Digital Commons Network^™

Diffusion Basis Spectrum Imaging Provides Insights Into Ms Pathology, Peng Sun, Ajit George, Dana C. Perantie, Kathryn Trinkaus, Zezhong Ye, Robert T. Naismith, Sheng-Kwei Song, Anne H. Cross

Open Access Publications

No abstract provided.

Resolution Of Secondary Hemophagocytic Lymphohistiocytosis After Treatment With The Jak1/2 Inhibitor Ruxolitinib, Scott R. Goldsmith, Sana Saif Ur Rehman, Cara L. Shirai, Kiran Vij, John F. Dipersio

Open Access Publications

No abstract provided.

New Statistical Method Identifes Cytokines That Distinguish Stool Microbiomes, Dake Yang, Jethro Johnson, Xin Zhou, Elena Deych, Berkley Shands, Blake Hanson, Erica Sodergren, George Weinstock, William D. Shannon

Open Access Publications

No abstract provided.

De Novo Assembly Of The Brugia Malayi Genome Using Long Reads From A Single Minion Flowcell, Joseph R. Fauver, John Martin, Gary J. Weil, Makedonka Mitreva, Peter U. Fischer

Open Access Publications

No abstract provided.

Report From A Multidisciplinary Meeting On Anxiety As A Non-Motor Manifestation Of Parkinson’S Disease, Gregory M. Pontone, Eric J. Lenze, Et Al.

Open Access Publications

No abstract provided.

Infammatory Bowel Disease-Associated Ubiquitin Ligase Rnf183 Promotes Lysosomal Degradation Of Dr5 And Trail-Induced Caspase Activation, Yan Wu, Yuka Kimura, Takumi Okamoto, Koji Matsuhisa, Rie Asada, Atsushi Saito, Fumika Sakaue, Kazunori Imaizumi, Masayuki Kaneko

Open Access Publications

No abstract provided.

Evaluating Glial And Neuronal Blood Biomarkers Gfap And Uch-L1 As Gradients Of Brain Injury In Concussive, Subconcussive And Non-Concussive Trauma: A Prospective Cohort Study, Linda Papa, Mark R Zonfrillo, Robert D Welch, Lawrence M Lewis, Carolina F Braga, Ciara N Tan, Neema J Ameli, Marco A Lopez, Crystal A Haeussler, Diego Mendez Giordano, Philip A Giordano, Jose Ramirez, Manoj K Mittal

Open Access Publications

Objectives: To evaluate the ability of glial fibrillary acidic protein (GFAP) and ubiquitin C-terminal hydrolase (UCH-L1) to detect concussion in children and adult trauma patients with a normal mental status and assess biomarker concentrations over time as gradients of injury in concussive and non-concussive head and body trauma.

Design: Large prospective cohort study.

Setting: Three level I trauma centres in the USA.

Participants: Paediatric and adult trauma patients of all ages, with and without head trauma, presenting with a normal mental status (Glasgow Coma Scale score of 15) within 4 hours of injury. Rigorous screening for concussive symptoms was conducted. …

The Effect Of Gut Microbiome Composition On Human Immune Responses: An Exploration Of Interference By Helminth Infections, Ivonne Martin, Maria M M Kaisar, Aprilianto E Wiria, Firdaus Hamid, Yenny Djuardi, Erliyani Sartono, Bruce A Rosa, Makedonka Mitreva, Taniawati Supali, Jeanine J Houwing-Duistermaat, Maria Yazdanbakhsh, Linda J Wammes

Open Access Publications

No abstract provided.

Vaccine-Induced Skewing Of T Cell Responses Protects Against Chikungunya Virus Disease, Rebecca M Broeckel, Nicole Haese, Takeshi Ando, Igor Dmitriev, Craig N Kreklywich, John Powers, Michael Denton, Patricia Smith, Thomas E Morrison, Mark Heise, Victor Defilippis, Ilhem Messaoudi, David T Curiel, Daniel N Streblow

Open Access Publications

Chikungunya virus (CHIKV) infections can cause severe and debilitating joint and muscular pain that can be long lasting. Current CHIKV vaccines under development rely on the generation of neutralizing antibodies for protection; however, the role of T cells in controlling CHIKV infection and disease is still unclear. Using an overlapping peptide library, we identified the CHIKV-specific T cell receptor epitopes recognized in C57BL/6 infected mice at 7 and 14 days post-infection. A fusion protein containing peptides 451, 416, a small region of nsP4, peptide 47, and an HA tag (CHKVf5) was expressed using adenovirus and cytomegalovirus-vectored vaccines. Mice vaccinated with …

Confronting The Opioid Crisis: Practical Pain Management And Strategies: Aoa 2018 Critical Issues Symposium, Hassan R Mir, Anna N Miller, William T Obremskey, A Alex Jahangir, Joseph R Hsu

Open Access Publications

The United States is in the midst of an opioid crisis. Clinicians have been part of the problem because of overprescribing of narcotics for perioperative pain management. Clinicians need to understand the pathophysiology and science of addiction to improve perioperative management of pain for their patients. Multiple modalities for pain management exist that decrease the use of narcotics. Physical strategies, cognitive strategies, and multimodal medication can all provide improved pain relief and decrease the use of narcotics. National medical societies are developing clinical practice guidelines for pain management that incorporate multimodal strategies and multimodal medication. Changes to policy that improve …

The Human Milk Protein-Lipid Complex Hamlet Disrupts Glycolysis And Induces Death In Streptococcus Pneumoniae, Hazeline Roche-Hakansson, Goutham Vansarla, Laura R. Marks, Anders P. Hakansson

Open Access Publications

No abstract provided.

