Digital Commons Network^™

Daily Eastern News: September 25, 2018, Eastern Illinois University

September

No abstract provided.

Antibacterial S-Heterosubstituted Disulfides, Edward Turos, Praveen Ramaraju

USF Patents

Synthetically-derived S,S-heterodisubstituted disulfides that exhibit potent in vitro antibacterial activity against a variety of bacteria, including Staphylococcus aureus, methicillin-resistant Staphylococcus aureus and Francisella tularensis. The present invention provides compounds, methods and compositions effective to treat microbial/bacterial infections, and, especially, infections arising from bacteria which have developed resistance to conventional antibiotics.

Systems And Methods For Controlling The Spatial Distribution Of An Electromagnetic Field, Jose I. Rey, Richard Gilbert, John Anthony Llewellyn, Richard J. Connolly, Mark Jaroszeski, Andrew M. Hoff

USF Patents

In one embodiment, controlling the spatial distribution of an electromagnetic field in a system involves determining an inflection frequency for energy applied to the system below which a first spatial distribution results and above which a second spatial distribution results, selecting an excitation frequency to be used to generate an electromagnetic field to be applied to the system based upon the determined inflection frequency, and applying an electromagnetic field generated using the selected excitation frequency.

Systems And Methods For Performing Quantitative Phase-Contrast Confocal Microscopy, Changgeng Liu, Myung K. Kim

USF Patents

A system for performing quantitative phase-contrast confocal microscopy includes a light source that emits light, a first beam splitter that splits the emitted light into an illumination path and a hologram path, means provided along the illumination path for delivering a first part of the emitted light to an object as a collimated line, a light sensor that captures light reflected off of the object to obtain an intensity image for the collimated line, and means provided along the hologram path for delivering a second part of the emitted light to the light sensor at an off-axis angle to obtain …

Compositions, Methods Of Use, And Methods Of Treatment, Roman Manetsch, Lindsey Neil Shaw, Kurt Steven Van Horn, Whittney Nicole Burda

USF Patents

Embodiments of the present disclosure, in one aspect, relate to a 2,4-diaminoquinazoline compound, pharmaceutical compositions including a 2,4-diaminoquinazoline compound, methods of treatment of a condition (e.g., infection) or disease, methods of treatment using compositions or pharmaceutical compositions, and the like.

Solution And Solid-State Emission Toggling Of A Photochromic Hydrazone, Baihao Shao, Massimo Baroncini, Laura Bussotti, Mariangela Di Donato, Alberto Credi, Ivan Aprahamian

Dartmouth Scholarship

The proliferation of light-activated switches in recent years has enabled their use in a broad range of applications encompassing an array of research fields and disciplines. All current systems, however, have limitations (e.g., from complicated synthesis to incompatibility in biologically relevant media and lack of switching in the solid-state) that can stifle their real-life application. Here we report on a system that packs most, if not all, the desired, targeted and sought-after traits from photochromic compounds (bistability, switching in various media ranging from serum to solid-state, while exhibiting ON/OFF fluorescence emission switching, and two-photon assisted near-infrared light toggling) in an …

The Current Volume 29 : Issue 7, Nova Southeastern University

Student Newspapers

No abstract provided.

Independent - Sep. 25, 2018, Cecilia G Hernandez

The Independent (1988-present)

No abstract provided.

Editorial: Ion Channel Trafficking And Cardiac Arrhythmias, Marcel A. G. Van Der Heyden, Brian P. Delisle, Hugues Abriel

Physiology Faculty Publications

No abstract provided.

De Novo Sequence And Copy Number Variants Are Strongly Associated With Tourette Disorder And Implicate Cell Polarity In Pathogenesis, Sheng Wang, Jeffrey D. Mandell, Yogesh Kumar, Nawei Sun, Montana T. Morris, Juan Arbelaez, Cara Nasello, Shan Dong, Clif Duhn, Xin Zhao, Zhiyu Yang, Shanmukha S. Padmanabhuni, Dongmei Yu, Robert A. King, Andrea Dietrich, Najah Khalifa, Niklas Dahl, Alden Y. Huang, Benjamin M. Neale, Giovanni Coppola, Carol A. Mathews, Jeremiah M. Scharf, Tourette International Collaborative Genetics Study (Tic Genetics), Tourette Syndrome Genetics Southern And Eastern Europe Initiative (Tsgenesee), Tourette Association Of America International Consortium For Genetics (Taaicg), Thomas V. Fernandez, Joseph D. Buxbaum, Silvia De Rubeus, Dorothy E. Grice, Jinchuan Xing, Gary A. Heiman, Jay A. Tischfield, Peristera Paschou, A Jeremy Wilsey, Matthew W. State

