overall assistance to the conference.

Appreciating the purpose of the conference and working in a cohesive, …

Differences In Tsimane Children’S Growth Outcomes And Associated Determinants As Estimated By Who Standards Vs. Within-Population References, Melanie Martin, Aaron Blackwell, Hillard Kaplan, Michael Gurven

Economics Faculty Articles and Research

Anthropometric measures are commonly converted to age stratified z-scores to examine variation in growth outcomes in mixed-age and sex samples. For many study populations, z-scores will differ if calculated from World Health Organization (WHO) growth standards or within-population references. The specific growth reference used may influence statistical estimates of growth outcomes and their determinants, with implications for biological inference. We examined factors associated with growth outcomes in a sample of 152 Tsimane children aged 0–36 months. The Tsimane are a subsistence-scale population in the Bolivian Amazon with high rates of infectious disease and growth faltering. To examine the influence of …

The Relationship Between Biological And Psychosocial Risk Factors And Resting‐State Functional Connectivity In 2‐Monthold Bangladeshi Infants: A Feasibility And Pilot Study, Ted K. Turesky, Sarah K.G. Jensen, Xi Yu, Swapna Kumar, Yingying Wang, Danielle D. Sliva, Borjan Gagoski, Joseph Sanfilippo, Lilla Zöllei, Emma Boyd, Rashidul Haque, Shahria Hafiz Kakon, Nazrul Islam, William A. Petri Jr., Charles A. Nelson, Nadine Gaab

Center for Brain, Biology, and Behavior: Faculty Publications

Childhood poverty has been associated with structural and functional alterations in the developing brain. However, poverty does not alter brain development directly, but acts through associated biological or psychosocial risk factors (e.g. malnutrition, family conflict). Yet few studies have investigated risk factors in the context of infant neurodevelopment, and none have done so in low‐resource settings such as Bangladesh, where children are exposed to multiple, severe biological and psychosocial hazards. In this feasibility and pilot study, usable resting‐state fMRI data were acquired in infants from extremely poor (n = 16) and (relatively) more affluent (n = 16) families in Dhaka, …

The Development Of Cervis: Cervical Cancer Early Response Visual Identification System, Nicola Gerbino, Dave Heil, Claire Hultquist, Julia Lanoha, Rosie Mcdonagh, Hallie Mcnamara, Mason Seeley

Helene Lafrance Library Undergraduate Research Award

The goal of CERVIS is to make a substantial, positive impact in the cervical cancer diagnostic space through the development of a minimally invasive, cost effective solution that enables women in low-resource settings to test for cervical cancer on a frugal and effective platform. In the developed world, there are a variety of options that can aid in early detection, including pap smears. However, due to the high cost and laboratory requirements that accompany this procedure, women in low-resource settings rarely have access to this preventative care or regular screenings for cervical cancer. Using new research about the changes in …

Glucosamine/L-Lactide Copolymers As Potential Carriers For The Development Of A Sustained Rifampicin Release System Using Mycobacterium Smegmatis As A Tuberculosis Model, Jorge Ragusa, Daniela Gonzalez, Sumin Li, Sandra Noriega, Maciej Skotak, Gustavo Larsen

Department of Chemical and Biomolecular Engineering: Faculty Publications

The present study aims at developing a new, ultrafine particle-based efficient antibiotic delivery system for the treatment of tuberculosis. The carrier material to make the rifampicin (RIF)-loaded particles is a low molecular weight starshaped polymer produced from glucosamine (core building unit) and L-lactide (GluN-LLA). Particles were made via electrohydrodynamic atomization. Prolonged release (for up to 14 days) of RIF from these particles is reported. Drug release data fits the Korsmeyer-Peppas equation, which suggests the occurrence of a modified diffusion-controlled RIF release mechanism in vitro and is also supported by differential scanning calorimetry and drug leaching tests. Cytotoxicity tests on Mycobacterium …

Cryptic Diversity And Ranavirus Infection Of A Critically Endangered Neotropical Frog Before And After Population Collapse, R. Puschendorf, M. Wallace, M. M. Chavarría, A. J. Crawford, F. Wynne, M. Knight, D. H. Janzen, W. Hallwachs, C. V. Palmer, S. J. Price

School of Biological and Marine Sciences

No abstract provided.

