Digital Commons Network^™

Virtual Experiments And Simulations In The Science Classroom, Nicole Merchant

Williams Honors College, Honors Research Projects

The main goal of this paper is to analyze the use of virtual experiments and simulations within the science classroom. This analysis will be completed by first reviewing the learning theories in education. Then I will specifically analyze virtual experiments and how they are used in the science classroom. At the time of this study I had the privilege of completing my student teaching experience in a high school science classroom. This gave me the ability to have direct contact with students in order to observe their interest and engagement with simulations as well as their learning throughout the semester. …

Antitumor Properties Of Imidazolium Salts, Jenna Frantz

Williams Honors College, Honors Research Projects

This is the final write-up for an honors research project for the University of Akron Williams Honors College. Synthesis of novel imidazolium salts was conducted. Following synthesis of imidazolium salts, the stability of the compound was tested at 37°C over a 72-hour period to give preliminary information about drug stability in vivo. 2D NMR was also conducted to confirm the structure of TPP-1. The student wrote an experimental protocol for the use of C57BL/6 mice and performed the online CITI training by the IRB to prepare to work with animals in a study of the antitumor properties of imidazolium salts …

M1 Melanopsin Ganglion Cells In The ​Mus Musculus​ Retina Are Similar In Shape And Size, Geoffrey K. Sarpong

Williams Honors College, Honors Research Projects

An M1 melanopsin retinal ganglion cell (mRGC) is a subtype of the five melanopsin ganglion cells. The M1-type mRGC is distributed on the dorsal retina of a mouse and has an extensively overlapping dendritic network in both the sublamina a (OFF) and sublamina b (ON) layers of the inner plexiform layer. In the dorsal retina, the M1-type mRGCs are distinct and asymmetric.

The aim of this study was to examine the morphological similarity (shape and size) of M1-type mRGCs. The study traced 20 neurons in the first four months of a glaucoma retina of a DBA mouse, made measurements of …

Bad World: The Negativity Bias In International Politics, D. D. P. Johnson, Dominic Tierney

Political Science Faculty Works

A major puzzle in international relations is why states privilege negative over positive information. States tend to inflate threats, exhibit loss aversion, and learn more from failures than from successes. Rationalist accounts fail to explain this phenomenon, because systematically overweighting bad over good may in fact undermine state interests. New research in psychology, however, offers an explanation. The “negativity bias” has emerged as a fundamental principle of the human mind, in which people's response to positive and negative information is asymmetric. Negative factors have greater effects than positive factors across a wide range of psychological phenomena, including cognition, motivation, emotion, …

The Cemetery Of Traitors, Osman Balkan

Political Science Faculty Works

No abstract provided.

Pwatem: An Anthology Of Literature And Art (2019)

Pwatem (Poictesme), 2006-

Pwatem is an anthology of literature and art from undergraduate students at Virginia Commonwealth University. Pwatem publishes poetry, prose and art of all kinds from talented undergraduate students of all majors.

Cripping Modernism: An Introduction, Maren Linett

Department of English Faculty Publications

This introduction briefly introduces literary disability studies and crip methodology. After informing readers about a few key concepts of disability studies and giving some examples of modernist writers’ use of disability metaphors, it raises questions about how disability inflects modernist themes and modernist form. It then offers synopses of the nine articles in the special issue, articles that treat a range of authors from the early to mid-twentieth century. The essays engage with literary theory, various early twentieth-century historical contexts, and issues of race, imperialism, gender, sexuality, and class.

