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The Thalidomide Tragedy And The United States, Kaylee J. Rice

Tenor of Our Times

This paper attempts to give a brief history of the drug Thalidomide, from its initial market success to the discovery of its relationship to infant birth defects, as well as arguing that it was the thalidomide tragedy in Europe that prompted the United States to enforce stricter drug testing laws. It proceeds by explaining the uses and side effects of thalidomide, as well as the sudden outbreak of phocomelia that swept across Europe after the drug became popular. The paper then concentrates on the relatively less severe phocomelia outbreak in the United States, attributing it to the work of Dr. …

A Brain-Computer Interface For Closed-Loop Sensory Stimulation During Motor Training In Patients With Tetraplegia, Sarah Helen Thomas

Theses and Dissertations--Biomedical Engineering

Normal movement execution requires proper coupling of motor and sensory activation. An increasing body of literature supports the idea that incorporation of sensory stimulation into motor rehabilitation practices increases its effectiveness. Paired associative stimulation (PAS) studies, in which afferent and efferent pathways are activated in tandem, have brought attention to the importance of well-timed stimulation rather than non-associative (i.e., open-loop) activation. In patients with tetraplegia resulting from spinal cord injury (SCI), varying degrees of upper limb function may remain and could be harnessed for rehabilitation. Incorporating associative sensory stimulation coupled with self-paced motor training would be a means for supplementing …

Life Is A Wonderful Thing, Urja Patel

Celebrating Writers and Writing in our Communities

No abstract provided.

Raven’S Work In Tlingit Ethno-Geography, Thomas F. Thornton, Douglas Deur, Bert Adams

Faculty, Staff, and Students

No abstract provided.

Voices Across Generations. Volume Two : A Collaboration Between Black Elk Elementary Third Grade, Uno Educational Leadership Graduate Program., University Of Nebraska At Omaha Service Learning Academy, Black Elk Elementary School, Royal Oaks Assisted Living

Voices Across Generations

Dear Reader,

From whom do you seek wisdom? Who do you share your insights with? In activities with multiple generations, new perspectives of information and insight can be shared through conversation and activity. This is exactly what we learned this spring in our 2019 collaborative activity with senior residents, graduate students, and 3rd graders.

In the following pages, you will read advice acrostic and “I Am” poems from the senior residents at Royale Oaks Assisted Living near 50th and Ames Street. You will read “I am” poems from the Black Elk Elementary 3rd grade students, near 180th and Harrison Street. …

Improvement Of Lipids And Reduction Of Oxidative Stress With Octacosanol After Taekwondo Training, Sang-Ho Lee, Steven D. Scott, Elizabeth J. Pekas, Jeong-Gi Lee, Song-Young Park

Health and Kinesiology Faculty Publications

Athletes in combat sports undergo rapid changes in body weight prior to competition in order to gain a size advantage over their opponent. However, these large weight changes with concomitant high-intensity exercise training create poor lipid profiles and high levels of oxidative stress, which can be detrimental to health and sport performance. Therefore, the purpose of this study was to investigate the ability of the nutritional supplement octacosanol to combat the physiological detriments that occur in taekwondo players during rapid weight loss with high-intensity exercise training. Methods: A total of 26 male taekwondo players were randomly divided into 2 groups: …

Good Places For All (Calvin Shorts), Mark D. Bjelland

Calvin Press

This short book invites readers into a deeper understanding of cities and suburbs and the challenges they face. Because places play such an important role in human well-being, loving our neighbors includes caring for and cultivating good places for all. Despite their great prosperity, North American communities are beset with challenges: fiscal crises, concentrated poverty, fragmentation and division, failing schools, unaffordable housing, and lack of community feeling. Good Places combines a biblical framework with an exploration of how cities, neighborhoods, housing markets, and transportation systems work. Readers will find themselves challenged to extend Christian hospitality beyond the walls of their …

“Something More Or Different”: George Macdonald And Victorian Art Photography, Flora Armetta

North Wind: A Journal of George MacDonald Studies

No abstract provided.

The Fear And Fascination Of The New Woman In George Macdonald’S Lilith, Erika Ditzman

North Wind: A Journal of George MacDonald Studies

No abstract provided.

Wearing Teo Hats: A Virtual Reality Experience Of College Life From The Perspective Of First-Genereation College Students Who Are First-Generation Americans, Lorena Kanzki

Renée Crown University Honors Thesis Projects - All

No abstract provided.

