Digital Commons Network^™

As Range Of Possible Therapies Grows, Chdi Expands Efforts To Defeat Huntington's Disease, Kenneth P. Serbin

At Risk for Huntington's Disease

No abstract provided.

Organic Anion Lithium Ionic Cocrystal Compounds And Compositions, Michael John Zaworotko, Naga Duggirala, Adam John Smith, Roland Douglas Shytle

USF Patents

A cocrystal having the formula LiX.aM, or a solvate or hydrate thereof, wherein X is a conjugate base of an organic acid, M is a neutral organic molecule, and a is from 0.5 to 4, pharmaceutical compositions comprising such cocrystals, cocrystal solvates, or cocrystal hydrates, and methods of preparing such cocrystals, cocrystal solvates, or cocrystal hydrates, and such pharmaceutical compositions.

Methods Of Measuring C19mc Mirna In A Post-Natal Tissue And Uses Thereof, Hana Totary-Jain, Ezinne Francess Mong

USF Patents

Provided herein are methods of measuring C19MC miRNA amount and/or expression in a post-natal cell and/or tissue. Provided herein are methods of measuring CpG methylation of the upstream C19MC miRNA promoter region in a post-natal cell and/or tissue. Also provided herein are methods of treating a cell, population thereof, and/or a subject in need thereof by administering a C19MC miRNA inhibitor or CRISPR to suppress the expression of specific miRNA within the C19MC or the entire C19MC cluster, population thereof, and/or the subject in need thereof.

Arginine Deiminase Gene Therapy For Disordered Proteins, Daniel C. Lee, Kevin Ron Nash

USF Patents

The invention relates to compositions comprising arginine deiminase and their use in a method of reducing aggregation of disordered protein in a subject.

Impacts Of Aquatic Walking On Arterial Stiffness, Exercise Tolerance, And Physical Function In Patients With Peripheral Artery Disease: A Randomized Clinical Trial, Song-Young Park, Elizabeth J. Pekas, Yi-Sub Kwak

Health and Kinesiology Faculty Publications

Peripheral artery disease (PAD) is an atherosclerotic disease that is associated with attenuated vascular function, cardiorespiratory capacity, physical function, and muscular strength. It is essential to combat these negative effects on health by incorporating lifestyle interventions to slow disease progression, such as exercise. We sought to examine the effects of aquatic walking exercise on cardiovascular function, cardiorespiratory capacity [maximal volume of oxygen consumption (V̇o2max)], exercise tolerance [6-min walking distance (6MWD)], physical function, muscular strength, and body composition in patients with PAD. Patients with PAD (n = 72) were recruited and randomly assigned to a 12-wk aquatic walking training group …

Fundamentalism Turns 100, A Landmark For The Christian Right, William Vance Trollinger

History Faculty Publications

These days, the term “fundamentalism” is often associated with a militant form of Islam.

But the original fundamentalist movement was actually Christian. And it was born in the United States a century ago this year.

Protestant fundamentalism is still very much alive. And, as Susan Trollinger and I discuss in our 2016 book, it has fueled today’s culture war over gender, sexual orientation, science and American religious identity.

Analysis Of Mutations In West Australian Populations Of Blumeria Graminis F. Sp. Hordei Cyp51 Conferring Resistance To Dmi Fungicides, Madeline A. Tucker, Francisco J. Lopez-Ruiz, Hans J. Cools, Jonathon G L Mullins, Kithsiri W. Jayasena, Richard P. Oliver

Biosecurity Research Articles

BACKGROUND

Powdery mildew caused by Blumeria graminis f. sp. hordei (Bgh) is a constant threat to barley production but is generally well controlled through combinations of host genetics and fungicides. An epidemic of barley powdery mildew was observed from 2007 to 2013 in the West Australian grain belt.

RESULTS

We collected isolates across Australia, examined their sensitivity to demethylation inhibitor (DMI) fungicides and sequenced the Cyp51B target gene. Five amino acid substitutions were found, of which four were novel. The most resistant haplotypes increased in prevalence from 0% in 2009 to 16% in 2010 and 90% in 2011. …

Mutation Of The Co-Chaperone Tsc1 In Bladder Cancer Diminishes Hsp90 Acetylation And Reduces Drug Sensitivity And Selectivity, Mark R. Woodford, Michael Hughes, Rebecca A. Sager, Sarah J. Backe, Alexander J. Baker-Williams, Michael S. Bratslavsky, Joseph M. Jacob, Oleg Shapiro, Michael Wong, Gennady Bratslavsky, Dimitra Bourboulia, Mehdi Mollapour

