Digital Commons Network^™

The Drug Discovery Of Potential Anti-Cancer Agents To Inhibit The Demethylation Catalytic Activity Of The Jmjc Domain Of Kdm3a, Balgees Alshanqeti

Electronic Theses & Dissertations

Lysine demethylase 3A (KDM3A) is an enzyme that specifically catalyzes the removal of 2 or three methyl groups from lysine 9 of histone 3 (KH3). It belongs to the family of histone demethylases that contain the Jumonji C (JmjC) domain, which means cruciform in Japanese. KDM3A also belongs to a family of hydroxylases that are alpha-ketoglutarate dependent. The role of KDM3A in the cell is not yet understood, however, and based on its demethylation of studies have showed that its expression is elevated in embryonic stem cells in humans and in mice. In general, patterns of elevated expression of KDM3A …

Investigating Ethical Dilemmas And Ethical Decision Making In The Field Of School Psychology Using The Multidimensional Scale For Ethics In School Psychology, Umbreen Iqbal

Theses and Dissertations

Ethical standards and principals are one of the most significant part of any professional field. Being an applied practice field, the application of ethical codes and conduct is a critical component for school psychologists. There have been numerous research studies on ethical decision making and ethical dilemmas in many applied fields to help update the ethics principles and codes, same is the case for the field of School Psychology (APA, 2017; NASP, 2010). The purpose of this study was to examine school psychologists’ professional characteristics with regards to managing critical incidents that pose potential ethical violations. An additional purpose was …

History, Status, And Resource Selection Of The American Black Bear In Mississippi, Stephanie Lynn Simek

Theses and Dissertations

Historically, black bears occurred throughout Mississippi but by 1932, <12 bears remained. Repatriation in neighboring states and conservation efforts in Mississippi have led to the recolonization of at least 2 subspecies (U. a. luteolus and U. a. americanus) of black bears in the state. I compiled available data to provide a synthesis of the history, current status, and management of black bears in Mississippi. Additionally, I used global positioning data collected from radio collared bears to determine the influence of distance to source population, cover type, distance to roads, distance to water, wetland reserve program areas, and human population density on black bear resource selection at various spatial scales. I studied characteristics of space use and resource selection of recolonizing bears in the Mississippi Alluvial Valley (Delta). I assessed the influence of environmental parameters at the female core annual home-range (using 50% kernel density estimator) and male and female seasonal and annual home-ranges (95% kernel density estimator). Distance to source population and distance to roads had significant influence at the core female home-range scale. I found a sex-based difference in annual and seasonal home-ranges. I also found that bears exhibited response to and selection for specific resources with an affinity toward hardwood stands, particularly young-aged hardwoods. My research illustrates the importance of analyzing resource selection at multiple scales to gain a full understanding of parameters that influence the recolonization of a bear population.

Breeding Of Cool-Season Forage Grasses For Abiotic And Biotic Stress Tolerance In The Southern United States, Eric Douglas Billman

Theses and Dissertations

Abiotic stress tolerance and biotic stress resistance have long been targets for trait improvement in the field of plant breeding. To date, much of the target crop focus has been centered on commodity crops such as corn, soybean, wheat, and rice. However, little work has been conducted on improvement of these traits in forage grasses. This is due to a number of issues, particularly that most species are obligately outcrossing, the traits are governed by many genes at unknown loci, and are greatly affected by environmental variation. This creates major complications in successfully selecting and breeding populations of forage grasses …

Beta Diversity Provides Evidence Of Niche Based Assembly In Temperate Forest Understory Assemblages Of Mississippi, David Steven Mason

Theses and Dissertations

Assembly is a process that shapes the abundance and identity of species in a community. Niche and neutral theory explain assembly processes with mechanisms driven by either species differences, or functional equivalence and stochastic dispersal. In 2017 I sampled vegetation and environmental variables at 59 sites in the Noxubee National Wildlife Refuge and Tombigbee National Forest of Mississippi to explore forest understory community assembly. I developed and assessed a framework of predictions concerning general patterns and underlying mechanism. Evidence of dispersal limitation and functional equivalence were expected under neutral theory. Local environmental characteristics, surrounding landscape variables, and fire were significant …

Perception And Training Needs Of Mississippi State University Extension Agents And The Level Of Demand They Receive For Information In Organic Agriculture, Thamir Niamah Al-Janabi

