Digital Commons Network^™

Using Non Stem-Cells To Understand Early Tumor Growth, Jake Hogan, Heiko Enderling, Joel Brown, Robert A. Gatenby

Library/Life Sciences Undergraduate Poster Competition 2018

Tumors of similar size and shape can exhibit different responses to the same treatment. Targeted therapy aims to better treat these tumors by classifying them according to genotypic traits. A better understanding of how tumor traits such as non-stem cells influence tumor growth could improve targeted therapy. We hypothesize that the production of non-stem cells may aid tumor growth in avascular tumors (tumors lacking blood vessels).

Honor And Violence: An Account Of Feuds, Duels, And Honor Killings, John Thrasher, Toby Handfield

Philosophy Faculty Articles and Research

We present a theory of honor violence as a form of costly signaling. Two types of honor violence are identified: revenge and purification. Both types are amenable to a signaling analysis whereby the violent behavior is a signal that can be used by out-groups to draw inferences about the nature of the signaling group, thereby helping to solve perennial problems of social cooperation: deterrence and assurance. The analysis shows that apparently gratuitous acts of violence can be part of a system of norms that are Pareto superior to alternatives without such signals. For societies that lack mechanisms of governance to …

Relationships Between The Digit Ratio (2d:4d) And Game‐Related Statistics In Professional And Semi‐Professional Male Basketball Players, Katelyn L. Klapprodt, John S. Fitzgerald, Sandra E. Short, John T. Manning, Grant R. Tomkinson

Education, Health & Behavior Studies Faculty Publications

Objectives

The primary aim of this study was to examine relationships between digit ratio (2D:4D) and game‐related statistics in professional and semi‐professional male basketball players. The secondary aim was to quantify differences in mean 2D:4Ds between starting and reserve players.

Methods

Using a cross‐sectional design, 93 male basketball players from the professional Australian National Basketball League and the semi‐professional South Australian Premier League were measured in‐season for height, mass, and 2D:4D, with game‐related statistics collected end‐season. Linear relationships between right and left 2D:4Ds and game‐related statistics were quantified using nonparametric partial correlations, and differences in mean 2D:4Ds between starting and …

Daily Eastern News: September 24, 2018, Eastern Illinois University

September

No abstract provided.

Lateral Eyes Direct Principal Eyes As Jumping Spiders Track Objects, Elizabeth M. Jakob, Skye M. Long, Duane P. Harland, Robert R. Jackson, Ashley Carey, Mary Emma Searles, Adam H. Porter, Cristina Canavesi, Jannick P. Rolland

All Peer-Reviewed Publications

One way of circumventing the functional tradeoffs on eye design [1,2] is to have different eyes for different tasks. For example, jumping spiders (Salticidae), known for elaborate, visually guided courtship and predatory behavior [3], view the same object simultaneously with two of their four pairs of eyes: the antero-lateral eyes (ALEs) and the principal eyes (reviewed in [2]; Figure 1A). The ALEs, with immobile lenses and retinas, wide fields of view, and hyperacute sensitivity to moving stimuli [4], are structurally distinct from the principal eyes, which have the best spatial acuity known for terrestrial invertebrates and can discern fine details …

Managing Diffuse Phosphorus At The Source Versus At The Sink, Katrina A. Macintosh, Brooke K. Mayer, Richard W. Mcdowell, Stephen M. Powers, Lawrence A. Baker, Treavor H. Boyer, Bruce E. Rittmann

Civil and Environmental Engineering Faculty Research and Publications

Judicious phosphorus (P) management is a global grand challenge and critical to achieving and maintaining water quality objectives while maintaining food production. The management of point sources has been successful in lowering P inputs to aquatic environments, but more difficult is reducing P discharges associated with diffuse sources, such as nonpoint runoff from agriculture and urban landscapes, as well as P accumulated in soils and sediments. Strategies for effective diffuse-P management are imperative. Many options are currently available, and the most cost-effective and practical choice depends on the local situation. This critical review describes how the metrics of P quantity …

Ohio Has Many Majors Inspired By Health And Fitness (September 24, 2018), University Communications And Marketing

OHIO News Articles Archive

No abstract provided.