Open Access Publications

The molecular chaperone Heat shock protein 90 (Hsp90) is essential for the folding, stability, and activity of several drivers of oncogenesis. Hsp90 inhibitors are currently under clinical evaluation for cancer treatment, however their efficacy is limited by lack of biomarkers to optimize patient selection. We have recently identified the tumor suppressor tuberous sclerosis complex 1 (Tsc1) as a new co-chaperone of Hsp90 that affects Hsp90 binding to its inhibitors. Highly variable mutations of TSC1 have been previously identified in bladder cancer and correlate with sensitivity to the Hsp90 inhibitors. Here we showed loss of TSC1 leads to hypoacetylation of Hsp90-K407/K419 …

Structured Inhibitory Activity Dynamics In New Virtual Environments, Moises Arriaga, Edward B. Han

Open Access Publications

Inhibition plays a powerful role in regulating network excitation and plasticity; however, the activity of defined interneuron types during spatial exploration remain poorly understood. Using two-photon calcium imaging, we recorded hippocampal CA1 somatostatin- and parvalbumin-expressing interneurons as mice performed a goal-directed spatial navigation task in new visual virtual reality (VR) contexts. Activity in both interneuron classes was strongly suppressed but recovered as animals learned to adapt the previously learned task to the new spatial context. Surprisingly, although there was a range of activity suppression across the population, individual somatostatin-expressing interneurons showed consistent levels of activity modulation across exposure to multiple …

Co-Localization Of Dna I-Motif-Forming Sequences And 5-Hydroxymethyl-Cytosines In Human Embryonic Stem Cells, Yogini P. Bhavsar-Jog, Eric Van Dornshuld, Tracy A. Brooks, Gregory S. Tschumper, Randy M. Wadkins

Chemistry Faculty Research & Creative Works

G-quadruplexes (G4s) and i-motifs (iMs) are tetraplex DNA structures. Sequences capable of forming G4/iMs are abundant near the transcription start sites (TSS) of several genes. G4/iMs affect gene expression in vitro. Depending on the gene, the presence of G4/iMs can enhance or suppress expression, making it challenging to discern the underlying mechanism by which they operate. Factors affecting G4/iM structures can provide additional insight into their mechanism of regulation. One such factor is epigenetic modification. The 5-hydroxymethylated cytosines (5hmCs) are epigenetic modifications that occur abundantly in human embryonic stem cells (hESC). The 5hmCs, like G4/iMs, are known to participate in …

The Impact Of Integrating Traditional Ecological Knowledge In Summer Camps On Middle School Students' Understanding Of The Nature Of Science, SapoóQ'Is WiíIt'es Ciarra Solina Greene

Dissertations and Theses

The Nature of Science (NOS) and traditional ecological knowledge (TEK) have commonalities in the knowledge bases: they are both ways of explaining the natural world; founded on a set of practices and the historical accumulation of knowledge; and part of the education is learning practices and developing knowledge of the concepts that are foundational to the disciplines. Throughout the United States, schools are attempting to strengthen students' understanding of NOS through various approaches, although few have adopted the integration of TEK into curriculum. This research assesses two summer camps for middle school students that are science focused, one with TEK …

A Warrant Requirement Resurgence? The Fourth Amendment In The Roberts Court, Benjamin J. Priester

St. John's Law Review

(Excerpt)

Over many years, the United States Supreme Court has developed an extensive body of precedent interpreting and enforcing the provisions of the Fourth Amendment to the United States Constitution, which prohibits unreasonable searches and seizures by law enforcement agents conducting criminal investigations. Commonly called the “warrant requirement,” one key component of this case law operates to deem some police investigatory techniques to be unconstitutional unless they are conducted pursuant to a search warrant issued in advance by a judge. The terms of the doctrine and its exceptions also authorize other investigatory actions as constitutionally permissible without a search warrant. …

The Influence Of Selected Factors Impacting The Incidence And Severity Of Accidents Involving Pedestrian/Bicyclists And Motorized Vehicles In Urban Areas Of Louisiana, Randall M. Verret Jr.

LSU Doctoral Dissertations

The primary purpose of this study was to determine the influence of selected demographic, environmental and infrastructure factors on the incidence and severity of traffic accidents involving a motorized vehicle and a non-motorized (pedestrian or bicyclist) individual. Identification of influential factors can aid in developing more effective countermeasures, targeted education and training programs to reduce the fatality and injury risks to vulnerable road users. A total of 9,538 crash data records involving vulnerable road users and motor vehicle drivers were utilized in this study.

