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2018

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Marketing Research In The 21st Century: Opportunities And Challenges, Joe F. Hair, Dana E. Harrison, Jeffrey J. Risher Oct 2018

Marketing Research In The 21st Century: Opportunities And Challenges, Joe F. Hair, Dana E. Harrison, Jeffrey J. Risher

ETSU Faculty Works

The role of marketing is evolving rapidly, and design and analysis methods used by marketing researchers are also changing. These changes are emerging from transformations in management skills, technological innovations, and continuously evolving customer behavior. But perhaps the most substantial driver of these changes is the emergence of big data and the analytical methods used to examine and understand the data. To continue being relevant, marketing research must remain as dynamic as the markets themselves and adapt accordingly to the following: Data will continue increasing exponentially; data quality will improve; analytics will be more powerful, easier to use, and more …

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Correlations Of Self-Reported Androgen Deficiency In Ageing Males (Adam) With Stress And Sleep Among Young Adult Males, Camille M. Charlier, Makenzie L. Barr, Sarah E. Colby, Geoffrey Greene, Melissa D. Olfert Oct 2018

Correlations Of Self-Reported Androgen Deficiency In Ageing Males (Adam) With Stress And Sleep Among Young Adult Males, Camille M. Charlier, Makenzie L. Barr, Sarah E. Colby, Geoffrey Greene, Melissa D. Olfert

Nutrition Faculty Publications

Androgen deficiency in males has traditionally been predominantly limited to older men aged 50+ years. However, little is known of the correlation between hormonal disruption, stress, and sleep in college-aged males. This cross-sectional study investigates lifestyle behavior patterns in young men and a screening for potential androgen deficiency. A survey of 409 male students, as part of a larger USDA-funded GetFruved study, was analyzed for this subproject. Survey instruments used include the Androgen Deficiency in the Aging Male Questionnaire (ADAM) to assess for inadequate ADAM scores, the Perceived Stress Scale to measure stress levels and the Pittsburgh Sleep Quality Index …

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Incommon- Fall 2018, Alumni Association Staff Oct 2018

Incommon- Fall 2018, Alumni Association Staff

InCommon

No abstract provided.

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Changes In Cortical Activity In Stroke Survivors Undergoing Botulinum Toxin Therapy For Treatment Of Focal Spasticity, Kelsey Dianne Tynes Oct 2018

Changes In Cortical Activity In Stroke Survivors Undergoing Botulinum Toxin Therapy For Treatment Of Focal Spasticity, Kelsey Dianne Tynes

Master's Theses (2009 -)

Functional magnetic resonance imaging (fMRI) has provided evidence of neuroplastic changes following rehabilitation in stroke survivors. Botulinum toxin (BoNT) injection therapy has become a common approach to combating spasticity—a motor disorder characterized by a velocity dependent increase in muscle tone. The neurotoxin acts to inhibit muscle contraction, relieving spasticity symptoms with peak effects occurring between 4 and 6 weeks. With decreases in muscle tone, BoNT injections could free arm movement for rehabilitation, creating the opportunity for enhanced control of the upper limb, which would have underpinnings in altered brain activity. Given evidence of cortical activation changes following other stroke rehabilitative …

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Uv-Based Advanced Oxidation Of P22 Bacteriophage And E. Coli Bacteria, Vincent Martino Oct 2018

Uv-Based Advanced Oxidation Of P22 Bacteriophage And E. Coli Bacteria, Vincent Martino

Master's Theses (2009 -)

Two novel, sustainable UV-LED advanced oxidation processes (AOPs) were evaluated for their ability to improve inactivation efficacy of P22 bacteriophage and E. coli bacteria. The first objective of this research was to determine the treatment efficacy of P22 bacteriophage and E. coli bacteria using UV-LED at wavelengths of 255, 265, and 285 nm. The UV-LED system demonstrated high inactivation potential for both contaminants at all wavelengths, suggesting it could be a potential alternative to typical low-pressure and medium-pressure mercury-based UV systems. Increased inactivation of both microorganisms was observed with decreasing wavelength (255>265>285 nm). As the peak UV absorbance …

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Columns Fall 2018, Southern Adventist University Oct 2018

Columns Fall 2018, Southern Adventist University

Alumni Newsletter

Features the article " Summer Learning, Summer Fun". God has a purpose for every young person, but it can be challenging for high school students to know all of their options. Southern offers a fun way to explore different careers through its Academic Summer Camps.

