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Aktivitas Antinosiseptif Fraksi Diklorometana Daun Kratom (Mitragyna Speciosa Korth.) Rute Oral Pada Mencit Jantan Swiss, Sri Luliana, Robiyanto Robiyanto, Muhamad Rido Islamy

Pharmaceutical Sciences and Research

Kratom leaves (Mitragyna speciosa Korth.) is known to have an opioid-like analgesic effect. One of the main compound in kratom leaf is mitragynine which has strong affinity to opioid receptor. Kratom leaf has many pharmacological effects, one of them is as an antinoceptive agent. The purpose of this research to investigate the antinociceptive effect of dicholoromethane fraction from kratom leaf and determine the percentage of antinociceptive on male Swiss mice. The method used in this study was hot plate method. The animal subjects were divided to five groups: normal group CMC Na 0.5%, morphine 5.46 mg/kgBW, dicholoromethane fraction of kratom …

Potensi Anthelmintik Ekstrak Etanol Daun Mangga Arumanis (Mangifera Indica L.) Pada Cacing Ascaridia Galli Dan Raillietina Tetragona Secara In Vitro, Robiyanto Robiyanto, Ria Kusuma, Eka Kartika Untari

Pharmaceutical Sciences and Research

Arumanis mango (Mangifera indica L.), a medicinal plant, is allegedly potential as an anthelmintic agent. This research aimed to investigate the in vitro anthelmintic activity of ethanolic extract of arumanis mango leaves against Ascaridia galli and Raillietina tetragona; know the effect of increasing extract concentration; and calculate the LC50 and LT50 value of the extract. The extract concentrations tested were 5, 25 and 50 (mg/ml) with normal control (NaCl 0,9%) and positive control (mebendazole 5 mg/ml). The time and number of worm deaths were observed and analyzed statistically using One Way Anova SPSS, Post hoc (LSD) and Probit. The results …

Pemodelan Molekul Turunan P-Metoksi Sinnamoil Hidrazida Sebagai Inhibitor Checkpoint Kinase 1 Dan Inhibitor Aromatase Secara In Silico, Galih Satrio Putra, Melanny Ika Sulistyowatya, Juni Ekowati, Tutuk Budiati

Pharmaceutical Sciences and Research

The development of anticancer drugs from ethyl p-methoxycinnamate (EPMC) derivatives has been done to compounds high activity in inducing cancer cells apoptosis and minimal side effects. p-Methoxycinnamoyl hydrazide derivates, modified from EPMC structure, were docked into the ligand-binding pocket of Check point kinase 1 enzymes (2YWP) and the aromatase enzyme (3S7S) using software Molegro Virtual Docker (MVD) Ver.5.5. We compared the Rerank score of native ligand with p-Methoxycinnamoyl hydrazide derivates. Rerank scores of compounds 4b and 4c (-99.98 Kcal/mol and -99.80 Kcal/mol) were lower than the native ligand A42 in inhibiting the enzyme checkpoint kinase 1. Rerank values of p-Methoxycinnamoyl …

Antimicrobial And Cytotoxic Properties Of The Ascidians Lissoclinum Patella, Oxycoryna Fascicularis, Didemnum Molle And Botryllus Schlosseri, Firmansyah Karim, Masteria Yunovilsa Putra, Tri Aryono Hadi, Muhammad Abrar

Pharmaceutical Sciences and Research

The aim of this research is to investigate antimicrobial and cytotoxic activity from Indonesian ascidians. Extracts prepared from the Indonesian ascidians Lissoclinum patella, Oxycoryna fascicularis, Didemnum molle and Botryllus schlosseri were assessed for anti-microbial and cytotoxic properties. Antibacterial activity of the extracts was tested against two Gram-positive bacteria, viz. Bacillus subtilis ATCC 6633 and Staphylococcus aureus ATCC 25923, and three Gram-negative bacteria, viz. Escherichia coli ATCC 25922, Vibrio cholerae ATCC 14035 and Pseudomonas aeruginosa ATCC 101454 using the disk diffusion test. Antifungal activity was also tested against Candida albicans ATCC 10231 and Aspergillus niger ATCC 16404. The minimum inhibitory concentrations …

New Robust Estimation In Compound Exponential Weibull-Poisson Distribution For Both Contaminated And Non-Contaminated Data, Intisar Uraybi Fadam Al-Duri

Journal of Economics and Administrative Sciences

The research Compared two methods for estimating fourparametersof the compound exponential Weibull - Poisson distribution which are the maximum likelihood method and the Downhill Simplex algorithm. Depending on two data cases, the first one assumed the original data (Non-polluting), while the second one assumeddata contamination. Simulation experimentswere conducted for different sample sizes and initial values of parameters and under different levels of contamination. Downhill Simplex algorithm was found to be the best method for in the estimation of the parameters, the probability function and the reliability function of the compound distribution in cases of natural and contaminateddata.

