Digital Commons Network^™

Broadening Footpaths: Trail Ecology And Ethic, Miles H. Frank

Student Theses 2015-Present

There is not always a clear distinction between what constitutes responsible use and what constitutes overuse with regard to recreation and the environment. Even on a small scale, outdoor recreation will always leave a footprint. This paper addresses the ecological impact that the growth of outdoor recreation has had on the environment. Using a multi-disciplinary approach, it provides a holistic analysis of the issue from the scale of local vegetation to that of national policy and wilderness philosophy. Chapter one focuses on the immediate impacts of the overuse of hiking trails and the subsequent environmental degradation of at-risk areas. It …

Breaking Ground On New Agricultural Models: Industrial Agriculture And The Local Food Movement, Elizabeth Nealon

Student Theses 2015-Present

This paper discusses and examines the longstanding issues surrounding industrial food production as it currently exists and the various ways that purpose-driven enterprises and environmentally-conscious consumers in the United States have been able to steer food production in a more sustainable direction. Over the course of the technological revolution, people living in metropolitan areas have become so distanced from farms and the processes of food production that many are ignorant of the realities of the food industry. Chapter 1 addresses these issues by presenting quantitative data that lays out a timeline of the evolution of the food and agriculture industry …

The Effects Of Replacement Of Fish Meal Protein With A Mixture Of Poultry By-Product Meal, Fish Silage And Fish Protein Hydrolysate On The Growth Performances Of Asian Sea Bass (Lates Calcarifer), Yu-Cong Hong, Angela Chien, Shyn-Shin Sheen

Journal of Marine Science and Technology–Taiwan

This feeding trial was conducted to investigate the effects of replacement of dietary fishmeal (FM) with a mixture of poultry by-product meal (PBM), fish silage (FS) and fish protein hydrolysate (FPH) on the growth performances of the Asian sea bass Lates calcarifer. Five isonitrogenous (46% crude protein) and isolipidic (12% crude lipid) diets were formulated to replace 0 (CON), 25 (FM 25), 50 (FM 50), 75 (FM 75) and 100% (FM 100) of fishmeal protein with the protein mixture (78% PBM, 11% FS, and 11% FPH). One additional diet, namely POM was designed to completely replace FM protein with PBM. …

Design And Development Of A Perfusion Bioreactor With Internal Volume Expansion And Cell Retention For Cell And Gene Therapy Manufacturing, Corinna Doris

KGI Theses and Dissertations

Economically producing patient-specific cell therapies at commercial levels remains a challenge as it requires manufacturing separate batches per patient where the production system must be scaled-out rather than scaled-up to supply more patient doses. The resulting high production cost and consequent price-point can limit patient access. Specifically, the current cell expansion processes are highly manual and laborious, with the number and complexity of operations and components increasing the opportunities for failure and contamination. This work therefore aims to design a mechanically simple bioreactor that is better suited for scale-out by consolidating the cell expansion process to fewer components, vessels, and …

Audience Engagement With The Marvel Studios’ Film Black Panther: Analyzing Fan Reactions Posted On An Online Forum, Jatin Vichare

Theses

This project examines audience response to the Black Panther movie by analyzing fan forums on SuperHeroHype website using a textual analysis approach. Grounded in film adaptation theory, (N = 200) comments posted by users were analyzed to identify fan reception of pre-release publicity of the film and post-release reactions. The results show that before the release of the movie, fans were excited about the adaptation of a comic book to a film. The analysis identified six themes in the comments posted on the website. Pre-release comments focused on a) casting, b) narrative arc, and c) music and locations. Post-release comments …

The Modular Approach To The Title Sequence, Nathan Sorrentino

Theses

Over the course of the past few decades, the role of opening title sequences has evolved from a simple objective to deliver top priority credits in the beginning of a film or show with basic to intermediate level branded graphics, to become a strong standing work of art within the feature itself. The old way of simply delivering a title has become something "anyone can do" on their home laptop computer with a consumer level NLE software. Today, it takes a high quality, intricately designed sequence to effectively hook and ensure the audience of the professional level of the film …

Mission As Virtuous Practice: A Theology Of Mission Through The Lens Of Virtue Ethics, Michael Niebauer

