Digital Commons Network^™

Thermoneutrality Does Not Affect Angiotensin Ii–Induced Aortic Aneurysms In Hypercholesterolemic Mice, Liyuan Zhu, Bowen Li, Michael K. Franklin, Deborah A. Howatt, Yuriko Katsumata, Alan Daugherty, Hong S. Lu

Physiology Faculty Publications

No abstract provided.

Conference Proceedings: Select Abstracts Presented At The 2025 Advocate Aurora Scientific Day, Advocate Aurora Scientific Day

Journal of Patient-Centered Research and Reviews

This abstract supplement includes findings presented through oral or poster presentations at the 51st annual Scientific Day event held on May 21, 2025. Scientific Day provides both an in-person and virtual forum for the sharing of research, quality improvement, and case studies conducted by Illinois- and Wisconsin-based faculty, fellows, residents, and other health professionals associated with Advocate Health.

High-Order Adaptive Solutions For Coupled Fractional Riccati Equations Via Daubechies Redundant Frames, Mutaz Mohammad, Alexander Trounev

Mathematical Modelling and Numerical Simulation with Applications

Coupled fractional Riccati equations play a fundamental role in modeling complex systems with memory effects and anomalous diffusion, frequently arising in engineering, control theory, finance, and quantum mechanics. Their analytical and numerical treatment remains highly challenging due to the nonlocal nature of fractional-order derivatives and the presence of nonlinear coupling terms. This study introduces an adaptive numerical framework that combines the Caputo fractional derivative with redundant Daubechies wavelet frames. The method leverages multi-resolution analysis, compact support, and controlled redundancy to achieve accurate approximation of both localized and global solution features, particularly in scenarios characterized by singular behavior and long-range memory …

The Consideration Of Two Scalarization Methods For The Multi-Objective Nurse-To-Patient Assignment Problem, Ilgın Acar, Steven E. Butt, Aydın Sipahioğlu, İslam Altın

Mathematical Modelling and Numerical Simulation with Applications

In this research, the application of two scalarization methods, namely the conic scalarization method and the $\varepsilon$-constraint method, is investigated within the context of a multi-objective optimization problem. These methods are used to address the challenge of assigning nurses to patients on a hospital unit during a shift. The two objective functions of this assignment problem are based on patient workload metrics and unit-related travel distance measures. The proposed solution approach demonstrates the ability to generate solutions that eluded the previous mathematical programming techniques that relied on simplistic weightings of conflicting objective functions. In addition, it is found that the …

Global Stability And Bifurcation Analysis Of A Predator-Prey Model Involving Allee Effect And Monod-Haldane Functional Response, Resmawan Resmawan, Agus Suryanto, Isnani Darti, Hasan S. Panigoro

Mathematical Modelling and Numerical Simulation with Applications

In this paper, the complexity of the dynamic behavior of the interaction between prey and predator is studied. The predator-prey relationship involves Allee effects and Monod-Haldane functional response. The constructed model has been shown to have validity in several respects, including the existence and uniqueness of the solution, as well as its non-negativity and boundedness. Three equilibrium points, namely trivial, axial, and coexistence points, are found, including their global dynamics using the Lyapunov function together with the LaSalle's invariance principle. The effect of the predation conversion rate causes changes in the dynamic behavior of predators and prey, which is characterized …

Solution Of Fractional Order Diffusion Equations With Clique Neural Network, Merve Zeynep Kaya, Mesut Karabacak, Ercan Çelik

Mathematical Modelling and Numerical Simulation with Applications

In this paper, the clique artificial neural network method is used to solve the fractional diffusion equation, which is a subclass of partial differential equations. The clique neural network architecture is constructed using input, hidden, and output layers. Several degrees of clique polynomials were used as activation functions, and the output layer was obtained by multiplying them with weight coefficients. Subsequently, the optimization equation was derived, and the exact solution, numerical solution, and error function graphs were obtained using a specialized algorithm. Analysis of the results demonstrates that the clique artificial neural network method provides quicker and more accurate results …

Synergistic Modeling Of Hydrogel Gelation Via Time-Delay Dynamics And Machine Learning Algorithms, Mine Babaoglu, Dipesh ., Pankaj Kumar, Jagjit Singh Dhatterwal, Mansoor Alsulami

