Digital Commons Network^™

Interpretable Deep Neural Network For Cancer Survival Analysis By Integrating Genomic And Clinical Data, Jie Hao, Youngsoon Kim, Tejaswini Mallavarapu, Jung Hun Oh, Mingon Kang

Computer Science Faculty Research

Background: Understanding the complex biological mechanisms of cancer patient survival using genomic and clinical data is vital, not only to develop new treatments for patients, but also to improve survival prediction. However, highly nonlinear and high-dimension, low-sample size (HDLSS) data cause computational challenges to applying conventional survival analysis. Results: We propose a novel biologically interpretable pathway-based sparse deep neural network, named Cox-PASNet, which integrates high-dimensional gene expression data and clinical data on a simple neural network architecture for survival analysis. Cox-PASNet is biologically interpretable where nodes in the neural network correspond to biological genes and pathways, while capturing the nonlinear …

Robust Cullin-Ring Ligase Function Is Established By A Multiplicity Of Poly-Ubiquitylation Pathways, Spencer Hill, Kurt Reichermeier, Daniel C. Scott, Lorena Samentar, Jasmin Coulombe-Huntington, Luisa Izzi, Xiaojing Tang, Rebeca Ibarra, Thierry Bertomeu, Annie Moridian, Michael J. Sweredoski, Nora Caberoy, Brenda A. Schulman, Frank Sicheri, Mike Tyers, Gary Kleiger

Life Sciences Faculty Research

The cullin-RING ligases (CRLs) form the major family of E3 ubiquitin ligases. The prototypic CRLs in yeast, called SCF enzymes, employ a single E2 enzyme, Cdc34, to build poly-ubiquitin chains required for degradation. In contrast, six different human E2 and E3 enzyme activities, including Cdc34 orthologs UBE2R1 and UBE2R2, appear to mediate SCF-catalyzed substrate polyubiquitylation in vitro. The combinatorial interplay of these enzymes raises questions about genetic buffering of SCFs in human cells and challenges the dogma that E3s alone determine substrate specificity. To enable the quantitative comparisons of SCF-dependent ubiquitylation reactions with physiological enzyme concentrations, mass spectrometry was employed …

Longitudinal Change In Regional Brain Volumes With Exposure To Repetitive Head Impacts, Charles Bernick, Guogen Shan, Henrik Zetterberg, Sarah Banks, Virendra R. Mishra, Lynn Bekris, James B. Leverenz, Kaj Blennow

Environmental & Global Health Faculty Research

Objective This study tests the hypothesis that certain MRI-based regional brain volumes will show reductions over time in a cohort exposed to repetitive head impacts (RHI). Methods Participants were drawn from the Professional Fighters Brain Health Study, a longitudinal observational study of professional fighters and controls. Participants underwent annual 3T brain MRI, computerized cognitive testing, and blood sampling for determination of neurofilament light (NfL) and tau levels. Yearly change in regional brain volume was calculated for several predetermined cortical and subcortical brain volumes and the relationship with NfL and tau levels determined. Results A total of 204 participants who had …

A Qualitative Study Of Older Adults' Perspectives On Initiating Exercise And Mindfulness Practice, Diana C Parra, Julie Loebach Wetherell, Alexandria Van Zandt, Ross C Brownson, Janardan Abhishek, Eric J Lenze

Open Access Publications

BACKGROUND: Mindfulness practice and exercise are ways by which older adults can improve and maintain their physical, emotional and cognitive health.

METHODS: This single-site qualitative study gathered insights of older adults' perceptions about initiating and maintaining mindfulness and exercise practices. We carried out focus groups with 41 adults aged 65-85 who had recently initiated Mindfulness Based Stress Reduction (MBSR), structured exercise, or their combination as part of participation in a clinical trial. We used a semi-structured interview to ask them open-ended questions regarding the benefits, barriers and facilitators of participating in mindfulness and/or exercise interventions. The interview also included questions …

Remediating Professionalism Lapses In Medical Students And Doctors: A Systematic Review, Nicola Brennan, Tristan Price, Julian Archer, Joe Brett, Nicola Brennan

Peninsula Medical School

No abstract provided.

