Digital Commons Network^™

Joint Primare And Uk&Chn|Core Summer School Programme: Hydrodynamic Modelling And Well-Being In Engineering, C Perez-Collazo

More Faculty of Science and Engineering Research

This is the Programme of the joint PRIMaRE and UK&CNH|CORE Summer School

College Of Education News, College Of Education, Georgia Southern University

College of Education: News & Publications (2003-2023)

• COE welcomes new faculty and staff for 2018-19

St. Norbert College Students Present At 2018 Mathfest, St. Norbert College

Press Releases 2018

No abstract provided.

Maternal Experiences Of Intimate Partner Violence And C-Reactive Protein Levels In Young Children In Tanzania, Natalie Slopen, Jing Zhang, Samuel S. Urlacher, Gretchen De Silva, Mona Mittal

Publications and Research

Intimate partner violence (IPV) is a critical public health issue that impacts women and children across the globe.Prior studies have documented that maternal experiences of IPV are associated with adverse psychological and physical health outcomes in children; however, research on the underlying physiological pathways linking IPV to these conditions is limited. Drawing on data from the 2010 Tanzania Demographic and Health Survey, we examined the relationship between maternal report of IPV in the past 12 months and inflammation among children ages 6 months to 5 years. Our study included 503 children who were randomly selected to provide a blood sample …

Ubiquitin Receptor Rpn13 Mediates The Inhibitory Interaction Of Diphenyldihaloketones Clefma And Ef24 With The 26s Proteasome, Geeta Rao, Gregory Nkepang, Jian Xu, Hooman Yari, Hailey Houson, Chengwen Teng Pharm.D., Ph.D., Vibhudutta Awasthi

Faculty Publications

The proteasome is a validated target in drug discovery for diseases associated with unusual proteasomal activity. Here we report that two diphenyldihaloketones, CLEFMA and EF24, inhibit the peptidase activity of the 26S proteasome. The objective of this study was to investigate interaction of these compounds with the proteasome and identify a putative target within the protein components of the 26S proteasome. We employed standard fluorogenic peptide-based proteasome activity assay for trypsin-like, chymotrypsin-like, and caspase-like activities of human purified 26S proteasome in cell-free conditions. GFPu-1 and HUVEC cells were used as proteasome reporter cells. Direct binding studies used purified 19S, 20S, …

Disequilibrium, Adaptation, And The Norse Settlement Of Greenland, Rowan Jackson, Jette Arneborg, Andrew Dugmore, Christian Madsen, Tom Mcgovern, Konrad Smiarowski, Richard Streeter

Publications and Research

There is increasing evidence to suggest that arctic cultures and ecosystems have followed non-linear responses to climate change. Norse Scandinavian farmers introduced agriculture to sub-arctic Greenland in the late tenth century, creating synanthropic landscapes and utilising seasonally abundant marine and terrestrial resources. Using a niche-construction framework and data from recent survey work, studies of diet, and regional-scale climate proxies we examine the potential mismatch between this imported agricultural niche and the constraints of the environment from the tenth to the fifteenth centuries. We argue that landscape modification conformed the Norse to a Scandinavian style of agriculture throughout settlement, structuring and …

Susceptibility Genes To Plant Viruses, Hernan Garcia-Ruiz

Nebraska Center for Virology: Faculty Publications

Plant viruses use cellular factors and resources to replicate and move. Plants respond to viral infection by several mechanisms, including innate immunity, autophagy, and gene silencing, that viruses must evade or suppress. Thus, the establishment of infection is genetically determined by the availability of host factors necessary for virus replication and movement and by the balance between plant defense and viral suppression of defense responses. Host factors may have antiviral or proviral activities. Proviral factors condition susceptibility to viruses by participating in processes essential to the virus. Here, we review current advances in the identification and characterization of host factors …

Phylogenomic Evidence For Ancient Recombination Between Plastid Genomes Of The Cupressus-Juniperus-Xanthocyparis Complex (Cupressaceae), Andan Zhu, Weishu Fan, Robert P. Adams, Jeffrey P. Mower

Department of Agronomy and Horticulture: Faculty Publications

Background: Phylogenetic relationships among Eastern Hemisphere cypresses, Western Hemisphere cypresses, junipers, and their closest relatives are controversial, and generic delimitations have been in flux for the past decade. To address relationships and attempt to produce a more robust classification, we sequenced 11 new plastid genomes (plastomes) from the five variously described genera in this complex (Callitropsis, Cupressus, Hesperocyparis, Juniperus, and Xanthocyparis) and compared them with additional plastomes from diverse members of Cupressaceae.