The Telomere-Binding Protein Rif2 And Atp-Bound Rad50 Have Opposing Roles In The Activation Of Yeast Tel1atm Kinase, Sarem Hailemariam, Paolo De Bona, Roberto Galletto, Marcel Hohl, John H. Petrini, Peter M. Burgers

Open Access Publications

No abstract provided.

Developing Priorities To Achieve Health Equity Through Diabetes Translation Research: A Concept Mapping Study, Allison Phad, Shelly Johnston, Rachel G Tabak, Stephanie Mazzucca, Debra Haire-Joshu

Open Access Publications

Introduction: The goal of diabetes translation research is to advance research into practice and ensure equitable benefit from scientific evidence. This study uses concept mapping to inform and refine future directions of diabetes translation research with the goal of achieving health equity in diabetes prevention and control.

Research design and methods: This study used concept mapping and input from a national network of diabetes researchers and public health practitioners. Concept mapping is a mixed-method, participant-based process. First, participants generated statements by responding to a focus prompt ("

Results: Ten clusters were identified containing between 6 and 12 statements from 95 …

Adaptation Of An Evidence-Based Cardiovascular Health Intervention For Rural African Americans In The Southeast, Kiana D. Bess, Leah Frerichs, Tiffany Young, Giselle Corbie-Smith, Gaurav Dave, Kia Davis, Shirley Mcfarlin, Sable Watson, Mysha Wynn, Crystal W. Cene

Open Access Publications

No abstract provided.

Edematous Severe Acute Malnutrition Is Characterized By Hypomethylation Of Dna, Katharina V. Schulze, Mark J. Manary, Indi Trehan, Et Al.

Open Access Publications

No abstract provided.

A Targeted Gene Panel That Covers Coding, Non-Coding And Short Tandem Repeat Regions Improves The Diagnosis Of Patients With Neurodegenerative Diseases, Allen Chi-Shing Yu, Aldrin Kay-Yuen Yim, Anne Yin-Yan Chan, Liz Y P Yuen, Wing Chi Au, Timothy H T Cheng, Xiao Lin, Jing-Woei Li, Larry W L Chan, Vincent C T Mok, Ting-Fung Chan, Ho Yin Edwin Chan

Open Access Publications

Genetic testing for neurodegenerative diseases (NDs) is highly challenging because of genetic heterogeneity and overlapping manifestations. Targeted-gene panels (TGPs), coupled with next-generation sequencing (NGS), can facilitate the profiling of a large repertoire of ND-related genes. Due to the technical limitations inherent in NGS and TGPs, short tandem repeat (STR) variations are often ignored. However, STR expansions are known to cause such NDs as Huntington's disease and spinocerebellar ataxias type 3 (SCA3). Here, we studied the clinical utility of a custom-made TGP that targets 199 NDs and 311 ND-associated genes on 118 undiagnosed patients. At least one known or likely pathogenic …

Local Health Department Accreditation Is Associated With Organizational Supports For Evidence-Based Decision Making, Peg Allen, Stephanie Mazzucca, Renee G Parks, Mackenzie Robinson, Rachel G Tabak, Ross Brownson

Open Access Publications

No abstract provided.

Small Bowel Obstruction Secondary To Wild Banana Seed Ingestion, Divya K Natarajan, Phonexay Homthavong, Indi Trehan

Open Access Publications

No abstract provided.

A Brief Review Of Low-Dose Rate (Ldr) And High-Dose Rate (Hdr) Brachytherapy Boost For High-Risk Prostate, Benjamin W Fischer-Valuck, Hiram A Gay, Sagar Patel, Brian C Baumann, Jeff M Michalski

Open Access Publications

For patients with unfavorable or high-risk prostate cancer, dose escalated radiation therapy leads to improved progression free survival but attempts to deliver increased dose by external beam radiation therapy (EBRT) alone can be limited by late toxicities to nearby genitourinary and gastrointestinal organs at risk. Brachytherapy is a method to deliver dose escalation in conjunction with EBRT with a potentially improved late toxicity profile and improved prostate cancer related outcomes. At least three randomized controlled trials have demonstrated improved biochemical control with the addition of either low-dose rate (LDR) or high-dose rate (HDR) brachytherapy to EBRT, although only ASCENDE-RT compared …

Structural And Functional Abnormities Of Amygdala And Prefrontal Cortex In Major Depressive Disorder With Suicide Attempts, Lifei Wang, Yimeng Zhao, Elliot K Edmiston, Fay Y Womer, Ran Zhang, Pengfei Zhao, Xiaowei Jiang, Feng Wu, Lingtao Kong, Yifang Zhou, Yanqing Tang, Shengnan Wei

