Digital Commons Network^™

Effective Treatment Of Ovarian Cancer Using Triciribine And Related Compounds, Jin Q. Cheng

USF Patents

The inventors have determined, contrary to the prior art and experience, how to successfully use triciribine to treat ovarian cancer by one or a combination of (i) administering triciribine only to patients which according to a diagnostic test described below, exhibit enhanced sensitivity to the drug; (ii) use of a described dosage level that minimizes the toxicity of the drug but yet still exhibits efficacy; or (iii) use of a described dosage regimen that minimizes the toxicity of the drug.

The Current Volume 29 : Issue 6, Nova Southeastern University

Student Newspapers

No abstract provided.

Experimental Evaluation Of The Importance Of Colonization History In Early-Life Gut Microbiota Assembly, Inés Martínez, Maria X. Maldonado-Gomez, João Carlos Gomes-Neto, Hatem Kittana, Hua Ding, Robert J. Schmaltz, Payal Joglekar, Roberto Jiménez Cardona, Nathan L Marsteller, Steven W. Kembel, Andrew K. Benson, Daniel A. Peterson, Amanda Ramer-Tait, Jens C. Walter

Department of Food Science and Technology: Faculty Publications

The factors that govern assembly of the gut microbiota are insufficiently understood. Here, we test the hypothesis that inter-individual microbiota variation can arise solely from differences in the order and timing by which the gut is colonized early in life. Experiments in which mice were inoculated in sequence either with two complex seed communities or a cocktail of four bacterial strains and a seed community revealed that colonization order influenced both the outcome of community assembly and the ecological success of individual colonizers. Historical contingency and priority effects also occurred in Rag1^-/- mice, suggesting that the adaptive immune system …

View Point: Gaps In The Current Guidelines For The Prevention Of Methicillin-Resistant Staphylococcus Aureus Surgical Site Infections, Kevin T. Kavanagh, Said Abusalem, Lindsay E. Calderon

EKU Faculty and Staff Scholarship

The authors advocate the addition of two preventative strategies to the current United State’s guidelines for the prevention of surgical site infections. It is known that Staphylococcus aureus, including Methicillin-resistant Staphylococcus aureus (MRSA), carriers are at a higher risk for the development of infections and they can easily transmit the organism. The carriage rate of Staph. aureus in the general population approximates 33%. The CDC estimates the carriage rate of MRSA in the United States is approximately 2%. The first strategy is preoperative screening of surgical patients for Staph. aureus, including MRSA. This recommendation is based upon the …

The Prospector, September 18, 2018, Utep Student Publications

The Prospector

Headline: Career Issue

Mismatch Repair Processing Of Dna Damage Causes Replication Stress, Dipika Gupta

Doctoral Dissertations

The DNA mismatch repair (MMR) pathway, a crucial post-replicative repair pathway, is essential to the maintenance of genomic stability. Consequentially, loss of MMR increases mutation frequency, promoting tumorigenesis. However, if and how MMR activity coordinates with cellular replication forks is unclear. Particularly, at forks encountering lesions that cannot be faithfully replicated, like O6-methylguanine (^MeG) lesions created by DNA alkylating agents, MMR-directed processing of resultant mismatches could disrupt fork progression. Yet the events following lesion recognition remain elusive. In transformed cells MMR-dependent ^MeG/T recognition in the first S phase elicits a permanent G₂ arrest in the subsequent …

Teacher Perceptions Of Students With Conduct Problems With And Without Callous Unemotional Traits, Casie L. Peet

USF Tampa Graduate Theses and Dissertations

Conduct problems describe behaviors that violate either age-appropriate societal norms or the rights of others. They include: physical or verbal aggression, theft, lying, arguing with authority, defiance, violation of rules, property destruction, fire setting, and truancy. Among youth with conduct problems, a subset display features known as callous-unemotional (CU) traits. CU traits, or interpersonal callousness, are exemplified in behaviors such as: (a) absence of remorse or guilt, (b) lack of empathy and, (c) callous use of others for personal gain (Frick & White, 2008). This study aims to fill the gap of examining these students in schools and which practices …

Web 2.0 & Public Health, Ubaid Ullah Shah

Library Philosophy and Practice (e-journal)

Abstract

Purpose: The purpose of the study is to know the awareness, usage, and impact of web 2.0 tools on the health of general public.

