Digital Commons Network^™

Activation Of Lxrβ Inhibits Tumor Respiration And Is Synthetically Lethal With Bcl-Xl Inhibition, Trang Thi Thu Nguyen, Chiaki Tsuge Ishida, Enyuan Shang, Chang Shu, Consuelo Torrini, Yiru Zhang, Elena Bianchetti, Maria J. Sanchez-Quintero, Giulio Kleiner, Catarina M. Quinzii, Mike-Andrew Westhoff, Georg Karpel-Massler, Peter Canoll, Markus D. Siegelin

Publications and Research

Liver-X-receptor (LXR) agonists are known to bear anti-tumor activity. However, their efficacy is limited and additional insights regarding the underlying mechanism are necessary. By performing transcriptome analysis coupled with global polar metabolite screening, we show that LXR agonists, LXR623 and GW3965, enhance synergistically the anti-proliferative effect of BH3 mimetics in solid tumor malignancies, which is predominantly mediated by cell death with features of apoptosis and is rescued by exogenous cholesterol. Extracellular flux analysis and carbon tracing experiments (U-¹³C-glucose and U-¹³C-glutamine) reveal that within 5 h, activation of LXRβ results in reprogramming of tumor cell metabolism, leading …

Initial Development Of A Prototype Sensor Testbed For Fetal Monitoring, Christian Beauvais

Theses and Dissertations

The objective of this research is to design and manufacture a device that exhibits some of the bio-physiological signals relevant to fetal health monitoring. Currently, limited options exist for testing the performance of monitoring devices such as the tocodynamometer (TOCO) and electrocardiograph (ECG) that measure the bio-physiological signals of a woman and her fetus. Sensor designers need ways of generating and acquiring signals that do not carry the ethical burden of human testing. The development of such a device, as considered in this work, may involve using muscle wire or an inflatable tube as prospective foundations for simulating uterine contraction. …

Population Trends Of The Native Fish Assemblage In Bonita Creek, Arizona, Usa, George N. Zaimes, David Arthun, Vasilios Liordos

Western North American Naturalist

The protection of riparian zones is critical for biodiversity conservation. The exclusion of human activities and invasive nonnative fish species have been used as measures to protect vulnerable native fish populations in Bonita Creek, Graham County, Arizona. The abundance of 5 native fish species, during 2005–2016, and mesohabitat proportions, during 2011–2016, were estimated at 4 sites to assess the effectiveness of these conservation measures. Interannual variation in numbers was high for all the species, with the speckled dace (Rhinichthys osculus) being the most abundant. The speckled dace significantly increased at one of the sites; the Sonora sucker ( …

Using Microsoft Hololens To Improve Memory Recall In Anatomy And Physiology: A Pilot Study To Examine The Efficacy Of Using Augmented Reality In Education, Chen Chen, Lei Zhang, Tony Luczak, Eboni Smith, Reuben F. Burch

Journal of Educational Technology Development and Exchange (JETDE)

This paper explores the use of augmented reality (AR) to improve memory recall and learning experiences in human anatomy and physiology. In particular, the opportunity to assess new computer technologies to improve learning environments may allow for an improvement in self-efficacy and a reduction in test anxiety. Twenty-two undergraduates participated in one of two study groups, the Microsoft HoloLens group (HLNS) or the traditional projector-based Microsoft Power Point group (PPT). Each group completed a five-minute, three-subject anatomy identification and brain physiology memory test. After a three-minute time delay, participants completed a fill-in-the-blank anatomy identification test and brain physiology question test, …

Deep Machine Learning Techniques For The Detection And Classification Of Sperm Whale Bioacoustics, Peter C. Bermant, Michael M. Bronstein, Robert J. Wood, Shane Gero, David F. Gruber

Publications and Research

We implemented Machine Learning (ML) techniques to advance the study of sperm whale (Physeter macrocephalus) bioacoustics. This entailed employing Convolutional Neural Networks (CNNs) to construct an echolocation click detector designed to classify spectrograms generated from sperm whale acoustic data according to the presence or absence of a click. The click detector achieved 99.5% accuracy in classifying 650 spectrograms. The successful application of CNNs to clicks reveals the potential of future studies to train CNN-based architectures to extract finer-scale details from cetacean spectrograms. Long short-term memory and gated recurrent unit recurrent neural networks were trained to perform classification tasks, including (1) …

Draft Genome Sequences Of Four Lactococcus Lactis Strains Isolated From Diverse Niches, Including Dairy Products, Grass, And Green Peas, Desirée Roman Naranjo, Michael Callanan, Et. Al.