Results: Phylogenetic analysis of protein-coding genes recovered a topology in which Juniperus is sister to Cupressus, whereas a tree based on …

Preservation Of Oncorhynchus Clarkii By Comparison Of Biomarkers, Chase Paulson, Dr. R. Paul Evans

Journal of Undergraduate Research

The purpose of this project is to analyze biomarkers present in cutthroat and cutbow (a mixture of cutthroat and rainbow trout) trout of the Payson Hatchery compared to typical cutthroat and rainbow markers to better understand if cutthroat trout are being preserved locally and in the Western United States.

The Effect Of The Overexpression Of Irf% In B-Cells On Inflammatory And Co-Stimulatory Activity, Reika Takita, Brian Poole

Journal of Undergraduate Research

Systemic Lupus Erythematosus is a chronic autoimmune disease characterized by inflammatory tissue damage inflicted by the body's rogue immune system (1). Although treatment is available for the disease, the pathogenesis of SLE remains unclear (2). However, researchers suspect the disease to be associated with environmental, genetic, and hormonal factors (1).

Environment And Past Land Use Together Predict Functional Diversity In A Temperate Forest, Meghna Krishnadas, Noelle G. Beckman, Jaun Carlos Peñagos Zuluaga, Yan Zhu, James Whitacre, John W. Wenzel, Simon A. Queenborough, Lize S. Comita

Biology Faculty Publications

Environment and human land use both shape forest composition. Abiotic conditions sift tree species from a regional pool via functional traits that influence species’ suitability to the local environment. In addition, human land use can modify species distributions and change functional diversity of forests. However, it is unclear how environment and land use simultaneously shape functional diversity of tree communities. Land-use legacies are especially prominent in temperate forest landscapes that have been extensively modified by humans in the last few centuries. Across a 900-ha temperate deciduous forest in the northeastern United States, comprising a mosaic of different-aged stands due to …

Reducing Sexual Victimization On College Campuses: The Impact Of A Collegiate-Level Human Sexual Behavior Course On Students’ Level Of Sexual Assertiveness, Ashlee D. Carter

Seton Hall University Dissertations and Theses (ETDs)

As the national conversation around the perpetration of sexual violence continues, research around sexual assault on college campuses continues to grow. By collecting both quantitative and qualitative data, this dissertation investigated the effects on students’ levels of sexual assertiveness, sexual awareness, communication skills, and sexual refusal skills as a result of taking a college-level human sexual behavior course. Through a lens of cognitive development theory and social cognitive theory, this study adds to the framework of promotion of cognitive development, which can assist in strengthening a young woman’s sexual assertiveness.

Results of this mixed methods analysis suggest that there is …

Membrane Expression Of Thymidine Kinase 1 And Potential Clinical Relevance In Lung, Breast, And Colorectal Malignancies, Evita G. Weagel, Weston Burrup, Roman Kovtun, Edwin J. Valazquez, Abigail M. Felsted, Michelle H. Townsend, Zachary E. Ence, Erica Suh, Stephen Piccolo, K. Scott Weber, Richard A. Robison, Kim Oneill

Faculty Publications

Background: Lung, breast, and colorectal malignancies are the leading cause of cancer-related deaths in the world causing over 2.8 million cancer-related deaths yearly. Despite efforts to improve prevention methods, early detection, and treatments, survival rates for advanced stage lung, breast, and colon cancer remain low, indicating a critical need to identify cancer-specific biomarkers for early detection and treatment. Thymidine kinase 1 (TK1) is a nucleotide salvage pathway enzyme involved in cellular proliferation and considered an important tumor proliferation biomarker in the serum. In this study, we further characterized TK1’s potential as a tumor biomarker and immunotherapeutic target and clinical relevance. …

Artibiotics: An Artificial Biology Musical Experiment, Er Miranda

School of Art, Design and Architecture

No abstract provided.