Electronic Theses and Dissertations

This work uses theological virtue ethics as a guide both for critiquing various models of Christian mission and for constructing a model of mission that adequately addresses these criticisms. The first section of the dissertation (chapters one, two, and three) is devoted to an assessment of three major models of mission, which I have labeled mission as the missio Dei, mission as growth, and mission as dialogue. This assessment generates three recurring issues within the field of missiology that have remained largely unresolved: the problems of distinction, agency, and persuasion. The second half of the dissertation (chapters four, five, …

A Theological Appraisal Of Marriage In Tiv Culture, Emmanuel Ahua

Electronic Theses and Dissertations

Marriage is humanity’s essential characteristic. It is the essential union between male and female geared towards raising and sustaining rational family life in society. This is what makes people human and differentiate them from other animals. Marriage is a natural institution and a socio-cultural reality in which each group of people should determine, according to their own context. In other words, every institution, society, and culture have a right to choose what type of marriage arrangement that best explains and works for it.

Nevertheless, the Western European understanding of marriage, as adopted by the Catholic Church’s Magisterium in her teaching, …

A Darker Side Of Venus: An Empirical-Phenomenological Study Of Women's Negative Experiences Encountering Pornographic Imagery, Rebecca Gimeno

Electronic Theses and Dissertations

This empirical-phenomenological study explores the psychological dimensions of negatively encountering a pornographic image. The study includes four participants, all adult women who have had an adverse encounter with a pornographic image within the past five years at the time of the data collection. The recollected experiences of the participants were collected through written narratives as well as semi-structured interviews.

The written narratives and recorded audio interviews were transcribed and subsequently analyzed using an empirical-phenomenological analysis, a process that yielded situated structures. From this analysis, thematic elements of each structure were brought to light. Some of the thematic elements that were …

"Frontline In Mental Healthcare": A Discourse Analytic Clinical Ethnography Of Crisis Intervention Team Trainings For Corrections, Daniel Gruner

Electronic Theses and Dissertations

Throughout the criminal justice system operates a discourse of corrections-reform. This responds to prisoner trauma and resistance by converting them into reforms that strengthen prisons and the larger carceral system while discounting issues of race and class that might undermine institutional legitimacy. The recent adoption of Crisis Intervention Team (CIT) Trainings in corrections is exemplary of corrections-reform discourse. ‘Crisis’ comes from the Greek krinein, meaning ‘to decide.’ The crisis in mental health in prisons involves deciding when to implement what “services” or “programming” for whom.

In this discourse analytic clinical ethnographic study, I focus on the trans-disciplinary corrections …

Bureaucratic Modernity And The Erosion Of Practical Reason: A Rhetorical Education As An Antidote, David Impellizzeri

Electronic Theses and Dissertations

To what extent and in what ways does modernity reveal itself through the bureaucratic? This project aims at an interpretive understanding of bureaucratic modernity. The rationalization of society and action in the (late) modern world requires that an increasing number of human activities and domains be explained in allegedly neutral, ‘rational’ terms and without reference to morally substantive ends. Ultimately, this entails a form of epistemic reductionism that elevates instrumental rationality to the exclusion of practical reason and probabilistic ways of knowing. Bureaucratic modernity signifies a decrease in choices that can be legitimized in public on some basis other …

Charismatic Renewal And Pentecostalism: The Renewal Of The Nigerian Catholic Church, Isidore Nkwocha

Electronic Theses and Dissertations

This project is using Charismatic and Pentecostal theology and praxes to argue for the renewal of the Nigerian Catholic church. It avers that the praxis-oriented and experiential theology of the Charismatics and Pentecostals, which characterize them as Spirit-filled groups and churches are enabling the Nigerian Catholic church to realize the potentials of a Spirit-driven church through the renewal of her pneumatological, ecclesiological, and liturgical doctrines and practices

Nanomedicine-Driven Neuropathic Pain Relief In Rat Model Is Associated With Macrophage Polarity And Mast Cell Activation, Muzamil Saleem

Electronic Theses and Dissertations

We explored the immune neuropathology underlying multi-day relief from neuropathic pain in a rat model initiated at the sciatic nerve by using a nanoemulsion-based nanomedicine as a biological probe. The nanomedicine is theranostic: both therapeutic (containing celecoxib drug) and diagnostic (containing near-infrared fluorescent (NIRF) dye) and is small enough to be phagocytosed by circulating monocytes. A model of neuropathic pain is initiated by tying four 1mm spaced knots around the sciatic nerve with chromic gut suture, which results in neuroinflammation, and a resultant pain-like behavior manifests. We show that pain-like behavior reaches a plateau of maximum hypersensitivity 8 days post-surgery, …