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October 2018 Quicknotes, Southern Adventist University Oct 2018

October 2018 Quicknotes, Southern Adventist University

QuickNotes – Advancement e-Newsletter

QuickNotes is an e-newsletter that comes from Advancement at Southern Adventist University. October 2018 edition features the article "Gifts from Adventist Health System Fully Funds Chairship".

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Tree Thinning And Fire Affect Ectomycorrhizal Fungal Communities And Enzyme Activities, Ann Rasmussen, J. Stephen Brewer, Colin R. Jackson, Jason D. Hoeksema Oct 2018

Tree Thinning And Fire Affect Ectomycorrhizal Fungal Communities And Enzyme Activities, Ann Rasmussen, J. Stephen Brewer, Colin R. Jackson, Jason D. Hoeksema

Faculty and Student Publications (Open Access)

No abstract provided.

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Hyperfiltration-Mediated Injury In The Remaining Kidney Of A Transplant Donor., Tarak Srivastava, Sundaram Hariharan, Uri S. Alon, Ellen T. Mccarthy, Ram Sharma, Ashraf El-Meanawy, Virginia J. Savin, Mukut Sharma Oct 2018

Hyperfiltration-Mediated Injury In The Remaining Kidney Of A Transplant Donor., Tarak Srivastava, Sundaram Hariharan, Uri S. Alon, Ellen T. Mccarthy, Ram Sharma, Ashraf El-Meanawy, Virginia J. Savin, Mukut Sharma

Manuscripts, Articles, Book Chapters and Other Papers

Kidney donors face a small but definite risk of end-stage renal disease 15 to 30 years postdonation. The development of proteinuria, hypertension with gradual decrease in kidney function in the donor after surgical resection of 1 kidney, has been attributed to hyperfiltration. Genetic variations, physiological adaptations, and comorbidities exacerbate the hyperfiltration-induced loss of kidney function in the years after donation. A focus on glomerular hemodynamics and capillary pressure has led to the development of drugs that target the renin-angiotensin-aldosterone system (RAAS), but these agents yield mixed results in transplant recipients and donors. Recent work on glomerular biomechanical forces highlights the …

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Desensitization But Not Sensitization From Commercial Chemesthetic Beverages, Cordelia Running Oct 2018

Desensitization But Not Sensitization From Commercial Chemesthetic Beverages, Cordelia Running

Department of Food Science Faculty Publications

Sensations such as spiciness or stinging are particularly challenging to assess in sensory evaluation tests, as sensitization (increase in intensity with repeated tasting) and desensitization (decrease in intensity with repeated tasting) phenomena can confound intensity ratings. However, much of the published work on these phenomena are with model solutions or complex meals rather than commercial beverages. Thus, we tested whether we could observe sensitization or desensitization using canned spicy ginger beer (contained chili extract) and seltzer water. Samples were presented in pairs, with a 20 s wait and no rinse within a pair, but a 4 min wait with rinsing …

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Chemical Stability And Reaction Kinetics Of Two Thiamine Salts (Thiamine Mononitrate And Thiamine Chloride Hydrochloride) In Solution, Lisa J. Mauer, Adrienne L. Voelker, Jenna Miller, Cordelia Running, Lynne S. Taylor Oct 2018