Kajian Pragmatik Pada Kosakata Dan Fonetis Bahasa Penderita Afasia Global, Nugroho Ponco Santoso, Andayani Andayani, Budhi Setiawan

Bahasa dan Seni: Jurnal Bahasa, Sastra, Seni, dan Pengajarannya

Aphasia is a language disorder caused by brain injury. This study aimed at describing how the pragmatic process and forms on words and language phonemes of those suffering from global aphasia. The study is qualitative research using case study approach. The primary data on this study were collected by purposive sampling whose subject was a global aphasia sufferer who had obtained language rehabilitation during one-year period. The secondary data were taken by using in-depth interview with the family, therapist, and subject's neighborhood. The data were analyzed by comparing the in-depth interview result and the field notes of research. The result …

August 30, 2018, The Daily Mississippian

Daily Mississippian (all digitized issues)

No abstract provided.

Intramammary Infusion Of Casein Hydrolysate For Involution Of Single Mastitic Mammary Quarters Elevating Cow-Level Somatic Cell Count, Justine Britten, Kerry A. Rood, David J. Wilson

Animal, Dairy, and Veterinary Science Faculty Publications

Mastitis in a single quarter can cause high somatic cell counts (SCC), clinical mastitis, and death in dairy cows. Currently, management of these mastitic quarters presents a problem for the dairy industry. Casein hydrolysate (CH) is an intramammary (IMM) infusion treatment reported to induce mammary involution. The primary objectives of this study were to investigate whether IMM CH treatment of single high SCC quarters, followed by cessation of quarter milk production for the remainder of lactation, was effective in reducing cow–level SCC and whether that quarter resumed milk production following calving. Three treatment groups were used: CH, non-hydrolyzed casein (NHC), …

The Association Between Physical Inactivity And Obesity Is Modified By Five Domains Of Environmental Quality In U.S. Adults: A Cross-Sectional Study, Christine L. Gray, Lynne C. Messer, Kristen M. Rappazzo, Jyotsna S. Jagai, Shannon C. Grabich, Danelle T. Lobdell

OHSU-PSU School of Public Health Faculty Publications and Presentations

Physical inactivity is a primary contributor to the obesity epidemic, but may be promoted or hindered by environmental factors. To examine how cumulative environmental quality may modify the inactivity-obesity relationship, we conducted a cross-sectional study by linking county-level Behavioral Risk Factor Surveillance System data with the Environmental Quality Index (EQI), a composite measure of five environmental domains (air, water, land, built, sociodemographic) across all U.S. counties. We estimated the county-level association (N = 3,137 counties) between 2009 age-adjusted leisure-time physical inactivity (LTPIA) and 2010 age-adjusted obesity from BRFSS across EQI tertiles using multi-level linear regression, with a random intercept for …

Pengaruh Pembelajaran Diskusi Kelas Menggunakan Isu Sosiosains Terhadap Literasi Sains Mahasiswa Baru Pada Kemampuan Akademik Berbeda, Amining Rahmasiwi, Herawati Susilo, Hadi Suwono

Jurnal Pendidikan: Teori, Penelitian, dan Pengembangan

This study aims to determine the effect of class discussion with sosioscientific issue, difference in academic ability, and their interaction toward biology students’ science literacy in Universitas Negeri Malang. This study use a quasi experimental approach with pretest-posttest non-equivalent control group design. The subject consist of two high and low academic ability classes. The research data were collected using scientific literacy test. Scientific literacy data were analyzed using ANACOVA with 5% significant level. The result showed that the classroom discussion with socioscientific issue had significant effect in increasing students’ science literacy and potentially increasing the science literacy of low academic …

Pengembangan Paket Pembelajaran Berbasis Inkuiri Pada Mata Pelajaran Biologi Kelas X, Angga Tri Aditia Permana, I Nyoman Sudana Degeng, Sihkabuden Sihkabuden

Jurnal Pendidikan: Teori, Penelitian, dan Pengembangan

The development of this learning package aims to produce inquiry-based teaching materials, teacher guides, and appropriate student guides, and to determine their effectiveness in learning. Development of this learning package using the development model of learning package is tested in SMK-PP Negeri Banjarbaru on Biology-based learning inquiry in class X second semester. The validation of the product is done by three experts namely media experts, design experts, and material experts. The result of the research was obtained by the appropriate and effective learning package used in the learning.

