Digital Commons Network^™

Ecological Interventions To Prevent And Manage Zoonotic Pathogen Spillover, Susanne H. Sokolow, Nicole Nova, Kim M. Pepin, Alison J. Peel, Juliet R.C. Pulliam, Kezia Manlove, Paul C. Cross, Daniel J. Becker, Raina K. Plowright, Hamish Mccallum, Giulio A. De Leo

United States Department of Agriculture Wildlife Services: Staff Publications

Spillover of a pathogen from awildlife reservoir into a human or livestock host requires the pathogen to overcome a hierarchical series of barriers. Interventions aimed at one or more of these barriers may be able to prevent the occurrence of spillover. Here, we demonstrate how interventions that target the ecological context in which spillover occurs (i.e. ecological interventions) can complement conventional approaches like vaccination, treatment, disinfection and chemical control. Accelerating spillover owing to environmental change requires effective, affordable, durable and scalable solutions that fully harness the complex processes involved in cross-species pathogen spillover.

This article is part of the theme …

Week Of May 20, 2019, New York Medical College

InTouch

• Employees Celebrated for Years of Service
• Convocation of Thanks Offers Closure to Students and Families of Donors
• Looking Back: The History of New York Medical College
• NYMC Celebrates Jewish American Heritage Month
• Grand Opening is Set for the Café

Scavenging In The Anthropocene: Human Impact Drives Vertebrate Scavenger Species Richness At A Global Scale, Esther Sebastián‐González, Jomar Magalhães Barbosa, Juan M. Pérez‐García, Zebensui Morales‐Reyes, Francisco Botella, Pedro P. Olea, Patricia Mateo‐Tomás, Marcos Moleón, Fernando Hiraldo, Eneko Arrondo, José A. Donázar, Ainara Cortés‐Avizanda, Nuria Selva, Sergio A. Lambertucci, Aishwarya Bhattacharjee, Alexis Brewer, Erin Abernethy, Olin E. Rhodes Jr., Kelsey Turner, James C. Beasley, Travis L. Devault, Andrés Ordiz, Camilla Wikenros, Barbara Zimmermann, Petter Wabakken, Christopher C. Wilmers, Justine A. Smith, Corinne J. Kendall, Darcy Ogada, Evan R. Buechley, Ethan Frehner, Maximilian L. Allen, Heiko U. Wittmer, James R.A. Butler, Johan T. Du Toit, John Read, David Wilson, Klemen Jerina, Miha Krofel, Rich Kostecke, Richard Inger, Arockianathan Samson, Lara Naves‐Alegre, José A. Sánchez‐Zapata

United States Department of Agriculture Wildlife Services: Staff Publications

Understanding the distribution of biodiversity across the Earth is one of the most challenging questions in biology. Much research has been directed at explaining the species latitudinal pattern showing that communities are richer in tropical areas; however, despite decades of research, a general consensus has not yet emerged. In addition, global biodiversity patterns are being rapidly altered by human activities. Here, we aim to describe large‐scale patterns of species richness and diversity in terrestrial vertebrate scavenger (carrion‐consuming) assemblages, which provide key ecosystem functions and services. We used a worldwide dataset comprising 43 sites, where vertebrate scavenger assemblages were identified using …

A Case-Study Approach To Investigate Transmission, Co-Infection, And Clinical Sequelae During Epidemics Of Dengue And Ebola Virus Disease, Jennifer Elizabeth Giovanni

LSU Doctoral Dissertations

From within their ecologic niches, zoonotic viruses emerge from animal reservoirs into the edges and centers of human habitation to exploit opportunities for unabated transmission within immunologically–naïve populations. Our understanding of where, in whom, and how these viruses emerge is under direct challenge, driving the evolution of modern infectious disease epidemiology within a rapidly-connected global community. The studies presented herein are based on analyses of both aggregate and case-level data, which, we argue, provide unique insight into the complexities of transmission, co-infection, and clinical sequelae occurring within, and arising from, epidemics of emerging zoonotic viruses. In Chapter II, we investigate …