Theses and Dissertations

The purpose of this study was to determine perception and training needs of Mississippi State University Extension agents in organic agriculture. The study followed the Borich Needs Assessment Model. Data were collected via Qualtrics. The population of the study was 154 Mississippi State University Extension agents with 77 Extension agents responding to the questionnaire. Most agents were 40 to 49 years old with an almost equal percentage being male and female. The majority of agents (75.3%) had master’s degree. More than one third of the agents indicated the level of demand towards raising livestock organically had stayed the same. Also, …

Factors Influencing White-Tailed Deer Mortality Risk Within A Multi-Predator System In Michigan, Usa, Todd M. Kautz

Theses and Dissertations

I monitored cause-specific mortality and factors influencing mortality risk for white-tailed deer in the Upper Peninsula of Michigan, USA, during two high mortality risk periods: adult female deer during Feb–May, and fawns from birth to 6 months. I observed high rates of predation and starvation for adult female deer during Apr–May, suggesting that late winter represents a survival bottleneck due to nutritional declines. A strong negative relationship existed between snow free days during late winter and mortality risk. Predation was the dominant mortality source for fawns but predation risk decreased with larger birth mass. Black bears and coyotes accounted for …

Impact Of Integrated Vegetation Management Practices On Green Antelopehorn Milkweed (Asclepias Viridis Walter) In Right-Of-Ways And Forages, Nolan Hendrix Thorne

Theses and Dissertations

Common integrated vegetation management (IVM) practices including herbicide and mowing applications on right-of-ways and forages were evaluated on green antelopehorn populations near Starkville, MS. Live stems in each plot were counted prior to treatment application and approximately one year after treatment (YAT). Analysis of the stem counts 1YAT indicated aminopyralid+metsulfuron, imazapyr, picloram+2,4-D, maximum rates of triclopyr ester or choline, glyphosate, imazapyr+aminocyclopyrachlor+metsulfuron reduced the number of green antelopehorn stems compared to the untreated. Aminocyclopyrachlor, aminocyclopyrachlor+chlorsulfuron, aminopyralid, aminopyralid+2,4-D, dicamba+2,4-D, foramsulfuron+iodosulfuron+thiencarbazone, fluroxypyr, hexazinone, metsulfuron, metsulfuron+chlorsulfuron, nicosulfuron+metsulfuron, sulfometuron, sulfosulfuron or low rates of triclopyr did not reduce the stem count 1YAT when compared to …

Computational Analysis Of Map3k Kinases Across Plant Genomes And Functional Characterization Of A Subset Of Map3ks In Nematode Resistance, Nobert Tamas Bokros

Theses and Dissertations

Plant MAP3Ks have expanded significantly compared to their metazoan counterparts. A new, sequential workflow combining multispecies ortholog clustering and newly built, family-specific HMMs is used to identify the MAP3K gene family within seven plant species, allowing for a refinement of previously proposed gene family cladding and the novel identification of the MAP3K gene families in the allotetraploid cotton Gossypium hirsutum and newly sequenced monocot seagrass Zostera marina. The MAP3K gene family architecture is further refined and validated using bioinformatics analyses before the recently characterized Arabidopsis Raf-like MAP3K ILK1 is identified and characterized in upland cotton. Transient gene silencing reveals an …

Understanding How Pin1-Substrate Interactions Modulate Affinity And Inter-Domain Dynamics, Hewa Pathiranalage Dinusha Sanjeewani Jinasena

Theses and Dissertations

Pin1 is an essential peptidyl-prolyl isomerase (PPIase) that catalyzes cis-trans prolyl isomerization in proteins containing phosphorylated serine/threonine-proline motifs (pSer/Thr-Pro). It has an N-terminal binding domain (WW) and a C-terminal PPIase domain. Pin1 targets pSer/Thr-Pro motifs by its WW domain and catalyzes isomerization through its PPIase domain. This dissertation is focused on elucidating the interactions between Pin1/substrate, the inter-domain dynamics upon binding, and the catalytic activity of Pin1 upon binding different substrates. Specifically, we investigated the Pin1-Histone H1 interaction and designed a series of chimeric peptides based on the H1.4 sequence (KATGAApTPKKSAKW). NMR titrations were performed for each peptide using both …

Using Agricultural Wastes And Additives To Improve Properties And Lower Manufacturing Costs Associated With Biomass Energy Pellets, Cody Blake

Theses and Dissertations

The objectives of this dissertation’s studies were to determine the effects of different additives on biomass wood pellets’ physical properties and the production energy required to produce each treatment. Chapter II was completed using a pneumatic pelletizer as a small scale test to determine effects of different additives. The pneumatic pelletizer was a good indicator of which additives can be successfully pelletized. The results of this chapter show that using bio-oil can significantly increase calorific value, without significantly decreasing durability and significantly increasing production energy required. Corn starch, in a 4% treatment, was shown to not hinder durability or calorific …