Overall, vulnerable road users were found to have higher incidences of impairment than motorized vehicle drivers …

Community Forest In Liberia: The Interface Between Sustainable Charcoal Production And Deforestation, Amavie Clement

Capstone Collection

The available data establishes a direct correlation between charcoal production and forest degradation and deforestation in Liberia. Charcoal is the primary energy source for Liberians, especially in urban areas where the bulk of the population lives. It is expected to be the mainstay energy source for years to come because it is affordable, accessible, and convenient to use compared to other forms of energy (i.e. electricity and petroleum gas). However, the current model of charcoal production, based on indiscriminate felling of trees, poses a danger to the environment as it results in widespread forest degradation and deforestation. Therefore, any successful …

Dental And Mandibular Anomalies In White-Tailed Deer (Odocoileus Virginianus) From Central Georgia, Patrick M. Powers, Alfred J. Mead

Georgia Journal of Science

The frequency of dental and mandibular anomalies in free-ranging white-tailed deer in the southeastern United States is not well documented. Characteristic irregularities include supernumerary and missing teeth, malocclusion, root abscesses due to bacterial infections, and tooth or bone damage due to trauma. In the present study, we examined 778 white-tailed deer dentaries collected from the Piedmont National Wildlife Refuge in central Georgia. All dentaries were inspected for lesions, tooth irregularities, developmental anomalies, and other pathologies. Thirty-two dentaries (4.1%) displayed signs of dental or bone abnormalities. More abnormalities were associated with infection or injury (22/778, 2.8%) compared to unusual tooth development …

The Ticker, October 7, 2019

The Ticker

The Ticker is the student newspaper of Baruch College. It has been published continuously since 1932, when the Baruch College campus was the School of Business and Civic Administration of the City College of New York.

Faculty Senate Monthly Packet October 2019, Portland State University Faculty Senate

Faculty Senate Monthly Packets

The October 2019 Monthly packet includes the October agenda and appendices and the Faculty Senate minutes and attachments from the meeting held June 3, 2019.

Stimulation Of Piezo1 By Mechanical Signals Promotes Bone Anabolism, Xuehua Li, Li Han, Intawat Nookaew, Erin Mannen, Matthew J. Silva, Maria Almeida, Jinhu Xiong

Open Access Publications

Mechanical loading, such as caused by exercise, stimulates bone formation by osteoblasts and increases bone strength, but the mechanisms are poorly understood. Osteocytes reside in bone matrix, sense changes in mechanical load, and produce signals that alter bone formation by osteoblasts. We report that the ion channel Piezo1 is required for changes in gene expression induced by fluid shear stress in cultured osteocytes and stimulation of Piezo1 by a small molecule agonist is sufficient to replicate the effects of fluid flow on osteocytes. Conditional deletion of

Association Of Urine Levels Of C-Reactive Protein With Clinical Outcomes In Patients With Pneumonia: A Pilot Study, Subathra Marimuthu, Vidyulata Salunkhe, Stephen P. Furmanek, Leslie A Wolf

The University of Louisville Journal of Respiratory Infections

Finding relevant biomarkers as a potential predictor of severity for patients hospitalized with community acquired pneumonia (CAP), in addition to the clinical scoring system, could advance progress towards more effective patient management. The inflammatory marker, C-reactive protein (CRP), which is elevated in the pathogenesis of many infectious diseases, may be a key biomarker target for CAP. Previous studies have shown that serum CRP may be a useful diagnostic marker for pneumonia in hospitalized patients with acute respiratory symptoms. The main aims of this study were to determine the correlation between serum and urine CRP levels in hospitalized patients with CAP, …

Rotunda - Vol 98, No. 6 - Oct 7, 2019, Longwood University

Rotunda

No abstract provided.

Week Of October 7, 2019 - October 11, 2019, Benjamin N. Cardozo School Of Law

Today at Cardozo 2019

Events occurring this week have been sponsored by:

• Black Law Students Association (BLSA)
• Cardozo Entertainment Law Society
• Cardozo Environmental Law Society (CELS)
• Cardozo FAME Center
• Cardozo Fashion Law Society
• Cardozo Journal of Equal Rights and Social Justice
• Cardozo Law Student Bar Association
• Cardozo National Lawyers Guild (NLG)
• Cardozo Office of Student Services & Advising
• Cardozo OUTLaw
• Cardozo Sports Law Society (CSLS)
• Cardozo Student Animal Legal Defense Fund (SALDF)
• Cardozo Women's Law Initiative (WLI)
• Heyman Center on Corporate Law and Governance
• Innocence Project
• Intellectual Property Law Society (IPLS)
• Jewish Law Students Association (JLSA)
• Latin American Law Student Association (LALSA)
• Reed Justice …

Ancient Maya Wetland Fields Revealed Under Tropical Forest Canopy From Laser Scanning And Multiproxy Evidence, Timothy Beach, Sheryl Luzzadder-Beach, Samantha Krause, Tom Guderjan, Fred Valdez Jr., Juan Carlos Fernandez-Diaz, Sara Eshleman, Colin Doyle

