Digital Commons Network^™

Targeting Innate Immunity For Tuberculosis Vaccination, Shabaana A. Khader, Maziar Divangahi, Willem Hanekom, Philip C. Hill, Markus Maeurer, Karen W. Makar, Katrin D. Mayer-Barber, Musa M. Mhlanga, Elisa Nemes, Larry S. Schlesinger, Reinout Van Crevel, Ramakrishna Vankalayapati, Ramnik J. Xavier, Mihai G. Netea, On Behalf Of The Bill And Melinda Gates Foundation Collaboration For Tb Vaccine Discovery Innate Immunity Working Group

Open Access Publications

No abstract provided.

A Window On The Lung: Molecular Imaging As A Tool To Dissect Pathophysiologic Mechanisms Of Acute Lung Disease, Guido Musch

Open Access Publications

No abstract provided.

Trial Of Sage-217 In Patients With Major Depressive Disorder, Handan Gunduz-Bruce, Christopher Silber, Inder Kaul, Anthony J. Rothschild, Robert Riesenberg, Abdul J. Sankoh, Haihong Li, Robert Lasser, Charles F. Zorumski, David R. Rubinow, Steven M. Paul, Jeffrey Jonas, James J. Doherty, Stephen J. Kanes

Open Access Publications

No abstract provided.

Tropomyosin Isoforms Differentially Tune Actin Filament Length And Disassembly, Silvia Jansen, Bruce L. Goode

Open Access Publications

No abstract provided.

Combined Anti-Inflammatory And Neuroprotective Treatments Have The Potential To Impact Disease Phenotypes In Cln3−/− Mice, Marta A. Tarczyluk-Wells, Christoph Salzlechner, Allison R. Najafi, Ming J. Lim, David Smith, Frances M. Platt, Brenda P. Williams, Jonathan D. Cooper

Open Access Publications

No abstract provided.

Advances In Cardiovascular Disease Lipid Research Can Provide Novel Insights Into Mycobacterial Pathogenesis, Shyamala Thirunavukkarasu, Shabaana A. Khader

Open Access Publications

No abstract provided.

Hyperadrenocorticism Of Calorie Restriction Contributes To Its Anti‐Inflammatory Action In Mice, Brian D. Allen, Chen-Yu Liao, Jianhua Shu, Louis J. Muglia, Joseph A. Majzoub, Vivian Diaz, James F. Nelson

Open Access Publications

No abstract provided.

Regulation Of Rhob Gene Expression During Tumorigenesis And Aging Process And Its Potential Applications In These Processes, Cedric A.R Bailey, Et Al

Open Access Publications

No abstract provided.

A Mutation In Site-1 Protease Is Associated With A Complex Phenotype That Includes Episodic Hyperckemia And Focal Myoedema, George G. Schweitzer, Connie Gan, Robert C. Bucelli, Daniel Wegner, Robert E. Schmidt, Marwan Shinawi, Brian N. Finck, Rita T. Brookheart

Open Access Publications

No abstract provided.

Mitofusin 2 Is Essential For Ip3-Mediated Sr/Mitochondria Metabolic Feedback In Ventricular Myocytes, Lea K. Seidlmayer, Christine Mages, Annette Berbner, Petra Eder-Negrin, Paula Anahi Arias-Loza, Mathias Kaspar, Moshi Song, Gerald W. Dorn Ii, Michael Kohlhaas, Stefan Frantz, Christoph Maack, Brenda Gerull, Elena N. Dedkova

Open Access Publications

No abstract provided.

Expression Signatures Of Cisplatin- And Trametinib-Treated Early-Stage Medaka Melanomas, Barbara Klotz, Susanne Kneitz, Yuan Lu, William Boswell, John Postlethwait, Wesley Warren, Ronald B. Walter, Manfred Shartl

Open Access Publications

No abstract provided.

Single-Molecule Trapping And Spectroscopy Reveals Photophysical Heterogeneity Of Phycobilisomes Quenched By Orange Carotenoid Protein, Allison H. Squires, Peter D. Dahlberg, Haijun Liu, Nikki Cecil M. Magdaong, Robert E. Blankenship, W.E. Moerner

Open Access Publications

No abstract provided.

Comparison Of The Pharmacokinetic Properties Of Triamcinolone And Dexamethasone For Local Therapy Of The Inner Ear, Alec Nicholas Salt, Jared James Hartsock, Jennifer Hou, Fabrice Piu

Open Access Publications

No abstract provided.

Modelling Resilience In Adolescence And Adversity: A Novel Framework To Inform Research And Practice, Gin S. Malhi, Pritha Das, Erica Bell, Greg Mattingly, Zola Mannie

Open Access Publications

No abstract provided.