Characterization Of The Effect Of Exercise Dose And Integrative Nonpharmacological Therapies In The Treatment Of Chronic Pain, Anna M. Polaski

Electronic Theses and Dissertations

Chronic pain includes debilitating conditions affecting large populations of people throughout the world. These diseases are further complicated by comorbid psychological disorders which make chronic pain conditions difficult to treat. Nonpharmacological treatment options have more recently become an important mainstay of effective therapies and are currently being used to supplement or replace traditional pharmacological treatment methods. Exercise-based therapies in particular are of interest due to their demonstrated success in reducing pain symptoms as well as improving psychological outcomes. Dose is an important factor in being able to effectively prescribe treatments in the context of specific exercise interventions and specific pain …

Natural Law, The Object Of The Act, And Double Effect: Moral Methodology For Catholic Health Care Ethics, Travis Stephens

Electronic Theses and Dissertations

Pope John Paul II’s Encyclical Veritatis Splendor is the first and only magisterial document that systematically articulates a moral methodology for Catholic moral theology. This dissertation makes explicit the methodological connection between Vatican teaching and the United States Bishops’ Ethical and Religious Directives for Catholic Health Care Services. The thesis of the dissertation explains the systematic connection between Natural Law, the Moral Object of the Act, and the Principle of Double Effect and by extension the ethical Principle of Cooperation. Second, the thesis applies this complex moral method of official teaching to health care ethics.

Following the introduction, chapter …

Females In Stem: Self-Efficacy Within Women Who Pursue Stem Majors, Lori Grata

Electronic Theses and Dissertations

While many efforts have been made within the United States, women are still underrepresented within STEM. Research within this document shows that women and men score similarly on STEM-related standardized tests. The question remains, why are there still large quantities of men outnumbering women in college majors and career fields of STEM? Looking at female STEM self-efficacy and gender role in culture could provide insight to the problem at hand. A survey was given to investigate self-efficacy and students’ STEM backgrounds of undergraduate female students who are currently in a 4-year STEM-related major within one university.

The Art Of Subtitling: A Case Study Of A Chinese Online Fansub Group, Xianwei Wu

Theses - ALL

Online fan subtitling (hereafter fansub) groups are a recent phenomenon that have quickly gained global popularity. They are groups of volunteers who produce and distribute subtitles of English televisions shows and films for free. However, to date not much academic attention has been paid to this phenomenon in a critical capacity, with the exception of anime fansubbing. This study closely examines one fansub group in China using a single-case design case study. The methods of data collection include: in-depth interviews with the translators; participant observation as a subtitle translator; and textual/discourse analysis of the subtitles. This study will use the …

Knowing Leaders: Centering Gender And Identity Among Women Leaders In Higher Education, Meredith Harper Bonham

Dissertations - ALL

This dissertation centered the experiences of women academic leaders – their backgrounds, educational experiences and leadership styles – to illuminate the intersection of identity and leadership. Using narrative inquiry as a methodological framework (Clandinin & Connelly, 2000; Creswell, 2013), the researcher conducted a qualitative study by interviewing seventeen women presidents and chief academic officers in a semi-structured format. In exploring and analyzing the stories of women leaders, the researcher avoided unidimensional characterizations and binary comparisons with male leaders. To incorporate the interlocking components of identity, the researcher considered the impact of race, class, gender, and first-generation status, as well as …

Homeostatic Elastic States And The Stability Of Elastic Arteries, Xinyu Zhang

Dissertations - ALL

Vascular mechanics has undergone significant growth within the last 50 years owing to the rapid development of nonlinear continuum mechanics occurring roughly within the same period and motivated primarily by rubber materials. However, one important distinction of blood vessels, in contrast to typical engineering materials is that, through a variety of physiological mechanisms, they seek to maintain constant a preferred mechanical state (mechanical homeostasis) thereby exhibiting a remarkable mechanical stability in response to temporal evolution and alterations in blood pressure, vessel tethering forces and geometry and material properties. The mechanical state experienced by blood vessels plays a critical role in …