Inhibition Of The Akt1-Mtorc1 Axis Alters Venous Remodeling To Improve Arteriovenous Fistula Patency, Arash Fereydooni

Yale Medicine Thesis Digital Library

Arteriovenous fistulae (AVF) are the most common access created for hemodialysis, but up to 60% do not sustain dialysis within a year, suggesting a need to improve AVF maturation and patency. In a mouse AVF model, Akt1 regulates fistula wall thickness and diameter. We hypothesized that inhibition of the Akt1-mTORC1 axis alters venous remodeling to improve AVF patency. Daily intraperitoneal injections of rapamycin reduced AVF wall thickness with no change in diameter. Rapamycin decreased smooth muscle cell (SMC) and macrophage proliferation; rapamycin also reduced both M1 and M2 type macrophages. AVF in mice treated with rapamycin had reduced Akt1 and …

Understanding Caregiver Perceptions Of Attachment With Drug Exposed Foster Children, Sarah Elizabeth Barr

Walden Dissertations and Doctoral Studies

Lacking a healthy attachment to a caregiver and having in-utero methamphetamine exposure have been linked to a variety of cognitive delays, developmental delays, and mental health issues throughout a person's lifespan. It is unknown if there is a relationship between in-utero methamphetamine exposure and the ability to build a healthy attachment to a caregiver. The purpose of this generic qualitative study was to improve understanding of the perceptions of caregivers about attachment efforts for foster children under the age of 3, who have had in-utero methamphetamine exposure. This study was guided by attachment theory. Purposeful sampling was used to select …

Effects Of Canines On Humans' Physiological And Perceived Stress, Beth Marie Bowin

Walden Dissertations and Doctoral Studies

The bond between pet and owner has been shown to decrease stress-related physical, mental, and emotional disorders by lowering blood pressure and heart rate. The purpose of this study was to examine whether a nonpet canine would have the same effect in reducing physical symptoms of stress as a known dog. Human-animal bond theory, Human pressor test. Data were analyzed using repeated measures, analyses of variance, and t tests. Results indicated that interaction with a strange dog lowered heart rate and blood pressure significantly faster in the experimental group than in the control group. The positive social change implications of …

Evaluating U.S. Counterterrorism Policy On Domestic Terrorism Using The Global Terrorism Database, Colleen Michelle Kennedy

Walden Dissertations and Doctoral Studies

The United States has a long history of domestic terrorism, yet U.S. counterterrorism policy has focused almost completely on the threat from international terrorism. The gap in the literature was the absence of an empirical evaluation of U.S. counterterrorism policy on domestic terrorism in general. The purpose of this quantitative study was to describe the impact of 21st century U.S. counterterrorism policy on incidence, lethality, and cost of domestic terrorism using data from the Global Terrorism Database. The multiple streams framework and the power elite theory were used. In this longitudinal trend study using secondary data analysis, domestic terrorism data …

Evaluation By Geospatial And Spatiotemporal Distribution Of Tularemia Cases In Arkansas, Toni Kathleen Beavers

Walden Dissertations and Doctoral Studies

Tularemia is a vector-borne disease of global concern with diverse regional foci. Arkansas is an endemic state with differences in case distribution and land suitability supporting host and vector sustainment. The aim of this study was to conduct a geospatial and spatiotemporal assessment of factors associated with case distribution and timeliness and completeness of public reporting. Guided with direction from spatial epidemiology and nidality, referring to the association of ecology, climate, and proximity of disease, analysis included secondary data collected from the Arkansas Department of Health between 1995 and 2018. Using Poisson-based software, 2 clusters were found: a high-risk cluster …

The Impact Of Service Dogs On Combat Veterans With Posttraumatic Stress Disorder, Christine R. Hansen

Walden Dissertations and Doctoral Studies

Combat veterans with posttraumatic stress disorder (PTSD) related symptoms often require the use of complementary therapeutic aids, such as service dogs, to assist them in their recovery in addition to traditional evidence-based therapy. Anecdotal literature was available on the use of service dogs, but quantitative research has not been conducted to answer the question of what the impact was of the use of service dogs on reducing symptoms of PTSD among combat and non-combat veterans. Attachment theory was one of the most common theoretical frameworks for exploring the use of service dogs for treating combat PTSD. The theoretical framework for …

Cybersecurity Strategies To Protect Information Systems In Small Financial Institutions, Johnny Fadel Rawass