The Zebrafish Xenograft Platform-A Novel Tool For Modeling Kshv-Associated Diseases, Eric S Pringle, Jaime Wertman, Nicole Melong, Andrew J Coombs, Andrew L Young, David O'Leary, Chansey Veinotte, Carolyn-Ann Robinson, Michael N Ha, Graham Dellaire, Todd E Druley, Craig Mccormick, Jason N Berman

Open Access Publications

Kaposi's sarcoma associated-herpesvirus (KSHV, also known as human herpesvirus-8) is a gammaherpesvirus that establishes life-long infection in human B lymphocytes. KSHV infection is typically asymptomatic, but immunosuppression can predispose KSHV-infected individuals to primary effusion lymphoma (PEL); a malignancy driven by aberrant proliferation of latently infected B lymphocytes, and supported by pro-inflammatory cytokines and angiogenic factors produced by cells that succumb to lytic viral replication. Here, we report the development of the first

Selective Small Molecule Parg Inhibitor Causes Replication Fork Stalling And Cancer Cell Death, Jerry H. Houl, Roderick A. Stegeman, Tom Ellenberger, In-Kwon Kim, Et Al.

Open Access Publications

No abstract provided.

Diffusion Basis Spectrum Imaging Provides Insights Into Ms Pathology, Peng Sun, Ajit George, Dana C. Perantie, Kathryn Trinkaus, Zezhong Ye, Robert T. Naismith, Sheng-Kwei Song, Anne H. Cross

Open Access Publications

No abstract provided.

The Effect Of Gut Microbiome Composition On Human Immune Responses: An Exploration Of Interference By Helminth Infections, Ivonne Martin, Maria M M Kaisar, Aprilianto E Wiria, Firdaus Hamid, Yenny Djuardi, Erliyani Sartono, Bruce A Rosa, Makedonka Mitreva, Taniawati Supali, Jeanine J Houwing-Duistermaat, Maria Yazdanbakhsh, Linda J Wammes

Open Access Publications

No abstract provided.

Attribution Of Ghrelin To Cancer; Attempts To Unravel An Apparent Controversy, Saeed Soleyman-Jahi, Fatemeh Sadeghi, Amin Pastaki Khoshbin, Leila Khani, Venus Roosta, Kazem Zendehdel

Open Access Publications

Ghrelin is an endogenous peptide hormone mainly produced in the stomach. It has been known to regulate energy homeostasis, stimulate secretion of growth hormone, and mediate many other physiologic effects. Various effects attributed to ghrelin contribute to many aspects of cancer development and progression. Accordingly, a large body of evidence has emerged about the association of ghrelin with several types of cancer in scales of cell-line, animal, and human studies. However, existing data are controversial. This controversy occurs in two main domains: one is the controversial results in local effects of ghrelin on different types of human cancer cell-lines; the …

Nanotherapy Targeting Nf-Κb Attenuates Acute Pain After Joint Injury, Huimin Yan, Xin Duan, Kelsey H Collins, Luke E Springer, Farshid Guilak, Samuel A Wickline, M Farooq Rai, Hua Pan, Christine T N Pham

Open Access Publications

Inflammation after joint injury leads to joint responses that result in eventual osteoarthritis development. Blockade of inflammation, by suppressing NF-κB expression, has been shown to reduce joint injury-induced chondrocyte apoptosis and reactive synovitis

Ctcf Variants In 39 Individuals With A Variable Neurodevelopmental Disorder Broaden The Mutational And Clinical Spectrum, Enrico D. H. Konrad, Marwan Shinawi, Emily Fassi, Et Al.

Open Access Publications

No abstract provided.

Genomic Characterization Of Antibiotic Resistant Escherichia Coli Isolated From Domestic Chickens In Pakistan, Muhammad Rafique, Robert F Potter, Aura Ferreiro, Meghan A Wallace, Abdul Rahim, Akbar Ali Malik, Naila Siddique, Muhammad Athar Abbas, Alaric W D'Souza, Carey-Ann D Burnham, Naeem Ali, Gautam Dantas

Open Access Publications

Poultry husbandry is important for the economic health of Pakistan, but the Pakistani poultry industry is negatively impacted by infections from

The Interplay Between Viral-Derived Mirnas And Host Immunity During Infection, Richa Mishra, Ashish Kumar, Harshad Ingle, Himanshu Kumar

Open Access Publications

MicroRNAs are short non-coding RNAs that play a crucial role in the regulation of gene expression during cellular processes. The host-encoded miRNAs are known to modulate the antiviral defense during viral infection. In the last decade, multiple DNA and RNA viruses have been shown to produce miRNAs known as viral miRNAs (v-miRNAs) so as to evade the host immune response. In this review, we highlight the origin and biogenesis of viral miRNAs during the viral lifecycle. We also explore the role of viral miRNAs in immune evasion and hence in maintaining chronic infection and disease. Finally, we offer insights into …

