Digital Commons Network^™

Toxoplasmosis In Immunocompetent Military Veteran With Overseas Field Deployment, Matthew Carpenter, Omer Shiekh, Jorge Diaz, Debalina Das, Yasmin Elshenawy

Appalachian Student Research Forum

Introduction: Toxoplasmosis is caused by infection with the protozoan Toxoplasma gondii (T. gondii), an obligate intracellular parasite. T. gondii infects a large portion of the world’s population, but uncommonly causes clinically significant disease. Those that are at greatest risk for more severe disease with toxoplasmosis are the immunologically impaired, fetuses, and newborns. T. gondii infection in immunocompetent patients can present as a self-limiting acute infection, or as an acute systemic disease. There are three main T. gondii genotypes, I, II, and III, with varying geographical prevalence. T. gondii is most commonly acquired via ingestion of infectious oocysts, from the …

Association Between Stigma And Intimate Partner Violence Among Newly Hiv-Diagnosed Chinese Men Who Have Sex With Men, Jie Yin, Na Wang, Bo Huang, Yuhua Ruan, K. Rivet Amico, Sten H. Vermund, Han-Zhu Qian, Shimin Zheng

Appalachian Student Research Forum

Introduction: Men who have sex with men (MSM) are more likely to experience Intimate partner violence (IPV) during their lifetime than heterosexual couples. HIV-status and related HIV stigma may play an important role in IPV within intimate partnerships among MSM. HIV- and MSM-related stigmas are common among Chinese MSM, yet there is sparse literature on IPV and its relationship with stigma in this vulnerable population. We evaluate the prevalence of IPV and its relationship with HIV- and MSM-related stigma among newly diagnosed HIV-infected MSM in Beijing, China.

Methods: Data were collected in the baseline survey among newly HIV-diagnosed Chinese MSM …

Extended Infusions Of Meropenem For Febrile Neutropenia, Daniel J. Przybylski, Pharmd, David J. Reeves, Pharmd, Bcop

BU Well

Background: Neutropenic fever is an oncologic emergency that requires quick intervention with anti-pseudomonal beta-lactam antibiotics, such as meropenem. Previous literature suggests that extended infusions of beta-lactam antibiotics may improve clinical outcomes. To date, there are 3 prior studies utilizing an extended infusion beta-lactam in this population; however, there is only one previous study investigating the use of extended infusion meropenem in patients with febrile neutropenia.

Objective: To describe the outcomes of eight patients receiving extended infusions of meropenem for the treatment of febrile neutropenia.

Methods: A retrospective chart review was completed including adult patients admitted to a community teaching hospital …

Vaccination Investigation, Lindsey Smith

Children's Book and Media Review

No abstract provided.

Freakboy, Abigail Packard

Children's Book and Media Review

When you go to the doctor’s office for an immunization you might not be thinking about the significance of that little poke, but there is so much more to it than you’d imagine. In Vaccination Investigation, Tara Haelle digs into the history and science behind vaccinations—how they work, why they’re important, and what happens when people refuse them. She also talks about the deeply historical origins of inoculation, the threat of deadly pathogens, and our world’s future as far as infectious diseases are concerned.

Undergraduate Research Forum, St. Norbert College

Undergraduate Research Forum Programs

The Undergraduate Research Forum highlights the valued tradition at St. Norbert College of collaboration taking place in laboratories, studios, and other scholarly or creative settings between our students and our faculty and staff, resulting in a rich array of scholarly research and creative work. This celebration features projects that evolved out of independent studies, directed research, class assignments, and casual interactions as well as formal collaborations supported by internal and external grant funding

Alumni News | Chapman Finds Career Success With Quidel, Ohio University College Of Arts & Sciences

All Forum Articles

No abstract provided.

The Emergence Of Population Health In Us Academic Medicine, Marc N. Gourevitch, Lesley H. Curtis, Maureen S. Durkin, Angela Fagerlin, Annetine C. Gelijns, Richard Platt, Belinda M. Reininger, Judith Wylie-Rosett, Katherine Jones, William M. Tierney

School of Medicine Publications

Importance In response to rapidly growing interest in population health, academic medical centers are launching department-level initiatives that focus on this evolving discipline. This trend, with its potential to extend the scope of academic medicine, has not been well characterized.

