Digital Commons Network^™

Grant Funding Needs Parallel The Start-Up Venture: An Analogy For Translational Research Success, Brian W. Pogue

Dartmouth Scholarship

This editorial offers some ways to think about how best to position a research group for funding, by examining the parallels between what is needed for translational grants versus industry start-ups.

Giving The Noose The Slip: An Analysis Of Female Murderers In Oregon, 1854-1950, Jenna Leigh Barganski

Dissertations and Theses

Analyzing the crimes of women murderers and how they fared in the criminal justice system demonstrates that though perceptions of gender evolved, resistance to sentencing women to death often persisted. The nature of homicides committed by women in Oregon set them apart from their male counterparts. Women were, and are, more likely to commit domestic homicides -- murders that involve a family member or partner. These crimes are typically not equated with crimes that warrant capital punishment. As a result, no woman has been subjected to the death penalty in the state.

This thesis analyzes the twenty-five women who were …

Evaluating Alternative Options For Managing Nitrogen Losses From Corn Production, Jing Liu, Thomas W. Hertel, Laura Bowling, Sadia Jame, Christopher Kucharik, Navin Ramankutty

Purdue Policy Research Institute (PPRI) Policy Briefs

This brief focuses specifically on agriculture in the Midwest where excess nitrogen presents a significant challenge for water quality – both locally and in the Gulf of Mexico. While the Gulf Hypoxia Task Force has called for a 45% reduction in watershed nitrate loading across the Corn Belt, our business as usual mid-century projections show this rate rising, rather than falling. Therefore, this brief explores policies aimed at reducing nitrogen losses from farms in the region. These include (among others) adoption of best management practices, drainage management, wetland restoration, cap and trade policies and modification to the biofuel mandates. We …

Global Drivers Of Land And Water Sustainability Stresses At Mid-Century, Iman Haqiqi, Laura Bowling, Sadia Jame, Thomas W. Hertel, Uris Baldos, Jing Liu

Purdue Policy Research Institute (PPRI) Policy Briefs

We quantify the local stresses related to land, water and nitrate leaching (spatially resolved at ~10km x 10km cells) across the continental U.S. arising from expansion and intensification of agriculture between the present and 2050. The stresses are decomposed into those due to population and income growth, climate change, biofuel demands and productivity improvements – both in the U.S. and abroad. We also highlight how these local stresses depend on local climate, soils, nitrogen applications and irrigation practices and identify the tradeoffs associated with achieving individual sustainability objectives. For example, restricting irrigation expansion puts added pressure on non-irrigated cropland expansion …

St. Luke's Medical Center Cancer Annual Report-1994/1995, Advocate Aurora Health

Aurora St. Luke’s Medical Center Books, Documents, and Pamphlets

St. Luke's Medical Center: 1994/1995 Cancer Annual Report from St. Luke's Medical Center in Milwaukee, Wisconsin. Report includes articles, a listing of 1994 cancer committee members, a glossary of terms, a listing of cancer and tumor board conferences, along with a summary of cancer statistics. Article topics include skin cancer, Vince Lombardi Cancer Clinic, and support group opportunities.

St. Luke's Medical Center Cancer Annual Report-1997, Advocate Aurora Health

Aurora St. Luke’s Medical Center Books, Documents, and Pamphlets

St. Luke's Medical Center: 1997 Cancer Annual Report from St. Luke's Medical Center in Milwaukee, Wisconsin. Report includes articles, a listing of 1996 cancer committee members, 1996 cancer data review, a glossary of terms, a listing of cancer and tumor board conferences, along with a summary of cancer statistics. Article topics include head and neck cancers (along with recommended bone/tissue cancer treatments and therapies), Vince Lombardi Cancer Clinic, spiritual corner, support group opportunities, and community education events.