Evolutionary And Genomic Insights Into Clostridioides Difficile Sequence Type 11: A Diverse Zoonotic And Antimicrobial-Resistant Lineage Of Global One Health Importance, Daniel R. Knight, Brian Kullin, Grace O. Androga, Frederic Barbut, Catherine Eckert, Stuart Johnson, Patrizia Spigaglia, Kazuhiro Tateda, Pei-Jane Tsai, Thomas V. Riley

Research outputs 2014 to 2021

Clostridioides difficile (Clostridium difficile) sequence type 11 (ST11) is well established in production animal populations worldwide and contributes considerably to the global burden of C. difficile infection (CDI) in humans. Increasing evidence of shared ancestry and genetic overlap of PCR ribotype 078 (RT078), the most common ST11 sublineage, between human and animal populations suggests that CDI may be a zoonosis. We performed whole-genome sequencing (WGS) on a collection of 207 ST11 and closely related ST258 isolates of human and veterinary/environmental origin, comprising 16 RTs collected from Australia, Asia, Europe, and North America. Core genome single nucleotide variant (SNV) analysis identified …

Characterizing The Cutaneous Microbiome Of The Peaks Of Otter Salamander (Plethodon Hubrichti) In The Context Of Infectious Disease, Haakon Nelson, Matthew Ridge, Collin Mackey

Liberty University Research Week

Undergraduate

Basic

How Professional Physical Therapist Education Programs Develop Cultural Competence Within Their Students: An Exploratory Concurrent Mixed Methods Study, Dustin E. Domingo

Dissertations

Purpose: The purpose of this exploratory concurrent mixed methods study was to describe experiences that shape the factors of cultural intelligence (CQ) as perceived by students of professional physical therapist education programs. In addition, it was the purpose of this study to determine whether any particular factor of cultural intelligence influenced one’s overall cultural competence according to the cultural competence continuum by Cross et al. (1989).

Methodology: Students in a professional physical therapist education program completed a questionnaire, which included Likert scale questions, open ended questions, and a 37-item self-assessment based on the expanded cultural intelligence scale by Van Dyne …

Mortality Influenced By Sepsis Bundle Compliance And Initial Lactic Acid In Severe Sepsis And Septic Shock, Evelyn George

DNP Projects

Sepsis, a life-threatening infection killing 270,000 yearly, is a concern to health care providers, policy makers, and patients due to its high volume and increasing cost. Patients older than 64 years have a higher occurrence of sepsis and greater mortality risk. The Surviving Sepsis Guidelines (SSG) recommends the use of the three-hour bundle that standardizes care to decrease cost, morbidity, and mortality. The three-hour bundle includes two treatments, intravenous fluids and antibiotics, and two tests, blood cultures and lactic acid level. One bundle element, lactic acid level, is associated with higher mortality rates, although only a few studies exist. The …

Iron-Containing Nanoparticles For The Treatment Of Chrionic Biofilm Infections In Cystic Fibrosis, Leisha M. A. Martin

Nanoscience and Microsystems ETDs

Cystic fibrosis (CF) is the most common genetic disease resulting in the morbidity and mortality of Caucasian children and adults worldwide. Due to a genetic mutation resulting in malfunction of the Cystic Fibrosis Transmembrane Conductance Regulator (CFTR) protein, CF patients produce highly viscous mucus in their respiratory tract. This leads to impairment of the mucociliary clearance of inhaled microbes. In addition to reduced microbial clearance, anoxic environmental conditions in the lungs promote biofilm-mode growth of the pathogenic bacterial species Pseudomonas aeruginosa. Chronic infections of P. aeruginosa begin in early childhood and typically persist until respiratory failure and death result. The …

The Case Of The Religious Gay Blood Donor, Brian Soucek

William & Mary Law Review

The Food and Drug Administration (FDA) prohibits sexually active gay men from donating blood. This Article envisions an original legal challenge to that rule: not the predictable equal protection suit, but a religious freedom claim brought by a gay man who wants to give blood as an act of charity. Because the FDA’s regulations substantially burden his exercise of religion—requiring a year of celibacy as its price—the FDA would be forced to show that its policy is the least restrictive means of preventing HIV transmission through the blood supply. Developments in testing technology and the experience of other countries suggest …

Rabies-Based Vaccine Induces Potent Immune Responses Against Nipah Virus., Rohan Keshwara, Thomas Shiels, Elena Postnikova, Drishya Kurup, Christoph Wirblich, Reed F. Johnson, Matthias J. Schnell