Walden Dissertations and Doctoral Studies

Leaders of financial institutions face challenges in protecting data because of the increased use of computer networks in the commerce and governance aspects of their businesses. The purpose of this single case study was to explore the strategies that leaders of a small financial institution used to protect information systems from cyber threats. The actor-network theory was the conceptual framework for this study. Data were collected through face-to-face, semistructured interviews with 5 leaders of a small financial institution in Qatar and a review of company documents relevant to information security, cybersecurity, and risk management. Using thematic analysis and Yin'€™s 5-€step …

Experiences Of African American Lesbians Who Attended A Historically Black College Or University, Lee Kimball Outlaw Barmore

Walden Dissertations and Doctoral Studies

The lived experiences of African American lesbians who attended historically Black colleges and universities (HBCUs) have not received sufficient empirical attention; therefore, this study was conducted to understand and describe their experiences. The study followed a qualitative phenomenological approach. The multidimensional identity model, developed by Reyolds and Pope, was used as the framework through which to understand the participants' experiences. Semistructured, 40 to 60-minute interviews were conducted with 6 women who identified as African American lesbians and attended HBCUs. Initial hand and subsequent NVivo coding of interview data led to the development of the following 7 themes: (a) either African …

A Survey Study Of Elementary Teachers' Perceptions Of Student Classroom Behavior, Duane L. Davis

Walden Dissertations and Doctoral Studies

In a midwest, rural, and high-poverty elementary school, teachers expressed concerns about difficult student behaviors in their classrooms. It was important to address the problem because student misbehavior disrupts the learning of all students in the classroom. To provide information to the school that could inform possible interventions, a survey was conducted that measured the perceptions of 24 classroom teachers about concerning student behaviors, their methods of dealing with such behaviors, their needs for further support, and their confidence in dealing with difficult student behaviors. The conceptual frameworks that guided this study were the behaviorist theories of Watson and Skinner. …

Citizen Perceptions Of Law Enforcement Shootings Involving Imitation Firearms, Kristine Angela Gregory

Walden Dissertations and Doctoral Studies

The purpose of this qualitative ethnographic study was to explore citizen perceptions of the phenomenon of law enforcement shootings involving an imitation firearm. A secondary purpose was to document knowledge of current imitation firearm policies and thoughts on the effectiveness of said policies. Kingdon's multiple streams approach was used as the theoretical framework. This theory addressed the sources of power that influence policy decisions, the stakeholders involved in agenda setting, and factors that shape policy debates. Data were collected using a combination of secondary data analysis, field observations and semi structured, face-to-face interviews with 23 citizens. Sampling strategies included a …

Association Of Adaptive Early Phase Study Design And Late Phase Study Results In Oncology, Donna Elise Levy

Walden Dissertations and Doctoral Studies

This quantitative study assessed the association of the design methods used for early phase oncology studies (adaptive versus traditional) and the outcome of late stage clinical trials. Differences by cancer type and by drug classification were also assessed. The theoretical and conceptual frameworks used were the general systems theory and the design and evaluation of complex interventions, respectively. Units of analysis were individual oncology studies in the ClinicalTrials.gov database and Bayesian logistic modeling was applied on a random sample of 381 studies initiated after November 1999 to December 2016. When assessing study design and outcome, there were lower odds of …

Forecast, 2019, Illinois State University, College Of Applied Science And Technology

foreCAST

Magazine of the Illinois State University College of Applied Science and Technology

Localized Hippocampal Glutamine Synthetase Knockout: A Novel Model Of Mesial Temporal Lobe Epilepsy, Maxwell Gerard Farina

Yale Medicine Thesis Digital Library

The purpose of this study was to create and optimize a model of mesial temporal lobe epilepsy through selective depletion of glutamine synthetase (GS) in the mouse hippocampus. Following validation of the model, preliminary studies attempted to characterize morphological astrocytic and synaptic changes that result from GS deficiency. Aim 1 established a novel mouse model of GS knockout in hippocampal astrocytes. Aim 2 tested whether localized hippocampal knockout of GS causes mice to exhibit an epilepsy-like phenotype. Aim 3 characterized the cellular effects of localized GS loss. To generate the knockout, Glul-floxed C57BL/6J mice were injected with four different adeno-associated …

Strategies For Small Business Sustainability, Victor K. Adoukonou

Walden Dissertations and Doctoral Studies

Small businesses represent more than 99% of all employers in the United States, but more than 50% of small businesses have failed before 5 years. Climate change, digitization, and social media contribute to a paradigm shift in consumers' habits, as more consumers have become environmentally and social justice conscious. Business leaders who are unable to follow the consumers' trends and changes of habit may not succeed in sustaining their businesses. The purpose of this multiple case study was to explore strategies owners of small businesses in the District of Columbia use to sustain their businesses for longer than 5 years …