Community-Based Responses To Negative Health Impacts Of Sexual Humanitarian Anti-Trafficking Policies And The Criminalization Of Sex Work And Migration In The Us, Heidi Hoefinger, Jennifer Musto, P.G. Macioti, Anne E. Fehrenbacher, Nicola Mai, Calum Bennachie, Calogero Giametta

Publications and Research

System-involvement resulting from anti-trafficking interventions and the criminalization of sex work and migration results in negative health impacts on sex workers, migrants, and people with trafficking experiences. Due to their stigmatized status, sex workers and people with trafficking experiences often struggle to access affordable, unbiased, and supportive health care. This paper will use thematic analysis of qualitative data from in-depth interviews and ethnographic fieldwork with 50 migrant sex workers and trafficked persons, as well as 20 key informants from legal and social services, in New York and Los Angeles. It will highlight the work of trans-specific and sex worker-led initiatives …

Parenting Paused: Pathological Video Game Use And Parenting Outcomes, Laura Stockdale, Sarah M. Coyne

Faculty Publications

For most people, playing video games is a normal recreational activity, with little disruption to gamers’ emotional, social, or physical health and well-being. However, for a small percentage of gamers, video gaming can become pathological (Fam, 2018). Substantial research has examined pathological gaming in teens and young adults (Cheng, Cheung, & Wang, 2018; Choo, Gentile, Sim, Khoo, & Liau, 2010), yet pathological gaming in adults (c.f.Holgren, 2017), especially in the context of parenthood, has been relatively ignored. The current study sought to address this limitation by studying associations between pathological gaming characteristics and parenting outcomes in a sample of men …

أثر استخدام أسلوب حل المشكلات في اكتساب طلبة السنة الأولى في جامعة عمان الأهلية لمهارات التفكير الإبداعي والتحصيل في مساق الإنسان والبيئة, ختام العناتي

Al-Balqa Journal for Research and Studies البلقاء للبحوث والدراسات

هدفت هذه الدراسة التعرف إلى أثر استخدام أسلوب حل المشكلات في اكتساب طلبة السنة الأولى في جامعة عمان الأهلية لمهارات التفكير الإبداعي والتحصيل في مساق البيئة والصحة . تكونت عينة الدراسة من (911) طالبا وطالبة من طلبة جامعة عمان الأهلية المسجلين في مساق الإنسان والبيئة ، حيث تم تقسيمهم إلى مجموعتين : مجموعة تدريبية وضمت (48) طالبا وطالبة ، ومجموعة ضابطة وضمت (43) طالبا وطالبة وقد أشارت الدراسة إلى النتائج التالية : - توجد فروق ذات دلالة إحصائية بين متوسط درجات أفراد المجموعتين التجريبية والضابطة لصالح المجموعة التجريبية في الاختبار البعدي لاختبار التفكير الإبداعي في كافة المجالات والاختبار الكلي . …

Didactic Potential Of The Chess Game And Its Impact On Students 'Academic Performance, Muksin Tadjievich Xodjiev, Аbdulxalim Xamidovich Maxmudov, Baxtier Xudayberdievich Raximov

Bulletin of Gulistan State University

One of the main tasks of modern schools is the development of children's creative potential and the formation of socially significant personal qualities. At school, they should not receive ready-made knowledge, but a model of adaptation to rapidly changing conditions. According to a number of psychological and pedagogical indicators, the chess game is an ideal explanatory model that allows students to form skills for successfully solving practice-oriented problems. Our research is devoted to revealing the didactic possibilities of this explanatory model, where the authors define approaches to the content interpretation and content of the concept of "didactic potential of chess", …

Innovative Ict-Based Foreign Language Learning: Evaluation Techniques, Assisted Learning And Foreign Language Teaching, Zaynab Аbduamitovna Karimova

Bulletin of Gulistan State University

В этой статье мы рассмотрим, как ИКТ (информационно-коммуникационные технологии) могут быть использованы в оценке преподавания английского языка. За прошедший период мы выработали лучшее понимание того, как мы могли бы помочь выучить язык, и эти изменения должны быть отражены в нашей оценке. Нам нужно развивать навыки и быть «пользователями» языка. Изменилась и цель оценки: речь идет не об оценке уровня умений студентов, а о мотивации и саморефлексии. В настоящее время ИКТ (информационно-коммуникационные технологии) имеют важнейший аспект в образовании и существенную роль в овладении иностранным языком, а также значительную проблему в современном образовании во всем мире, которая будет способствовать овладению студентами и …