Mathematical Modelling and Numerical Simulation with Applications

This paper presents an integrated framework in which delay differential equation (DDE) modeling and machine learning (ML) approaches are coupled to study hydrogel formation kinetics, with emphasis on delayed crosslinker addition. Conventional mechanistic models disclose many physical and kinetic complexities of reacting mixtures; they seldom depict the nonlinear and time-evolving complexities inherent in developing polymer networks. To address this, a mathematical model is developed that examines how the insertion of crosslinkers affects system stability and equilibrium. Analytical and numerical results show that delays nearing critical levels cause bifurcation behavior with substantial implications on gelation kinetics. Sophisticated machine learning systems, including …

Some New Three-Term Conjugate Gradient Methods For Riemannian Optimization With Application To The Gough-Stewart Platform, Nasiru Salihu, Poom Kumam, Lin Wang, Sani Salisu

Mathematical Modelling and Numerical Simulation with Applications

Three-term conjugate gradient (TTCG) methods have been extensively studied for optimization within Euclidean geometry, with some inherently satisfying the sufficient descent property, thus enhancing their theoretical superiority. However, other TTCG methods have been developed that incorporate restarting the search direction, simplify the steepest descent approach, or rely on the convexity assumptions of f to establish their convergence results. This paper introduces the Riemannian three-term conjugate gradient (RTTCG) methods. The search direction in these RTTCG methods consistently satisfies the sufficient descent condition, regardless of the line search employed, and does so without requiring a restart mechanism. By utilizing retraction and vector …

Ketorolac Use Following Operative Clavicle Fracture Fixation Is Not Associated With Increased Nonunion Or Surgical Complications: A Propensity-Matched Analysis, Tuckerman Jones, Tej Joshi, Akhil Katakam, Daniella Ogilvie, Sefy Paulose, Balazs Galdi

Wills Eye Hospital Papers

OBJECTIVES: Nonsteroidal anti-inflammatory drugs (NSAIDs), including ketorolac, are commonly used for postoperative pain management. Concerns about their potential impact on bone healing have been raised. This study investigated the relationship between ketorolac use and postoperative complications following clavicle surgery, including nonunion rates.

METHODS: This retrospective cohort study used the TriNetX Research Database to identify patients who underwent surgical fixation of clavicle fractures between 2002 and 2022. Two propensity-matched cohorts were created: patients who received postoperative ketorolac and those who did not. Primary outcomes included nonunion diagnosis and revision surgery; secondary outcomes included opioid use, wound disruption, surgical site infection, and …

Neutrosophic Set Model For Controlling Electronic Waste Requirements Management Policies To Minimize Ecological Impact And Improving Resilience And Sustainability, Mohamed Abouhawwash, Nitin Mittal, Sudeep Tanwar

Neutrosophic Systems with Applications

The growing issue of electronic waste (e-waste) necessitates management approaches that promote sustainability and resilience while reducing environmental effects, particularly considering global disruptions and pressure on manufacturers to implement extended producer responsibility laws. There is a research gap in our knowledge of the link between sustainability and resilience since most of the literature currently available on e-waste management focuses on either operational efficiency or sustainability. This study proposes multi-criteria decision making (MCDM) methodology for controlling electronic waste requirements management policies to minimize ecological impact and improving resilience and sustainability. We use the EDAS methodology to rank the alternatives. The criteria …

Application Of Dematel Based On Bipolar Neutrosophic Sets For Sustainable Agriculture Practices, Lazim Abdullah, Nor Liyana Amalini Binti Mohd Kamal

Neutrosophic Systems with Applications

The development of natural capital is a fundamental objective within sustainable agricultural systems, where the optimization of both crop and livestock production is vital to addressing global food demands. Despite this imperative, major agricultural sectors such as paddy and rubber production, often fall short of satisfying consumption needs. This study aims to identify and prioritize the most influential criteria for sustainable agriculture using the Bipolar Neutrosophic Set-based Decision-Making Trial and Evaluation Laboratory (BNS-DEMATEL) method. Expert evaluations were elicited from five agricultural specialists using linguistic assessments to analyze the performance and interdependencies among sustainability criteria. Computational analyses were conducted using MATLAB …