The Economic Impacts Of Blackbird (Icteridae) Damage To Sunflower In The Usa, Karina Ernst, Julie Elser, George Linz, Hans Kandel, Jason Holderieath, Samantha Degroot, Steven Shwiff, Stephanie Shwiff

United States Department of Agriculture Wildlife Services: Staff Publications

BACKGROUND: Blackbird (Icteridae) damage to ripening sunflower (Helianthus annuus L.) has been a persistent economic issue in the USA for the last five decades. To quantify losses, we surveyed blackbird damage from 2001 to 2013 (excluding 2004) to physiologically mature sunflower in eight states: North Dakota, South Dakota, Texas, Nebraska, Minnesota, Colorado, Kansas, and Vermont.

RESULTS:We pooled data gathered during the most recent 5 years (2009 to 2013) of the survey and found losses averaged $US2.5 million and $US11.3 million for confectionery and oilseed hybrids, respectively. Three states, North Dakota, South Dakota, and Nebraska, had sufficient acreage and bird damage …

Htlv-1 Latency-Maintenance Factor P30ii Modulates Tax-Induced Nf-Kappa B Signaling Through A P53-Regulated Mechanism, Aditi Malu

Biological Sciences Theses and Dissertations

The human T-cell leukemia virus type-1 (HTLV-1) infects CD4+ T-cells and is the etiological agent of adult T-cell leukemia/lymphoma (ATL), an aggressive and often-fatal lymphoproliferative neoplastic disease. The major transactivator protein, Tax, drives proviral gene expression and replication and plays a key role during the early-stage immortalization of T-cells by HTLV-1. Tax has also been shown to regulate many host cellular signaling pathways, including CREB/ATF, SRF, and NFκB. Another accessory viral protein p30_II acts as a latency-maintenance factor and negatively regulates proviral gene expression and replication. The p30^II protein counters Tax-dependent gene expression at the transcriptional and posttranscriptional …

Undergraduate Commencement Exercises Program, May 18, 2019

Bryant University Commencements

Bryant University Undergraduate Commencement Exercises Program, May 18, 2019

Policy Alternatives That Provide California School Districts With The Policy Options Necessary To Develop Facilities To Enhance Student Learning Opportunities And Optimize Financial Resources, Brett Mitchell

Dissertations

Purpose: The purpose of this study was to develop policy alternatives by the years 2019 to 2025 that would assist state policy makers, legislators, and advocates in adding definition to California school facility development and funding.

Methodology: This study involved descriptive statistics using a Delphi study method. Within the theoretical framework established for policy analysis, this Delphi study was inclusive of the knowledge and expertise of an expert panel that was nominated through peers. The Delphi panel consisted of 24 experts knowledgeable about statewide school facilities policy in California. The Delphi study was comprised of 3 rounds of electronic questionnaires …

Implementation Of Change Of Shift Huddles In An Urban Medical Center, Benson Kahiu

Seton Hall University DNP Final Projects

Since 1999 when the Institute of Medicine (IOM) highlighted medical errors in hospitals, healthcare leaders continue to pursue relevant and sustainable patient safety initiatives. Some of these initiatives include projects that increase accountability while encouraging enhanced teamwork and communication between team members. The lack of consistent communication results in decreased patient outcomes and patient dissatisfaction. Decreased camaraderie in organizations, results in fiscal waste associated with employee tardiness and call-outs. This paper reviews the process and impact of implementing change of shift huddles in an urban medical center. Literature reviews concluded that positive outcomes were associated with implementation of huddles during …

Habitat Selection By American Beaverat Multiple Spatial Scales, Guiming Wang, Lance F. Mcclintic, Jimmy D. Taylor

United States Department of Agriculture Wildlife Services: Staff Publications

Background: Semiaquatic mammals require both aquatic and terrestrial habitats, particularly interfaces between the two habitats. As ecosystem engineers, American beaver (Castor canadensis) consume and fell a great amount of deciduous trees. We tested the prediction that open water and amounts of food resources, including hardwood forests (i.e., deciduous trees as the dominant form of vegetation), herbaceous and woody wetlands, and shrubs, would influence the second-order habitat selection (i.e., placing home ranges on the landscape) by American beaver, whereas the third-order habitat selection of American beaver would be associated with woody wetland and shrub edges. We investigated hierarchical habitat selection by …