Noncontact Speckle Contrast Diffuse Correlation Tomography Of Blood Flow Distributions In Tissues With Arbitrary Geometries, Siavash Mazdeyasna, Chong Huang, Mingjun Zhao, Nneamaka B. Agochukwu, Ahmed A. Bahrani, Lesley Wong, Guoqiang Yu

Biomedical Engineering Faculty Publications

A noncontact electron multiplying charge-coupled-device (EMCCD)-based speckle contrast diffuse correlation tomography (scDCT) technology has been recently developed in our laboratory, allowing for noninvasive three-dimensional measurement of tissue blood flow distributions. One major remaining constraint in the scDCT is the assumption of a semi-infinite tissue volume with a flat surface, which affects the image reconstruction accuracy for tissues with irregular geometries. An advanced photometric stereo technique (PST) was integrated into the scDCT system to obtain the surface geometry in real time for image reconstruction. Computer simulations demonstrated that a priori knowledge of tissue surface geometry is crucial for precisely reconstructing the …

The Daily Gamecock, Monday, September 24, 2018, University Of South Carolina, Office Of Student Media

September

No abstract provided.

The Chapman Bone Algorithm: A Diagnostic Alternative For The Evaluation Of Osteoporosis, Elise Levesque, Anton Ketterer, Wajiha Memon, Cameron James, Noah Barrett, Cyril Rakovski, Frank Frisch

Mathematics, Physics, and Computer Science Faculty Articles and Research

Osteoporosis is the most common metabolic bone disease and goes largely undiagnosed throughout the world, due to the inaccessibility of DXA machines. Multivariate analyses of serum bone turnover markers were evaluated in 226 Orange County, California, residents with the intent to determine if serum osteocalcin and serum pyridinoline cross-links could be used to detect the onset of osteoporosis as effectively as a DXA scan. Descriptive analyses of the demographic and lab characteristics of the participants were performed through frequency, means and standard deviation estimations. We implemented logistic regression modeling to find the best classification algorithm for osteoporosis. All calculations and …

From 14 To 64, Um Freshman Class Spans The Ages, Michael Newsom

University of Mississippi News

Gifted teen, veteran highlight wide range of educational opportunities

The Guardian, Week Of September 24, 2018, Wright State University Student Body

The Guardian Student Newspaper

News articles from The Guardian for the week of September 24, 2018. The Guardian is the official student-run newspaper for Wright State University. It has been published regularly since March of 1965.

Efforts Towards The Discovery Of Novel Methods For The Synthesis Of Pharmacologically Relevant Molecular Scaffolds, Graham Joseph Haun

Theses and Dissertations

With the introductions of pharmaceuticals into modern day society many people have been using them to improve their lives. Due to this high increase in demand along with the ever-growing concern of environmental impact pharmaceutical companies have been pressed to synthesis new and existing drugs at a higher rate. This increased rate can cause low yield drugs or have a heavy environmental impact. As the use of pharmaceuticals becomes more widespread the need for greener and simpler organic synthesis methods to make these pharmaceuticals becomes more needed.

Herein is reported the methodological development of different pharmacologically relevant scaffolds. This work …

Characterization Of The Neuroinflammatory Response To Thiol-Ene Shape Memory Polymer Coated Intracortical Microelectrodes, Andrew J. Shoffstall, Marina Yu, Jennifer E. Paiz, Elizabeth Mancuso, Hillary W. Bedell, Jeffrey R. Capadona

Faculty Scholarship

Thiol-ene based shape memory polymers (SMPs) have been developed for use as intracortical microelectrode substrates. The unique chemistry provides precise control over the mechanical and thermal glass-transition properties. As a result, SMP substrates are stiff at room temperature, allowing for insertion into the brain without buckling and subsequently soften in response to body temperatures, reducing the mechanical mismatch between device and tissue. Since the surface chemistry of the materials can contribute significantly to the ultimate biocompatibility, as a first step in the characterization of our SMPs, we sought to isolate the biological response to the implanted material surface without regards …

Vertical Foraging Shifts In Hawaiian Forest Birds In Response To Invasive Rat Removal, Erin E. Wilson Rankin, Jessie L. Knowlton, Daniel S. Gruner, David J. Flaspohler, Christian P. Giardina, Devin R. Leopold, Anna Buckardt, William C. Pitt, Tadashi Fukami