Department of Biological Sciences Publications

Lactococcus lactis has been used for millennia as a starter organism in the production of many fermented dairy products. This announcement includes the draft genome sequences of four strains of Lactococcus lactis, two of dairy origin and two from nondairy sources.

Occupied, Judy Diamond, Tom Floyd, Rebecca Smith, Ann Downer-Hazell, Martin Powell, Nick Poliwko, Angie Fox, Amy Spiegel, Patricia Wonch Hill, Julia Mcquillan

Zea E-Books Collection

Our bodies are home to more microbes than human cells. The balance of helpful to harmful microbes in our bodies can make us sick or healthy. The Biology of Human project focuses on helping people understand themselves by exploring scientific principles that underlie modern research in human biology. Biology of Human is an alliance of science educators, artists, science writers, and biomedical researchers working to increase public understanding about viruses and infectious disease. In this comic, Daniel and Miguel find themselves in the world of the microbes, where they meet the Roid (Bacteroides), Longo biffi (Bifidobacterium longum), E. …

Whole Slide Imaging For High-Throughput Monitoring Of Microbial Growth And Its Application To Rapid Antimicrobial Susceptibility Testing, Donghui Song

Doctoral Dissertations

Archival abstract submitted

On The Topic Of Spatial Capture-Recapture Modeling, Paul Mclaughlin

Doctoral Dissertations

Over the past two decades there have been many advancements in modeling capture-recapture (CR) data to account for emerging data collection technology and techniques. Spatial capture-recapture (SCR) models have been introduced to estimate population size and numerous other demographic parameters from spatially explicit CR data. Here we offer a comprehensive review of the development of CR modeling up to and including SCR models.

We then introduce a new SCR model which allows for attractions between individuals via their daily movements. A simulation study is used to demonstrate accounting for these attractions can improve population size estimation. Additionally, we apply our …

Role Of Tissue Inhibitor Of Matrix Metalloproteinase-1 In The Development Of Hypersensitivity Using An Animal Model Of Cutaneous Inflammation, Brittany Knight

Doctoral Dissertations

Persistent pain is a significant clinical problem that affects millions of people worldwide. The severity of acute pain and inflammatory signaling during tissue damage can predispose an individual to develop pain that persists past the normal healing time. In my thesis work, I focused on how molecules involved in the regulation of inflammation and normal wound healing contribute to the progression of pain.

During tissue damage and inflammation, Tissue inhibitor of metalloproteinase-1 (TIMP-1) is upregulated to maintain tissue homeostasis as well as promote normal inflammatory signaling. Recent evidence suggests that TIMP-1 may reduce the development of nerve-injury induced pain, however …

A Microspectra Analysis Of Synthetic Wig Fibers, Jaclyn R. Beshlian

Student Theses

The goal of this study was to determine whether differentiation between 20 visually similar light brown synthetic wig fibers was possible with the use of a microspectrophotometer (MSP). Visually similar fibers were chosen to display the power of the instrument over the human eye. An MSP is an instrument that has the ability to aid in the analysis of certain microscopical samples. With this particular instrument one is able to collect the absorption and fluorescence spectra of microscopical colored samples without destroying the piece of evidence itself. Prior to any analysis with the MSP, the material of the fibers was …

Why Weightlifters Grunt: A Classroom Exercise That Introduces Students To Evolution, H. Charles Romesburg

Environment and Society Faculty Publications

A classroom exercise is described in which college students take part in creating and supporting an evolutionary hypothesis that explains effort grunting. The exercise holds their interest throughout and readies them to understand hypotheses of animal and plant evolution. It informs them about the dependence of cultural evolution upon biological evolution, and it connects widely to curricula.

Prevalence Of Goiter Among Children In Ethiopia And Associated Factors: A Systematic Review And Meta-Analysis., Getenet Dessie, Desalegne Amare, Amare Belachew Dagnew, Henok Mulugeta, Dessalegn Haile Kassa, Ayenew Negesse, Getachew Mullu Kassa, Fasil Wagnew, Sheikh Mohammed Shariful Islam, Sahai Burrowes

BACKGROUND: The distribution of goiter among children and its risk factors are not well investigated in Ethiopia. Therefore, this systematic review and meta-analysis was designed to determine the pooled prevalence of goiter and its associated factors among children in Ethiopia.