St. Luke's Medical Center Cancer Annual Report-1991, Advocate Aurora Health

Aurora St. Luke’s Medical Center Books, Documents, and Pamphlets

St. Luke's Medical Center: 1991 Cancer Annual Report from St. Luke's Medical Center in Milwaukee, Wisconsin. Report includes a list of cancer committee members as well as discussion about the following topics: lung cancer, radiation therapy technology, Vince Lombardi Cancer Clinic program review, prostate screening update, visiting nurses association hospice, and cancer support issues. The annual program supplement includes the cancer registry support, presentations and instructional sessions, and St. Luke's Medical Center Cancer Conferences.

St. Luke's Medical Center Cancer Annual Report-1992, Advocate Aurora Health

Aurora St. Luke’s Medical Center Books, Documents, and Pamphlets

St. Luke's Medical Center: 1992 Cancer Annual Report from St. Luke's Medical Center in Milwaukee, Wisconsin. Report includes a list of cancer committee members and glossary terms as well as discussion about the following topics: colon cancer, colorectal cancer, The Gastrointestinal Center, Surgical Oncology Roundtable Series, and a Melanoma vaccine. The annual program supplement includes the cancer registry report, presentations and instructional sessions, St. Luke's Medical Center Cancer Conferences, and community education events.

St. Luke's Medical Center Cancer Annual Report-1990, Advocate Aurora Health

Aurora St. Luke’s Medical Center Books, Documents, and Pamphlets

St. Luke's Medical Center: 1990 Cancer Annual Report from St. Luke's Hospital in Milwaukee, Wisconsin. Report includes a list of cancer committee members, comprehensive discussion of the care and treatment for prostrate cancer, new developments and current practices in cancer research, glossary of terms, conference listings, and an annual program supplement which includes cancer program statistics for 1990.

Western News, August, 30, 2018, Western Michigan University

Western News (1972-2018)

Vol. 45 No. 1

WMU goes all in to promote student success

New administrators named, VP search launched

Around campus and beyond

Summer News

Fall News

On Campus

Increasing Efforts In Ssma: What Does It Take?, Ursign Hofmann, Samuel Paunila, Katherine Prizeman

The Journal of Conventional Weapons Destruction

The inadequate management of conventional ammunition results in negative consequences such as diversion to illicit groups and unplanned explosions at munitions sites (UEMS). Both diversion and unintended blasts can result in a severe humanitarian impact, undermine development efforts, compromise defense capabilities, and lead to instability.

In recognition of this recurring danger, political, normative, and operational efforts have increased to promote the safe and secure management of ammunition (SSMA). As the issue enjoys greater national, regional, and international attention, stakeholders should simultaneously take stock of achievements, consider if current efforts address the challenges at hand, and appreciate what further steps are …

Prospectus, August 30, 2018, Parkland College, Ashley House, Emma Fleming, Paul Benson, Savannah Weishaar

Prospectus 2018

Fall semester at Parkland College in full swing; Astronomy Club: Students Reach for the Stars; Center for Academic Success Offers Faculty Tutoring to Students; Forgot your phone charger? The Parkland Library is here to help! Parkland women's soccer suffer defeat in season opener

Effects Of Organization And Disorganization On Pleasantness, Calmness, And The Frontal Negativity In The Event-Related Potential, Sandra Langeslag

Psychology Faculty Works

A preference for organization is associated with several disorders, but is widespread in the general population as well. It remains unclear whether organization and various degrees of disorganization elicit pleasant or unpleasant feelings (i.e., valence), calming or arousing feelings (i.e., arousal), and a frontal negativity in the event-related potential (ERP) related to cognitive control. This study tested how organization, slight disorganization, and total disorganization affect valence, arousal, and the frontal negativity. Participants passively viewed organized, slightly disorganized, totally disorganized, and control pictures while their electroencephalogram was recorded. They also rated the valence and arousal elicited by each picture and completed …

Mohlenkamp Is Associate Editor For Siam Journal On Matrix Analysis And Applications, Ohio University College Of Arts & Sciences

All Forum Articles

No abstract provided.