Kinetics Of Hiv-1 Uncoating In C20 Microglial Cells, Melanie Anne Taylor

Graduate Theses/Dissertations

Uncoating is a poorly understood yet required step of HIV-1 replication that is defined as the disassembly of the viral capsid structure. The goal of this project is to characterize uncoating in C20 microglial cells. These cells are a natural target of HIV-1 that are infected to establish latent viral reservoirs and HIV-associated neurological disorders. A stable C20 cell line that expresses TRIM-CypA was established to study the kinetics of uncoating with the CsA washout assay. The expression of TRIM-CypA was confirmed by western blot and the functionality of the protein was confirmed by a viral infectivity assay. Using this …

Determining The Immune Status Of Steller Sea Lions (Eumetopias Jubatus): An Environmental Agents Of Disease Perspective, Stephanie Nichole Kennedy

Chemistry and Biochemistry

The integrity of the immune system is paramount for preserving overall health for many organisms. Investigating environmental and physiological factors that may be associated with alterations of the immune status in non-traditional sentinel species, like the Steller sea lion (SSL), is a prominent undertaking in eco-immunology research. Changes to immune homeostasis likely impacts the health and survival of SSLs. Recent studies have reported that mercury concentrations in hair in 24 to 36% of newborn SSLs of the Western Aleutian Islands (WAI) exceed thresholds (>30 ppm) for potential adverse effects. Many of these individuals were from WAI rookeries that have …

A Toolkit For Administration Of Antipsychotic Medications In Nursing Homes, Nino Dantes Flores

Doctor of Nursing Practice (DNP) Projects

Psychotropic medications should be used with extreme caution in older adults residing in long- term care facilities. Delirium and altered mental status are associated with multiple complex underlying medical conditions and can be difficult to recognize, particularly among the elderly residing in long-term care facilities. The use of the California Department of Public Health (CDPH) Skilled Nursing Facility (SNF) Antipsychotic Toolkit allows for ethical and evidence- based care of the elderly within the regulations and best practice for use of antipsychotics. This Doctor of Nursing Practice quality improvement project is designed to provide a toolkit for practitioners of behavioral modification …

Improving Emergency Department Staff Compliance To The Sepsis Core Measure: A Quality Improvement Project, Maryoll Llanera

Master's Projects and Capstones

The Centers for Medicare & Medicaid Services (CMS) has reported the percentage of patients who received appropriate care for severe sepsis and septic shock for each Joint Commission-accredited hospital during its latest data collection period from 04/01/2017 - 03/31/2018. This has prompted many healthcare organizations in the United States to make compliance to the CMS mandated sepsis core measure a priority and explore different improvement strategies and techniques. A small community-based hospital in northern California is among these organizations and has focused specifically on its emergency department (ED). An internal audit was performed to identify areas of deficiency, and an …

An Examination Of The Potential Threat Of A State-Sponsored Biological Attack Against The United States: A Study Of Policy Implications, Courtney Anne Pfluke

Graduate Theses/Dissertations

In 2002, US Navy Seals found a list of pathogens in an Afghanistan cave that Al Qaeda had planned to use in a series of biological attacks. Unique about the discovery was that the pathogens were not limited to human ones. Six pathogens targeted livestock and four targeted crops. Despite this discovery, limited attention has been given to the possibility of a state-sponsored terrorist attack utilizing biological agents against the US population, food source, or water supply. Throughout history, biological agents have been developed for use as an offensive weapon for both states and terrorist groups. The United States may …

The Assessment Of Predictor Variables For Hard Tick Abundance In Southwestern Missouri, Casey L. Adkins

Graduate Theses/Dissertations

The risk of tick-borne infection is increasing across the United States, and in Missouri, ticks are expanding into novel regions due to climate change, habitat fragmentation, and biodiversity loss. Regions in which ticks are encroaching experience novel vectors for lineage associated pathogens. Novel tick detection can be low due to sampling practices targeting known ticks, which can lead to unreliable distribution maps and poor predictive distribution models. Such models should account for biotic factors, abiotic factors, and their interactions to provide a dynamic view of their impact on tick abundance and identify variables that can serve as indicators. Further, a …