Using Geospatial Techniques To Assess Responses Of Black Bear Populations To Anthropogenically Modified Landscapes: Conflict & Recolonization, Jamie Elizabeth Mcfadden

Theses and Dissertations

The convergence of three young scientific disciplines (ecology, geospatial sciences, and remote sensing) has generated unique advancements in wildlife research by connecting ecological data with remote sensing data through the application of geospatial techniques. Ecological datasets may contain spatial and sampling biases. By using geospatial techniques, datasets may be useful in revealing landscape scale (e.g., statewide) trends for wildlife populations, such as population recovery and human-wildlife interactions. Specifically, black bear populations across North America vary greatly in their degree of distribution stability. The black bear population in Michigan may be considered stable or secure, whereas the population in Missouri is …

Functional Role Of Protein Kinases And Phosphatase In Abiotic Stress Response In Plants, Saroj Kumar Sah

Theses and Dissertations

Soybean (Glycine max) and rice (Oryza sativa) are the most important crops cultivated worldwide. The productivity of both crops is severely limited due to drought stresses. Abscisic acid (ABA) signaling is one of the crucial phytohormones which acts as the signaling mediator in different environmental stress for adaptive response of plants. In this study, functional characterization of abscisic acid-activated protein kinase-like kinase 1 (AALK1), and low molecular weight protein tyrosine phosphatase (LMWPTP) were studied by developing gain-ofunction and loss-ofunction phenotypes by transgenesis. Physiological response of AALK1 showed that AALK1 modulates the drought stress response ins soybean plants. The study has …

Failing The Mothers Of New York City, Irene Spezzamonte, Vanessa Swales

Capstones

Between 2015 and 2011, about 4,000 women lost their lives while delivering a baby in the United States. That’s 1,000 lost lives every year.

The causes of these deaths are often preventable and are the mere result of racial discrimination. African-American mothers, for instance, have a three-time higher rate of dying than White mothers. Several investigative investigations have been conducted on the racial disparities and the lack of resources offered nationwide, but, so far, none has focused on the local level. This capstone focuses solely in New York City and the three populations that are being affected the most by …

Clinical And Genetic Associations Of Renal Function And Diabetic Kidney Disease In The United Arab Emirates: A Cross-Sectional Study, Wael M. Osman, Herbert F. Jelinek, Guan K. Tay, Ahsan H. Khandoker, Kinda Khalaf, Wael Almahmeed, Mohamed H. Hassan, Habiba S. Alsafar

Research outputs 2014 to 2021

OBJECTIVES: Within the Emirati population, risk factors and genetic predisposition to diabetic kidney disease (DKD) have not yet been investigated. The aim of this research was to determine potential clinical, laboratory and reported genetic loci as risk factors for DKD.

RESEARCH DESIGN AND METHODS: Four hundred and ninety unrelated Emirati nationals with type 2 diabetes mellitus (T2DM) were recruited with and without DKD, and clinical and laboratory data were obtained. Following adjustments for possible confounders, a logistic regression model was developed to test the associations of 63 single nucleotide polymorphisms (SNPs) in 43 genetic loci with DKD (145 patients with …

Music Education And Its Impact On L2 Learning, Johanna Nilsson

Master's Projects and Capstones

English Language Learners are disproportionately underrepresented in secondary music classes in the United States. They are systematically excluded due to overly restrictive schedules, high emphasis on test scores and academic remediation, real and perceived cost of participation, and the types of courses that are offered at most secondary schools. At the same time, musical intervention research has revealed that musical ability is linked to literacy, pronunciation, and vocabulary retention, all aspects of second language acquisition. By excluding English Language Learners from music education, we could be denying them a tool that could positively impact their language acquisition. However, most of …

Renouncing The Universal Museum’S Imperial Past: A Call To Return The Rosetta Stone Through Collaborative Museology, Anna Volante

Master's Projects and Capstones

In colonial times, Western empires used orientalism to justify and perpetuate colonialism and imperialism over countries that they believed inferior to their own. These imperial powers plundered cultural heritage artifacts from the nations they oppressed and took these objects back to their national museums to be displayed as trophies of subjugation. The ownership of cultural heritage remains a point of contention throughout the field of museum studies. Despite cries for repatriation, these artifacts continue to be housed in universal museums today. One of the most well-known cases is that of the Rosetta Stone, stripped from the city of Rashid, Egypt …

The Impact Of The Dual-Enrollment Modality On Subsequent Collegiate Performance, Daniel Archer