Department of Biological Sciences Faculty Publications

We previously established the contribution of de novo damaging sequence variants to Tourette disorder (TD) through whole-exome sequencing of 511 trios. Here, we sequence an additional 291 TD trios and analyze the combined set of 802 trios. We observe an overrepresentation of de novo damaging variants in simplex, but not multiplex, families; we identify a high-confidence TD risk gene, CELSR3 (cadherin EGF LAG seven-pass G-type receptor 3); we find that the genes mutated in TD patients are enriched for those related to cell polarity, suggesting a common pathway underlying pathobiology; and we confirm a statistically significant excess of de novo …

Fine Mapping Of Mhc Region In Lung Cancer Highlights Independent Susceptibility Loci By Ethnicity, Aida Ferreiro-Iglesias, Corina Lesseur, James Mckay, Rayjean J. Hung, Younghun Han, Xuchen Zong, David Christiani, Mattias Johansson, Xiangjun Xiao, Yafang Li, David C. Qian, Xuemei Ji, Geoffrey Liu, Neil Caporaso, Ghislaine Scelo, David Zaridze, Anush Mukeriya, Milica Kontic, Simona Ognjanovic, Jolanta Lissowska, Małgorzata Szołkowska, Beata Swiatkowska, Vladimir Janout, Ivana Holcatova, Ciprian Bolca, Milan Savic, Miodrag Ognjanovic, Stig Egil Bojesen, Xifeng Wu, Demetrios Albanes, Susanne M. Arnold

Markey Cancer Center Faculty Publications

Lung cancer has several genetic associations identified within the major histocompatibility complex (MHC); although the basis for these associations remains elusive. Here, we analyze MHC genetic variation among 26,044 lung cancer patients and 20,836 controls densely genotyped across the MHC, using the Illumina Illumina OncoArray or Illumina 660W SNP microarray. We impute sequence variation in classical HLA genes, fine-map MHC associations for lung cancer risk with major histologies and compare results between ethnicities. Independent and novel associations within HLA genes are identified in Europeans including amino acids in the HLA-B*0801 peptide binding groove and an independent HLA-DQB1*06 loci group. In …

Executive Committee - Agenda, 9/25/2018, Academic Senate

Academic Senate Agendas

No abstract provided.

Physiological And Behavioral Plasticity Of The Sea Cucumber Holothuria Forskali (Echinodermata, Holothuroidea) To Acidified Seawater, Xiutang Yuan, Sophie J. Mccoy, Yongfen Du, Stephen Widdicombe, Jason M. Hall-Spencer

School of Biological and Marine Sciences

No abstract provided.

Biotechnology Research Pattern In Four Saarc Countries From 2007 To 2016, Manendra Singh Mr.

Library Philosophy and Practice (e-journal)

The study presents the trends in authorship pattern and author collaborative in the Biotechnology research field with the sample of 18119 articles which collected from Scopus database for the year 2007 to 2016. The search string used for data download is same for all country and all data downloaded for each country. The three scientometric tools; Collaboration Coefficient, Authorship pattern and Activity Index have been used for the data analysis. The multi- authorship articles are greater than single authorship. The study found that the researchers in Biotechnology move towards team research or group research rather than solo research. The average …

Moisture Robustness Of Eaves Solutions For Ventilated Roofs – Experimental Studies, Steinar Grynning, Silje Kathrin Asphaug, Lars Gullbrekken, Berit Time

International Building Physics Conference 2018

Ventilated pitched wooden roofs with eaves (roof overhangs) is a common building practice in the Scandinavian countries. The eaves are protecting the façade from rain, wind driven rain (WDR) and snow, and it covers the roof ventilation aperture. The eaves should be designed so that the least possible amounts of rainwater and snow enters the ventilation aperture between the roof cladding- and underlayer roofing. At the same time, adequate ventilation of the roof must be ensured to promote proper drying-out capabilities of the roof and to avoid problems of snow melt and ice formation at eaves and gutters during winter …