Applying Empathy-Driven Participatory Research Methods To Higher Education New Degree Development, Lisa Bosman, Abrar Hammoud, Sandhya Arumugam

Technology Leadership and Innovation Faculty Publications

Purpose: Innovation and entrepreneurship are economic drivers promoting competition and growth among organizations throughout the world, many of which would not exist without well-established new product development processes coupled with intentional and strategic focus on research and development. New product development processes, such as the lean start-up methodology and design thinking, are well-known and thriving as a result of empirically-grounded research efforts. Unfortunately, educational institutions and educational researchers, alike, are lagging when it comes to new program/degree development processes. Although the quantity of new degree offerings has increased substantially over the past several decades (in particular for multidisciplinary, interdisciplinary, and …

The Compass, Summer 2019

The Compass, 2018-

The Compass is an annual orientation guide for VCU students produced by the Student Media Collective in the VCU Student Media Centered. The guide is distributed physically during summer orientation sessions for new and transfer students. The publication includes short articles, illustrations, letters of welcome from students and administrators, comics, and advertisements from VCU and Richmond organizations.

2018 Great Lakes Science Boot Camp Schedule And Assessment Survey, Bethany S. Mcgowan

Libraries Faculty and Staff Creative Materials

The 2018 Great Lakes Science Boot Camp for Librarians was hosted at Purdue University from July 24-27, 2018. The Great Lakes Science Boot Camp is an annual, regional professional development opportunity that exposes STEM librarians to trends in scientific research. These files include a copy of the schedule of events for the 2018 GLSBC, as well as a copy of the survey assessment distributed to participants.

Potential Reductions In Greenhouse Gas And Fine Particulate Matter Emissions Using Corn Stover For Ethanol Production In China, Yang Yang, Ji-Qin Ni, Weiqing Bao, Lei Zhao, Guang Hui Xie

School of Agricultural & Biological Engineering Faculty Publications

Corn stover is an abundant raw material that can be used to produce ethanol and reduce air pollution. This paper studied the potential reductions in greenhouse gas (GHG) and fine particulate matter (PM_2.5) emissions across China if corn stover was used for ethanol production. Field surveys in nine provincial regions were conducted. Life-cycle assessment (LCA) was used to assess the GHG and PM_2.5 emissions from a corn stover based ethanol system. The LCA system boundaries included several process stages from corn planting to ethanol fuel used in vehicles. Corn stover geographical distributions and emission reduction factors were …

Life Cycle Assessment Of Large-Scale Compressed Bio-Natural Gas Production In China: A Case Study On Manure Co-Digestion With Corn Stover, Yang Yang, Ji-Qin Ni, Wanbin Zhu, Guanghui Xie

School of Agricultural & Biological Engineering Faculty Publications

Compressed bio-natural gas (CBG) production from large-scale systems has been recognized as promising because of the abundance of manure and crop residue feedstocks and its environmental friendliness. This study is a life cycle assessment using the local database of an operating large-scale CBG system of manure co-digestion with corn stover in China and eBalance software. The results showed that the system’s Primary Energy Input to Output (PEIO) ratio was 20%. Its anaerobic digestion process was the main contributor to energy consumption, accounting for 76%. Among the six environmental impacts investigated in this study, the global warming potential (GWP) was the …

Feature Acquisition In Second Language Phonetic Development: Evidence From Phonetic Training, Daniel J. Olson

School of Languages and Cultures Faculty Publications

This study employed a targeted phonetic instruction to explore the mechanisms that underpin second language (L2) phonetic acquisition. Broadly, two general approaches to phonetic acquisition have been previously proposed. A segmental approach suggests that learners acquire a series of individual, discrete phonemes (e.g., Flege, 1995), while a featural approach posits that L2 phonetic development occurs at the subsegmental level of the feature, which may be shared across multiple phonemes (e.g., de Jong, Hao, & Park, 2009). This study extended this line of research, using a visual feedback paradigm to train English speakers on one of the three voiceless stop consonants …

An Ecological Survey Of Forest Succession In A Northeast Ohio Ecosystem Following An Emerald Ash Borer Infestation, Joseph Haas

Williams Honors College, Honors Research Projects

This paper will be an ecological survey of a selected 28 acre piece of land in northeast Ohio impacted by the Emerald Ash Borer. This invasive species arrived in North America in 2002 and has since spread throughout the country wreaking havoc on the ash tree population. The purpose of this study is to determine what tree species are replacing the native ash trees in the succession of the forest. In order to achieve this goal, a section of the selected land will be blocked off and subdivided into manageable sections to facilitate data collection, namely the location of the …