Chemical Stability And Reaction Kinetics Of Two Thiamine Salts (Thiamine Mononitrate And Thiamine Chloride Hydrochloride) In Solution, Lisa J. Mauer, Adrienne L. Voelker, Jenna Miller, Cordelia Running, Lynne S. Taylor

Department of Food Science Faculty Publications

Two types of thiamine (vitamin B1) salts, thiamine mononitrate (TMN) and thiamine chloride hydrochloride (TClHCl), are used to enrich and fortify food products. Both of these thiamine salt forms are sensitive to heat, alkali, oxygen, and radiation, but differences in stability between them have been noted. It was hypothesized that stability differences between the two thiamine salts could be explained by differences in solubility, solution pH, and activation energies for degradation. This study directly compared the stabilities of TMN and TClHCl in solution over time by documenting the impact of concentration and storage temperature on thiamine degradation and …

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Hypothesis Paper: Mechanism For Primary Blast Induced Traumatic Brain Injury With Minimal Head Motion, Charles F. Babbs Oct 2018

Hypothesis Paper: Mechanism For Primary Blast Induced Traumatic Brain Injury With Minimal Head Motion, Charles F. Babbs

Weldon School of Biomedical Engineering Faculty Working Papers

Transit of the human skull by blast waves produces diffuse brain injury. The exact mechanisms are unknown. This paper describes plausible mechanisms in which steep intracranial pressure gradients, demonstrated in prior computational models of blast-skull interaction, produce subsequent deformation and motion of the whole brain within the skull, without obvious movement of the head. Equations of motion are derived to describe the acceleration, velocity, and relative position of both the skull and the brain in response to known extracranial and intracranial pressures both during and several hundred milliseconds after blast wave passage. A finite element model is solved to visualize …

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Folding Of Gα Subunits: Implications For Disease States, Matthew Najor, Brian D. Leverson, Jesse L. Goossens, Saad Kothawala, Kenneth W. Olsen, Duarte Mota De Freitas Oct 2018

Folding Of Gα Subunits: Implications For Disease States, Matthew Najor, Brian D. Leverson, Jesse L. Goossens, Saad Kothawala, Kenneth W. Olsen, Duarte Mota De Freitas

Chemistry: Faculty Publications and Other Works

G-proteins play a central role in signal transduction by fluctuating between “on” and “off” phases that are determined by a conformational change. cAMP is a secondary messenger whose formation is inhibited or stimulated by activated Giα1 or Gsα subunit. We used tryptophan fluorescence, UV/vis spectrophotometry, and circular dichroism to probe distinct structural features within active and inactive conformations from wild-type and tryptophan mutants of Giα1 and Gsα. For all proteins studied, we found that the active conformations were more stable than the inactive conformations, and upon refolding from higher temperatures, activated wild-type subunits recovered significantly more native structure. We also …

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Battery-Free Eye Tracker On Glasses, Tianxing Li, Xia Zhou Oct 2018

Battery-Free Eye Tracker On Glasses, Tianxing Li, Xia Zhou

Dartmouth Scholarship

This paper presents a battery-free wearable eye tracker that tracks both the 2D position and diameter of a pupil based on its light absorption property. With a few near-infrared (NIR) lights and photodiodes around the eye, NIR lights sequentially illuminate the eye from various directions while photodiodes sense spatial patterns of reflected light, which are used to infer pupil’s position and diameter on the fly via a lightweight inference algorithm. The system also exploits characteristics of different eye movement stages and adjusts its sensing and computation accordingly for further energy savings. A prototype is built with off-the-shelf hardware components and …

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Use Of "The Guidelines" For Financial Record Keeping By Kentucky Small- And Mid-Scale Farmers, Jean Dominique Gumirakiza, Mary Catherine Kamer Oct 2018

Use Of "The Guidelines" For Financial Record Keeping By Kentucky Small- And Mid-Scale Farmers, Jean Dominique Gumirakiza, Mary Catherine Kamer