Relationship Between Novice Counselors' Supervisory Attachments And Boundary Practices And Perceptions, Glenda Hill Nanna

Walden Dissertations and Doctoral Studies

Novice counselors may struggle to understand and follow ethical guidelines for boundary behaviors with clients. When counselors violate therapeutic boundaries, harmful consequences can result for clients and counselors. The purpose of this quantitative study was to examine the possible relationship between novice counselors' (NCs') attachment to supervisors and NCs' ethical perceptions and boundary practices. This study addressed the possible predictor variables of age, gender, relationship status, and practice setting. Bowlby's attachment theory provided the framework for the study. Survey data from 114 NCs were analyzed using descriptive statistics and hierarchical linear regression. Each regression analyzed predictors of age, gender, relationship …

An Army Of One: Predaceous Diving Beetle Life History Stages Affect Interactions With Shared Mosquito Prey, Carmen E. Bofill, Donald A. Yee

Faculty Publications

Predators with complex life cycles often differ in their morphology, behavior, and trophic position across their ontogeny, and may thus have variable effects on shared prey. We used the predaceous diving beetle Laccophilus fasciatus rufus as our predator, whose larvae and adults often co-occur in freshwater lentic systems. As a shared prey we used early and late instar Culex quinquefasciatus, a common wetland mosquito. We found that single adult predators were more likely to consume late instar prey compared to juvenile predators, who ate early and late instar prey equally. A mixture of juvenile and adult predator stages led …

Exploring The Challenges Non-Clinical Departments Encounter During Eden Alternative Implementation, Keith George

Walden Dissertations and Doctoral Studies

The Centers for Medicare and Medicaid Services recommends new guidelines that shift healthcare delivery in nursing homes and long-term care facilities from an institutional model to a person-centered care model. Although clinical outcomes are measured and tracked, there was limited literature about the challenges non-clinical departments face in a nursing facility during implementation of a person-centered model. The purpose of this qualitative study was to explore the challenges non-clinical staff experience while transitioning to an Eden Alternative philosophy, a person-centered care model. The theoretical foundation of this study relied upon Bressers' Contextual Interaction Theory. The research questions for this study …

Petro-Texts, Plants, And People In The Anthropocene: The Dark Green, Heather I. Sullivan

Modern Languages and Literatures Faculty Research

The ‘dark green’ refers to the green plant-human relationships that undergird human cultures as well as the darkly petroleum-fueled industrialization, mass species extinctions, and strange new ecosystems in the Anthropocene. I consider briefly three petro-culture novels based on various ‘road trips’ that explicitly address both the long-term and massive, albeit oft-ignored, ecological power of plants whether in living vegetal form or in their rotted, processed form of petroleum products: Frank Herbert’s Dune, portraying worm ‘spice’ as a stand-in for oil; Cormac McCarthy’s The Road, eliminating all energy and plant life leaving only hungry humans; and Paolo Bacigalupi’s cli …

Faithful Execution And Article Ii, Andrew Kent, Ethan J. Leib, Jed Shugerman

Faculty Scholarship

Article II of the U.S. Constitution twice imposes a duty of faithful execution on the President, who must “take Care that the Laws be faithfully executed” and take an oath or affirmation to “faithfully execute the Office of President.” These Faithful Execution Clauses are cited often, but their background and original meaning have never been fully explored. Courts, the executive branch, and many scholars rely on one or both clauses as support for expansive views of presidential power, for example, to go beyond standing law to defend the nation in emergencies; to withhold documents from Congress or the courts; or …

A Possible Link Between R-Wave Amplitude Alternans And T-Wave Alternans In Ecgs, Sahar Alaei

Theses and Dissertations--Biomedical Engineering

Sudden Cardiac Death (SCD) is the largest cause of natural deaths in the USA, accounting for over 300,000 deaths annually. The major reason for SCD is Ventricular Arrhythmia (VA). Therefore, there is need for exploration of approaches to predict increased risk for VA. Alternans of the T wave in the ECG (TWA) is widely investigated as a potential predictor of VA, however, clinical trials show that TWA has high negative predictive value but poor positive predictive value. A possible reason that TWA has a large number of false positives is that a pattern of alternans known as concordant alternans, may …