Objective To describe the emergence of departments of population health at academic medical centers in the United States, including shared areas of focus, opportunities, and challenges.

Design, Setting, and Participants This qualitative study was based on a structured in-person convening of a working group of chairs of population health–oriented departments on November 13 and 14, 2017, complemented by a survey …

Aktivitas Antimalaria Berbasis Penghambatan Β-Hematin Dalam Ekstrak Air Daun Jung Rahab (Baeckea Frutecens L), Yatri Hapsari, Gede Adhi Mahayoga, Wien Kusharyoto, Partomuan Simanjuntak

Chimica et Natura Acta

Malaria merupakan penyakit menular yang disebabkan oleh parasit Plasmodium sp. yang ditularkan melalui gigitan nyamuk betina Anopheles. Jung rahab (Bruckea frutescens L) diketahui memiliki aktivitas dalam menekan pertumbuhan Plasmodium falciparum. Penelitian ini bertujuan untuk mengetahui senyawa kimia yang memiliki aktivitas sebagai antimalaria berbasis penghambatan β-hematin dalam ekstrak air daun jung rahab. Tahapan penelitian yang dilakukan adalah ekstraksi daun jung rahab dengan air, kromatografi kolom, skrining hasil fraksinasi kolom, Kromatografi lapis tipis (KLT) preparatif dan identifikasi senyawa kimia berdasarkan interpretasi spektra FT-IR dan GCMS. Hasil penelitian menunjukkan bahwa senyawa yang memiliki aktivitas sebagai antimalaria berdasarkan interpretasi spektra FTIR dan GCMS adalah …

Restricted Access And Delays To Hcv Treatment Among Medicaid Patients In Louisiana, Morris M. Kim, Keanan M. Mcgonigle

Journal of Health Disparities Research and Practice

Background: Many people living with chronic Hepatitis C Virus (HCV) have seen delays in accessing treatment or been denied entirely due to Medicaid restrictions requiring patients to meet certain criteria prior to receiving approval for medication pre-authorization.

Methods: This study identified a cohort of Medicaid-insured patients with chronic HCV infection within New Orleans, LA. Patient medical records were reviewed and information regarding HCV care was gathered. This study sought to determine the degree to which HCV care was delayed for this population and describe common reasons for prior-authorization denials for direct-acting antiviral (DAA) medications.

Results: For this population of Medicaid-insured …

Prediction Of Host-Pathogen Protein-Protein Interactions Using Machine-Learning, Cristian Loaiza

Student Research Symposium

Host-pathogen protein-protein interactions (HPIs) plays vital roles among several biological processes. Furthermore, there is an interest in those interactions that are related with infectious diseases, which seems crucial to understand the mechanism behind the infection process per se and therefore, unravel potential targets to develop therapeutic approaches. Recently, efforts have been made to collect most of the data present in the literature about HPIs and algorithms to transfer that knowledge into unknown systems has been implemented. Although, beyond intra-species PPIs there is not information about modeling those wide-range databases using machine learning techniques, which have been proved ideal to summarize …

Overview To The Institutions, Asylums, Etc. Binder Catalogue, Veronica Bagley

Student Projects from the Archives

This project involves compiling different tables, graphs, and indexes that cover the Institutions, Asylums, Etc. binder. I also made a glossary that covers some of the names of the institutions for which definitions may not be obvious. The intention was that these can be added to the binder for future researchers.

The David P. Campbell Postcard Collection, searchable at postcard.uakron.edu, is a key collection of the CCHP’s Institute for Human Science and Culture.

2019-April-11-It's 'Epidemic', University Marketing And Communications, East Tennessee State University

ETSU News

No abstract provided.