Journal of Extension

We describe awareness of the Financial Guidelines for Agricultural Producers ("the Guidelines") and illustrate their use on Kentucky small and mid-size farms. Using survey data we collected in 2016 from 103 farms, we found that 89% of the small- and mid-scale farmers who responded were unaware of the Guidelines and, therefore, did not follow them. Additionally, 75% of the farmers used a single-entry cash-basis accounting system. We consequently suggest the implementation of awareness campaigns, educational strategies, and technical assistance to increase farmers' awareness and usage rates with regard to the Guidelines. We also suggest that there is a need for …

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The Graduate Extension Scholars Program: Professional Development To Connect Research And Education, Hannah H. Scherer, Ayla Wilk, Shannon Wiley, Matthew Spindler Oct 2018

The Graduate Extension Scholars Program: Professional Development To Connect Research And Education, Hannah H. Scherer, Ayla Wilk, Shannon Wiley, Matthew Spindler

Journal of Extension

The Graduate Extension Scholars program represents a novel approach that brings together graduate students, 4-H agents, and secondary agriculture teachers in an educational resource development project. We conducted process evaluation research based on program goals for the pilot implementation year using participant interviews and program artifacts. Program participants reported an overall positive experience and identified new programming and partnerships that would not have been possible without involvement in the program. Goals were enacted to varying degrees, with challenges occurring related to collaborative planning, educational module development, and building of partnerships between Extension and school-based educators. Recommendations for Extension program development …

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Strategies For Enhancing University Extension's Role As An Agricultural Information Source, Matthew Houser, Riva C.H. Denny, Adam Reimer, Sandra T. Marquart-Pyatt Oct 2018

Strategies For Enhancing University Extension's Role As An Agricultural Information Source, Matthew Houser, Riva C.H. Denny, Adam Reimer, Sandra T. Marquart-Pyatt

Journal of Extension

In this article, we identify factors contributing to the low use of Extension as an information source for farm management decisions and make recommendations for how to increase use of Extension in the context of midwestern row crop agriculture. Results from our mixed-methods analysis show that conservative recommendations, declines in public funding, and the perception of "cutting-edge" private sector information contribute to low use of Extension. We recommend changes to Extension at system and ground levels that could potentially increase its use among farmers. As many of the issues facing farmers and Extension span the nation, our findings and recommendations …

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Anisotropic Tissue Maker, Jake Ireland, Jaryd Huffman, Sarah Mohrmann, Daniel Cano Oct 2018

Anisotropic Tissue Maker, Jake Ireland, Jaryd Huffman, Sarah Mohrmann, Daniel Cano

Mechanical Engineering Design Project Class

Traumatic brain injury (TBI) is a common injury that is not thoroughly understood. Data on brain mechanics and motion are not abundant during the time of impact. In order to accumulate more data and achieve a better understanding of how the injury occurs tissue mimics can be made.

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Autonomous Ground Photographer, Sylvia Tan, Nicholas C. Smith, Kate Padilla, Elise Ashley Oct 2018

Autonomous Ground Photographer, Sylvia Tan, Nicholas C. Smith, Kate Padilla, Elise Ashley

Mechanical Engineering Design Project Class

Dr. Penczykowski, a biology professor at Washington University in St. Louis, researches the effects of powdery mildew on three plant species. Her lab currently collects data in the field by manually counting the number of infected plants with the assistance of a simple PVC grid. Therefore, this projects aims to automate this process by capturing images that can then be processed in her lab after.