Designing The City, Sustainably: Sustainability And Climate Change Resiliency In New York City, Cosima Balletti-Thomas

Student Theses 2015-Present

Abstract

This paper explores how New York City and especially Manhattan has integrated sustainability into its agenda as a coastal metropolitan nucleus. Secondly, it assesses the New York City’s resiliency strategies that utilize environmental policy and design to confront its vulnerability to changes in the environment on account of global climate change, which has primarily manifested in the Northeastern region in the form of sea level rise, storm surge, and frequent flooding. Chapter 1 uses quantitative climate data from a multitude of sources such as the New York State Department of Environmental Conservation'sreport on the “Impacts of Climate Change …

Preparing For Climate Change In New York City - Geographic Information Systems As A Valuable Tool For Natural Hazard Management, Amy Carrillo

Student Theses 2015-Present

This paper addresses the impact of climate change in New York City. Chapter 1 focuses on details found in the United Nations Intergovernmental Panel on Climate Change Report on the impact of climate change worldwide. At the city level, this paper analyzes New York City’s Risk Landscape: A Guide to Hazard Mitigation and New York City Panel on Climate Change 2019 Report, which provides data on how climate change will impact NYC, specifically. Chapter 2 explores the history of Geographic Information Systems (GIS) and its use in mitigation and conservation practices over time. Chapter 3 studies how GIS has been …

Delivery Of Small Molecule And Rna Using Synthetic Polymeric Micelles And Multifunctional Exosomes For The Treatment Of Type 1 Diabetes, Yang Peng

Theses & Dissertations

Type 1 diabetes is one of the most challenging chronic autoimmune diseases. The destruction and dysfunction of insulin-secreting β cells are the results of inflammatory infiltration and the synergistic effect of multiple immune cells. The aim of this dissertation is to develop novel and reliable therapeutic approaches to advance the treatment of T1D: including chemical modification of a broad-spectrum immunosuppressant, co-application of small molecule based immune intervention and siRNA based β cell preservative therapy, and administration of a PI3K-δ/γ dual inhibitor to specifically target immune cells, utilizing synthetic polymeric micelles or natural produced multi-functional exosomes derived from human bone marrow …

Synthesis And Characterization Of Long Acting Darunavir Prodrugs, Mary Banoub

Theses & Dissertations

Patient adherence is critical for ART success to ensure adequate viral suppression, therefore, long-acting antiretrovirals are soon replacing current daily regimens. In recent years, two drugs were successfully transformed into long-acting injectables; CAB LA and RPV LA. These long-acting nanoformulations made it possible to abandon the daily pill burden, instead approximately a bimonthly injection of both drugs is enough to suppress and maintain viral load suppression. Our laboratory has been instrumental in transforming FDA-approved and experimental-HIV medications into long-acting slow effective release drugs, also known as LASER ART. LASER ART consists of slow drug metabolism and high permeability and retention …

The Role Of Histone Chaperone Fact Complex In Base Excision Repair Pathway And Its Therapeutic Potential In Colon Cancer And Medulloblastoma, Heyu Song

Theses & Dissertations

Base excision repair (BER) pathway is required for the removal of damaged bases caused by alkylation, oxidation and ring-saturation. Human apurinic/apyrimidinic endonuclease 1 (APE1) plays a central role in BER pathway. Although repair of damaged bases by recombinant APE1 has been well investigated in vitro, how APE1 gains access to damaged bases in the context of chromatin is largely unknown. A prominent member of the histone chaperone family, FACT (Facilitates Chromatin Transcription) is thought to reorganize nucleosomes through the destabilization of multiple intra-nucleosome contacts. FACT complex is composed of two polypeptides identified as SPT16 (Suppressor of Ty 16) and SSRP1 …

Enhancing The Identification Of Rheumatoid Arthritis-Associated Lung Disease, Bryant England

Theses & Dissertations

Rheumatoid arthritis (RA) is a systemic autoimmune disease that predisposes afflicted individuals to reduced quality of life, physical disability, and premature mortality. While joint involvement is the primary manifestation of RA, extra-articular features including lung disease are responsible for a significant portion of the excess mortality. In this dissertation I demonstrate the contribution of chronic lung diseases to premature mortality in RA, contrasting with the more widely recognized comorbidity in RA of cardiovascular disease. Then, I establish that a novel serum biomarker, anti-malondialdehyde-acetaldehyde adduct (MAA) antibody, is associated with the presence of interstitial lung disease (ILD) in RA subjects. Further …