Comparative Analysis Of Rhetoric In The English And Uzbek Doctors’ Speech, Khushnuda Botirovna Samigova, Bekhzod Rakhmankulovich Sultanov

Bulletin of Gulistan State University

В статье авторы рассматривают проблему, посвященную к риторическому аспекту культуры речи. Очень многие работы были посвящены для изучения риторического аспекта культуры речи учеными в разных языках, но лингвокультурологические особенности медицинской риторики в английском и узбекском языках до сих пор не изучены ими и это доказывает актуальность разработки этой проблемы авторами. Авторы приведя семантическое значение термина риторики, указывают на важность риторики в повседневном речевом акте. Они посвещяют эту работу для исследования медицинской речи в изучаемых языках, дают примеры из диалогов. В конце приводят свои выводы на основе сопоставительного анализа медицинской речи. Это статья имеет важную роль для читателей, особенно для студентов …

Transition Of Care In Paediatric Surgery: Current Practices And Perspectives Of Paediatric Surgeons In Malaysia, Shung K. Tan, Anand Sanmugam, Mahmoud Ramanujam, Tindivanam M., Mohan A. Nallusamy, Zakaria Zahari, Thambidorai R. Rao

Sultan Qaboos University Medical Journal

Objectives: Transition of care (TOC) from paediatric to adult care is still at an early stage in Malaysia. This study aimed to explore current practices and perspectives regarding TOC among paediatric surgeons in Malaysia. Methods: This study was carried out between June and December 2017. All 48 paediatric surgeons currently working in Malaysia were invited to participate in a questionnaire-based survey to assess demographic characteristics and practices and perspectives regarding TOC. Results: A total of 38 paediatric surgeons participated in the survey (response rate: 79.2%). Overall, 97.4% did not have an organised TOC model in their institution, with most (65.8%) …

Oman Urological Society Conference 2019, Sultan Qaboos University

Sultan Qaboos University Medical Journal

No abstract provided.

A Five Year Longitudinal Study Of The Educational Environment In A Newly Integrated Medical Curriculum, Syed I. Shehnaz

Sultan Qaboos University Medical Journal

Objectives: The College of Medicine at Gulf Medical University (GMU), Ajman, United Arab Emirates, was subjected to a curricular reform, which shifted the institution from a traditional curriculum to a hybrid, studentcentred, integrated curriculum. There are no previous studies analysing the consequences of such a curricular modification on the educational environment (EE). Therefore, this study aimed to analyse the EE of a pioneer cohort of the innovative curriculum over their five-year course of study. Methods: This prospective longitudinal study was conducted between September 2009 and September 2013 at the College of Medicine. The Dundee Ready Education Environment Measure questionnaire was …

A Review Of Obstetrical Outcomes And Complications In Pregnant Women After Bariatric Surgery, Yasmeen A. Haseeb

Sultan Qaboos University Medical Journal

Bariatric surgery (BS) is a novel treatment for weight reduction with longer lasting health benefits. This review aimed to summarise the available evidence regarding the fetomaternal outcomes and the most common challenges and complications in pregnancies following BS. Google Scholar (Google LLC, Mountain View, California, USA) and PubMed^® (National Library of Medicine, Bethesda, Maryland, USA) databases were searched for articles published until December 2018. A total of 64 articles were included in this review and results showed that BS mitigates the risk of gestational diabetes mellitus, hypertensive disorders in pregnancy and fetal macrosomia. However, it can also have detrimental …

Pharmacological Approaches To Diabetic Gastroparesis: A Systematic Review Of Randomised Clinical Trials, Mohammad Z. Asha, Sundos Fh Khalil

Sultan Qaboos University Medical Journal

Pharmacological interventions of diabetic gastroparesis (DG) constitute an essential element of a patient’s management. This article aimed to systematically review the available pharmacological approaches of DG, including their efficacy and safety. A total of 24 randomised clinical trials (RCTs) that investigated the efficacy and/or safety of medications targeting DG symptoms were identified using several online databases. Their results revealed that metoclopramide was the only approved drug for accelerating gastric emptying and improving disease symptoms. However, this medication may have several adverse effects on the cardiovascular and nervous systems, which might be resolved with a new intranasal preparation. Acceptable alternatives are …