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Nanofluidic Applications Of Silica Membranes, John Michael Stout Oct 2018

Nanofluidic Applications Of Silica Membranes, John Michael Stout

Theses and Dissertations

This work presents membrane development applicable in nanofluidic devices. These membranes can also be termed suspended thin films, supported on two or more edges. I first discuss motivation and background for developing these structures. Then I derive the formative principles for nanofluidic systems. Following the derivation of the Navier-Stokes and Washburn equations, I discuss applying these theories to planar nanofluidic capillaries and finish the derivation by discussing the forces that drive liquid flow in nanochannels. I next discuss the membrane development process, starting with my work in static height traps, and develop the concept of analyzing nanoparticles using suspended membranes. …

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Composing With Biomemristors: Is Biocomputing The New Technology Of Computer Music?, Eduardo Reck Miranda, Edward Braund, Satvik Venkatesh Oct 2018

Composing With Biomemristors: Is Biocomputing The New Technology Of Computer Music?, Eduardo Reck Miranda, Edward Braund, Satvik Venkatesh

School of Art, Design and Architecture

Our research concerns the development of biocomputers using electronic components grown out of biological material. This article reports the development of a novel biological memristor and an approach to using such biomemristors to build interactive generative music systems. The memristor is an electronic component regarded as a resistor with memory. After an introduction to harnessing the Physarum polycephalum organism to implement biomemristors, the article presents PhyBox, a biocomputer that uses four biomemristors to generate music interactively. The resistance of a biomemristor varies as a function of the voltage that has passed through it. Music input is represented in terms of …

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Development And Use Of Lipidomics And Proteomics Methods To Identify And Measure Pro-Survival Metabolic Pathways In Cancer, Monique Merilyn Speirs Oct 2018

Development And Use Of Lipidomics And Proteomics Methods To Identify And Measure Pro-Survival Metabolic Pathways In Cancer, Monique Merilyn Speirs

Theses and Dissertations

Throughout society’s continual war against cancer, we have attempted pharmacological intervention only to find that tumors develop modes of resistance. It is well known that genetics play an integral role in cancer. Technological advances have greatly improved our ability to study cancer biochemistry beyond the genome by measuring changes in the expression and activity of RNA, proteins, and lipids in experimental models and human patients. As our techniques and technology to perform cancer research progresses, it is becoming more evident that cancer cells develop stress tolerance mechanisms at multiple levels within the central dogma, including altering mRNA expression, enzyme concentrations, …

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Epidemiology Of Moderate Alcohol Consumption And Breast Cancer: Association Or Causation?, Samir Zakhari, Jan B. Hoek Oct 2018

Epidemiology Of Moderate Alcohol Consumption And Breast Cancer: Association Or Causation?, Samir Zakhari, Jan B. Hoek

Department of Pathology, Anatomy, and Cell Biology Faculty Papers

Epidemiological studies have been used to show associations between modifiable lifestyle habits and the incidence of breast cancer. Among such factors, a history of alcohol use has been reported in multiple studies and meta-analyses over the past decades. However, associative epidemiological studies that were interpreted as evidence that even moderate alcohol consumption increases breast cancer incidence have been controversial. In this review, we consider the literature on the relationship between moderate or heavy alcohol use, both in possible biological mechanisms and in variations in susceptibility due to genetic or epigenetic factors. We argue that there is a need to incorporate …

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Information Management As Nexus To Promote Indigenous Medicine Use To Enhance Public Healthcare Delivery: A Bibliometric Analysis, Patrick Ajibade (Phd), Stephen M. Mutula Prof. Oct 2018

Information Management As Nexus To Promote Indigenous Medicine Use To Enhance Public Healthcare Delivery: A Bibliometric Analysis, Patrick Ajibade (Phd), Stephen M. Mutula Prof.

Library Philosophy and Practice (e-journal)

The paper uses a bibliometric analysis explore citations trend of ethnomedicine and information management, and text mining algorithm of a total number of 8, 333 publications (n = 8,333) were conducted based on the title, abstract and keywords to find co-occurrence of key terms in indigenous medicine and information management. The objectives of this study were to first, analyze the authorship, outputs and citation trend and to find out if researchers have been able to establish a nexus between indigenous herbal use and the role of information management in promoting such use. Second, to establish if there is an …

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Allosteric Regulation Of Pyruvate Carboxylase, Yumeng Liu Oct 2018