Review On Exploring The Potential Of Black Soldier Fly (Hermetia Illucens) As A Novel Feed Ingredient For Poultry, Muhammad Naeem Jan, Nasir Rajput, Muhammad Naeem, Sher Ali, Ghulam Shabir Barham, Tehseen Fatima Miano

Journal of Bioresource Management

Poultry provides both direct and indirect employment opportunities to individuals. Every farm owner desires a reduced investment with more earnings. Over 50 % of the overall cost of chicken rearing is allocated to feed stuff. Among all feed ingredients, protein sources are the most expensive, yet protein is essential for production and growth. This exorbitant price cannot be sustained by the small-scale farmers. Consequently, contemporary scientists are attempting to substitute the protein supply with black soldier fly in their formulations. This review study examines the advantageous effect of utilizing Black Soldier Fly powder, larvae or oil, as demonstrated in scientific …

Collaborative Reflections On A Practical Journey Through Transcendental Phenomenology Data Analysis, Tyler Kulp, Hissah Alzahrani, Michele Parker

The Qualitative Report

Although transcendental phenomenology is widely recognized in qualitative research, there is limited discussion of how researchers come to understand and apply its methods in practice. This paper examines how reflective collaboration enhances the understanding and use of transcendental phenomenological analysis. It involves the first author, a recent doctoral graduate, the second author, a current doctoral student, and the third author, the doctoral advisor, using a collaborative approach. We draw upon the first author’s dissertation, providing clear, actionable guidance for simplifying the analysis process. The discussion highlights the value of collaborative reflection in making the methodology more accessible and enriching understanding …

Diversity Of Butterflies (Lepidoptera) In Kanju, District Swat, Khyber Pakhtunkhwa, Pakistan, Said Miraj Ud Din, Khushbakht Asad, Hamid Ur Rahman, Attiya Iqbal

Journal of Bioresource Management

Butterflies are one of the most beautiful creatures on earth. They belong to the phylum Arthropoda, class Insecta, and order Lepidoptera. Butterflies play an important role in the ecosystem, contributing significantly to pollen transfer. They play an important role in pollination, and their foraging behavior enhances the genetic diversity. Additionally, they also play an important role in the food chain and serve as prey for birds, reptiles, and other insectivore organisms. The current study was conducted to find out the diversity and distribution of butterflies in Kanju district Swat, Khyber Pakhtunkhwa, Pakistan. A total 203 specimens were collected from August …

A Review On The Ethnozoological Remedies With The Help Of Animal Body Parts And Its Impact On Their Conservation Status, Minahal Fatima, Bushra Nisar Khan, Mudasser Hasan, Amina Tufail, Farhat Batool, Majida Maqbool, Fakhra Nazir

Journal of Bioresource Management

The use of wildlife in biomedical science has had a long history as it has been used as experimental animals, Sources of unusual physiology, and of bioactive compounds on which life-saving medicines are based. Amphibians are a Source of antimicrobial peptides, analgesic alkaloids, and regeneration. Immune adaptations and venoms of reptiles have produced cardiovascular medications, anti-clotting solutions and diabetes treatment. Birds serve as models of zoonotic diseases and provide immunological tools e.g. IgY antibodies and support embryology and neurobiology. Advanced studies on human disease, vaccines, cancer resistance and hypoxia tolerance have been facilitated by mammals such as rodents, primates, bats, …

Spartan Daily, September 30, 2025, San Jose State University, School Of Journalism And Mass Communications

Spartan Daily, 2025

Volume 165, Issue 16

Network Pharmacology And Molecular Docking Analysis Of Nephelium Lappaceum (Rambutan) Compounds As Potential Alternative Treatments For Lung Cancer, Dwi Utami, Muhammad Farid, Rachma Greta Perdana Putri

Makara Journal of Science

Introduction: Lung cancer is characterized by high mortality rates and poor prognosis, further requiring alternative therapies owing to the adverse effects of conventional chemotherapy. Rambutan (Nephelium lappaceum L.) has antimicrobial, antiproliferative, and antioxidant properties and can cure cancer. Method: Compounds from rambutan peel were identified through PubChem and analyzed for physicochemical properties using SwissADME. Target proteins were identified using SuperPred and compared with lung cancer–related proteins from GeneCards via Venny. Protein interactions were examined and visualized using STRING and Cytoscape, respectively. Protein activity was analyzed using WebGestalt, and docking simulations were performed using Autodock 4.2.6. Result: Physicochemical analysis of …