Near-Infrared Photothermal Release Of Sirna From The Surface Of Colloidal Gold-Silver-Gold Core-Shell-Shell Nanoparticles Studied With Second-Harmonic Generation, Raju R. Kumal, Mohammad Abu-Laban, Prakash Hamal, Blake Kruger, Holden T. Smith, Daniel J. Hayes, Louis H. Haber

Faculty Publications

© 2018 American Chemical Society. Photothermal release of oligonucleotides from the surface of plasmonic nanoparticles represents a promising platform for spatiotemporal controlled drug delivery. Here we demonstrate the use of novel gold-silver-gold core-shell-shell (CSS) nanoparticles to study the photothermal cleaving and release of micro-RNA (miRNA) mimics or small interfering RNA (siRNA) under near-infrared (NIR) irradiation. The furan-maleimide-based Diels-Alder adduct cleaves thermally above 60 °C and is used to bind siRNA to the colloidal nanoparticle surface in water. We investigate the photothermal cleaving kinetics of siRNA under different NIR laser powers using surface-sensitive time-dependent second-harmonic generation (SHG) spectroscopy. The photothermal release …

Aspen Recruitment In The Yellowstone Region Linked To Reduced Herbivory After Large Carnivore Restoration, Luke E. Painter, Robert L. Beschta, Eric J. Larsen, William J. Ripple

Aspen Bibliography

Quaking aspen (Populus tremuloides) recruitment during the 1980s–90s was suppressed by Rocky Mountain elk (Cervus canadensis) herbivory on winter ranges in the Yellowstone region, and saplings (young aspen taller than 2 m) were rare. Following the 1995–96 reintroduction of gray wolves (Canis lupus), browsing decreased and sapling recruitment increased in Yellowstone National Park. We compared aspen data from inside the park to data collected in three winter ranges outside the park. For most areas, the percentage of young aspen browsed annually was 80–100% in 1997–98, decreasing to 30–60% in 2011–15. Sapling recruitment was inversely …

Effects Of Stand Structure, Browsing, And Biophysical Conditions On Regeneration Following Mountain Pine Beetle In Mixed Lodgepole Pine And Aspen Forests Of The Southern Rockies, Kristen A. Pelz, Frederick W. Smith

Aspen Bibliography

Aspen (Populus tremuloides) and lodgepole pine (Pinus contorta var. latifolia) co-occur in the southern Rocky Mountains (USA), where mountain pine beetle (MPB, Dendroctonus ponderosae) has caused extensive lodgepole pine mortality since the late 1990s. Both species excel in post-disturbance high-light environments, but lodgepole pine has generally been thought to establish poorly on undisturbed seedbeds, and aspen suckering may be inhibited by intact aspen overstory. We ask whether lodgepole pine and aspen will regenerate in sufficient quantities to revegetate these forests. We visited a random sample of aspen and lodgepole pine stands across the affected landscape …

Updated Distributional Records Of Selected Kentucky Fishes, David J. Eisenhour, Matthew R. Thomas, J. Jacob Culp, Michael C. Compton, Stephanie L. Brandt, Rodney Pierce

Southeastern Fishes Council Proceedings

Distribution records for 15 fish species of conservation interest are included for Kentucky. Notropis dorsalis, previously undocumented in Kentucky, is reported for the first time (Mayfield Creek drainage). Also reported are state rediscoveries of three species thought to be extirpated from Kentucky: Ichthyomyzon gagei (Tennessee River drainage), Hemitremia flammea (Lower Cumberland and Green river drainages), and Hybopsis amnis (upper Cumberland River drainage). Unreported drainage records comprise nine species: Ichthyomyzon castaneus (Salt River drainage and Upper Green River drainage); Ichthyomyzon unicuspis (Salt River drainage and upper Big Sandy River drainage); Campostoma pullum (Tennessee River drainage); Umbra limi (Obion Creek drainage); …

Soft-Served Deserts: Soft Retributivism As A Free Will-Independent Alternative For The Criminal Justice System, Theodore Benson Randles

Catholic University Law Review

Human free will is foundational to our criminal justice system, yet contemporary scientific understanding casts doubt on a robust sense of human free will. If a person’s actions are wholly determined by the laws of physics, is that person morally deserving of punishment? This Article argues that our criminal justice system can be put on a footing that is not threatened by physical determinism. It suggests that a coherent system of criminal punishment can be founded on Daniel Farrell’s notion of “weak retributivism.” The Article build on Farrell’s work and develops a system built up from the universal right to …

Daily Eastern News: August 30, 2018, Eastern Illinois University

August

No abstract provided.