Mobilized Peripheral Blood: An Updated Perspective, Darja Karpova, Michael P Rettig, John F Dipersio

Open Access Publications

Enforced egress of hematopoietic stem cells (HSCs) out of the bone marrow (BM) into the peripheral circulation, termed mobilization, has come a long way since its discovery over four decades ago. Mobilization research continues to be driven by the need to optimize the regimen currently available in the clinic with regard to pharmacokinetic and pharmacodynamic profile, costs, and donor convenience. In this review, we describe the most recent findings in the field and how we anticipate them to affect the development of mobilization strategies in the future. Furthermore, the significance of mobilization beyond HSC collection, i.e. for chemosensitization, conditioning, and …

Clinical Performance Of A Novel Fully Synthetic Dura Substitute, Umang Khandpur, Wilson Ray, Matthew Macewan

Open Access Publications

No abstract provided.

Somatosensory Predictors Of Response To Pregabalin In Painful Chemotherapy-Induced Peripheral Neuropathy: A Randomized, Placebo-Controlled, Crossover Study, Alexander Hincker, Karen Frey, Lesley Rao, Nina Wagner-Johnston, Arbi Ben Abdallah, Benjamin Tan, Manik Amin, Tanya Wildes, Rajiv Shah, Pall Karlsson, Kristopher Bakos, Katarzyna Kosicka, Leonid Kagan, Simon Haroutounian

Open Access Publications

No abstract provided.

Improving Spatial Predictions Of Animal Resource Selection To Guide Conservation Decision Making, Brian Gerber, Joseph M. Northrup

Natural Resources Science Faculty Publications

Resource selection is often studied by ecologists interested in the environmental drivers of animal space use and movement. These studies commonly produce spatial predictions, which are of considerable utility to resource managers making habitat and population management decisions. It is thus paramount that predictions from resource selection studies are accurate. We evaluated model building and fitting strategies for optimizing resource selection function predictions in a use‐availability framework. We did so by simulating low‐ and high‐intensity spatial sampling data that respectively predicted study area and movement‐based resource selection. We compared one of the most commonly used forms of statistical regularization, Akaike's …

Foreign-Born Workers' Effect On Agricultural Industry In Iowa, Hannah Mcdevitt

Honors Program Theses

It is no secret that Iowa’s reputation relies heavily on farms. Several years ago, a woman from California actually asked me if I ride my tractor to school. I wish I could tell you that was just a fun hook to get you interested in my paper, but it happened. Farming is a part of Iowa’s culture and an essential piece of the state’s economy. Iowa is one of the main pork, corn, and soybean producers in the United States, and its farming roots extend deep into the state’s rich soil.

Patently Uncertain, Daniel R. Cahoy

Northwestern Journal of Technology and Intellectual Property

Innovation is an inherently uncertain process. Success is typically coupled with risk and we can only hope that those with great ideas will persevere. To encourage innovation, society reduces some of the innovation risk through structures like funding systems, regulation, and of course intellectual property rights. But what happens when uncertainty strikes the legal protection devices themselves? Faced with unclear rules and increasingly speculative rewards, some innovators may simply stop playing the game.

Such uncertainty has recently been a topic of great concern in the U.S. patent system. Some believe that the suddenly unknowable nature of fundamental questions like what …

Multi-Antigen Vaccination With Simultaneous Engagement Of The Ox40 Receptor Delays Malignant Mesothelioma Growth And Increases Survival In Animal Models, Peter R. Hoffmann, Fukun W. Hoffmann, Thomas A. Premeaux, Tsuyoshi Fujita, Elisa Soprana, Maddalena Panigada, Glen M. Chew, Guilhem Richard, Pooja Hindocha, Mark Menor, Vedbar S. Khadka, Youping Deng, Leonard Moise, Lishomwa C. Ndhlovu, Antonio Siccardi, Andrew D. Weinberg, Anne S. De Groot, Pietro Bertino

Cell and Molecular Biology Faculty Publications

Malignant Mesothelioma (MM) is a rare and highly aggressive cancer that develops from mesothelial cells lining the pleura and other internal cavities, and is often associated with asbestos exposure. To date, no effective treatments have been made available for this pathology. Herein, we propose a novel immunotherapeutic approach based on a unique vaccine targeting a series of antigens that we found expressed in different MM tumors, but largely undetectable in normal tissues. This vaccine, that we term p-Tvax, is comprised of a series of immunogenic peptides presented by both MHC-I and -II to generate robust immune responses. The peptides were …