Anthropology Faculty Publications and Presentations

We report on a large area of ancient Maya wetland field systems in Belize, Central America, based on airborne lidar survey coupled with multiple proxies and radiocarbon dates that reveal ancient field uses and chronology. The lidar survey indicated four main areas of wetland complexes, including the Birds of Paradise wetland field complex that is five times larger than earlier remote and ground survey had indicated, and revealed a previously unknown wetland field complex that is even larger. The field systems date mainly to the Maya Late and Terminal Classic (∼1,400–1,000 y ago), but with evidence from as early as …

The Daily Gamecock, Monday, October 7, 2019, University Of South Carolina, Office Of Student Media

October

No abstract provided.

The Guardian, Week Of October 7, 2019, Wright State Student Body

The Guardian Student Newspaper

News articles from The Guardian for the week of October 7, 2019. The Guardian is the official student-run newspaper for Wright State University. It has been published regularly since March of 1965.

Gut Microbiome Diversity Is Associated With Sleep Physiology In Humans, Robert Smith, Cole Easson, Sarah M. Lyle, Ritishka Kapoor, Chase P. Donnelly, Eileen Davidson, Esha Parikh, Jose Lopez, Jaime L. Tartar

Biology Faculty Articles

The human gut microbiome can influence health through the brain-gut-microbiome axis. Growing evidence suggests that the gut microbiome can influence sleep quality. Previous studies that have examined sleep deprivation and the human gut microbiome have yielded conflicting results. A recent study found that sleep deprivation leads to changes in gut microbiome composition while a different study found that sleep deprivation does not lead to changes in gut microbiome. Accordingly, the relationship between sleep physiology and the gut microbiome remains unclear. To address this uncertainty, we used actigraphy to quantify sleep measures coupled with gut microbiome sampling to determine how the …

Ohio University Faculty Senate Minutes October 7, 2019, Ohio University Faculty Senate

Faculty Senate Minutes

No abstract provided.

Improving Neonatal Outcomes: Multidisciplinary Treatment Approach To Caring For Pregnant Persons With Opioid Use Disorder, Nancy S. Goldstein, Erica Nichole Ramirez, Lauren Elizabeth Greenwood, Kodiak Ray Sung Soled, Laura Stinnette Lucas

Biennial Convention (CONV)

A trauma-informed, multidisciplinary team (MDT) approach has shown improved outcomes for childbearing individuals with opioid use disorder (OUD) and their neonates. Opioid agonist treatment (OAT) remains the first-line treatment option. Evidence-based practice should guide practitioners to utilize a variety of interventions, particularly during this vulnerable and medically resource intensive time.

Ilc3s Integrate Glycolysis And Mitochondrial Production Of Reactive Oxygen Species To Fulfill Activation Demands, Blanda Di Luccia, Susan Gilfillan, Marina Cella, Marco Colonna, Stanley Ching-Cheng Huang

Open Access Publications

Group 3 innate lymphoid cells (ILC3s) are the innate counterparts of Th17 that require the transcription factor RORγt for development and contribute to the defense against pathogens through IL-22 and IL-17 secretion. Proliferation and effector functions of Th17 require a specific mTOR-dependent metabolic program that utilizes high-rate glycolysis, while mitochondrial lipid oxidation and production of reactive oxygen species (mROS) support alternative T reg cell differentiation. Whether ILC3s employ a specific metabolic program is not known. Here, we find that ILC3s rely on mTOR complex 1 (mTORC1) for proliferation and production of IL-22 and IL-17A after in vitro activation and Citrobacter …

The Influence Of Using Animal Card Media On The Ability Of Mild Mental Retardatin To Write Simple Sentence, Geas Yunianti, Mohammad Efendi, Agung Kurniawan, Sopingi Sopingi

Journal of ICSAR

This study aims to assess influence the using animal car media on the ability of students with mild mental retardation to write the simple sentence. The study use a qualitative method by an experiment one group pretest-postest design. The data were analized by Wilcoxon signed ranks test. The result show that using animal card media have a significant influence to increasec the ability of students with mild mental retardatio to write the simple sentence.

The Influence Of Using Animal Card Media On The Ability Of Mild Mental Retardatin To Write Simple Sentence, Geas Yunianti, Mohammad Efendi, Agung Kurniawan, Sopingi Sopingi

Journal of ICSAR

This study aims to assess influence the using animal car media on the ability of students with mild mental retardation to write the simple sentence. The study use a qualitative method by an experiment one group pretest-postest design. The data were analized by Wilcoxon signed ranks test. The result show that using animal card media have a significant influence to increasec the ability of students with mild mental retardatio to write the simple sentence.