Stress And Body Composition Of Juvenile Alligator Snapping Turtles (Macrochelys Temminckii), Brandon Scott Tappmeyer

Graduate Theses/Dissertations

The alligator snapping turtle (Macrochelys temminckii), is a species of conservation concern that is the subject of multiple head-start and reintroduction efforts across its range. In captive propagation programs, producing offspring that are in optimal physiological condition maximizes the likelihood of success after release. The purpose of my study was to compare stress and body composition between one free-ranging reintroduced population and two captive populations. The two captive populations were both housed in southern Oklahoma, but one group was reared indoors whereas the other inhabited outdoor ponds at a national fish hatchery. I used circulating glucocorticoid (corticosterone) concentrations as an …

Serological Evidence Of Flavivirus Circulation In Human Populations In Northern Kenya: An Assessment Of Disease Risk 2016-2017, E. Chepkorir, D. P. Tchouassi, S. L. Konongoi, J. Lutomiah, C. Tigoi, Z. Irura, F. Eyase, M. Venter, R. Sang

All Peer-Reviewed Publications

Background: Yellow fever, Dengue, West Nile and Zika viruses are re-emerging mosquito-borne Flaviviruses of public health concern. However, the extent of human exposure to these viruses and associated disease burden in Kenya and Africa at large remains unknown. We assessed the seroprevalence of Yellow fever and other Flaviviruses in human populations in West Pokot and Turkana Counties of Kenya. These areas border Uganda, South Sudan and Ethiopia where recent outbreaks of Yellow fever and Dengue have been reported, with possibility of spillover to Kenya. Methodology: Human serum samples collected through a cross-sectional survey in West Pokot and Turkana Counties were …

Evaluating The Effectiveness Of Peer Engagement And Knowledge (Peak): A Community-Based Group Intervention For Youth In Hawai‘I, Jennifer T. T. Ho

Doctoral Dissertations

This study is a program evaluation with a mixed methods design that evaluated the effectiveness of Peer Engagement and Knowledge (PEAK), a six-week community-based group intervention that incorporates mindfulness-based interventions (MBIs) to address multiple health behaviors for multiracial youth in Hilo, Hawai‘i. A total of 51 youth, ages 12-23 years old, participated in this study which included pre-/posttest analyses of health risk factors such as substance use and depression and health promoting factors such as resilience, self-esteem, and mindfulness. Responses from two subsets of participants, who engaged in a focus group (n = 11) and composed gratitude letters ( …

Understanding The Role Of Macrophages In Lung Inflammation Through Mathematical Modeling, Sarah B. Minucci

Biology and Medicine Through Mathematics Conference

No abstract provided.

Provider Education And Rapid Antigen Detection Test Use In An Academic Pediatric Clinic, Steven Dahl

Research Days

No abstract provided.

Genome To Phenome: Improving Animal Health, Production, And Well-Being – A New Usda Blueprint For Animal Genome Research 2018–2027, Caird Rexroad, Jeffrey Vallet, Lakshmi Kumar Matukumalli, James Reecy, Derek Bickhart, Harvey Blackburn, Mark Boggess, Hans Cheng, Archie C. Clutter, Noelle Cockett, Catherine Ernst, Janet E. Fulton, John Liu, Joan Lunney, Holly Neibergs, Catherine Purcell, Timothy P. L. Smith, Tad Sonstegard, Jerry Taylor, Bhanu Telugu, Alison Van Eenennaam, Curtis P. Van Tassell, Kevin Wells

Roman L. Hruska U.S. Meat Animal Research Center: Reports

In 2008, a consortium led by the Agricultural Research Service (ARS) and the National Institute for Food and Agriculture (NIFA) published the “Blueprint for USDA Efforts in Agricultural Animal Genomics 2008–2017,” which served as a guiding document for research and funding in animal genomics. In the decade that followed, many of the goals set forth in the blueprint were accomplished. However, several other goals require further research. In addition, new topics not covered in the original blueprint, which are the result of emerging technologies, require exploration. To develop a new, updated blueprint, ARS and NIFA, along with scientists in the …

Impact Of A Mobile Device-Based Clinical Decision Support Tool On Guideline Adherence And Mental Workload Among Trainee And Attending Physicians, Katherine M. Richardson

Presentations

This study evaluated PedsGuide, an app used to evaluate serious bacterial infections in febrile infants.