Toxoplasma Gondii Seropositivity And Substance Use In Us Adults, Bruce L. Brown, Andrew N. Berrett, Shawn D. Gale, Lance D. Erickson, Evan L. Thacker, Dawson W. Hedges

Faculty Publications

The intracellular parasite Toxoplasma gondii (Nicolle et Manceaux, 1908) infects humans resulting in acute toxoplasmosis, an infection that in immunocompetent people is typically mild but results in persistent latent toxoplasmosis. In that T. gondii appears to affect dopamine synthesis and because addicting drugs affect midbrain dopamine transmission, latent toxoplasmosis could influence substance use. Using both the third and continuous National Health and Nutrition Examination Surveys from the US Centers for Disease Control and Prevention, we used logistic regression to test for associations between T. gondii seropositivity and subject self-report of having ever used tobacco, alcohol, marijuana, cocaine, heroin, or methamphetamine. …

An Integrated Genomic Analysis Of Anaplastic Meningioma Identifies Prognostic Molecular Signatures., Grace Collord, Patrick Tarpey, Natalja Kurbatova, Inigo Martincorena, Sebastian Moran, Manuel Castro, Tibor Nagy, Graham Bignell, Francesco Maura, Md Young, Jorge Berna, Jose M.C. Tubio, Chris E. Mcmurran, Amh Young, Mathijs Sanders, Imran Noorani, Stephen J. Price, Colin Watts, Elke Leipnitz, Matthias Kirsch, Gabriele Schackert, Danita Pearson, Abel Devadass, Zvi Ram, V. Peter Collins, Kieren Allinson, Michael D. Jenkinson, Rasheed Zakaria, Khaja Syed, C. Oliver Hanemann, Jemma Dunn, Mw Mcdermott, Ramez W. Kirollos, George S. Vassiliou, Manel Esteller, Sam Behjati, Alvis Brazma, Thomas Santarius, U Mcdermott

Peninsula Medical School

Anaplastic meningioma is a rare and aggressive brain tumor characterised by intractable recurrences and dismal outcomes. Here, we present an integrated analysis of the whole genome, transcriptome and methylation profiles of primary and recurrent anaplastic meningioma. A key finding was the delineation of distinct molecular subgroups that were associated with diametrically opposed survival outcomes. Relative to lower grade meningiomas, anaplastic tumors harbored frequent driver mutations in SWI/SNF complex genes, which were confined to the poor prognosis subgroup. Aggressive disease was further characterised by transcriptional evidence of increased PRC2 activity, stemness and epithelial-to-mesenchymal transition. Our analyses discern biologically distinct variants of …

Wilberta Naden Pickett, Wilberta Naden Pickett '50

All oral histories

Bachelor of Music, IWU, 1950. According to the 1950 Wesleyana, she was a member of the Indee Women, Egas, Alpha Lambda Delta, Women's Chorus, Colleqiate Choir, University Chorus, Episcopoi, Sunday Evening Fellowship, Vesper Chairman, Vesper Organist, Park Hall President, and was in productions of "Faust" and "Of Thee I Sing."

Mrs. Pickett later attained the following additional accomplishments:

• Master of Sacred Music, Union Theological Seminary, 1952
• Choir Master degree, American Guild of Organists, 1956
• Certified Church Musician, Presbyterian Association of Musicians, 1978

A Culture Of Resistance: An Ethnography Of Tampa Bay’S Racial Justice Activist Community, Emily Janna Weisenberger

USF Tampa Graduate Theses and Dissertations

Racial justice activists in Tampa Bay comprise a community and culture structured as a movement of social transformation. Data from eleven interviews and more than 100 hours of participant observation show that activists consist of a diverse array of Tampa Bay residents of varying ages, genders, sexualities, racial/ethnic identities and livelihoods. This community is best described by their beliefs and practices of ideology steeped in intersectionality and anti-capitalism, and are motivated by or empathetic to racial injustices directly experienced by them or those around them. The intention of this paper is to describe activists as they are rather than as …

Medical School Watercooler Newsletter - September 9, 2018, Lindsey Lyle

Watercooler Newsletter

This is the September 9, 2018 edition of the Frederick P. Whiddon College of Medicine's newsletter - Watercooler.

Contents Include:

• USA Welcomes Nephrologist Dr. Emad Al Jaber to Internal Medicine
• Dr. James Toldi Joins USA Family Medicine
• Richard Trieu Participates in NIDDK Medical Student Research Program in Diabetes
• Pediatrics Grand Rounds Set for Sept. 21
• Dr. Perkins Receives HRSA Grant for Opioid Misuse Training
• USA Welcomes Cardiologist Dr. Farnoosh Rahimi to Internal Medicine
• USA Hosts Southern All of Us Network Regional Meeting

Morris Article Probes Role Of Appetite Regulation In Obesity Metabolic Disorders In Swordtail Fish, Ohio University College Of Arts & Sciences

All Forum Articles

No abstract provided.