Design/methodology/approach: Questioners were prepared and distributed among the departments under applied sciences of the University of Kashmir. Simple random sampling technique was employed.

Findings: Although people are well aware of the term Web and Web 2.0 tools but least are these tools used for health purposes like self-diagnosis, self-medication, online doctor consultation etc. The study also reveals that usage of Web 2.0 tools helps in reducing the mental stress in common public.

Practical implications: Health …

Molecular Surveillance Of Respiratory Viruses With Bioaerosol Sampling In An Airport, E. S. Bailey, J. Y. Choi, J. Zemke, M. Yondon, G. C. Gray

Public Health

No abstract provided.

Cseas Weekly Bulletin (September 17, 2018), Center For Southeast Asian Studies

CSEAS Bulletin

No abstract provided.

Glutathione-Mediated Oxidative Response In Uvb-Irradiated Hacat Cells, Patrick Badger, Dr. Jason Hansen

Journal of Undergraduate Research

Ultraviolet light (UV) plays a critical role in the etiology of skin cancer, contributing to over 95% of both melanoma and non-melanoma diagnoses. It consists of several wavelengths, among which UVB is the most harmful, causing inflammation associated with sunburn and constituting the principal cause of skin cancer-related death.

Synchronization Of Energy Consumption By Human Societies Throughout The Holocene, Jacob Freeman, Jacopo A. Baggio, Erick Robinson, David A. Byers, Eugenia Gayo, Judson Byrd Finley, Jack A. Meyer, Robert L. Kelly, John M. Anderies

Sociology, Social Work and Anthropology Faculty Publications

We conduct a global comparison of the consumption of energy by human populations throughout the Holocene and statistically quantify coincident changes in the consumption of energy over space and time—an ecological phenomenon known as synchrony. When populations synchronize, adverse changes in ecosystems and social systems may cascade from society to society. Thus, to develop policies that favor the sustained use of resources, we must understand the processes that cause the synchrony of human populations. To date, it is not clear whether human societies display long-term synchrony or, if they do, the potential causes. Our analysis begins to fill this knowledge …

The Statesman, V. 62, I. 04, Stony Brook University

Stony Brook Statesman-Sucolian

v. 62, i. 04;

Triel-Bonded Complexes Between Trr3 (Tr = B, Al, Ga; R = H, F, Cl, Br, Ch3) And Pyrazine, Mariusz Michalczyk, Wiktor Zierkiewicz, Steve Scheiner

Chemistry and Biochemistry Faculty Publications

Complexes between TrR3 (Tr = B, Al, Ga; R= H, F, Cl, Br, CH3)molecules and pyrazine have been characterized at the MP2 and CCSD(T) levels of theory. The adducts can be grouped according to the type of molecular arrangement. The first situation places the Tr atom in the plane of the pyrazine ring and contains a triel bond to the N lone pair. For the boron complexes the orbital interaction energy is almost equal to the electrostatic component, while the former is only half the latter for Tr= Al and Ga. The two monomers are stacked above one another in …

Faculty Senate Executive Committee Agenda, September 17, 2018, Utah State University

Faculty Senate & Faculty Senate Executive Committee

• EPC Monthly Report - September 6, 2018
• EPC Annual Report
• Honors Annual Report
• Faculty Senate Meeting Time Change
• Code 403.3.1 Standards of Conduct-Faculty Responsibilities to Student
• Code 403.3.2 Standards of Conduct-Professional Obligations
• Code 407.1.1 Non-punitive Measures
• Code 407.11.2 Inquiry into Allegations of Violation Policies 407.8 and/or 407.9
• Code 407.11.3 Protection of Complainant and Others

September 2018 Cafe Newsletter, Center For Advancing Faculty Excellence

CAFE Faculty Newsletters

No abstract provided.