Interpretation Of The Individual Effect Under Treatment Spillover, Forrest W. Crawford, Morozova, Ashley L. Buchanan, Donna Spiegelman

Pharmacy Practice and Clinical Research Faculty Publications

Some interventions are intended to benefit both individuals and the groups to which they belong. When a treatment given to one person exerts a causal effect on others, the treatment is said to exhibit spillover, dissemination, or interference. However, defining meaningful causal effects under spillover can be challenging. In this commentary, we discuss the meaning of the “individual effect,” a quantity proposed to summarize the effect of treatment on the person who receives it, when spillover may be present.

Genome To Phenome: Improving Animal Health, Production, And Well-Being – A New Usda Blueprint For Animal Genome Research 2018–2027, Caird Rexroad, Jeffrey Vallet, Lakshmi Kumar Matukumalli, James Reecy, Derek Bickhart, Harvey Blackburn, Mark Boggess, Hans Cheng, Archie Clutter, Noelle Cockett, Catherine Ernst, Janet E. Fulton, John Liu, Joan Lunney, Holly Neibergs, Et Al.

Animal, Dairy, and Veterinary Science Faculty Publications

In 2008, a consortium led by the Agricultural Research Service (ARS) and the National Institute for Food and Agriculture (NIFA) published the “Blueprint for USDA Efforts in Agricultural Animal Genomics 2008–2017,” which served as a guiding document for research and funding in animal genomics. In the decade that followed, many of the goals set forth in the blueprint were accomplished. However, several other goals require further research. In addition, new topics not covered in the original blueprint, which are the result of emerging technologies, require exploration. To develop a new, updated blueprint, ARS and NIFA, along with scientists in the …

Microscopic Saviors: The Use Of Phages In Medicine, Roger Sherman

D.U.Quark

The influenza virus has plagued humans for centuries. Recently antiviral medications, which shorten the duration of the flu, have been introduced into society. These medications along with vaccinations, which try to give the body immunity before the virus strikes, help to stop the flu before it attacks the host. The virus, however, replicates using host cells and can slightly change itself with each replication, which over time could lead to a strain immune to the current antiviral medication and vaccines. However, using more preventative measures could help slow the changing strains of the flu virus. Using vaccines to stop the …

The Environmental Impact And Formation Of Meals From The Pilot Year Of A Las Vegas Convention Food Rescue Program, Samantha To, Courtney Coughenour, Jennifer Pharr

Environmental & Global Health Faculty Research

Annually, millions of tonnes of leftover edible foods are sent to landfill. Not only does this harm the environment by increasing the release of greenhouse gases which contribute to climate change, but it poses a question of ethics given that nearly 16 million households are food insecure in the US, and hundreds of millions of people around the globe. The purpose of this study was to document the amount of food diverted from landfill in the pilot year of a convention food rescue program and to determine the amount of greenhouse gas (GHG) emissions avoided by the diversion of such …

Full Issue, Gabriel Benson, Savannah Stevens

Augsburg Honors Review

No abstract provided.

Noble Savage, Noble Scotsman: The Act Of Union As A Dubious Model For British Colonialism, Kelton Holsen

Augsburg Honors Review

It has become almost a cliché that during the period of intense colonialism by the great powers of Europe 'the sun never set on the British empire'. The reason that this cliché persists is that the idea behind it is true: according to the Encyclopaedia Britannica, "[b]y the end of the 19th century, the British Empire comprised nearly one-quarter of the world’s land surface and more than one-quarter of its total population" (Britannica). This vast conquest was not done on a whim: it had deep roots in ideas of cultural and economic superiority and, more to the point, the (demonstrably …

Ebola: Impact Of Hospital's Admission Policy In An Overwhelmed Scenario, Mondal H. Zahid

Biology and Medicine Through Mathematics Conference

No abstract provided.