Towards A New Way Of Capturing Occupant Well-Being, Mark Allen, Mauro Overend

International Building Physics Conference 2018

Occupant well-being is undergoing a surge of interest in both the research community and industry, as the potential benefits of increased levels of well-being become better quantified and understood. Well-being science itself is also constantly evolving, moving from the traditional negative view of depression and mental disorders as markers of well-being, towards the more positive notion of flourishing, which is feeling good and functioning well. This paper first sets out the key elements of well-being, as found in psychology literature. Surveys and interviews are the main methods used to capture the well-being of individuals and populations, yet completion rates can …

Experimental Analysis Of Micro-Cracks On The Change Of Moisture Transport Properties Of Aac, Jiří Maděra, Jan Kočí, Václav Kočí, Miloš Jerman, Magdaléna Doleželová

International Building Physics Conference 2018

In this paper, series of experiment measurements is carried out in order to study effect of freeze/thaw loading on the change of moisture transport properties of autoclaved aerated concrete. The samples were subjected to 15, 30 and 45 freeze/thaw cycles and subsequently basic physical properties, pore size distribution and water vapor and liquid water transport properties were investigated. The results showed significant changes in material properties of the material. The results of this research can be further implemented into computational models in order to bring the simulation results closer to the reality.

Extracting Radiant Cooling From Building Exhaust Air Using The Maisotsenko Cycle Principle, Théo Keeley-Leclaire, Eric Teitelbaum, Suin Shim, Michael Bozlar, Howard A. Stone, Forrest Meggers

International Building Physics Conference 2018

Indirect evaporative cooling has exciting implications for air based thermal comfort. With recent advances in the research and commercialization of Maisotsenko Cycle (M-Cycle), or dew-point, evaporative cooling, thermodynamics can be fully leveraged to provide effectively free air cooling. However, few studies seek to generate cool surfaces by evaporation for radiant cooling. As a method to reduce building energy consumption, such an evapo-radiative system would maintain occupant thermal comfort at higher ventilation air temperatures and provide cooling at low cost. This study explores an analytical model for an M-Cycle evapo-radiative cooling system that derives a 1-D temperature profile throughout an experimental …

Polyestyrene And Low Density Polyethylene Oregano´S Essential Oil Functionalization For Possible Antimicrobial Active Packaging Applications, Edgar Díaz-Acosta, Claudia Rodríguez-González, Laura Valencia-Gómez, Santos Adriana Martel-Estrada, Maria Hernández-González, Hortensia Reyes-Blas, Imelda Olivas Armendáriz 1761524

Journal of Applied Packaging Research

Low density polyethylene (LDPE) and polystyrene (PS) samples were functionalized with oregano´s essential oil (OEO) for possible antimicrobial packing applications. Different concentrations of OEO were used (0.5-1.5 % v/v). Polymers were UV light irradiated during 60 min to improve the OEO adhesion through the polar groups (COOH, OH or COO-) generation on their surface. The effect of OEO different concentration on their antimicrobial activity, mechanical properties and cytotoxicity of the functionalized polymers were analyzed. All functionalized samples showed antimicrobial activity against Gram positive and Gram negative bacteria and this activity increased with OEO concentration. The addition of OEO did not …

Searching For The Parental Causes Of The School-To-Prison Pipeline Problem: A Critical, Conceptual Essay, Reginald Leamon Robinson

Journal of Civil Rights and Economic Development

(Abstract)

In this critical, conceptual essay, the author argues that the School-to-Prison Pipeline (“STPP”) simply does not exist. Long before Columbine and the enactment of zero tolerance, caregivers have been wrongly harming their children, something causing them toxic stress that triggers their stress-response system, and making it nigh impossible for children easily ensnared by suspensions, expulsions, referrals to alternative schools, and SRO arrests to have the best developmental start and cognitive abilities to succeed in public schools. Further, teachers and administrators who are pressured to report great educational metrics, and for their own childhood reasons have a near inflexible need …

Rational Selection Of Experimental Readouts For Hygric Material Characterisation, Evy Vereecken, Hans Janssen, Staf Roels

International Building Physics Conference 2018

No abstract provided.

Marine Biodiversity: A Larval Perspective Bio 425g, Michael Cerbo

Library Impact Statements

No abstract provided.

Curricular Changes Proposed For 2019-2021 Morris Catalog, Curriculum Committee

Curriculum Committee Reports

No abstract provided.