Comparative Investigations Of Social Context-Dependent Dominance In Captive Chimpanzees (Pan Troglodytes) And Wild Tibetan Macaques (Macaca Thibetana), Jake A. Funkhouser, Jessica A. Mayhew, Lori K. Sheeran, John B. Mulcahy, Jin-Hua Lee

All Faculty Scholarship for the College of the Sciences

Theoretical definitions of dominance, how dominance is structured and organized in nature, and how dominance is measured have varied as investigators seek to classify and organize social systems in gregarious species. Given the variability in behavioral measures and statistical methods used to derive dominance rankings, we conducted a comparative analysis of dominance using existing statistical techniques to analyze dominance ranks, social context-dependent dominance structures, the reliability of statistical analyses, and rank predictability of dominance structures on other social behaviors. We investigated these topics using behavioral data from captive chimpanzees (Pan troglodytes) and wild Tibetan macaques (Macaca thibetana). We used a …

Evaluating The Performance Of Gene-Based Tests Of Genetic Association When Testing For Association Between Methylation And Change In Triglyceride Levels At Gaw20, Jason Vander Woude, Jordan Huisman, Lucas Vander Berg, Jenna Veenstra, Abbey Bos, Anya Kalsbeek, Karissa Koster, Nathan Ryder, Nathan L. Tintle

Faculty Work Comprehensive List

Although methylation data continues to rise in popularity, much is still unknown about how to best analyze methylation data in genome-wide analysis contexts. Given continuing interest in gene-based tests for next-generation sequencing data, we evaluated the performance of novel gene-based test statistics on simulated data from GAW20. Our analysis suggests that most of the gene-based tests are detecting real signals and maintaining the Type I error rate. The minimum pvalue and threshold-based tests performed well compared to single-marker tests in many cases, especially when the number of variants was relatively large with few true causal variants in the set.

The Rider (2018-09-17), Victor G. Ramirez

The Rider Archives

Vol.4 No.4

Faculty Senate Executive Committee Minutes, September 17, 2018, Utah State University

Faculty Senate & Faculty Senate Executive Committee

• EPC Monthly Report – September 6, 2018 - Ed Reeve
• EPC Annual Report - Ed Reeve
• Honors Annual Report - Kris Miller
• Faculty Senate Meeting Time Change - Becki Lawver
• Nominating Committee Code
• Code 403.3.2 Standards of Conduct-Professional Obligations
• Code 407.1.1 Non-punitive Measures
• Code 407.11.2 Inquiry into Allegations of Violation Policies 407.8 and/or 407.9
• Code 407.11.3 Protection of Complainant and Others

Data For Gaw20: Genome-Wide Dna Sequence Variation And Epigenome-Wide Dna Methylation Before And After Fenofibrate Treatment In A Family Study Of Metabolic Phenotypes, Stella Aslibekyan, Laura Almasy, Michael A. Province, Devin M. Absher, Donna K. Arnett

Epidemiology and Environmental Health Faculty Publications

GAW20 provided participants with an opportunity to comprehensively examine genetic and epigenetic variation among related individuals in the context of drug treatment response. GAW20 used data from 188 families (N = 1105) participating in the Genetics of Lipid Lowering Drugs and Diet Network (GOLDN) study (clinicaltrials.gov identifier NCT00083369), which included CD4+ T-cell DNA methylation at 463,995 cytosine-phosphate-guanine (CpG) sites measured before and after a 3-week treatment with fenofibrate, single-nucleotide variation at 906,600 loci, metabolic syndrome components ascertained before and after the drug intervention, and relevant covariates. All GOLDN participants were of European descent, with an average age of …

Searching Images And The Meaning Of Alarm Calls, Alan B. Bond

Alan Bond Publications

The snake alarm call of Japanese tits prompts nesting adults to search for and mob the reptile until it is driven away. From playback experiments, Suzuki (2018) has inferred that the call provides an associative cue, evoking a searching image of the salient visual features of the predator—a novel approach to exploring visual attention and vocal communication in the wild.