A Study On The Prevalence And Impact Of Infectious Causes Of Abortion In Women, Shaimaa M.S. Zainulabdeen, Najee B. Haifaa, Zahraa Abd Alhammza Abbass, Iman Ali Atyah

Muthanna Medical Journal

Abortion is the termination of a pregnancy before the fetus can survive outside the uterus, either spontaneously (miscarriage) or intentionally (induced). On the other hand, induced abortions carried out for various reasons are referred to as elective abortions, whereas therapeutic abortions are performed to protect the pregnant woman's health. The gestational period is a particularly delicate time because it is characterized by major physiological changes in both the mother and the fetus. Human immunodeficiency virus (HIV), cytomegalovirus (CMV), and Toxoplasma gondii are among the pathogenic agents that have been associated with pregnancy problems, including miscarriage. About 75% of all pregnancy …

Hawthorn (Crataegus Spp.): Unlocking Its Potential For Health And Environmental Sustainability – A Comprehensive Review, Abdelhak Maghchiche

Journal of Bioresource Management

Hawthorn (Crataegus spp.), traditionally regarded as an important medicinal plant and frequently cited in the literature, presents significant potential for sustainable development and medical biotechnology. This review looks at several areas of Hawthorn that can be explored in response to current healthcare and environmental sustainability issues. Bioactive compounds from hawthorn, including active compounds primarily comprised of flavonoids, procyanidins, and triterpenoids, are responsible for potent antioxidant, anti-inflammatory, cardio-protective, and antimicrobial activities, potentially providing a source of potent therapeutic alternatives. Moreover, hawthorn has a well-documented record as a source of cardiovascular benefits to address arterial hypertension, congestive heart failure, and arrhythmias. In …

Contributing To Acari Knowledge: The First Report Of Trombidium Grandissimum From The Soils Of Cholistan Desert, Rahim Yar Khan, Punjab, Pakistan, Muhammad Adnan Bodlah, Alishbah Mohsin, Ayesha Younas, Aleena Kanwal, Imran Bodlah, Yasir Niaz, Shumaila Khan, Shabbir Hussain

Journal of Bioresource Management

Trombidium grandissimum is also known by names, red velvet mite, real velvet mite, giant red velvet mite and rain bug, belongs to the family Trombidiidae and subclass Acari. Red velvet mite has four life stages: egg, larva, nymph, and adult. Adult red velvet mites were collected from agricultural farm area of Khwaja Fareed University of Engineering & Information Technology. Important taxonomic features were revealed by morphological study, including a body length of around half of an inch, velvety, unridged skin with dense hairs, stalked eyes, and specialized organs on the anterior legs including sensilla and claws. Carotene-induced bright red coloring …

Study On The Beneficial Effects Of Garlic, Tribulus Terrestris, And Vitamin E Supplementation On Semen Quality, Fertility, And Hatchability Of Desi Male Chicken, Iqrar Uddin Lashari, Muhammad Mohsen Rahimoon, Qudratullah Kalwar, Zafar Ali Khoso, Barkat Ali Jataoi, Majid Hussain Soomro, Hidayatullah Soomro

Journal of Bioresource Management

This study evaluated the effects of dietary supplementation with garlic, Tribulus terrestris, and vitamin E on semen quality parameters in desi male chickens maintained under local farming conditions in Sindh, Pakistan. A total of twenty-four non-descriptive desi chickens (8 males and 16 females, aged 19–20 weeks) were allocated to four dietary groups for 42 days: G1 (basal diet with 150 g/kg garlic), G2 (basal diet with Tribulus terrestris at 1 capsule/liter of water), G3 (basal diet with vitamin E at 1 capsule/liter of water), and G4 (control with basal breeding ration only). Semen samples collected from treated males were analyzed …

Seroprevalence, Risk Factors, And Diagnostic Accuracy Of Brucellosis In Upper Dir District, Khyber Pakhtunkhwa, Pakistan, Sidra Sanam, Kamran Khan