Perangkat Pembelajaran Kecerdasan Eksistensial Dan Keterampilan Berpikir Kreatif Siswa Dalam Pembelajaran Biologi, Ratna Sari, Elsje Theodora Massawet, Muh. Amir Masruhim

Jurnal Pendidikan: Teori, Penelitian, dan Pengembangan

Goals of this analysis are to determine teacher’s understanding level related to learning tools that already exist, the appropriate application of learning models and problems of students. The samples in this analysis is the teacher of Senior High School students of biology and Natural Science in Samarinda. The results of analysis showed 88,88% of teachers have problems in applying the learning model, all teachers said students tend not to think critically in learning. The way that can be taken to overcome the problem is to apply the learning tool existential Intelligence, but no one of teachers understand the syntax of …

Leadership, Big Data, Digital Divide

JLAMS

No abstract provided.

Minor Review: An Overview Of A Synthetic Nanophase Bone Substitute, Steven J. Eppell, Weidong Tong, James Mcmasters, Yohannes Soenjaya, Anca M. Barbu, Alvin B. Ko, Jonathan Z. Baskin

Otolaryngology Articles

Material is reviewed that consists of reconstituted collagen fibril gel mineralized in a manner that produces biomimetically sized nanoapatites intimately associated with the fibrils. This gel is formed into usable shapes with a modulus and strength that allow it to be surgically press fitted into bony defects. The design paradigm for the material is that the nanoapatites will dissolve into soluble Ca²⁺ as the collagen is degraded into RGD-containing peptide fragments due to osteoclastic action. This is intended to signal to the osteoclasts to continue removing the material in a biomimetic fashion similar to bony remodeling. Preliminary experiments in …

Technology Integration: A Mixed Methods Study Of Best Practices Of Technology Integration As Perceived By Expert Middle School Teachers, Carliza Bataller

Dissertations

Purpose: The purpose of this mixed methods sequential explanatory study was to identify and describe best practices in technology integration in middle school classrooms as perceived by expert middle school teachers. Additionally, it was the purpose of the study to determine the most important best practices and perceived barriers to successful technology integration as perceived by expert middle school teachers.

Methodology: This study included a survey sent to 34 middle school teachers from five counties in northern California who were considered experts in technology integration. Data were gathered from the initial survey instrument and followed up by interviews with participant …

Occupancy And Habitat Use By Six Species Of Forest Ungulates On Tiwai Island, Sierra Leone, Kathryn R. Mccollum, Emily Belinfante, April L. Conway, John P. Carroll

School of Natural Resources: Faculty Publications

Forest ungulates in West Africa are common bushmeat species and are subject to habitat degradation through deforestation. Based on historical data, there are possibly 12 species of forest Bovidae and Tragulidae found in eastern Sierra Leone. We used camera trapping to assess occupancy by forest ungulates on and around a small protected area, Tiwai Island, Sierra Leone. We then assessed habitat over two field seasons during 2008–2011 for those species where we had sufficient numbers of detections. We detected 6 of 12 potential species and obtained enough data to further assess the habitat of two species. Species detected included the …

The Collegian: August 29, 2018, The Collegian Staff, South Dakota State University

The Collegian, 2018-2019

Volume: 134

Issue: 2

Electrical Conductivity Of Nutrient Solution Influenced Photosynthesis, Quality, And Antioxidant Enzyme Activity Of Pakchoi (Brassica Campestris L. Ssp. Chinensis) In A Hydroponic System, Xiaotao Ding, Yuping Jiang, Hong Zhao, Doudou Guo, Lizhong He, Fuguang Liu, Qiang Zhou, Dilip Nandwani, Dafeng Hui, Jizhu Yu