Ecological Mechanisms Can Modify Radiation Effects In A Key Forest Mammal Of Chernobyl, Tapio Mappes, Zbyszek Boratynski, Kati Kivisaari, Anton Lavrinienko, Anders P. Moller, Eugene Tukalenko, Phillip C. Watts

Faculty Publications

Nuclear accidents underpin the need to quantify the ecological mechanisms which determineinjury to ecosystems from chronic low-dose radiation. Here, we tested the hypothesis that ecological mech-anisms interact with ionizing radiation to affect natural populations in unexpected ways. We used large-scale replicated experiments and food manipulations in wild populations of the rodent, Myodes glareolus,inhabiting the region near the site of the Chernobyl disaster of 1986. We show linear decreases in breedingsuccess with increasing ambient radiation levels with no evidence of any threshold below which effects arenot seen. Food supplementation of experimental populations resulted in increased abundances but only inlocations where radioactive …

Mathematical Modeling: Lanchester Equations And The Zombie Apocalypse, Hailey Bauer

Student Scholar Showcase

Mathematical models are systems using mathematical concepts to explain various problems. Mathematical models examine realistic issues such as the different outcomes of wars and fictional problems such as the upcoming zombie apocalypse. The original predictor models of warfare were the Lanchester models, while the zombie apocalypse is a fictional expansion upon mathematical models for infectious diseases. In this paper, we examined and compared the basic versions of these dynamic models by analyzing each model’s set of variables, assumptions, and objectives. The basic versions of the Lanchester equations are the area aimed model and the aimed fire model. While the zombie …

Lipoarabinomannan From Mycobacterium Smegmatis Stimulates An Inflammatory Response In Raw 264.7 Murine Macrophages, Aysha Zaman

Student Scholar Showcase

Macrophages are a key leukocyte in defense against Mycobacterium tuberculosis infection. The precise mechanism by which M. tuberculosis evades host macrophage defenses remains unknown, so understanding how macrophages interact with cell wall components of mycobacteria is critical. Lipoarabinomannan (LAM) is a glycolipid Toll-like receptor-2 (TLR-2) ligand found on the cell wall of mycobacteria, and is thought to contribute to the cell wall structural integrity. When LAM binds to TLR on host leukocytes, this activates cellular responses and phagocytosis by host macrophages. Nitric oxide production can be used as a measure of inflammatory response and can be evaluated via nitrite response …

Reverse Transcriptase And The Inability Of Samhd1 To Fully Restrict Macrophage Infection By Hiv-1, Timothy Edward Plitnik

Open Access Dissertations

HIV/AIDS continues to cause significant morbidity and mortality across the globe. Even though current drug therapy can reduce the disease burden, a cure to HIV-1 infection remains elusive due to the relatively stable viral reservoir. Infected macrophages are of particular importance to the viral reservoir as they are long-lived cells that are often located in immune privileged sites and resistant to the cytopathic effects of the virus. Invasion of the cell by the primate lentiviruses HIV/SIV, is opposed by cellular restrictions including APOBEC3G, Tetherin/BST2, and SAMHD1. SAMHD1 is a dNTP triphosphohydrorylase that reduces cellular dNTP levels in non-mitotic cells, such …

The Landscape Of Cellular And Gene Therapy Products: Cost, Approvals, And Discontinuations, Vaishali Shukla, Enrique Seoane-Vazquez, Souhiela Fawaz, Lawrence M. Brown, Rosa Rodriguez-Monguio

Pharmacy Faculty Articles and Research

Background The past 10 years witnessed a significant increase in the approval of cellular and gene therapy products worldwide. The US Food and Drug Administration (FDA) approved 3 gene therapy products within the last 4 months of 2017. The objective of this study was to examine the approval characteristics, discontinuations and cost of all cellular and gene therapy products approved worldwide. Data and Methods We conducted an electronic search of approved cell and gene therapy products from the databases of the main drug regulatory agencies including the US Food and Drug Administration, the European Medicines Agency (EMA), the Korea Ministry …

The Experience Of Chief Nurses In Military Operations Other Than War, Martha H. Turner