Morris Coauthors Examine Reproductive Tactics Of Swordfish At Evolutionarily Stable State, Ohio University College Of Arts & Sciences

All Forum Articles

No abstract provided.

#Digitalactivism: Examining #Yesallwomen And Teaching Social Media Activism In Technical Communication, Karishma Verma

Theses and Dissertations

In May 2014, 22-year-old Elliot Rodger killed six people and injured fourteen others near

the University of California campus in Santa Barbara. A “hatred of women” was cited as the

reason for his crimes. This incident inspired the hashtag movement #YesAllWomen on social

media. Users shared examples of how although “not all men” engage in violent behaviors that

Rodger exhibited, all women go through their lives fearing. This thesis uses a technofeminist

framework to examine how the #YesAllWomen movement functioned as an online social

movement on Twitter to encourage conversation as well as promote change. I also discuss how

technical …

Arabic Translation, Validation And Cultural Adaptation Of The 7-Item Hamilton Depression Rating Scale In Two Community Samples, Ahmad N. Alhadi, Mohammed A. Alarabi, Abdulaziz T. Shuqdar, Raafat M., Mohammad T. Alsuwaidan, Roger S. Mcintyre

Sultan Qaboos University Medical Journal

Objectives: Depression is a common mental disorder, the severity of which is frequently assessed via interview-based clinical scales such as the 7-item Hamilton Depression Rating Scale (HAMD-7). The current study aimed to translate and examine the validity of an Arabic version of the HAMD-7 scale. Methods: This study took place between February and March 2016 in the Psychiatry Department of King Saud University, Riyadh, Saudi Arabia. The HAMD-7 scale was translated into Arabic using forward and backward translation methods. A total of 153 Arabic speakers were recruited to test the translated scale, including 57 medical students and 96 members of …

Pregnancy Anxiety Predicts Shorter Gestation In Latina And Non-Latina White Women: The Role Of Placental Corticotrophin-Releasing Hormone, Isabel F. Ramos, Christine M. Guardino, Maxwell Mansolf, Laura M. Glynn, Curt A. Sandman, Calvin J. Hobel, Christine Dunkel Schetter

Psychology Faculty Articles and Research

Objective

Previous research has shown that a woman’s anxiety about her pregnancy predicts gestational length. Placental corticotrophin-releasing hormone (CRH) is a stress-responsive peptide proposed as a mechanism. We examined placental CRH as a physiological mediator of the association between pregnancy anxiety and gestational length in Latina and non-Latina White women to replicate evidence of associations between pregnancy anxiety, placental CRH and gestational length; to test whether placental CRH levels or changes mediate effects of pregnancy anxiety on gestational length; to examine ethnic differences in pregnancy anxiety, placental CRH, and gestational length; and to explore whether the effects of pregnancy anxiety …

The Role Of N-Acetylcysteine Supplementation On The Oxidative Stress Levels, Genotoxicity And Lineage Commitment Potential Of Ex Vivo Murine Haematopoietic Stem/Progenitor Cells, Zariyantey A. Hamid, Hui Y. Tan, Paik W. Harto, Khairul Aw, Chin Y. Chan, Jamaludin Mohamed

Sultan Qaboos University Medical Journal

Objectives: The ex vivo maintenance of haematopoietic stem/progenitor cells (HSPCs) is crucial to ensure a sufficient supply of functional cells for research or therapeutic applications. However, when exposed to reactive oxygen species (ROS) in a normoxic microenvironment, HSPCs exhibit genomic instability which may diminish their quantity and quality. This study aimed to investigate the role of N-acetylcysteine (NAC) supplementation on the oxidative stress levels, genotoxicity and lineage commitment potential of murine haematopoietic stem/progenitor cells (HSPCs). Methods: This study was carried out at the Universiti Kebangsaan Malaysia, Kuala Lumpur, Malaysia, between June 2016 and July 2017. Bone marrow cells were isolated …