METHODS: Electronic web-based searches of PubMed, Google Scholar, EMBASE, and the World Health Organization's Hinari portal (which includes the SCOPUS, African Index Medicus, and African Journals Online databases) were conducted to find primary studies. Relevant data were extracted and descriptive summaries of the studies were presented in tables. The I

RESULTS: Our search identified 982 studies, of which, 19 articles …

The George-Anne, Georgia Southern University

The George-Anne

• Netflix: Using Diversity as a Bargaining Chip
• Fall 2019 and spring 2020 Georgia Southern commencement plans released
• 51 Upperclassmen Moved to Off-campus Housing, All Freshmen Living in Dorms
• Department of Biological Sciences Helps Target Invasive Species
• Georgia Southern Athletics seeks interest for student section leaders at first SGA meeting
• I.T. Online
• Blue Room on Wheels
• Battle in the Bayou
• Behind Enemy Bylines

Functional Secrecy, Laura K. Donohue

Georgetown Law Faculty Publications and Other Works

Many theorists consider secrecy inimical to liberal democracy. Precise examination of the role that it plays in contemporary government, however, including its strengths and weaknesses, has been limited. This chapter, accordingly, lays out a functional theory of secrecy, considering its role in the three branches of government in four contexts: deliberation, information security, law, and adjudicatory processes. Whether and to what extent cloaking information advances the interests of the state and society varies according to how it operates in each category. First, deliberative secrecy carries significant advantages: it can facilitate informed debate and honest exchange, allowing individuals to alter their …

Annual And Seasonal Variation In Hydrologic Performance Of Ecoroofs Of Multiple Depths, Portland, Or, Ashley Michelle Baker

Dissertations and Theses

It is essential that cities adopt new approaches to stormwater management in the face of changing precipitation regime. In some locations, ecoroofs have been incorporated into city plans as a stormwater control measure, and thus their real-world performance under current conditions can assist with adequate planning. In this study rainfall retention data collected during a three year period, between 2014-2017, is analyzed for 75mm and 125mm ecoroof plots in Portland, Oregon, USA. There is no difference in annual rainfall retention performance between the shallower and deeper plots. However, the 36% mean annual retention of the ecoroof plots is a significant …

Use Of Multimedia Technology Among The Lecturer And Students Of Osun State University, Komolafe Ramilowo Saidat, Otonekwu Onyeisi Florence, Francis Olusanjo Oyeyemi

Library Philosophy and Practice (e-journal)

The aim of this study is to investigate the use of multimedia technology by lecturers and undergraduate students in Osun State University. The study was guided by four research questions. The study adopted descriptive survey design sample was selected using stratified random sampling method, to select 192 lecturers, and 377 undergraduate students. Data collected were analyzed using frequency counts and percentages, and T-test to test the only null hypothesis of the study. The study found out that there was an existence of multimedia technologies (MMT) in the institution. Furthermore, the result showed that both lecturers and students hold positive perception …

A Comparison Of Cave Microbial Communities To Cave Roosting Bat Microbiota In El Malpais National Monument, Usa, Nicole A. Caimi

Biology ETDs

The arrival of white-nose syndrome (WNS), a devastating fungal disease, has highlighted the need to better understand bat microbiota and how bats acquire their microbiota. To address this need, we investigated how bat microbiota compare to microbiota from the cave walls in two El Malpais National Monument caves. The external surfaces of six roosting bats from each cave, representing four different bat species, and their associated microbial mats were sampled. One to three air samples were taken in each cave. Samples were sequenced using Illumina MiSeq sequencing of the 16S rRNA gene for bacterial diversity and the ITS region for …

An Integrated Approach To Determine Interactive Genotoxic And Global Gene Expression Effects Of Multiwalled Carbon Nanotubes (Mwcnts) And Benzo[A]Pyrene (Bap) On Marine Mussels: Evidence Of Reverse ‘Trojan Horse’ Effects, Audrey Barranger, Graham A. Rance, Yann Aminot, Lorna J. Dallas, Susanna Sforzini, Nicola J. Weston, Rhys W. Lodge, Mohamed Banni, Volker M. Arlt, Michael N. Moore, James W. Readman, Aldo Viarengo, Andrei N. Khlobystov, Awadhesh N. Jha

School of Biological and Marine Sciences

No abstract provided.