Dissertations

The purpose of this research was to describe the experience of chief nurses in military operations other than war. The study is significant to the profession because nurses will continue to provide care in humanitarian operations, peacekeeping missions and disaster relief efforts. Inquiry into the experience will lead to an understanding of the foundations of the global caregiving community. Hermeneutic phenomenology provided a description and thematic interpretation of the meaning of the experience. Purposeful sampling yielded thirteen participants, eleven women and two men. Duration of the deployments ranged from 3-7 months. Sites included Saudi Arabia, Oman, Panama, Cuba, Somalia, Guam, …

Histological Chorioamnionitis Induces Differential Gene Expression In Human Cord Blood Mononuclear Leukocytes From Term Neonates., Suhita Gayen Nee’ Betal, Swati Murthy, Michael Favara, Gina Fong, Joanna Chan, Sankar Addya, Thomas H. Shaffer, Jay S. Greenspan, Vineet Bhandari, Irfan Rahman, Zubair H. Aghai

Department of Pediatrics Faculty Papers

Histological chorioamnionitis (HCA) is an infection of fetal membranes and complicates 5.2% to 28.5% of all live births. HCA is associated with increased mortality and morbidity in both premature and term neonates. Exposure to HCA may have long-term consequences, including an increased risk for allergic disorders and asthma later in childhood, the mechanism(s) of which are still not yet well understood. The objective of this study was to determine the mRNA transcriptome of cord blood mononuclear leukocytes from term neonates to identify key genes and pathways involved in HCA. We found 366 differentially expressed probe IDs with exposure to HCA …

Board Invited Review: Prospects For Improving Management Of Animal Disease Introductions Using Disease-Dynamic Models, Ryan S. Miller, Kim M. Pepin

United States Department of Agriculture Wildlife Services: Staff Publications

Management and policy decisions are continually made to mitigate disease introductions in animal populations despite often limited surveillance data or knowledge of disease transmission processes. Science-based management is broadly recognized as leading to more effective decisions yet application of models to actively guide disease surveillance and mitigate risks remains limited. Disease-dynamic models are an efficient method of providing information for management decisions because of their ability to integrate and evaluate multiple, complex processes simultaneously while accounting for uncertainty common in animal diseases. Here we review disease introduction pathways and transmission processes crucial for informing disease management and models at the …

Status Of Sex And Gender In Emergency Medicine A Five Year Follow Up Report, Basmah Safdar Md, Msc, Kimberly E. Ona Ayala Ba, Syed Shayan Ali Md, Benjamin J. Seifer Bsme, Michelle Hong Bs, Ms, Marna R. Greenberg Do, Mph, Facep, Esther K. Choo Md, Mph, Alyson J. Mcgregor Md, Ma

Department of Emergency Medicine

No abstract provided.

Factors Limiting Organic Carbon Degradation By Antibiotic-Resistant Heterotrophic Microorganisms In Wastewater Contaminated Sediments, Katelyn Whitburn

Theses

This study aims to assess the interactions between antibiotic resistance and the ability of heterotrophs effected by highly polluted environments to remediate antibiotics from soil via biodegradation. These findings would reveal whether a self-cleaning process is occurring in the waters of Western NY. Water and sediment heterotrophs were obtained from wastewater contaminated environments to understand the factors influencing metabolism. A total of 113 isolates from Charlotte, Durand, and Payne Beaches, the Genesee River, and Hemlock Lake were cultured and detected for antibiotic resistance to 24 different antibiotics. Of these, seven robust bacteria from sediments were considered for their ability to …

Body Mass Index In Multiple Sclerosis Modulates Ceramide-Induced Dna Methylation And Disease Course, Kamilah Castro, Achilles Ntranos, Mario Amatruda, Maria Petracca, Peter Kosa, Emily Y. Chen, Johannes Morstein, Dirk Trauner, Corey T. Watson, Michael A. Kiebish, Bibiana Bielekova, Matilde Inglese, Ilana Katz Sand, Patricia Casaccia

Advanced Science Research Center

Background: Multiple Sclerosis (MS) results from genetic predisposition and environmental variables, including elevated Body Mass Index (BMI) in early life. This study addresses the effect of BMI on the epigenome of monocytes and disease course in MS.