Interferon Priming Is Essential For Human Cd34+ Cell-Derived Plasmacytoid Dendritic Cell Maturation And Function, A. Lausten, R. O. Bak, C. Krapp, L. Kjær, J. H. Egedahl, C. C. Petersen, S. Pillai, H. Q. Tang, N. Uldbjerg, M. Porteus, N. R. Roan, M. Nyegaard, Paul W. Denton, M. R. Jakobsen

Biology Faculty Publications

Plasmacytoid dendritic cells (pDC) are essential for immune competence. Here we show that pDC precursor differentiated from human CD34+ hematopoietic stem and progenitor cells (HSPC) has low surface expression of pDC markers, and has limited induction of type I interferon (IFN) and IL-6 upon TLR7 and TLR9 agonists treatment; by contrast, cGAS or RIG-I agonists-mediated activation is not altered. Importantly, after priming with type I and II IFN, these precursor pDCs attain a phenotype and functional activity similar to that of peripheral blood-derived pDCs. Data from CRISPR/Cas9-mediated genome editing of HSPCs further show that HSPC-pDCs with genetic modifications can be …

Science And Startups, Jeremy Gasowski

UNH Today Archive

No abstract provided.

Multidomain Architecture Of Estrogen Receptor Reveals Interfacial Cross-Talk Between Its Dna-Binding And Ligand-Binding Domains, Wei Huang, Yi Peng, Janna G. Kiselar, Xuan Zhao, Aljawharah Albaqami, Daniel Mendez, Yinghua Chen, Hung-Ying Kao, Mark R. Chance, Sichun Yang

Faculty Scholarship

Human estrogen receptor alpha (hERα) is a hormone-responsive nuclear receptor (NR) involved in cell growth and survival that contains both a DNA-binding domain (DBD) and a ligand-binding domain (LBD). Functionally relevant inter-domain interactions between the DBD and LBD have been observed in several other NRs, but for hERα, the detailed structural architecture of the complex is unknown. By utilizing integrated complementary techniques of small-angle X-ray scattering, hydroxyl radical protein footprinting and computational modeling, here we report an asymmetric L-shaped “boot” structure of the multidomain hERα and identify the specific sites on each domain at the domain interface involved in DBD–LBD …

Anticoagulant And Antithrombotic Properties Of Three Structurally Correlated Sea Urchin Sulfated Glycans And Their Low-Molecular-Weight Derivatives, Ariana Vasconcelos, Isabela D. Sucupira, Alessandra L. Guedes, Ismael N. Queiroz, Flavia S. Frattani, Roberto J. Fonseca, Vitor H. Pomin

Faculty and Student Publications (Open Access)

The anticoagulant and antithrombotic properties of three structurally correlated sea urchin-derived 3-linked sulfated α-glycans and their low molecular-weight derivatives were screened comparatively through various in vitro and in vivo methods. These methods include activated partial thromboplastin time, the inhibitory activity of antithrombin over thrombin and factor Xa, venous antithrombosis, the inhibition of platelet aggregation, the activation of factor XII, and bleeding. While the 2-sulfated fucan from Strongylocentrotus franciscanus was observed to be poorly active in most assays, the 4-sulfated fucan from Lytechinus variegatus, the 2-sulfated galactan from Echinometra lucunter and their derivatives showed multiple effects. All marine compounds showed no …

Perangkat Pembelajaran Kecerdasan Eksistensial Dan Keterampilan Berpikir Kreatif Siswa Dalam Pembelajaran Biologi, Ratna Sari, Elsje Theodora Massawet, Muh. Amir Masruhim