Strategies To Enhance The Anti-Leukemic Activity Of Venetoclax (Abt-199) In Aml Through Targeting Of Mcl-1, Daniel Luedtke

Wayne State University Dissertations

Acute Myeloid Leukemia (AML) is a frustratingly difficult to treat disease (67% 5 year survival for children and 24% for adults). The standard of care, similar to outcomes, has seen few improvements over the last several decades. The Bcl-2 family, which controls cell survival and apoptosis, is dysregulated in AML. Bcl-2, which is overexpressed in AML and associated with chemoresistance, is a promising therapeutic target. The now FDA approved venetoclax (ABT-199) is a BH3 mimetic that is able to bind to anti-apoptotic Bcl-2 and prevent it from sequestering pro-apoptotic Bim. While overall response rates are promising, our lab and others …

A Rhetoric Of Zaniness: The Case Of Pepe The Frog, Sean Milligan

Wayne State University Dissertations

A Rhetoric of Zaniness: The Case of Pepe the Frog argues that Sianne Ngai’s aesthetic category of zaniness is an essential concept for understanding and studying digital rhetoric in the post-truth era. To illustrate how zaniness has come to define online discourse, the dissertation traces the character of Pepe the Frog through various moments of, what Laurie Gries calls, “rhetorical transformation.” Specifically, the dissertation focuses on his initial appearance in Matt Furie’s Boy’s Club comics and transformation into a meme, his appropriation by the alt-right, and his adoption as propaganda for the Trump presidential campaign.

Design And Practical Implementation Of Harmonic-Transponder Sensors, Nasser Alkhaldi

Wayne State University Dissertations

Harmonic radar is a nonlinear detection technology that transmits and receives

radio-frequency (RF) signals at orthogonal frequencies, so as to suppress the undesired

clutters, echoes and electromagnetic interreferences due to multipath scattering.

Its implementation generally comprises a nonlinear tag (i.e, a harmonic transponder),

which picks the interrogation signal at specific fundamental frequency (f0) and converts

it into a high/sub-harmonic signal (nf0). Such a technology has been successfully

applied to tracking small insects and detection of electrically-small objects in

the rich-scattering environment. Similarly, a harmonic sensor is used to interrogate

electrically-small and passive sensors, of which the magnitude and peak frequency …

Cultivating Transmedia Storytelling: Real World Perceptions Derived From Popular Media, Tabitha Lynn Cassidy

Wayne State University Dissertations

With continued interest in media convergence, transmedia storytelling is as prevalent to communication studies as ever. However, research into the effects of transmedia storytelling remains scarce. Looking at the difference between heavy and light viewers, cultivation theory purports that those who more frequently view violent programming on television are more likely to think the world is a violent place. As of writing, such effects have not yet been extended to transmedia storytelling. This dissertation fills in those gaps in research by examining the cultivation effects of transmedia storytelling usage on participants. First, the main themes or messages of content within …

Development Of More Light Sensitive And Red-Shifted Channelrhodopsin Variants For Optogenetic Vision Restoration, Tushar Harishkumar Ganjawala

Wayne State University Dissertations

Discovery of channelrhodopsin (ChR), a light sensitive protein from green algae, has revolutionized the field of neuroscience research by empowering scientist to control neuron through the light, the technology popularly known as optogenetics. The ChR based optogenetics is one of the promising approaches for treating blindness caused by photoreceptor degenerative diseases such as retinitis pigmentosa (RP) and age-related macular degeneration (AMD). Fundamentally, the approach is about imparting light sensitivity to surviving inner retinal cells by ectopic expression of genetically encoded light sensitive proteins, such as ChR2. Although the concept of optogenetic approach has been proved by using ChR2, a major …

The Use Of Cultural Algorithms To Learn The Impact Of Climate On Local Fishing Behavior In Cerro Azul, Peru, Khalid Kattan

Wayne State University Dissertations

Recently it has been found that the earth’s oceans are warming at a pace that is 40% faster than predicted by a United Nations panel a few years ago. As a result, 2019 has become the warmest year on record for the earth’s oceans. That is because the oceans have acted as a buffer by absorbing 93% of the heat produced by the greenhouse gases [40].