Agricultural and Environmental Sciences Faculty Research

To find an electrical conductivity (EC) in the nutrient solution used for pakchoi (Brassica campestris L. ssp. Chinensis) cultivation that optimizes the plant’s physiology, growth, and quality, we conducted an experiment with eight EC treatments (from EC0 to EC9.6) in a hydroponic production system (i.e. soilless culture) under greenhouse condition in Shanghai, China. Plants biomass production, leaf photosynthesis, vegetable quality variables, tissue nitrate and nitrite contents, and antioxidant enzyme activities were measured. The results showed that very high (EC9.6) or low EC (EC0-0.6) treatments clearly decreased plants fresh weight (FW) and dry weight (DW), leaf size, leaf water content, leaf …

Spartan Daily, August 29, 2018, San Jose State University, School Of Journalism And Mass Communications

Spartan Daily, 2018

Volume 151, Issue 4

The Importance Of Solvent Effects On The Mechanism Of The Pfeiffer Effect, Jamie Lunkley, Ngoc Nguyen, Kristina Tuminaro, Dana Margittai, Gilles Muller

Faculty Publications, Chemistry

The Pfeiffer effect is observed when an optically active compound such as an amino acid is introduced to a solution containing a labile racemic metal complex, and an equilibrium shift is obtained. The “perturbation” results in an excess of one enantiomer over the other. The shift is a result of a preferential outer sphere interaction between the introduced chiral species and one enantiomeric form (Λ or ∆) of a labile metal complex. Speculations regarding the mechanism of the Pfeiffer effect have attributed observations to a singular factor such as pH, solvent polarity, or numerous other intermolecular interactions. Through the use …

A Landscape-Level Assessment Of Whitebark Pine Regeneration In The Rocky Mountains, Usa, Sara A. Goeking, Deborah K. Izlar, Thomas C. Edwards Jr.

Wildland Resources Faculty Publications

Whitebark pine (Pinus albicaulis Engelm.) has recently experienced high mortality due to multiple stressors, and future population viability may rely on natural regeneration. We assessed whitebark pine seedling densities throughout the US Rocky Mountains and identified stand, site, and climatic variables related to seedling presence based on data from 1,217 USDA Forest Service Forest Inventory and Analysis plots. Although mean densities were highest in the whitebark pine forest type, 83% of sites with seedlings present occurred in non-whitebark pine forest types, and the highest densities occurred in the lodgepole pine forest type. To identify factors related to whitebark pine …

Genetics Of A De Novo Origin Of Undifferentiated Multicellularity, Matthew D. Herron, William C. Ratcliff, Jacob Boswell, Frank Rosenzweig

Biological Sciences Faculty Publications

The evolution of multicellularity was a major transition in evolution and set the stage for unprecedented increases in complexity, especially in land plants and animals. Here, we explore the genetics underlying a de novo origin of multicellularity in a microbial evolution experiment carried out on the green alga Chlamydomonas reinhardtii. We show that large-scale changes in gene expression underlie the transition to a multicellular life cycle. Among these, changes to genes involved in cell cycle and reproductive processes were overrepresented, as were changes to C. reinhardtii-specific and volvocine-specific genes. These results suggest that the genetic basis for the experimental evolution …

Theatre Uab Presents First Reading Of New Play "Ushuaia Blue" On Sept. 22, Shannon Thomason

Browse All News

No abstract provided.

Integrating Climate Forecasts With The Soil And Water Assessment Tool (Swat) For High-Resolution Hydrologic Simulations And Forecasts In The Southeastern U.S., Vinit Sehgal, Venkataramana Sridhar, Luke Juran, Jactone Arogo Ogejo

Faculty Publications

This study provides high-resolution modeling of daily water budget components at Hydrologic Unit Code (HUC)-12 resolution for 50 watersheds of the South Atlantic Gulf (SAG) region in the southeastern U.S. (SEUS) by implementing the Soil and Water Assessment Tool (SWAT) model in the form of a near real-time, semi-automated framework. A near real-time hydrologic simulation framework is implemented with a lead time of nine months (March-December 2017) by integrating the calibrated SWAT model with National Centers for Environmental Prediction coupled forecast system model version 2 (CFSv2) weather data to forecast daily water balance components. The modeling exercise is conducted as …