Michigan Tech Publications, Part 1

Worldwide, native species increasingly contend with the interacting stressors of habitat fragmentation and invasive species, yet their combined effects have rarely been examined. Direct negative effects of invasive omnivores are well documented, but the indirect effects of resource competition or those caused by predator avoidance are unknown. Here we isolated and examined the independent and interactive effects of invasive omnivorous Black rats (Rattus rattus) and forest fragment size on the interactions between avian predators and their arthropod prey. Our study examines whether invasive omnivores and ecosystem fragment size impact: 1) the vertical distribution of arthropod species composition and …

Marine Threats Overlap Key Foraging Habitat For Two Imperiled Sea Turtle Species In The Gulf Of Mexico, Kristen M. Hart, Autumn R. Iverson, Ikuko Fujisaki, Margaret M. Lamont, David Bucklin, Donna J. Shaver

United States Geological Survey: Staff Publications

Effective management of human activities affecting listed species requires understanding both threats and animal habitat-use patterns. However, the extent of spatial overlap between high-use foraging areas (where multiple marine species congregate) and anthropogenic threats is not well-known. Our modeling approach incorporates data on sea turtle spatial ecology and a suite of threats in the Gulf of Mexico to identify and map “hot spots” of threats to two imperiled turtle species. Of all 820 “high” threats grid cells, our tracked turtles foraged at least 1 day in 77% of them. Although threat data were not available outside the U.S. Exclusive Economic …

State V. Swalley Respondent's Brief Dckt. 45490

Not Reported

No abstract provided.

September 24, 2018: President's Welcome, Bar Task Force Update, Mfa Series Features Kevin Young, Saint Mary's College Of California

SMC Bulletin 2013-2020

No abstract provided.

Effect Of The Synthetic Bile Salt Analog Camsa On The Hamster Model Of Clostridium Difficile Infection, Amber Howerton, Cale O. Seymour, Senthil K. Murugapiran, Zhenlin Liao, Jacqueline R. Phan, Alan Estrada, Adam J. Wagner, Chrisabelle C. Mefferd, Brian P. Hedlund, Ernesto Abel-Santos

Life Sciences Faculty Research

Clostridium difficile infection (CDI) is the leading cause of antibiotic-associated diarrhea and has gained worldwide notoriety due to emerging hypervirulent strains and the high incidence of recurrence. We previously reported protection of mice from CDI using the antigerminant bile salt analog CamSA. Here we describe the effects of CamSA in the hamster model of CDI. CamSA treatment of hamsters showed no toxicity and did not affect the richness or diversity of gut microbiota; however, minor changes in community composition were observed. Treatment of C. difficile-challenged hamsters with CamSA doubled the mean time to death, compared to control hamsters. However, CamSA …

Applications Of Magnetotactic Bacteria, Magnetosomes And Magnetosome Crystals In Biotechnology And Nanotechnology: Mini-Review, Gabriele Vargas, Jefferson Cypriano, Tarcisio Correa, Pedro Leão, Dennis A. Bazylinski, Fernanda Abreu

Life Sciences Faculty Research

Magnetotactic bacteria (MTB) biomineralize magnetosomes, which are defined as intracellular nanocrystals of the magnetic minerals magnetite (Fe3O4) or greigite (Fe3S4) enveloped by a phospholipid bilayer membrane. The synthesis of magnetosomes is controlled by a specific set of genes that encode proteins, some of which are exclusively found in the magnetosome membrane in the cell. Over the past several decades, interest in nanoscale technology (nanotechnology) and biotechnology has increased significantly due to the development and establishment of new commercial, medical and scientific processes and applications that utilize nanomaterials, some of which are biologically derived. One excellent example of a biological nanomaterial …

The Rider (2018-09-24), Victor G. Ramirez

The Rider Archives

Vol.4 No.5

Lanthorn, Vol. 53, No. 06, September 24, 2018, Grand Valley State University

Volume 53, July 9, 2018 - June 10, 2019

Lanthorn is Grand Valley State's student newspaper, published from 1968 to the present.