Jurnal Pendidikan: Teori, Penelitian, dan Pengembangan

Goals of this analysis are to determine teacher’s understanding level related to learning tools that already exist, the appropriate application of learning models and problems of students. The samples in this analysis is the teacher of Senior High School students of biology and Natural Science in Samarinda. The results of analysis showed 88,88% of teachers have problems in applying the learning model, all teachers said students tend not to think critically in learning. The way that can be taken to overcome the problem is to apply the learning tool existential Intelligence, but no one of teachers understand the syntax of …

The Cowl - V.83 - N.1 - Aug 30, 2018

The Cowl

The Cowl - student newspaper of Providence College. Vol 83 - No. 1 - August 30, 2018. 24 pages.

Sources Of Students’ Difficulties In Learning Chemistry, David F. Treagust, Reinders Duit, Martina Nieswandt

Administration and Staff Articles and Research

Chemistry is a difficult subject to teach and to learn at both secondary and tertiary levels. Major learning difficulties are due to the particular views of chemistry phenomena that in many ways contradict intuitive and everyday views of the learners. As a result, major misunderstandings occur when students try to comprehend chemical explanations within the framework of their pre-instructional conceptions. This paper describes research findings on students’ pre-instructional conceptions in the domain of chemistry and on attempts to guide students from their conceptions to the core ideas of chemistry. Rather than providing an overview of students’ conceptions in various topics, …

Understanding The Death Of Massive Stars Using An Astrophysical Transients Observatory, Peter W. Roming, Eddie Baron, Amanda J. Bayless, Volker Bromm, Peter J. Brown, Michael W. Davis, Anastasia Fialkov, Brian Fleming, Kevin France, Chris L. Fryer, Thomas K. Greathouse, Jed J. Hancock, D. Andrew Howell, Andrew J. Levan, Abraham Loeb, Raffaella Margutti, Mark L. Mcconnell, Paul T. O'Brien, Julian P. Osborne, Daniel A. Perley, Eric M. Schlegel, Rhaana L. C. Starling, Nial R. Tanvir, Mark Tapley, Patrick A. Young, Bing Zhang

Physics & Astronomy Faculty Research

The death of massive stars, manifested as gamma-ray bursts and core-collapse supernovae, critically influence how the universe formed and evolves. Despite their fundamental importance, our understanding of these enigmatic objects is severely limited. We have performed a concept study of an Astrophysical Transient Observatory (ATO) that will rapidly facilitate an expansion of our understanding of these objects. ATO combines a very wide-field X-ray telescope, a near-infrared telescope, a multi-mode ultraviolet instrument, and a rapidly slewing spacecraft to realize two primary goals: (1) characterize the highest-redshift massive stars and their environments, and (2) constrain the poorly understood explosion mechanism of massive …

Relationships With Stakeholders In International Research Projects In Poland, Aleksandra Spik, Michał Mijal

European Management Studies

The paper investigates the main areas of friction between managers and stakeholders of scientific projects. Five areas are defined and examples of problems are given. Not unlike similar research in other countries, the main factors influencing the overall efficiency of the management process are: communication, lack of institutional support, attitudes towards the project, financing system and lack of industry interest. The findings and limitations are laid out and the ways of developing the research into other research projects are pointed out.

Are Enhanced Warfighters Weapons, Means, Or Methods Of Warfare?, Rain Liivoja, Luke Chircop

International Law Studies

Advances in science and technology have made it possible to improve the physical and cognitive capabilities of warfighters by biomedical interventions, such as the administration of drugs, the implantation of devices, and the magnetic stimulation of the brain. These advances raise the question as to whether enhanced warfighters ought to be considered weapons, means of warfare, or methods of warfare, for the purposes of the law of armed conflict. An affirmative answer to this question would make human enhancement subject to various restrictions arising from the law of armed conflict as well as arms control law. This article disagrees with …