Digital Commons Network^™

Promiscuous Coxiella Burnetii Cd4 Epitope Clusters Associated With Human Recall Responses Are Candidates For A Novel T-Cell Targeted Multi-Epitope Q Fever Vaccine, Anja Scholzen, Guilhem Richard, Leonard Moise, Laurie A. Baeten, Patrick M. Reeves, William D. Martin, Timothy A. Brauns, Christine M. Boyle, Susan Raju Paul, Richard Bucala, Richard A. Bowen, Anja Garritsen, Anne S. De Groot, Ann E. Sluder, Mark C. Poznansky

Cell and Molecular Biology Faculty Publications

Coxiella burnetii, the causative agent of Q fever, is a Gram-negative intracellular bacterium transmitted via aerosol. Regulatory approval of the Australian whole-cell vaccine Q-VAX^® in the US and Europe is hindered by reactogenicity in previously exposed individuals. The aim of this study was to identify and rationally select C. burnetii epitopes for design of a safe, effective, and less reactogenic T-cell targeted human Q fever vaccine. Immunoinformatic methods were used to predict 65 HLA class I epitopes and 50 promiscuous HLA class II C. burnetii epitope clusters, which are conserved across strains of C. burnetii. HLA binding …

Knitting 101: Why Law Professors Should Share Their Hobbies With Their Students, Susan Greene

Hofstra Law Faculty Scholarship

For many students, adrift in a sea of outlines and anxiety over the pressures of being a law student, cultivating a hobby or even developing a new one seems a luxury in time and energy that they cannot afford. Therefore, it is incumbent upon law professors to lead by example.

The Smile Attractiveness Of Patients Successfully Treated According To The Finishing Standards Of The American Board Of Orthodontics, Tayem Abou Saleh

All ETDs from UAB

Smiling is the most useful way people can use to express their emotions, therefore, it is critical to build our treatment plan not just around establishing a stable functional occlusion but also to achieve beautiful harmonious smile. It has been suggested that the smile may be made up of 3 components: Gingival component, soft tissue component, and dental component, and the ultimate smile beauty can be achieved by trying to find the balance in between these components. We collected 68 smiling photos for cases were taken to American board of orthodontics clinical exam and they were considered successfully treated, all …

Identification And Application Of Gingival Mesenchymal Stem Cells For Dental Tissue Regenration, Yousuf Al-Aboosi

All ETDs from UAB

Mesenchymal stem cells have been very attractive treatment modality in regenerative medicine, but not so much in regenerative dentistry. This can be attributed to the difficulty in obtaining dental origin stem cells without extracting a tooth or other invasive procedures. Autogenous gingival graft harvested from palatal tissue is used as the gold standard for treating single tooth recession. The healing of the gingival graft has been shown to be mostly depended on the recipient side more than the graft itself. This study is aiming to find if the palatal tissue has cells with mesenchymal characteristics that are helping in the …

Inhibition Of The Self-Assembly Of Aβ And Of Tau By Polyphenols: Mechanistic Studies, Qiuchen Zheng, Micheal T. Kebede, Merc M. Kemeh, Saadman Islam, Bethany Lee, Stuart D. Bleck, Liliana A. Wurfl, Noel D. Lazo

Chemistry

The amyloid-β (Aβ) peptide and tau protein are thought to play key neuropathogenic roles in Alzheimer’s disease (AD). Both Aβ and tau self-assemble to form the two major pathological hallmarks of AD: amyloid plaques and neurofibrillary tangles, respectively. In this review, we show that naturally occurring polyphenols abundant in fruits, vegetables, red wine, and tea possess the ability to target pathways associated with the formation of assemblies of Aβ and tau. Polyphenols modulate the enzymatic processing of the amyloid-β precursor protein and inhibit toxic Aβ oligomerization by enhancing the clearance of Aβ42 monomer, modulating monomer–monomer interactions and remodeling oligomers to …

Attainment And Maintenance Of Pubertal Cyclicity May Predict High A4 Cows With Reduced Fertility, Sarah Nafziger

Department of Animal Science: Dissertations, Theses, and Student Research

Puberty attainment was investigated in heifers. Blood samples were collected from weaning until breeding during 6 years from heifers born in 2012-2017. Plasma progesterone concentrations ≥ 1 ng/ml were used to indicate cyclicity, and heifers were categorized into one of four puberty groups using SAS: 1) Early heifers reached puberty before March 12 and cycled continuously during the sampling period, 2) Typical heifers reached puberty on or after March 12 and cycled continuously, 3) Start-Stop heifers had at least one occurrence of progesterone ≥ 1 ng/ml but discontinued cycling during the sampling period, and 4) Non-Cycling heifers had no occurrence …

Allium Cepa Extract Attenuates Ccl4-Induced Oxidative Stress In Rat Brain, Israel Oghenevwodokohwo Okoro, Helen Ejiro Kadiri, Augusta Inegbedion

The Thai Journal of Pharmaceutical Sciences

Introduction: Carbon tetrachloride (CCl4) has been used extensively to evaluate the probable mechanisms of toxicity in experimental animals. The CCl4 induced oxidative stress in rat brain has been established. This study aim to investigate the neuro-prot.