Mynews, Georgia Southern University

My News (2014-2020)

• Blind Willie McTell statue placed in front of Statesboro Convention and Visitors Bureau a symbol of working together
• Georgia Southern’s Armstrong Visiting Writers Series to host reading with acclaimed poet
• Georgia Southern alumna nominated for Country Music Association award
• Georgia Southern University celebrates Latino Heritage Month
• Women’s Rifle Program has their sights set on the Olympic Training Center
• This Georgia Southern Eagle is going to be on ‘Jeopardy!’
• Georgia Southern alumna conducts aquaculture research in Iceland
• On-Campus News
• In the Media

Mcdonnell V. United States: Legalized Corruption And The Need For Statutory Reform, Khadija Lalani

NULR Online

No abstract provided.

Mcdonnell V. United States: Legalized Corruption And The Need For Statutory Reform, Khadija Lalani

NULR Online

No abstract provided.

Pediatric Obesity: Influence On Drug Dosing And Therapeutics, Barbara Ameer Pharmd, Mba, Bcps, Fcp, Michael Weintraub Md

Department of Medicine Faculty Papers

Obesity is an ongoing global health concern and has only recently been recognized as a chronic disease of energy homeostasis and fuel partitioning. Obesity afflicts 17% of US children and adolescents. Severe obesity (³120% of the 95^th percentile of BMI-for-age, or a BMI of ³35 kg/m²) is the fastest growing subgroup and now approaches 6% of all US youth. Health consequences (e.g., type 2 diabetes, coronary heart disease) are related in a dose-dependent manner to severity of obesity. Since therapeutic interventions are less effective in severe obesity, prevention is a high priority.

Treatment plans involving combinations of …

Tuflux Tpe Tubing For Pharma Processing, Pradnya Parulekar, Michael Drechsel

Single-Use Technologies III: Scientific and Technological Advancements

The guidelines for launching new products and manufacturing those approved products are becoming more stringent on a routine basis. Quality certifications, clean room requirements, forwards and backwards traceability on all components are the new standard for providing FDA-approve products. Part of insuring that quality criteria are being met is to understand how the raw material is created, how it is processed in to a technologically useful processing aid (tube) and then how is that tube tested. Thermoplastic resin is the key ingredient in creating TuFlux tubing. The broad chemistry footprint allows specialized compounders to create unique blends of components (using …

Process Intensification In Biomanufacturing Driven By Advances In Single Use Technologies, Stefan Schmidt

Single-Use Technologies III: Scientific and Technological Advancements

Single use technologies now represent the state of the art in biomanufacturing, but still the full potential of a broad application has not been tapped yet. One strategy that captures most of disposable benefits is process intensification. Here single use systems are optimized to achieve similar output levels as traditional stainless-steel facilities but at much lower capital expenditure, smaller footprints and faster implementation times. This presentation gives an overview on current approaches, describes the opportunities and limits of disposables and delivers recommendations to what should be done by suppliers and users in the near future.

Identification And Clinical Validation Of Novel Prostate Cancer Biomarkers Filamin A (Flna), Filamin B (Flnb), And Keratin 19 (Krt19) Using Patient-Derived Omics And Bayesian Artificial Intelligence, Niven Rajin Narain

Open Access Dissertations

This dissertation herein describes a novel strategy for Prostate Cancer (PCa) biomarker discovery employing use of systems biology causal modeling using omics, molecular phenotyping, and Bayesian artificial intelligence. Three studies were conducted towards this goal. In Study 1, a novel strategy that combines biological outputs with Bayesian network learning to identify potential biomarkers for prostate cancer was utilized. This methodology identified two proteins, filamin B (FLNB) and keratin-19, as potential biomarkers for prostate cancer. The network map also identified a direct linkage between FLNB and filamin A (FLNA), a protein previously identified as playing a role in prostate cancer etiology. …

Mulberiddlesex, Catriona Sandilands

The Goose

Through a careful tracing of the botanical presence of mulberry trees in Middlesex, Sandilands argues for a reading practice that takes plants seriously. Thinking with plants interrupts the tendency to consider literary plants primarily as motifs, metaphors or agents of crude naturalization. Sandilands insists on involving plants in reading Middlesex in order to take the novel in less anthropocentric directions: even as Cal enlists mulberries to signal inevitability, their own stories overflow the novel’s deterministic views of race, species, territory, and gender identity.