Journal of Bioresource Management

Brucellosis is a zoonotic disease caused by the gram-negative, intracellular bacterium Brucella. Although it is endemic in Pakistan, comprehensive data on its prevalence, risk factors, and diagnostic accuracy remain limited. Therefore, this study aimed to assess these parameters in local communities of District Dir Upper, Khyber Pakhtunkhwa, Pakistan. A total of 345 individuals suspected of brucellosis were investigated. Blood samples and structured questionnaires were collected to determine prevalence and identify associated risk factors. Additionally, 50 culture-confirmed positive cases and 50 negative controls were used to evaluate the diagnostic performance of Enzyme-Linked Immunosorbent Assay (ELISA) and Serum Plate Agglutination Test …

Effect Of Dietary Supplementation Of Symbiotic, Prebiotics And Probiotics On Conformation Of Teats In Rabbits, Saqib Kakar, Allah Bux Kachiwal, Saeed Ahmed Soomro, Akeel Ahmed Memon

Journal of Bioresource Management

This study evaluated the effects of dietary supplementation with prebiotics, probiotics, and symbiotics on the reproductive and physiological performance of New Zealand White rabbits, emphasizing teat conformation. Forty-eight rabbits were divided into four groups: control (a), prebiotics (b), probiotics (c), and symbiotics (d). During the first parity, teat conformation varied across dietary treatments, with group d (symbiotic supplementation) generally exhibiting superior teat morphology. Horizontal teat length was highest in group a (4.38±0.35) and lowest in group d (4.02±0.43). The rear teat distance from the floor was longest in group d (1.71±0.25) and shortest in group a (1.41±0.50), with a similar …

Trophic Niche Overlap Between Native And Alien Fish Species: A Challenge For The Aquatic Ecosystems, Rana Manzoor Ahmad, Abdul Majid Khan, Mariya Basharat, Muhammad Rizwan, Neelam Shahzadi, Muhammad Imran

Journal of Bioresource Management

The different physiological and biological challenges are introduced not only on land but also in aquatic ecosystems due to increasing climatic changes and human needs. One of these challenges is the introduction of invasive alien species to the native freshwater ichthyofauna. These species not only disturb the ecological balance of the native water bodies but can also be a vector for parasitic diseases. The current study is designed to disclose the trophic niche overlap among exotic (Cyprinus carpio and Oreochromis mozambicus) and indigenous fish species (Labeo calbasu and Cirrhinus mrigala) from Head Baloki (Ravi River), Punjab, …

Biodiversity Performance Of Living Wall Systems In Temperate Urban Environments: Plant Selection And Substrate Effects On Multi-Taxa Communities: Biodiversity Performance Of Living Wall Systems In Urban Environments, Paul Lunt, Thomas Murphy, James Buckley

School of Geography, Earth and Environmental Sciences

Urban densification threatens biodiversity, yet conventional greenspace expansion is con-strained by limited land availability. Living wall systems (LWS) offer potential biodiversity enhancement through vertical green infrastructure, though their ecological value re-mains underexplored. This study evaluated the biodiversity performance of three LWS in Plymouth, UK, using multi-taxa surveys to assess invertebrate communities, bird assemblages, and bat activity. A scoping review of 2,638 publications revealed limited research on LWS biodiversity, with only 27% of biodiversity-focused papers referencing specific species. Field surveys employed standardized protocols including flower-visiting pollinator observations, spider assessments, soil invertebrate extraction using Tullgren funnels, acoustic bird monitoring, and bat emergence …

Observational Activation Of Anterior Cingulate Cortical Neurons Coordinates Hippocampal Replay In Social Learning, Xiang Mou, Daoyun Ji

Faculty, Staff and Students Publications

Social learning enables a subject to make decisions by observing the actions of another. How neural circuits acquire relevant information during observation to guide subsequent behavior is unknown. Utilizing an observational spatial working memory task, we show that neurons in the rat anterior cingulate cortex (ACC) associated with spatial trajectories during self-running in a maze are reactivated when observing another rat running the same maze. The observation-induced ACC activities are reduced in error trials and are correlated with activities of hippocampal place cells representing the same trajectories. The ACC activities during observation also predict subsequent hippocampal place cell activities during …