Electronic Theses and Dissertations

Dual-enrollment College Algebra is offered in three modalities: at the college, at the high school, and online. The purpose of this study was to examine if the dual-enrollment College Algebra modality impacts early collegiate performance. A program evaluation was conducted using a causal-comparative design to explore potential cause-and-effect relationships between the dual-enrollment College Algebra modalities and five outcomes. The population included Oklahoma State System of Higher Education students who completed dual-enrollment College Algebra and subsequently earned freshman College Algebra postrequisite math grades, freshman College Algebra postrequisite science grades, or college credit in the fall semester after high school graduation. One-way …

Genetics Of Sexually Dimorphic Development Of Butterfly Wing Patterns, Luis Fernando Rodriguez Caro

Theses and Dissertations

Butterfly wing color patterns result from the arrangement of monochromatic scales containing chemical pigments and a delicate architecture that can cause interference or diffraction of light, generating iridescent colors. The latter mechanism is known as structural coloration and, despite its ecological importance, little is known about the molecular mechanisms underlying the development of this trait. The Southern Dogface butterfly, Zerene cesonia, exhibits sexually dimorphic development of ultraviolet wing reflectance. Males possess a UV-reflective patch on the forewing that results from nano-structures on the wing scales, which are absent in females. This dimorphism offers an excellent opportunity to explore the genetic …

Complex Network Analysis For Early Detection Of Failure Mechanisms In Resilient Bio-Structures, Reena R. Patel

Theses and Dissertations

Bio-structures owe their remarkable mechanical properties to their hierarchical geometrical arrangement as well as heterogeneous material properties. This dissertation presents an integrated, interdisciplinary approach that employs computational mechanics combined with flow network analysis to gain fundamental insights into the failure mechanisms of high performance, light-weight, structured composites by examining the stress flow patterns formed in the nascent stages of loading for the rostrum of the paddlefish. The data required for the flow network analysis was generated from the finite element analysis of the rostrum. The flow network was weighted based on the parameter of interest, which is stress in the …

Revision Of The Subgenus Prionus (Neopolyarthron) Semenov (Coleoptera: Cerambycidae: Prioninae) In North America, With Notes On Prionus (Antennalia) Casey, Terence L. Schiefer

Theses and Dissertations

The classification of North American species of Prionus (Prionus) Geoffroy is reevaluated, with three subgenera recognized: P. (Antennalia) Casey, revived status, P. (Neopolyarthron) Semenov, revived status, and P. (Prionus). Prionus (Neopolyarthron) is revised and consists of P. imbricornis (Linnaeus), P. debilis Casey, revived status, and P. cuneatus Casey, revived status, with the latter two species removed from synonymy with P. imbricornis. Prionus robustus Casey, new synonymy, and P. fissicornis parviceps Casey, revised synonymy, are transferred from synonymy with P. imbricornis to synonymy with P. cuneatus and P. fissicornis respectively. Keys to North American subgenera of Prionus and to species of …

Quantifying Pre-Industrial To Mid-Late 20th Century Anthropogenic Lead, Mercury And Cadmium Pollution In Caribbean Marine Environments Using Skeletonized Sea Turtle Remains, Felicia L. Pena

Theses and Dissertations

Various lines of evidence indicate that levels of anthropogenic pollutants, such as lead, mercury and cadmium, have increased in terrestrial and atmospheric environments since the early 19th century and the advent of industrialization. While the exposure to these three trace elements is a global concern, this study focused primarily on marine environments located throughout the Caribbean. Using ICP-MS, this study aimed to detect and quantify anthropogenic pollutants, specifically lead (Pb), mercury (Hg) and cadmium (Cd), using skeletonized remains of sea turtles as biological proxies for environmental quality. Archaeologically derived (n=5) and mid-late 20th century (n=6) Hawksbill and Green turtles were …

Tailoring Math Curricula For Community Colleges: A Process Approach, Ira Lindsay Mcfarland Kinard

Theses and Dissertations

Community college instructors continue to search for effective instructional methods that promote student success in developmental mathematics courses such as intermediate algebra. According to research, mathematics is a major obstacle for students succeeding, persisting, and completing community college programs. Each student enrolled in intermediate algebra has an ACT sub-score of 16 to 18 or an ACCUPLACER sub-score of 57 to 75. Most community colleges in Mississippi use placement testing to determine the strengths and needs of students. However, students approach math with high anxiety, more than any other areas, which interferes with their learning. Research indicates that to improve students’ …

Short Sleep Duration And Obesity Among Children: A Meta-Analysis, Katherine Faye Real Villar

International Nursing Research Congress (INRC)

This meta-analytical study examined whether there is an association between lesser sleep duration and risk of childhood obesity and to determine which gender is more common in childhood obesity.