Methods: Fifty-four therapy-naive Relapsing Remitting (RR) MS patients with high and normal BMI received clinical and MRI evaluation. Blood samples were immunophenotyped, and processed for unbiased plasma lipidomic profiling and genome-wide DNA methylation analysis of circulating monocytes. The main findings at baseline were validated in an independent cohort of 91 therapy-naïve RRMS patients. Disease course was evaluated by a two-year longitudinal follow up …

Enhanced Oxidative Phosphorylation In Nkt Cells Is Essential For Their Survival And Function, Ajay Kumar, Kalyani Pyaram, Emily L. Yarosz, Hanna Hong, Costas A. Lyssiotis, Shailendra Giri, Cheong-Hee Chang

Neurology Articles

Cellular metabolism and signaling pathways are key regulators to determine conventional T cell fate and function, but little is understood about the role of cell metabolism for natural killer T (NKT) cell survival, proliferation, and function. We found that NKT cells operate distinct metabolic programming from CD4 T cells. NKT cells are less efficient in glucose uptake than CD4 T cells with or without activation. Gene-expression data revealed that, in NKT cells, glucose is preferentially metabolized by the pentose phosphate pathway and mitochondria, as opposed to being converted into lactate. In fact, glucose is essential for the effector functions of …

Eis Inhibitors, Sylvie Garneau-Tsodikova, Oleg V. Tsodikov

Pharmaceutical Sciences Faculty Patents

Compounds and compositions are disclosed, which are useful as inhibitors of acetyltransferase Eis, a mediator of kanamycin resistance in Mycobacterium tuberculosis.

Rsv-Encoded Ns2 Promotes Epithelial Cell Shedding And Distal Airway Obstruction, R. M. Liesman, U. J. Buchholz, C. L. Luongo, A. D. Proia, J. P. Divicenzo, P. L. Collins, R. J. Pickles

Osteopathic Medicine, Jerry M. Wallace School of

Respiratory syncytial virus (RSV) infection is the major cause of bronchiolitis in young children. The factors that contribute to the increased propensity of RSV-induced distal airway disease compared with other commonly encountered respiratory viruses remain unclear. Here, we identified the RSV-encoded nonstructural 2 (NS2) protein as a viral genetic determinant for initiating RSV-induced distal airway obstruction. Infection of human cartilaginous airway epithelium (HAE) and a hamster model of disease with recombinant respiratory viruses revealed that NS2 promotes shedding of infected epithelial cells, resulting in two consequences of virus infection. First, epithelial cell shedding accelerated the reduction of virus titers, presumably …

Nh Veterinary Diagnostic Lab Recognized As Leaders In Mitigating Antimicrobial Resistanc, Lori Wright

UNH Today Archive

No abstract provided.

Nh Veterinary Diagnostic Lab Recognized For Efforts To Rapidly Identify Infections In Animals, Lori Tyler Gula

Media Relations

No abstract provided.

Using The Consolidated Framework For Implementation Research To Investigate Daily Pre-Exposure Prophylaxis (Emtricitabine/Tenofovir Df) Implementation Via Community-Based Hiv Testing Sites In Florida, Deanne E. Turner

USF Tampa Graduate Theses and Dissertations

Background: Pre-exposure prophylaxis (PrEP) is a daily pill that can reduce a person’s chances of acquiring HIV. HIV testing and counseling is a critical point during which non-clinical staff could intervene, discuss and/or refer clients for PrEP. However, not all HIV testing/counseling staff take part in PrEP implementation in the same way. This study investigated: 1) the underlying PrEP implementation subgroups of staff who perform HIV testing and 2) PrEP implementation as a function of key constructs from the Consolidated Framework for Implementation Research (CFIR).

Methods: This study was a mixed methods concurrent triangulation design, in which qualitative and quantitative …