Does Corporate Social Responsibility Reduce The Costs Of High Leverage? Evidence From Capital Structure And Product Market Interactions, Kee-Hong Bae, Sadok El Ghoul, Omrane Guedhami, Chuck C.Y. Kwok, Ying Zheng

Finance Department Faculty Journal Articles

Research on capital structure and product market interactions shows that high leverage is associated with substantial losses in market share due to unfavorable actions by customers and competitors. We examine whether corporate social responsibility (CSR) affects firms’ interactions with customers and competitors, and whether it can reduce the costs of high leverage. We find that CSR reduces losses in market share when firms are highly leveraged. By reducing adverse behavior by customers and competitors, CSR helps highly leveraged firms keep customers and guard against rivals’ predation. Our results support the stakeholder value maximization view of CSR.

St. Francis Borgia Deaf Center Church Bulletin, December 22, 2019

Saint Francis Borgia Deaf Center Church Bulletin

A newsletter published for Deaf Catholics in Chicago, IL

Saint Francis Brogia Deaf Center Church Bulletin Finding Aid

Storm On The Horizon: Climate Change, Hurricanes, And The Future Of The Eastern Caribbean, Joseph P. Odegaard

Student Theses 2015-Present

Hurricanes are a fact of life in the Caribbean. This meteorological reality has shaped the islands’ development throughout its history. However, in recent years, the Atlantic’s most fearsome storms have been unprecedented, both in strength and number. This paper explores the relationship between climate change and hurricanes and the effect this relationship has on the Eastern Caribbean. Chapter 1 uses quantitative data from a variety of sources, including the Intergovernmental Panel on Climate Change and the Millennium Ecosystem Assessment of the United Nations, as well as the National Oceanic and Atmospheric Association and the National Climate Assessment of the United …

The Reggio Approach In Motion. Documenting Experiences, Reflecting Upon Practice And Disseminating The Ideas., P Sorzio, V Campbell Barr

School of Law, Humanities and Social Sciences

No abstract provided.

Effects Of Two Intake Levels Of Leucaena Leucocephala On Rumen Function Of Sheep, Marcos Barros-Rodríguez, Javier Solorio-Sánchez, Carlos Sandoval-Castro, Athol V. Klieve, Eduardo Briceño-Poot, Luis Ramírez-Avilés, Rafael Rojas-Herrera

IGC Proceedings (1977-2023)

Ruminant production systems based on grass pastures often produce poor animal performance as expressed by growth or reproductive rates. The nutrient imbalance affecting rumen function is due to their low energy and protein intake. The incorporation of leguminous forages such as Leucaena leucocephala, in the diet of ruminants, can stimulate rumen function by providing protein-rich forage (Barros-Rodriguez et al. 2012). This increases the availability of compounds such as ammonia, amino acids and peptides as well as branched short-chain fatty acids, which are produced as a result of degradation of proteins. These substances promote fibre breakdown by acting as ruminal …

Language Picture Of Children’S World Illustrated In “Divanu Lugat-It Turk", Zokir Boynazarov Researcher

Philology Matters

This article explores the language picture of the World and its varieties, the role of children's world picture and the features of its study. Also,special attention is paid to the Turkic children's worldview of the 11th century, set forth in the famous "Divan" by Mahmoud Kashgary. Some comments are given to the analysis of the concept of "children's world picture ".The study of the language concepts of the world, which we have analyzed in the book “Devanu lugat-it Turk” (DLT), which covers LPW in every aspect of the social life of the Turkic peoples in the 11th century, is also …

Some Methods Of Teaching Consecutive Interpreting In The Situational Conditions, Djamilya Abduganieva Researcher

Philology Matters

The article analyses the game method, as a method of teaching consecutive interpretation of senior students of a language university. At present, the role of the interpreter as an intercultural intermediary is growing, that implies the mastery of students’ skills in interpretation activities in various communication situations. The exercises-games presented in the article allow teachers to model different types of interpretation situations in the classroom and promote the willingness of future interpreters to carry out interpretation activities in real conditions of intercultural communication.The relevance of the purposeful formation of students' skills in consecutive interpreting is caused, on the one hand, …