Recombinant Human Proteoglycan-4 Reduces Phagocytosis Of Urate Crystals And Downstream Nuclear Factor Kappa B And Inflammasome Activation And Production Of Cytokines And Chemokines In Human And Murine Macrophages, Marwa Qadri, Gregory D. Jay, Ling X. Zhang, Wendy Wong, Anthony M. Reginato, Changqi Sun, Tannin A. Schmidt

Pharmacy Faculty Articles and Research

Microbial biofilms are organized communities of cells that are associated with a wide spectrum of resistant and chronic infections that lead to the treatment failure. Accordingly, there is an urgent demand to create novel effective therapeutic drugs that can inhibit biofilm formation with new mechanisms of action to surmount the current escalating resistance. In this study, in silico hybrid model was utilized to develop three novel short linear peptides (4, 5, and 6) with potential biofilm inhibiting activities (scores > 1.0). The peptides were composed of cationic and hydrophobic residues. They were synthesized using solid-phase strategy. Synthesized peptides were purified and …

Ohio Welcomes Yutaka Hirata From Chubu University To Campus (August 29, 2018), University Communications And Marketing

OHIO News Articles Archive

No abstract provided.

Hypoglycemic, Hypolipidemic And Antioxidant Effects Of Iridoid Glycosides Extracted From: Corni Fructus: Possible Involvement Of The Pi3k-Akt/Pkb Signaling Pathway, Jiefang Kang, Chen Guo, Rodolfo Thome, Ning Yang, Yuan Zhang, Xing Li, Xiaoyan Cao

Department of Neurology Faculty Papers

Iridoid glycosides (CIG) are the major component of Corni fructus. In this work, we researched the antioxidative, hypoglycemic and lowering blood lipids effects of CIG on diabetic mice induced by a high-fat diet (HFD) and streptozotocin (STZ). Furthermore, to investigate the molecular mechanism of action, the phosphorylation and protein expression of phosphoinositide 3-kinase (PI3K) and its downstream proteins, such as insulin receptor (INSR), protein kinase B (Akt/PKB) and glucose transporter 4 (GLUT4) have been detected. The results showed that CIG significantly improved oral glucose tolerance in diabetic mice. Biochemical indices also revealed that CIG had a positive effect on lipid …

Coping With Chronic Fungal Rhinosinusitis: Diagnosis To Therapy, Veronica Corcino, Leslie Beavin, Shengli Lu, Ashley Ross, Carmen V. Sciortino Jr.

The University of Louisville Journal of Respiratory Infections

No abstract provided.

Metabolic Comparison Of One-Anastomosis Gastric Bypass, Single-Anastomosis Duodenal-Switch, Roux-En-Y Gastric Bypass, And Vertical Sleeve Gastrectomy In Rat, Deanna M. Arble, Simon S. Evers, Nadajda Bozadjieva, Henriette Frikke-Schmidt, Andriy Myronovych, Alfor Lewis, Mouhamadoul Habib Toure, Randy J. Seeley

Biological Sciences Faculty Research and Publications

Background

One-anastomosis gastric bypass (OAGB) and single-anastomosis duodenal switch (SADS) have become increasingly popular weight loss strategies. However, data directly comparing the effectiveness of these procedures with Roux-en-Y gastric bypass (RYGB) and vertical sleeve gastrectomy (SG) are limited.

Objectives

To examine the metabolic outcomes of OAGB, SADS, RYGB, and SG in a controlled rodent model.

Setting

Academic research laboratory, United States.

Methods

Surgeries were performed in diet-induced obese Long-Evans rats, and metabolic outcomes were monitored before and for 15 weeks after surgery.

Results

All bariatric procedures induced weight loss compared with sham that lasted throughout the course of the study. …

The Ecology Of A Tallgrass Treasure: Audubon’S Spring Creek Prairie, Paul A. Johnsgard

Zea E-Books Collection

This book describes the major plant and animal components of Spring Creek Prairie Audubon Center, an 850-acre National Audubon Society tallgrass prairie in Lancaster County, southeastern Nebraska. In addition to providing a species list of the area’s plants (368 species), there are comprehensive annotated lists of its birds (240), mammals (43), reptiles (23), and amphibians (10). There are also variably complete annotated lists of the area’s butterflies (76), sphinx moths (30), silk moths (7), dragonflies (24), damselflies (11), grasshoppers (9), katydids (11), mantids (2), and walkingsticks (2). Brief profiles of life histories and ecologies of 55 animal and 7 plant …