Integration Of Cone Photoreceptor Signals In Macaque Lgn Neurons, Paul B. Brown

All ETDs from UAB

Despite advances in the understanding of the primate visual system, much is yet to be learned about the way light signals sum to create our perception of the world. This is especially true at the simplest level of visual processing—the summation of two individual cone photoreceptor signals. How such signals combine to create visual perception has not been assessed in vivo. We used an adaptive optics scanning laser ophthalmoscope (AOSLO) to deliver binarized noise movies to identified groups of cones within the receptive fields of neurons in the macaque lateral geniculate nucleus (LGN). Recordings of neural action potentials within the …

Validity Of Actigraph Gt3x Accelerometer In Determining Energy Expenditure, Brandon Dean Beamon

All ETDs from UAB

ABSTRACT The purpose of this investigation was to examine estimates of energy expenditure from the Actigraph GT3X tracking device compared to that obtained by indirect calorimetry. Twenty-seven healthy Caucasian males at the University of Alabama at Birmingham (age 20-30 y) with a BMI range of 19.5 and 30 kg/m2 were asked to wear an Actigraph GT3X on the wrist, hip, and ankle while performing exercise on a treadmill, bike, and upper body ergometer in randomized order. After twelve regressions divided into two sections 4 with ankle, hip, and wrist included in the model, and 4 with the ankle site omitted) …

The Relationship Between Cortical Excitability And Neuropsychological Functioning In Patients With Idiopathic Generalized Epilepsies (Iges), Lauren Bolden

All ETDs from UAB

Recent advances in neurostimulation and neuromodulation techniques, such as transcranial magnetic stimulation (TMS), may offer alternative treatment options to patients with idiopathic generalized epilepsies (IGEs). In a previous study, we utilized TMS to demonstrate a relationship between increased cortical excitability (i.e. hyperexcitability), attentional dysfunction, and mood disturbance in a sample of healthy adults. In general, patients with IGEs are found to exhibit cortical hyperexcitability, cognitive dysfunction, and mood problems; however, a relationship between these variables in IGEs has not yet been investigated. Importantly, patients with treatment-resistant IGEs (trIGEs) are shown to demonstrate greater cortical excitability, cognitive deficits, and mood problems …

Assessment Of Factors Affecting Quality Of Life In Oral Squamous Cell Carcinoma Patients Using University Of Washington Quality Of Life Questionnaire, Syed Abbas, Muhammad Usman Tariq, Abdul Rehman, Javeria Saeed, Syed S. Hashmi, Musa Karim, Mazhar Ali

Section of Otolaryngology, Head & Neck Surgery

Introduction Post-treatment Quality of Life (QOL) is considered an important outcome in cancer patients. A number of questionnaire tools have been designed for its assessment. University of Washington Quality of Life (UW QOL) questionnaire version four is a reliable tool for assessment of post-treatment QOL in oral squamous cell carcinoma (OSCC) patients. Our aim was to identify the post-treatment problems faced by OSCC patients and to assess the impact of clinical factors affecting post-treatment QOL by using UW QOL (version four) questionnaire. Methods The study was conducted on 59 patients with OSCC who were treated with curative intent at Patel …

Deciphering The Roles Of Hopd1 In Carbon Metabolism During Pathogen Infection, Yali Sun

All ETDs from UAB

Plants are equipped with various immune responses including MAMP-triggered immunity (MTI) and effector-triggered immunity (ETI) to fight against pathogens, while virulent pathogens release virulent proteins (effectors) and phytotoxins to compete with host immune responses. Comprehensively, plant-pathogen interactions involve multi- layered and highly coordinated processes, and dynamic regulation at both transcriptional and translational levels plays a pivotal role in plant defense. For example, NPR1, a key immune regulator, is regulated by hosts and manipulated by pathogens at different levels during different stages of plant-pathogen interaction. However, besides the competition over immune responses, bacterial pathogens also need to gain nutrients from host …

A Microfocal Effect In Photoreceptor Light Capture, Vasantha Kumari Kanukuntla

All ETDs from UAB

In human eyes, accomodation brings light rays into focus on the retina in order to achieve a clear images. The plane of best focus within the depth of the retina is thought to be within the photoreceptor layer, but pinpointing the exact focal position axially has not been determined. With help of adaptive optics aberration correction and its ability to have microscopic control of a retinal stimulus, we explored how sensitive human subjects are to defocus on the micron scale. We found that focal position can be reliably judged within 0.02 D, which is equivalent to about 6 microns in …