Features Of Comparative Phraseological Units, Dilbar Djumanova Doctor Of Philological Sciences, Associate Professor, Shoira Isaeva Independent Researcher

Philology Matters

This article focuses on peculiarities of comparative phraseologisms, as this group of phraseologisms is the most frequently met in Russian discourse. This group of phraseologisms is analyzed from the view point of semantic merge of its components, structure, system,contents, functioning in the speech, emotionally expressive colouring and etymology. The article provides huge amount of examples, as well as highlights interesting facts about etymology of some corporative phraseologisms.

Functional-Semantic Features Of Lexical Doublets In English, Otabek Yusupov Senior Teacher

Philology Matters

This article discusses the etymology of lexical doublets in English, approaches of scholars to the development of lexical doublets, their division into semantic groups, their use in languages, in discourse and their functional and semantic aspects. Semantic grouping of lexical doublets from different languages has been explored with examples. In addition, borrowings, formation of vocabulary derived from different languages as lexical doublets, and their structural, semantic, functional and linguocultural features were compared and analyzed for their similarities and differences.

Improving The Effectiveness Of The English Language Lessons, Lobar Usmanova Researcher

Philology Matters

The author of the article considers one of the most topical issues of our time – teaching of a foreign language at school. The author underlines a lot of opportunities for increasing the effectiveness of foreign language lessons where the process of linguistic, cognitive, social and creative factors is at play. Students need to master the skills of academic writing not only for acquiring the knowledge, but also for their further education. It is also significant for teachers to know who their students are, what they think and how teachers can best assist them.This study examines the last-year schoolchildren at …

The Role Of The Speech Of The Character, Portrait And Landscape In Opening The Spirit Of The Character, Ulughbek Kuchimov Phd Student

Philology Matters

In the works of fiction, the writer creates an artistic world that can happen in life, and shows life and imaginary events in our eyes as if they are true, real, had happened. Sometimes this literary phenomenon requires such an artistic composition that it breaks the boundaries of reality. In the following years, as in all types and genres literature, specific changes, evolutions are taking place in the world of fantasy works, themes, poetics, style, and images.
In the works of Ray Bradbury and Hojiakbar Shaikhov, a number of features such as myth, the stream of consciousness, the image of …

The Role Of Symbols In “The Kite Runner” By Khaled Hosseini, Gulhayо Achilova Researcher

Philology Matters

The main focus of this research work is to analyze the symbols and their role in interpreting the novel “The Kite Runner” by Afghan-born American writer Khaled Hosseini who has widely used artistic signs in his novel. With the help of symbols the essence of the work has been conveyed to the reader through the sensitivity of artistic principles. The symbols in the novel were analyzed being divided into categories as characters, places, things and complex symbols. The introduction of the symbols in the novel, as the secret information of the author to the reader, is a masterpiece of the …

Conceptual Image Of English, Russian And Uzbek Socio-Political Discourse (Comparison), Gulnoza Amonova Phd Student

Philology Matters

The thesaurus of socio-political vocabulary is based on intra-systemic conceptual relations between units of this lexical group. The concept “power” is a structure-formed mean for this vocabulary. Being the main descriptors of the thesaurus of socio-political vocabulary, concepts project a number of their characteristics on to the lexical groups organized by them. Moreover, the structure of the corresponding branches of the thesaurus is largely determined by the internal, structural features of the concepts. As a result of this, it seems necessary to analyze these key concepts for socio-political vocabulary, as well as the concepts “people” and “nation” that are significant …

Classifications Of The Names Of English And Uzbek Famous Prople By Means Of Periphrases, Xushnuda Samigova Samigova Associate Professor Of The Translation Theory And Practice Department

Philology Matters

Topicality of the research is justified with followings: the periphrasis as a stylistic device was studied by many scholars, however, expressing the names of the famous people in periphrasis of two different languages has not been studied yet. Aim and tasks of the research are to study the etymological derivations of the periphrasis units of the names of famous people from different sources and analyzing and estimating linguocultural attributes of the collected examples and to find their similar and distinctive features in the correlation of two languages. Tasks of the following article are: the classification of the names of English …