Department of Microbiology and Immunology Faculty Papers

Nipah Virus (NiV) is a re-emerging zoonotic pathogen in the genus Henipavirus of the Paramyxoviridae family of viruses. NiV is endemic to Bangladesh and Malaysia and is highly fatal to both livestock and humans (human case fatality rate = 74.5%). Currently, there is no approved vaccine against NiV on the market. The goal of this study was to use a recombinant RABV vector expressing NiV glycoprotein (NiV G) to develop a bivalent candidate vaccine against NiV disease and rabies virus (RABV) disease, which is also a significant health burden in the regions where NiV is endemic. The rabies vector is …

March/April 2019, Randy Curry, Cindy Brooks

RURAL ROCKS

Rural Rocks, the Rural Health Network newsletter by the SWOSU College of Pharmacy

Synthesis And Evaluation Of 1,2,4-Oxadiazolidinones: The Search For Potential Non-Β-Lactam Β-Lactamase Inhibitors., Chimdi E. Kalu, Noah Lyons, Abbas G. Shilabin, Chimdi Kalu

Appalachian Student Research Forum

β-lactam antibiotics have been the most widely used drug of choice to combat infectious disease caused by bacteria. Unfortunately, the effectiveness of these antibiotics is drastically threatened by bacterial β-lactamases. β-lactamases are currently responsible for the resistance to most β-lactam antibiotic drugs. For decades, β-lactam β-lactamases inhibitors have been used to reduce bacterial resistance, however, in this study, we will employ the use of 1,2,4-oxadiazolidinone derivatives as a non-β-lactam β-lactamases inhibitor against TEM-1 and P99 β-lactamases. The significance of oxadiazolidinone is the prominent five-membered ring in its structure, which is configurationally stable and present in other biologically active compounds such …

Exploring Cancer Health Disparities Among Formerly Incarcerated African Americans, Vickii Coffey, Tera Ivy, Brittany Harding, Mary Muse, Carolyn Rodgers, Lori Crowder, Shirley Spencer, Joseph Strickland, Giesela Grumbach, Linda Campos-Moreira, Delawnia Comer-Hagans, Alicia Matthews

Research Days

Incarcerated populations have a higher burden of chronic disease and elevated risk factors for cancer (BJS, 2012). In 2013, cancer (31%) and heart disease (26%) accounted for over half of all prisoner deaths. The Genomics Research Program of the National Cancer Institute’s Division of Cancer Control and Population Sciences (2016) identified incarcerated persons as an understudied population about which there is limited data regarding cancer risks and outcomes. A majority of studies on corrections populations focus on health issues associated with reduction of infectious diseases such as HIV, Tuberculosis, and Hepatitis. Scant research has been conducted on issues associated with …

Cardiovirology Clinic For Primary Prevention In Hiv Patients: A Quality Improvement Assessment, Jae G. Maeng, Stephen A. Geraci

Appalachian Student Research Forum

INTRODUCTION

With effective highly active antiretroviral therapy (HAART), individuals with human immunodeficiency virus (HIV) infection now enjoy life expectancies approaching those of uninfected individuals. Prolonged longevity has increased the prevalence of non-communicable comorbidities within the HIV patient population. HIV is a known independent risk factor for atherosclerotic cardiovascular disease (ASCVD), imparting a 1.5-2 -fold higher incidence of major adverse cardiovascular events (MACE) on infected patients. Deaths from ASCVD have increased as a result, despite a decline in total mortality. The Center of Excellence for HIV/AIDS care established a Cardiovirology Clinic (CvC) focused on providing primary and secondary preventative cardiovascular care …

Osteonecrosis Of Jaw: Common Etiologies, Uncommon Treatments, Utsab Panta, Adam Chan, Debalina Das

Appalachian Student Research Forum

Introduction

First described in 2002, osteonecrosis of the jaw (ONJ, or avascular necrosis of the jaw) is an uncommon but potentially serious side effect of treatment with bisphosphonates. Although typically identified in patients with multiple myeloma and other malignancies, a few cases have been reported in patients taking bisphosphonates - a potent drug class used in the treatment of osteoclast-mediated bone resorption issues, including postmenopausal osteoporosis, Paget's disease, multiple myeloma, and malignant hypercalcemia. The clinical diagnosis of ONJ can be obscured by jaw pain, abscess, swelling, and fistulas, but exposed bone is a distinctive sign. This reports a case of …