Mcmc-Net: Accelerating Markov Chain Monte Carlo With Neural Networks For Inverse Problems, Anuj Abhishek

Faculty Scholarship

In many computational problems, using the Markov Chain Monte Carlo (MCMC) can be prohibitively time-consuming. We propose MCMC-Net, a simple yet efficient way to accelerate MCMC via neural networks. The key idea of our approach is to substitute the true likelihood function of the MCMC method with a neural operator based surrogate. We extensively evaluate the accuracy and speedup of our method on three different partial differential equation-based inverse problems where likelihood computations are computationally expensive, namely electrical impedance tomography, diffuse optical tomography, and quantitative photoacoustic tomography. MCMC-Net performs similar to the classical likelihood counterpart but with a significant speedup. …

Engineered Exosomes With Krasg12d Specific Sirna In Pancreatic Cancer: A Phase I Study With Immunological Correlates, Valerie S Kalluri, Brandon G Smaglo, Krishnan K Mahadevan, Michelle L Kirtley, Kathleen M Mcandrews, Mayela Mendt, Sujuan Yang, Ana S Maldonado, Hikaru Sugimoto, Maria E Salvatierra, Luisa M Solis Soto, Cara Haymaker, Rick Finch, Mihai Gagea, Adam C Fluty, Steven J Ludtke, J Jack Lee, Abhinav K Jain, Gauri Varadhachary, Rachna T Shroff, Anirban Maitra, Elizabeth Shpall, Shubham Pant, Raghu Kalluri

Faculty, Staff and Students Publications

Oncogenic KRAS is amongst the key genetic drivers for initiation and maintenance of pancreatic ductal adenocarcinoma (PDAC). Here, we show that engineered exosomes with KrasG12D specific siRNA (iExoKrasG12D) reveal a biodistribution in pancreas with negligible toxicity in preclinical studies in mice and Rhesus macaques. Clinical testing of iExoKrasG12D in the iEXPLORE (iExoKrasG12D in Pancreatic Cancer) Phase I study employed a non-randomized single-arm classical 3 + 3 dose escalation design (Phase Ia), followed by an accelerated titration design (Phase Ib) (NCT03608631). The primary outcomes included safety, tolerability and target engagement, and the secondary outcomes aimed to assess disease control. …

Strongyloides Seropositivity Among Children Utilizing A Mobile Clinic, Lynda Aririguzo, Aditi Gupta, Norma Castillo, Cassandra Duran, Eva H Clark, Ankona Banerjee, Sanghamitra Misra

Faculty, Staff and Students Publications

Experts recommend screening for or presumptively treating strongyloidiasis in foreign-born immigrant children, though prevalence is unknown. Health care providers encounter barriers to following this recommendation. We aimed to describe Strongyloides seropositivity and risk factors among pediatric patients on a mobile clinic. Participants completed a written survey and provided blood for absolute eosinophil count (AEC) and Strongyloides IgG enzyme-linked immunosorbent assay (ELISA). From October 2022 to June 2023, 206 patients participated; 201 (97.6%) were born outside the United States; 97.1% (n = 200) were Hispanic. Most (68.9%) arrived less than 1 year before study enrollment. Four (1.9%) and 3 (1.5%) had …

Cyp1b1 Mediates Cigarette Smoke-Induced Lipid Accumulation In Alveolar Type 2 Cells, Yin Zhu, Siddhika Gamare, Francesca Polverino, Caroline A Owen, Payaningal R Somanath, Xiaoyun Wang, Duo Zhang

Faculty, Staff and Students Publications

Alterations in lipid profiles have been shown in patients with chronic obstructive pulmonary disease (COPD), but the underlying molecular mechanisms remain unclear. In this study, we aimed to investigate the role of cytochrome P450 family-1 subfamily B member 1 (CYP1B1) in cigarette smoke (CS)-induced lipid accumulation in alveolar type II epithelial (AT2) cells. We observed a steady increase in CYP1B1 protein levels in AT2 cells from COPD patients. Additionally, CS exposure induced CYP1B1 expression in AT2 cells of murine lungs. In vitro, treatment with cigarette smoke extract (CSE) not only upregulated CYP1B1 expression but also triggered lipid accumulation in AT2-like …