Open Access Publications

Finding neural features of suicide attempts (SA) in major depressive disorder (MDD) may be helpful in preventing suicidal behavior. The ventral and medial prefrontal cortex (PFC), as well as the amygdala form a circuit implicated in emotion regulation and the pathogenesis of MDD. The aim of this study was to identify whether patients with MDD who had a history of SA show structural and functional connectivity abnormalities in the amygdala and PFC relative to MDD patients without a history of SA. We measured gray matter volume in the amygdala and PFC and amygdala-PFC functional connectivity using structural and functional magnetic …

Antibiotic Stewardship Teams And Clostridioides Difficile Practices In United States Hospitals: A National Survey In The Joint Commission Antibiotic Stewardship Standard Era, Valerie M Vaughn, M Todd Greene, David Ratz, Karen E Fowler, Sarah L Krein, Scott A Flanders, Erik R Dubberke, Sanjay Saint, Payal K Patel

Open Access Publications

OBJECTIVE: Clostridioides difficile infection (CDI) can be prevented through infection prevention practices and antibiotic stewardship. Diagnostic stewardship (ie, strategies to improve use of microbiological testing) can also improve antibiotic use. However, little is known about the use of such practices in US hospitals, especially after multidisciplinary stewardship programs became a requirement for US hospital accreditation in 2017. Thus, we surveyed US hospitals to assess antibiotic stewardship program composition, practices related to CDI, and diagnostic stewardship.

METHODS: Surveys were mailed to infection preventionists at 900 randomly sampled US hospitals between May and October 2017. Hospitals were surveyed on antibiotic stewardship programs; …

Regional Differences In The Expression Of Tetrodotoxin-Sensitive Inward Ca2+ And Outward Cs+ /K+ Currents In Mouse And Human Ventricles, Wei Wang, Rebecca L. Mellor, Jeanne M. Nerbonne, C. William Blake

Open Access Publications

No abstract provided.

Associations Between Family Weight-Based Teasing, Eating Pathology, And Psychosocial Functioning Among Adolescent Military Dependents, Arielle T Pearlman, Denise E Wilfley, Et Al

Open Access Publications

Weight-based teasing (WBT) by family members is commonly reported among youth and is associated with eating and mood-related psychopathology. Military dependents may be particularly vulnerable to family WBT and its sequelae due to factors associated with their parents' careers, such as weight and fitness standards and an emphasis on maintaining one's military appearance; however, no studies to date have examined family WBT and its associations within this population. Therefore, adolescent military dependents at-risk for adult obesity and binge-eating disorder were studied prior to entry in a weight gain prevention trial. Youth completed items from the Weight-Based Victimization Scale (to assess …

Embracing Differences To Improve Success: American Orthopaedic Association Presidential Address, Boston, Massachusetts, June 23, 2017: Aoa Critical Issues, Regis J O'Keefe

Open Access Publications

No abstract provided.

Melanoma In Individuals With Neurofibromatosis Type 1: A Retrospective Study, May Zhang, Trisha Bhat, David H. Gutmann, Kimberly J. Johnson

Open Access Publications

No abstract provided.

Mission Critical Partnership For Infection Prevention Success, Karen Hoffmann, Hilary M Babcock

Open Access Publications

No abstract provided.

Protocol For The Effectiveness Of An Anesthesiology Control Tower System In Improving Perioperative Quality Metrics And Clinical Outcomes: The Tectonics Randomized, Pragmatic Trial, Christopher R King, Joanna Abraham, Thomas G Kannampallil, Bradley A Fritz, Arbi Ben Abdallah, Yixin Chen, Bernadette Henrichs, Mary Politi, Brian A Torres, Angela Mickle, Thaddeus P Budelier, Sherry Mckinnon, Stephen Gregory, Sachin Kheterpal, Troy Wildes, Michael S Avidan, Tectonics Research Group

Open Access Publications

No abstract provided.

Nanotherapy Targeting Nf-Κb Attenuates Acute Pain After Joint Injury, Huimin Yan, Xin Duan, Kelsey H Collins, Luke E Springer, Farshid Guilak, Samuel A Wickline, M Farooq Rai, Hua Pan, Christine T N Pham

Open Access Publications

Inflammation after joint injury leads to joint responses that result in eventual osteoarthritis development. Blockade of inflammation, by suppressing NF-κB expression, has been shown to reduce joint injury-induced chondrocyte apoptosis and reactive synovitis

Management Of Adrenal Insufficiency Risk After Long-Term Systemic Glucocorticoid Therapy In Duchenne Muscular Dystrophy: Clinical Practice Recommendations, Sasigarn A. Bowden, Anne M. Connolly, Kathi Kinnett, Philip S. Zeitler

Open Access Publications

No abstract provided.

Ctcf Variants In 39 Individuals With A Variable Neurodevelopmental Disorder Broaden The Mutational And Clinical Spectrum, Enrico D. H. Konrad, Marwan Shinawi, Emily Fassi, Et Al.

Open Access Publications

No abstract provided.