The Benefit Of Resilience: Examining The Roles Of Family Resilience And Parental Education In Child Anxiety, Bria Kathryn Morgan

All ETDs from UAB

Extensive literature addresses the associations between parental education and children’s mental health outcomes; however, the role of parental education and family resilience in child anxiety is unclear. The purpose of this study is to obtain a greater understanding of the role of parental education in child anxiety. Additionally, the study aims to investigate the role and potential varying effects of family resilience. Building upon Bowen’s Family Systems Theory and Walsh’s Systems Theory of Family Resilience, I hypothesize that parental education will be negatively associated with child anxiety and that family resilience will be negatively associated with child anxiety. I also …

Kidney Resident Macrophages Utilize Developmental Programming During Healing From Acute Kidney Injury, Jeremie Matthew Peabody Lever

All ETDs from UAB

Acute kidney injury (AKI) can be a devastating condition, affecting up to sixty percent of critically ill patients in the United States. Despite the fact that AKI is associated with an increased risk of chronic kidney disease (CKD) and mortality, there are no targeted therapies available to treat it. Kidney resident macrophages (KRM) are likely necessary for healing and resolution of animal models of AKI. However, there remains a gap in knowledge regarding how KRM effect this function. The purpose of my thesis was to elucidate lineage relationships and functionally relevant adaptations of KRM and monocyte-derived mononuclear phagocytes (infiltrative MP) …

Targeting The Nad Salvage Pathway For The Treatment Of The Parasitic Disease Schistosomiasis, Michael David Schultz

All ETDs from UAB

Schistosomiasis, also known as bilharzia, is the third most common parasitic infection worldwide and a major source of morbidity and mortality in developing countries. Caused by trematodes in the genus Schistosoma, this parasitic disease has no vaccine therapy and resources for drug development are scarce. Despite an unknown mechanism of action, praziquantal has become the primary source of treatment due to its efficacy against all species of Schistosoma. However, with increased drug resistance in endemic areas and low activity against immature parasites, relying on this single drug is unsustainable and risky. Hence, there is a growing need for new, safe …

Analysis Of Microbial Load And Diversity In Crickets (Gryllus Bimaculatus And Scapsipedus Icipe) Used As A Source Of Protein For Food, Jedida Wanjiru Gatheru

All Master’s Theses

Crickets are drawing interest as sustainable source of protein for food and feed worldwide. However, there is little information on microbial quality of edible crickets thus the need for a profound insight into their safety. The objective of the study was to determine the microbial load of two edible cricket species Scapsipedus icipe and Gryllus bimaculatus and to evaluate the efficiency of different processing methods (boiling, sundrying, freeze-drying, snap freezing and deep frying) in reducing microbial counts. The wild-caught crickets were obtained from Nguruman (Kajiado County) and Mbita (Homa Bay County) while the farmed crickets were reared at Animal Rearing …

Fertilizer - Root Knot Nematodes Interactions In High Tunnel Tomato Production, Daisy Chepkoech Ngeno

All Master’s Theses

Tomato (Solanum lycopersicum) is one of the important vegetables grown in Kenya. It is the second leading vegetable in terms of production and nutritional value after the potato. Tomatoes are mainly grown by small scale farmers in most arable areas with the main production areas being in Kiambu County. Production of tomatoes in Kenya has been mainly under open field conditions until recently where modified high tunnels (‘greenhouse') were introduced. Tomato production in greenhouse in Kenya is hampered by pests and diseases mainly Meloidogyne spp., known as root knot nematodes (RKNs).RKNs are the most serious threat to utilization of the …

Fifty Years Of Foia In Operation, 1967-2017, Tuan N. Samahon

Villanova Law Review (1956 - )

No abstract provided.

The Potential Use Of Seagrass Herbivory Patterns As An Indicator Of Herbivore Community Change After Tropical Marine Protected Area Establishment, John M. Carroll, Amber D. Stubler, Christopher M. Finelli, Bradley J. Peterson

Gulf and Caribbean Research

Throughout the Caribbean, fishing pressure has decreased the abundance of many species, including both large predators and larger-bodied herbivores. In an effort to reverse these trends and reduce harvest pressure on vulnerable fish populations, Marine Protected Areas (MPAs) have been established throughout the Caribbean. Yet, the effort to monitor fish communities, is variable, and there are MPAs where no monitoring program exists. It is possible that other metrics may be used to determine whether the impact of MPA establishment. By comparing two seagrass herbivory experiments, one pre- and one post-MPA establishment, we provide evidence that the MPA established in Discovery …