Imaginations Of Different Animals In The System Of The Traditional World Outlook Of Uzbek Folk, X. Rakhmatillayev, S. Sokhibov

Scientific journal of the Fergana State University

The given article deals with the issues of snake cult in Ferghana Valley. Snake has a special place in belief of people, which was kept in some rituals. Author analyzed modern views and beliefs of local people.

Imaginations Of Different Animals In The System Of The Traditional World Outlook Of Uzbek Folk, X. Rakhmatillayev, S. Sokhibov

Scientific journal of the Fergana State University

The given article deals with the issues of snake cult in Ferghana Valley. Snake has a special place in belief of people, which was kept in some rituals. Author analyzed modern views and beliefs of local people.

The Collegian: August 29, 2019, The Collegian Staff, South Dakota State University

The Collegian, 2019-2020

Volume: 135

Issue: 1

Spartan Daily, August 28, 2019, San Jose State University, School Of Journalism And Mass Communications

Spartan Daily, 2019

Volume 153, Issue 3

Commonwealth Times 2019-08-28

Commonwealth Times, 1969-

No abstract provided.

The Misconception Of College Life: How Popular Media Is Making It Worse, Jenna Bucher

Pop Culture Intersections

This article explores the misconceptions of the life of a college student and the daily struggles that get overlooked. Colleges provide support for the most prevalent cases of mental illness but disregard those who do not display these obvious signs. This focus on only those with extreme needs leaves the majority of students feeling lost and not knowing where to go for help; their feelings are not warranted and unless they are suicidal, it is not of a concern. I will argue that on top of the stresses of acclimating to college, daily work and social pressures, social media has …

The Lumberjack Newspaper, August 28, 2019, The Lumberjack Staff

2019

The student newspaper of Humboldt State University

Modeling Interval Timing By Recurrent Neural Nets, Theodore Raphan, Eugene Dorokhin, Andrew R. Delamater

Publications and Research

The purpose of this study was to take a new approach in showing how the central nervous system might encode time at the supra-second level using recurrent neural nets (RNNs). This approach utilizes units with a delayed feedback, whose feedback weight determines the temporal properties of specific neurons in the network architecture. When these feedback neurons are coupled, they form a multilayered dynamical system that can be used to model temporal responses to steps of input in multidimensional systems. The timing network was implemented using separate recurrent “Go” and “NoGo” neural processing units to process an individual stimulus indicating the …

Ag Lenders Panel Provides Insight Into Beef Systems Initiative, Jay Parsons, D. D. Redfearn, Mary E. Drewnoski

Cornhusker Economics

In 2017, the University of Nebraska-Lincoln Institute of Agricultural and Natural Resources (IANR) and Nebraska Extension made a commitment to implement a multidisciplinary Beef Systems Initiative (BSI). The BSI is administered by the Center for Grassland Studies and is comprised of six projects designed to develop and support the implementation of beef production systems that optimize feed resource use, natural resource conservation, and producer success in Nebraska through improved management of perennial grasslands and systems of integrated crop-beef cattle production. In addition to the BSI, a parallel project funded by the Foundation for Food and Agriculture Research (FFAR) is studying …

Notch Coordinates Periodontal Ligament Maturation Through Regulating Lamin A, B. J. Denes, C. Bolton, C. S. Illsley, W. L. Kok, J. V. Walker, A. Poetsch, C. Tredwin, S. Kiliaridis, B. Hu

Peninsula Dental School

No abstract provided.

Resolving The Genetic Paradox Of Invasions: Preadapted Genomes And Postintroduction Hybridization Of Bigheaded Carps In The Mississippi River Basin, Jun Wang, Sarah Gaughan, James T. Lamer, Cao Deng, Wanting Hu, Michael Wachholtz, Shishang Qin, Hu Nie, Xiaolin Liao, Qufei Ling, Weitao Li, Lifeng Zhu, Louis Bernatchez, Chenghui Wang, Guoqing Lu

Biology Faculty Publications

The genetic paradox of biological invasions is complex and multifaceted. In particular, the relative role of disparate propagule sources and genetic adaptation through postintroduction hybridization has remained largely unexplored. To add resolution to this paradox, we investigate the genetic architecture responsible for the invasion of two invasive Asian carp species, bighead carp (Hypophthalmichthys nobilis) and silver carp (H. molitrix) (bigheaded carps) that experience extensive hybridization in the Mississippi River Basin (MRB). We sequenced the genomes of bighead and silver carps (~1.08G bp and ~1.15G bp, respectively) and their hybrids collected from the MRB. We found moderate‐to‐high …