Demonstrating The Efficacy Of The Health Sciences And Technology Academy: Using Archival Standardized Test Scores To Analyze An Ost College-Preparatory Program For Underserved Youth, Feon Smith, Sherron Mckendall, Ann Chester, Bethany Hornbeck, Alan Mckendall

Faculty & Staff Scholarship

To combat educational and health disparities, out-of-school-time (OST) STEM enrichment programs provide services to underserved youth to encourage them to pursue college and health careers. This article describes a study conducted to determine if the Health Sciences and Technology Academy (HSTA) program participants who receive year-round educational interventions to prepare them for STEM and health sciences majors performed better on the West Virginia Educational Standards Test (WESTEST2) than non-participants. This study provides descriptive and inferential statistics, specifically one-way ANOVAs with one-to-one matching based on grade level, gender, race, and GPA at the end of the 8th grade year for 336 …

Eumeces Fasciatus, Roger W. Barbour

Roger W. Barbour Slide Collection

Eumeces fasciatus

New Functions For The Proprioceptive System In Skeletal Biology, Ronen Blecher, Lia Heinemann-Yerushalmi, Eran Assaraf, Nitzan Konstantin, Jens R. Chapman, Timothy C. Cope, Guy S. Bewick, Robert W. Banks, Elazar Zelzer

Neuroscience, Cell Biology & Physiology Faculty Publications

Muscle spindles and Golgi tendon organs (GTOs) are two types of sensory receptors that respond to changes in length or tension of skeletal muscles. These mechanosensors have long been known to participate in both proprioception and stretch reflex. Here, we present recent findings implicating these organs in maintenance of spine alignment as well as in realignment of fractured bones. These discoveries have been made in several mouse lines lacking functional mechanosensors in part or completely. In both studies, the absence of functional spindles and GTOs produced a more severe phenotype than that of spindles alone. Interestingly, the spinal curve phenotype, …

Griffithsin Carrageenan Fast Dissolving Inserts Prevent Shiv Hsv-2 And Hpv Infections In Vivo, Nina Derby, Manjari Lal, Meropi Aravatinou, Larisa Kizima, Patrick Barnable, Axia Rodriguez, Manshun Lai, Asa Wesenberg, Shweta Ugaonkar, Keith Levendosky, Olga Mizenina, Kyle Kleinbeck, Jeffrey D. Lifson, M. Melissa Peet, Zachary Lloyd, Michael Benson, Walid Heneine, Barry R. O'Keefe, Melissa Robbiani, Elena Martinelli, Brooke Grasperge, James Blanchard, Agegnehu Gettie, Natalia Teleshova, José Fernández-Romero, Thomas M. Zydowsky

Publications and Research

Human immunodeficiency virus (HIV) pre-exposure prophylaxis (PrEP) strategies with proven in vivo efficacy rely on antiretroviral drugs, creating the potential for drug resistance and complicated treatment options in individuals who become infected. Moreover, ondemand products are currently missing from the PrEP development portfolio. Griffithsin (GRFT) is a non-antiretroviral HIV entry inhibitor derived from red algae with an excellent safety profile and potent activity in vitro. When combined with carrageenan (CG), GRFT has strong activity against herpes simplex virus-2 (HSV-2) and human papillomavirus (HPV) in vitro and in vivo. Here, we report that GRFT/CG in a freeze-dried fast dissolving insert (FDI) …

The Statesman, V. 62, I. 05, Stony Brook University

Stony Brook Statesman-Sucolian

v. 62, i. 05;

Prevention And Therapy May Be The Key To Slowing Down How We Age Successfully, Alicia Rohan

Browse All News

No abstract provided.

Bone Morphogenetic Protein Signaling Is Required For Rad51-Mediated Maintenance Of Genome Integrity In Vascular Endothelial Cells, Sanna Vattulainen-Collanus, Mark Southwood, Xu Dong Yang, Stephen Moore, Prajakta Ghatpande, Nicholas W. Morrell, Giorgio Lagna, Akiko Hata

Biology

The integrity of blood vessels is fundamental to vascular homeostasis. Inactivating mutations in the bone morphogenetic protein (BMP) receptor type II (BMPR2) gene cause hereditary vascular disorders, including pulmonary arterial hypertension and hereditary hemorrhagic telangiectasia, suggesting that BMPR2 and its downstream signaling pathway are pivotal to the maintenance of vascular integrity through an unknown molecular mechanism. Here we report that inactivation of BMPR2 in pulmonary vascular endothelial cells results in a deficit of RAD51, an enzyme essential for DNA repair and replication. Loss of RAD51, which causes DNA damage and cell death, is also detected in animal models and human …