Powered, Wearable, Reprogrammable (Pwr) Led Clothing, Blake Johansen

Electrical and Computer Engineering

• Many people today want to have an element of creative control over the products they want to use
• Clothing is an industry that people can’t design or customize for themselves
• This project incorporates a series of NeoPixel lights on the front of a piece of clothing that a user can create custom animations for
• To ensure ease of use, a bluetooth app was developed to transmit animations to the vest
• To allow users to customize their clothing animations, a design program was developed that lets users design animations for themselves

Student Perceptions And Grade Comparisons After Exposure To Instructor-Made Skills Videos In A Kinesiology Course, Pamela Karp, Robert G. Gallagher

Journal of Occupational Therapy Education

The purpose of this mixed method, descriptive case study was to determine whether the use of pre-recorded instructor-made videos (PRIMVs) in a kinesiology course, along with curricular design changes, facilitated increased conceptual and practical student learning. The study examined three student cohorts in one occupational therapy program. Two of the student cohorts had unrestricted access to the PRIMVs designed to support student learning of bone and muscle palpation and joint actions. Students from the two cohorts completed a survey about their experience of having access to the videos. Exam data from the student cohorts who had access to the videos …

Animal Science E-Newsletter, January 2019, University Of Arkansas, Fayetteville. Department Of Animal Sciences

Animal Science e-Newsletter

No abstract provided.

Present And Future Adventures In Illustration, Jaleen Grove, Illustration Department

Faculty & Librarian Work

This article discusses current trends and the future of illustration. Several illustrators and educators are interviewed, such as Anita Kunz, Armando Veve, Barbara Nessim, and Martin Salisbury. Topics include publishing, virtual reality, children's books, diversity and representation, high tuition, and the lesser respect and pay that many illustrators experience. The article also relates the history of American illustration 1959-2019 in the form of a tongue-in-cheek boardgame The Illustration Game, in which players advance through the years, encountering typical events in the industry. The game-board is scattered with historical funny-in-hindsight quotes of well-known illustrators, designers and other professionals, which illuminate …

The Illustration Game: Quotes & Notes, Jaleen Grove, Illustration Department

Faculty & Librarian Work

Liner noes included with The Illustration Game boardgame providing sources of quotes and in-depth commentary by creator Jaleen Grove.

Losac Annual Report 2018-2019, Library Operating Staff Advisory Committee

University Libraries Archives

No abstract provided.

An Assessment Of The Potential Impacts Of Climate Change On The Freshwater Habitats Of Indiana, U.S.A., Tomas Höök, Carolyn Foley, Paris Collingsworth, Leslie Dorworth, Brant Fisher, Jason Hoverman Dr., Elizabeth Larue, Mark Pryon, J. L. Tank

Aquatic Ecosystems Publications

Recent climate-driven, physico-chemical changes documented in aquatic systems throughout the world are expected to intensify in the future. Specifically, changes in key environmental attributes of aquatic systems, such as water quantity, clarity, temperatures, ice cover, seasonal flow regimes, external loading, and oxygen content, will undoubtedly have a broad set of direct and indirect ecological consequences. Some anticipated impacts may be similar across different aquatic ecosystems, while others may be system-specific. Here, we review the potential effects of climatic changes for different freshwater habitats within the state of Indiana, USA, a Midwestern state with diverse land and water features. Given this …

Bone Age Practices In Infants And Older Children Among Practicing Radiologists In Pakistan: Developing World Perspective, W. Akhtar, Mukhtiar Memon, Syed Mustafa, Umm E Laila, Arif Ali, Nouman Hashmai, Naila Nadeem, Nadeem Ahmed

Department of Radiology

Objective To investigate which bone age assessment techniques are utilized by radiologists in Pakistan to determine skeletal age in three defined age groups: less than one year, one to three years and three to 18 years. We also assessed the perceived confidence in skeletal age assessments made by respondents using their chosen bone age assessment technique, within each defined age group. Materials and methods A cross-sectional survey was conducted among 147 practicing radiologists in Pakistan. A pre-validated survey form was adopted from a similar study conducted amongst members of the Society for Pediatric Radiology. The survey collected demographic information, choice …

Catalpa, University Of Tennessee At Chattanooga

Catalpa

No abstract provided.

Of Bee Stings, Mud Pies, And Outhouses: Exploring The Value Of Satire Through The Theory Of Useful Untruths, Leonard M. Niehoff

Other Publications

In this article, I attempt to fill this conceptual gap within Hustler by offering a theory of how satire functions and why it has a distinctively important place in our public discourse. That theory draws on the work of philosophers like Kwame Anthony Appiah, Hans Vaihinger, Kendall Walton, and Lon Fuller, who have discussed the concept of “useful untruths”—lines of thought where we proceed as if something we know to be false is in fact true, because doing so serves a useful and valuable purpose. In my view, the philosophy of useful untruths can help us understand the complexity of …