Theranostics For Antiretroviral Biodistribution And Pharmacokinetics, Brendan M. Ottemann

Theses & Dissertations

RATIONALE: Our laboratories birthed the field of human immunodeficiency virus (HIV) theranostics. The new field allows simultaneous detection (diagnostics) and treatment (therapeutic) for the identification, treatment and inevitable elimination of virus in cell and tissue compartments. By employing theranostics, antiretroviral drugs (ARVs) can be tracked in lymph nodes, gut, spleen and liver. Cellular viral reservoirs including CD4+ T cell populations and mononuclear phagocytes (MP; monocytes, macrophages, microglia and dendritic cells) along with subcellular endosomal structures can now be targeted for drug delivery bringing therapeutics to areas where virus replicates. The overarching idea rests in improving precision targeted ARV delivery. …

Role Of Astrocyte-Derived Extracellular Vesicles In Neuroinflammation Mediated By Drug Abuse, Ke Liao

Theses & Dissertations

Neuronal damage and neuroinflammation is a hallmark feature of HIV-associated neurological disorders (HANDs). Opioids abuse accelerates the incidence and progression of HAND; however, the mechanisms underlying the potentiation of neuropathogenesis by these drugs remain elusive. Extracellular vesicles (EVs) are essential conduits in HIV and drug abuse-mediated synaptodendritic injury and neuroinflammation. Findings from our group have demonstrated that astrocyte-derived EV (ADEV)-miRNA-29b mediates HIV Tat and morphine-induced neuronal injury, thus underscoring the importance of such interactions in NeuroHIV.

Besides, HIV Tat and morphine-mediated synaptodendritic injury via ADEVs, we are also interested in whether ADEVs contributes to neuroinflammation. Microglia are critical players in …

Identification Of More Potent And Efficacious Analogs Of The Novel Host-Derived Immunostimulant Ep67, Abdul Alshammari

Theses & Dissertations

EP67 is a human C5a-derived decapeptide agonist of C5a Receptor 1 (C5aR1/CD88) that selectively activates mononuclear phagocytes over neutrophils to stimulate protective innate and adaptive immune responses while potentially minimizing neutrophil-mediated toxicity. Two N-alkyl amino acids Pro⁷ and N-methyl-Leu⁸ (nme-Leu⁸) within EP67 induce structural changes that increase potency and selective activation of mononuclear phagocytes over neutrophils. Cis/trans isomerization at these positions, however, likely limits the activity of EP67 and low coupling efficiency between Pro⁷ and nme-Leu⁸ increases scale-up costs for clinical use. Thus, the goals of this study were to …

Roles Of Autism Gene Arid1b In Murine Brain Development And Behavior, Amanda L. Smith

Theses & Dissertations

Autism spectrum disorder (ASD) and intellectual disability (ID) are highly prevalent neurodevelopmental disorders characterized by social and communication deficits, stereotyped behaviors, cognitive dysfunction, and deficits in adaptive behaviors. The pathogenesis underlying these disorders remains unknown, and thus no pharmacologic or genetic therapies are currently available. Recent progress in the field has shown that haploinsufficiency of the AT-rich interactive domain-containing 1B (ARID1B) gene is a genetic cause of ASD and ID. Our lab recently developed an Arid1b knockout mouse model to better study its role in the pathogenesis of these disorders. One theory regarding the cause of neurodevelopmental disorders …

Evaluating The Use Of Competing Items In A Multiple Schedule During Reinforcement Schedule Thinning, Scott A. Miller

Theses & Dissertations

Multiple schedules are schedules of reinforcement that are often used to facilitate more manageable rates of a replacement behavior such as a communication response following functional communication training as an intervention for destructive behavior. Commonly, reinforcement schedule thinning involves multiple fading steps that can take more than 100 sessions to achieve therapeutic goals. The purpose of this experiment was to evaluate a method for rapidly achieving fading steps in a multiple schedule by including competing items during the extinction interval. Four children diagnosed with autism successfully reached the terminal extinction interval with a ≥80% reduction in problem behavior. Two of …