Dietary Polyunsaturated Fatty Acids Regulate Mammary Tumor Growth And Metastasis By Modulating Tissue Microenvironments, Saraswoti Khadge

Theses & Dissertations

Omega (ω)-6 and ω-3 polyunsaturated fatty acids (PUFAs) are essential fatty acids (FAs) and the precursors of pro- and anti-inflammatory mediators respectively. Epidemiological studies have shown a lower incidence of breast cancer (BC) in the countries where long-chain (LC)-ω-3FAs consumption is higher; however, the role of ω-3FAs in BC growth and metastasis is poorly understood. We used isocaloric, isolipidic ω-6 and ω-3 (contains LC-ω-3FAs) diets and a pair-fed model to evaluate the effects of dietary PUFAs in mammary tumor metastasis. Our studies have resulted in several novel observations including that dietary LC-ω-3FAs modulate mammary gland (MG) microenvironments in non-tumor bearing …

Regulation Of Canonical And Non-Canonical Hippo Pathway Components In Mitosis And Cancer, Seth Stauffer

Theses & Dissertations

The Hippo pathway is conserved regulator of organ size through control of proliferation, apoptosis, and stem-cell self-renewal. In addition to this important function, many of the canonical signaling members have also been shown to be regulated during mitosis. Importantly, Hippo pathway components are frequently dysregulated in cancers and have attracted attention as possible targets for improved cancer therapeutics. Further exploration of Hippo-YAP (yes-associated protein) signaling has revealed new regulators and effectors outside the canonical signaling network and has revealed a larger non-canonical network of signaling proteins in which canonical Hippo pathway components crosstalk with important cellular homeostasis and apoptosis signaling …

Attitudes Of Sinjari Yezidis In Iraq Regarding The Rape Of Yezidi Women And The Babies Born From Rape During The Isis Genocide, Jordan Greaser

Theses & Dissertations

This thesis evaluated the attitude of acceptance among Sinjari Yezidis toward Yezidi women who were captured and raped by ISIS captors. In addition, attitudes of acceptance were also studied on behalf of the children born due to rape. These attitudes were recorded by a 25-question attitudinal survey and then analyzed on a question by question bases. The outcome of the following study showed an overwhelming acceptance of the women but a mixed acceptance of their children. Based on the study findings, religious beliefs may be the best way to understand the level of acceptance the Yezidi community has toward the …

Examining Barriers To Sexual And Reproductive Health Services For Adolescents And Young Adults In Nebraska, Marisa Rosen

Theses & Dissertations

Despite recent declines in unintended pregnancy rates among adolescent and young adult women, barriers to family planning services and contraception continue to exist for young women living in the United States. Various initiatives have been implemented over the years from programmatic interventions to enactment of policies around family planning, yet more work needs to be done to help adolescent and young adult women successfully prevent unintended pregnancy. The Contraceptive Access Project (CAP) is a multi-component initiative in Nebraska to reduce unintended pregnancy among women aged 15-24. This dissertation comprises three separate studies each of which contributes to the overall objective …

Red Panda: A Novel Method For Detecting Variation In Single-Cell Rna Sequencing, Adam Cornish

Theses & Dissertations

Single-cell sequencing enables the rapid acquisition of genomic and transcriptomic data from individual cells to better understand genetic diseases, such as cancer or autoimmune disorders, which are often affected by changes in rare cells. Currently, no existing software is aimed at identifying single nucleotide variations or micro (1-50bp) insertions and deletions in single-cell RNA sequencing (scRNA-seq) data. However, generating high quality data is vital to the study of the aforementioned diseases, among others. Our goal is to create such a tool and use in-house sequencing to validate its effectiveness. Our software employs the unique information found in scRNA-seq data to …

An Assessment Of Preparations Made In The United States For Highly Hazardous Communicable Diseases Following The 2014-2016 Ebola Virus Disease Epidemic, Jocelyn J. Herstein

Theses & Dissertations

The 2014-2016 Ebola virus disease (EVD) epidemic in West Africa was unprecedented in magnitude and scope. The threat of imported cases of EVD in the United States prompted the Centers for Disease Control and Prevention (CDC) to establish a tiered network of hospitals to enhance domestic isolation capacity, including the designation of select hospitals as Ebola treatment centers (ETCs). As of spring 2015, no information existed on the capacity, physical infrastructure, staffing models, or infection control protocols of these newly-established ETCs, nor was there information on other highly hazardous communicable diseases (HHCDs) these units would admit. Moreover, no documentation was …