Estimating Dominant Runoff Modes Across The Conterminous United States, Brian Buchanan, Daniel A. Auerbach, James Knighton, Darrick Evensen, Daniel R. Fuka, Zachary Easton, Michael Wieczorek, Josephine A. Archibald, Brandon Mcwilliams, Todd Walter

United States Geological Survey: Staff Publications

Effective natural resource planning depends on understanding the prevalence of runoff generating processes. Within a specific area of interest, this demands reproducible, straightforward information that can complement available local data and can orient and guide stakeholders with diverse training and backgrounds. To address this demand within the contiguous United States (CONUS), we characterized and mapped the predominance of two primary runoff generating processes: infiltration‐excess and saturation‐excess runoff (IE vs. SE, respectively). Specifically, we constructed a gap‐filled grid of surficial saturated hydraulic conductivity using the Soil Survey Geographic and State Soil Geographic soils databases. We then compared surficial saturated hydraulic conductivity …

Crow's Nest, September 17, 2018, Crow's Nest Staff

Crow's Nest

The September 17, 2018, issue of the Crow's Nest.

Longitudinal Data Methods For Evaluating Genome-By-Epigenome Interactions In Families, Justin C. Strickland, I-Chen Chen, Chanung Wang, David W. Fardo

Psychology Faculty Publications

Background: Longitudinal measurement is commonly employed in health research and provides numerous benefits for understanding disease and trait progression over time. More broadly, it allows for proper treatment of correlated responses within clusters. We evaluated 3 methods for analyzing genome-by-epigenome interactions with longitudinal outcomes from family data.

Results: Linear mixed-effect models, generalized estimating equations, and quadratic inference functions were used to test a pharmacoepigenetic effect in 200 simulated posttreatment replicates. Adjustment for baseline outcome provided greater power and more accurate control of Type I error rates than computation of a pre-to-post change score.

Conclusions: Comparison of all modeling approaches indicated …

Application Of Novel And Existing Methods To Identify Genes With Evidence Of Epigenetic Association: Results From Gaw20, Angga M. Fuady, Samantha Lent, Chloé Sarnowski, Nathan L. Tintle

Faculty Work Comprehensive List

Background: The rise in popularity and accessibility of DNA methylation data to evaluate epigenetic associations with disease has led to numerous methodological questions. As part of GAW20, our working group of 8 research groups focused on gene searching methods.

Results: Although the methods were varied, we identified 3 main themes within our group. First, many groups tackled the question of how best to use pedigree information in downstream analyses, finding that (a) the use of kinship matrices is common practice, (b) ascertainment corrections may be necessary, and (c) pedigree information may be useful for identifying parent-of-origin effects. Second, many groups …

Epigenome Wide Association Study Of Snp–Cpg Interactions On Changes In Triglyceride Levels After Pharmaceutical Intervention: A Gaw20 Analysis, Jenna Veenstra, Anya Kalsbeek, Karissa Koster, Nathan Ryder, Abbey Bos, Jordan Huisman, Lucas Vander Berg, Jason Vander Woude, Nathan L. Tintle

Faculty Work Comprehensive List

In the search for an understanding of how genetic variation contributes to the heritability of common human disease, the potential role of epigenetic factors, such as methylation, is being explored with increasing frequency. Although standard analyses test for associations between methylation levels at individual cytosine-phosphateguanine (CpG) sites and phenotypes of interest, some investigators have begun testing for methylation and how methylation may modulate the effects of genetic polymorphisms on phenotypes. In our analysis, we used both a genome-wide and candidate gene approach to investigate potential single-nucleotide polymorphism (SNP)–CpG interactions on changes in triglyceride levels. Although we were able to identify …

Carol Bruess Kicks Off St. Norbert College's Killeen Chair Lecture Series, St. Norbert College

Press Releases 2018

No abstract provided.

Intermittent Interfaces: Bioinspired Strategies Towards Material Resilience, H.Daniel Wagner, Israel Greenfeld, Wenyong Zhang, Xiaomeng Sui

IUTAM Symposium Architectured Materials Mechanics

No abstract provided.

Extending Origami: Crease Pre-Stressing For Functional Adaptation, Andres Arrieta, Jakob Faber, Katherine Riley, André Studart

IUTAM Symposium Architectured Materials Mechanics

No abstract provided.