The impact of the oceanic warming has already been felt in terms of the periodic warming of the Pacific Ocean as an effect of the ENSO process. The ENSO process is a cycle of …

Utilizing Immunopet To Measure Tumor Response To Treatment In Breast Cancer, Brooke Mcknight

Wayne State University Dissertations

With a broad spectrum of therapies available for treating breast cancer, the need for personalized medicine tailoring the cure according to phenotype is evident. Such an approach may be fully realized with the development of quantitative imaging technologies for disease detection, staging and diagnosis, without increasing patient burden. Immuno-positron emission tomography (PET) combines the targeted specificity of antibodies with the sensitivity of PET for whole body imaging by targeting molecular features amplified in lesions. ImmunoPET probes targeting different antigens and their utility to measure response to treatment were explored. 89Zr-trastuzumab was employed as a surrogate readout of Src inhibition after …

The Center Of All Beauty: Radical Democracy, Materiality, And The Poetic Subject In Twentieth-Century American Poetry, Marcus Merritt

Wayne State University Dissertations

In The Center of All Beauty, I trace a strain of poetics in twentieth-century American poetry from William Carlos Williams through Frank O’Hara, Alice Notley, and Amiri Baraka. This poetics is founded in a radically democratic conception of the poetic subject and in the use of poetry as a tool for developing critical knowledge about the material conditions within which the poetic subject is constituted. In Spring and All and The Embodiment of Knowledge, Williams articulates a poetics that denies the authority of any grounds upon which any poetic subject would be considered inadequate to poetic speech and outlines a …

Learning From Heterogeneous Data, Lu Wang

Wayne State University Dissertations

Data with both heterogeneity and homogeneity is now ubiquitous due to the development of multitudinous data collection techniques. To encode the data heterogeneity and homogeneity, we focus on unsupervised and supervised learning approaches. In unsupervised learning, to consider both data heterogeneity and homogeneity, we develop three clustering frameworks to maximize the heterogeneity among data sub-groups and homogeneity within each data sub-group for over-dispersed data in three different data types, i.e., alphabetic, network and mixed feature types data. In supervised learning, the traditional approaches, however, either build a global model for a whole group including all sub-groups, which fail to consider …

“I Was Prepared To Stay Here And Die With My Animals”: Pet Owners, Hurricane Harvey, And The Role Of Communication In Disaster Sense-Making, Ashleigh Day

Wayne State University Dissertations

Companion animals (also referred to as “pets”) are omnipresent in society and, increasingly, many companion animals are considered members of the family unit. However, crisis planning, preparedness, and communication efforts are sparse in including pets and their owners/guardians. This study investigates the disaster experience(s) and sense-making process(es) of pet owners (POs) and animal guardians (AGs) that were affected by the 2017 Hurricane Harvey. More specifically, examination pays close attention to the role and function of PO/AG identity and crisis and risk communication in individuals’ sense-making of their disaster experience. Importantly, participant experiences provide the means to examine the larger context …

Self-Defined: A Womanist Exploration Of Michelle Obama, Viola Davis, And Beyonce Knowles, Idrissa Nichelle Snider

Wayne State University Dissertations

Intersectional research that focuses on the experiences and representations of Black women should place emphasis on examining the communication of resistance. This dissertation builds upon the work of Womanist (Walker, 1983) and Black Feminist scholars (Collins, 1991; Harris-Perry, 2011) in order to identify and interrogate the harmful systemic nature of various stereotypes and controlling images of Black women. These controlling images historically include representations such as the Mammie, Sapphire, Jezebel, tragic mulatto, and even newer images like the angry black woman. Through a close reading of Josephine Baker’s “Danse Sauvage" performance, the research points to modern day examples of when …