Evaluation Of Mitotic Figures And Cellular And Nuclear Morphometry Of Various Histopathological Grades Of Oral Squamous Cell Carcinoma: Comparative Study Using Crystal Violet And Feulgen Stains, Kashmira Kesarkar, Avinash Tamgadge, Treville Tamgadge, Sandhya, Swati Gotmare, Pooja Kamat

Sultan Qaboos University Medical Journal

Objectives: The objectives of this study were to quantitatively estimate the number of mitotic figures (MFs) and evaluate the cellular and nuclear features of various histological grades of oral squamous cell carcinoma (OSCC) using Feulgen and 1% crystal violet stains. Methods: This case-control study took place at the Dr D. Y. Patil Dental College & Hospital in Mumbai, Maharashtra, India, between June and December 2016. A total of 51 samples were retrieved from the hospital archives. Of these, 15 well-differentiated, 15 moderately-differentiated and six poorly-differentiated OSCC samples formed the case group while 15 samples of normal gingival mucosa constituted the …

Pepducin-Mediated Cardioprotection Via Β-Arrestin-Biased Β2-Adrenergic Receptor-Specific Signaling, Laurel A. Grisanti, Toby P. Thomas, Rhonda L. Carter, Claudio De Lucia, Erhe Gao, Walter J. Koch, Jeffrey L. Benovic, Douglas G. Tilley

Department of Biochemistry and Molecular Biology Faculty Papers

Reperfusion as a therapeutic intervention for acute myocardial infarction-induced cardiac injury itself induces further cardiomyocyte death. β-arrestin (βarr)-biased β-adrenergic receptor (βAR) activation promotes survival signaling responses in vitro; thus, we hypothesize that this pathway can mitigate cardiomyocyte death at the time of reperfusion to better preserve function. However, a lack of efficacious βarr-biased orthosteric small molecules has prevented investigation into whether this pathway relays protection against ischemic injury in vivo. We recently demonstrated that the pepducin ICL1-9, a small lipidated peptide fragment designed from the first intracellular loop of β2AR, allosterically engaged pro-survival signaling cascades in a βarr-dependent manner in …

Conservation Of Aquatic Biodiversity In The Context Of Multiple-Use Management On National Forest System Lands, Brett B. Roper, James M. Capurso, Yvette Paroz, Michael K. Young

Watershed Sciences Faculty Publications

The U.S. Department of Agriculture Forest Service (USFS) manages 193 million acres of public lands across 43 states and Puerto Rico. The original intent behind reserving lands managed by the USFS was to improve and protect forests, secure favorable conditions for water flows, and furnish a continuous supply of timber for the nation. Through time national forests have evolved, so they are managed for a broad array of uses. Differing expectations have led to conflicts between aquatic conservation and other aspects of the USFS’ mandate. In the 1990s, these conflicting goals came to a head with the listing of the …

Foliar Water Uptake: Processes, Pathways, And Integration Into Plant Water Budgets, Z. Carter Berry, Nathan C. Emery, Sybil G. Gotsch, Gregory R. Goldsmith

Biology, Chemistry, and Environmental Sciences Faculty Articles and Research

Nearly all plant families, represented across most major biomes, absorb water directly through their leaves. This phenomenon is commonly referred to as foliar water uptake. Recent studies have suggested that foliar water uptake provides a significant water subsidy that can influence both plant water and carbon balance across multiple spatial and temporal scales. Despite this, our mechanistic understanding of when, where, how, and to what end water is absorbed through leaf surfaces remains limited. We first review the evidence for the biophysical conditions necessary for foliar water uptake to occur, focusing on the plant and atmospheric water potentials necessary to …

Open Access At Mit And Beyond: A White Paper Of The Mit Ad Hoc Task Force On Open Access To Mit’S Research, Katharine Dunn, Hal Abelson, Chris Bourg, Ellen Finnie

Copyright, Fair Use, Scholarly Communication, etc.

MIT researchers, students, and staff have long valued and put into action MIT’s mission to generate and disseminate knowledge by openly and freely sharing research and educational materials. Indeed, the Institute has been at the forefront of the sharing culture: MIT launched OpenCourseWare (OCW), a free webbased publication of virtually all MIT course content in 2001; in 2002 released DSpace, an open-source platform for managing research materials and publications co-created by MIT Libraries staff; and adopted the first campus-wide faculty open access (OA) policy in the US in 2009.

Convening an open access task force was one of the 10 …