Stress-Dependent Regulation Of A Major Node Of The Insulin-Like Peptide Network That Modulates Survival, Rashmi Chandra

Wayne State University Dissertations

Chronic stress disrupts insulin signaling, predisposing human populations to diabetes, cardiovascular disease, Alzheimer’s Disease, and other metabolic and neurological disorders, including post-traumatic disorders (PTSD). Thus, efficient recovery from stress optimizes survival. However, stress recovery in humans is difficult to study, but is much easier to dissect in model organisms. The worm genetic model Caenorhabditis elegans can switch between stressed and non-stressed states, and this switch is largely regulated by insulin signaling. Previously, the Alcedo lab proposed that insulin-like peptides (ILPs), which exist as multiple members of a protein family in both C. elegans and humans, implements a combinatorial coding strategy …

Defining The Effect Of Environmental Perturbation On The Male Germline, Molly Estill

Wayne State University Dissertations

Periconceptional environment, according to the Developmental Origins of Health and Disease (DOHaD) theory, influences offspring phenotype, primarily via epigenetic mechanisms. Although the paternal component in humans is poorly understood, both maternal and paternal peri-conceptional environment are now believed to contribute to this phenomenon. Manipulation of the early embryo for treating human infertility, is suspected of contributing to offspring abnormalities through epigenetic mechanisms. To directly address the effects of common assisted reproductive technology procedures on the offspring epigenome, the DNA methylation profiles of newborns conceived naturally, or through the use of intrauterine insemination (IUI), or in vitro fertilization (IVF) using Fresh …

Biochemical, Structural, And Drug Design Studies Of Aspartate Transcarbamoylase From Pseudomonas Aeruginosa And Staphylococcus Aureus, Chandni Patel

Wayne State University Dissertations

Sepsis affects 1.7 million people in the United States every year and nearly 270,000 people die as a result. Sepsis is characterized by systemic inflammation from an infection leading to organ dysfunction and death. Multi-drug resistance in bacteria is increasing globally, and Pseudomonas aeruginosa and Staphylococcus aureus are notorious for their multi-drug resistance and pose a serious need for the development of new antibiotics. The levels of pyrimidines in blood are too low to sustain the growth of bacteria, so they must rely on pyrimidine biosynthesis. Previous studies have shown that a defect in several pyrimidine biosynthetic enzymes resulted in …

Investigation Of The Role For Methyl-Cpg Binding Protein 2 Variant Mbd2_V2 In Cancer Stem Cells And Obesity-Associated Cancers, Emily A. Teslow

Wayne State University Dissertations

Obesity is a risk factor for both TNBC and PCa, and pro-inflammatory features associated with obesity, including upregulated production of ROS, promote CSCs. Previously published work from the Bollig-Fischer laboratory established that TNBC CSCs could be inhibited by neutralizing ROS in culture with H2O2 targeted antioxidants. In this report, antioxidant treatment resulted in the downregulation of mRNA splicing variant MBD2_v2. MBD2_v2 was highly expressed in CSCs versus bulk TNBC cells and supported self-renewal in vitro. As obesity is coupled with increased ROS, we hypothesized that obesity could drive CSCs via MBD2_v2 expression. The work presented in this thesis addressed this …

The Balance Between Prostaglandin E2 Ep3 And Ep4 Receptors Determines Severity Of Cardiac Damage In Myocardial Infarction And An Angiotensin Ii-Induced Model Of Hypertension, Timothy Dean Bryson

Wayne State University Dissertations

According to the center for disease control about 610,000 people die every year in the United States from heart disease, of which, coronary heart disease is the most common form. One major risk factor for heart attack is hypertension, which affects nearly half of all Americans [472, 473]. PGE2 plays an important role in regulating cardiovascular function and mediating inflammation, both of which contribute to the development of hypertension and/or heart disease. Prostaglandin E2 can act as a vasodilator or vasoconstrictor depending on which of its receptor subtypes are activated.

In general, activation of the EP1 and EP3 receptors is …