Allosteric Regulation Of Pyruvate Carboxylase, Yumeng Liu

Dissertations (1934 -)

Pyruvate carboxylase (PC; E.C.6.4.1.1) is a multifunctional, biotin-dependent enzyme that catalyzes the MgATP-dependent carboxylation of pyruvate to oxaloacetate. The overall reaction is accomplished by the coupling of two half reactions occurring at two spatially distinct catalytic domains by the translocation of a carrier domain, resulting in a net transfer of CO2 from bicarbonate to pyruvate. PC activity is regulated by multiple allosteric effectors with acetyl CoA serving as an activator in most species and L-aspartate serving as an inhibitor for microbial PC. The kinetic characterization of PC from different species have revealed that PC homologs are subject to divergent degrees …

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Importance Of S. Cerevisiae Rcf1 And Rcf2 Proteins For The Mitochondrial Protonmotive Force Generation, Vera Strogolova Oct 2018

Importance Of S. Cerevisiae Rcf1 And Rcf2 Proteins For The Mitochondrial Protonmotive Force Generation, Vera Strogolova

Dissertations (1934 -)

Mitochondria are the site of oxidative phosphorylation (OXPHOS) pathway, which can supply majority of energy in a eukaryotic cell. OXPHOS enzyme activities generate electrochemical gradient known as mitochondrial protonmotive force (PMF). PMF coordinates OXPHOS enzyme activities and supports essential cell survival functions such as transport of proteins and metabolites in and out of mitochondria. PMF is maintained despite variations in cellular energy demand and oxygen availability.Mitochondrial proteins belonging to the conserved hypoxia induced gene domain (HIGD) family improve cell survival during the hypoxic and hypoglycemic stress. Their molecular function is not fully understood but they seem to act through …

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Understanding Water Diffusion In Experimental Spinal Cord Injury Remote From Injury Epicenter, Alice Motovylyak Oct 2018

Understanding Water Diffusion In Experimental Spinal Cord Injury Remote From Injury Epicenter, Alice Motovylyak

Dissertations (1934 -)

Diffusion tensor imaging (DTI) has demonstrated success as a biomarker of spinal cord injury (SCI) severity as shown from numerous preclinical studies. However, artifacts from stabilization hardware at the lesion have precluded its use for longitudinal assessments. Previous research has documented ex vivo diffusion changes in the spinal cord both caudal and rostral to the injury epicenter. The aim of this dissertation was to quantify the structural changes that lead to different diffusion measures in the rat cervical spinal cord after a thoracic contusion injury in an attempt to find a biomarker of injury. Animals received a thoracic contusion injury …

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Mechanisms Of Impaired Motor Unit Firing Behavior In The Vastus Lateralis Muscle After Stroke, Spencer Murphy Oct 2018

Mechanisms Of Impaired Motor Unit Firing Behavior In The Vastus Lateralis Muscle After Stroke, Spencer Murphy

Dissertations (1934 -)

The purpose of this dissertation research project was to examine the role of impaired motor unit firing behavior on force generation after a stroke. We studied the relationship between intrinsic motoneuron properties and inhibitory sensory pathways to deficient motoneuron activity in the vastus lateralis muscle after a stroke. Individuals with stroke often have deficits with force generation and volitional relaxation. Current models of impaired force output after a stroke focus primarily on the pathology within the corticospinal pathway because of decreased descending drive. Though this is an important aspect of deficient motoneuron output, it is incomplete because motoneurons receive other …

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Lifesaving In Every Way: The Role Of Companion Animals In The Lives Of Older Lesbian, Gay, Bisexual, And Transgender Adults Age 50 And Over, Anna M. Muraco, Jennifer Putney, Chengshi Shiu, Karen I. Fredriksen-Goldsen Oct 2018

Lifesaving In Every Way: The Role Of Companion Animals In The Lives Of Older Lesbian, Gay, Bisexual, And Transgender Adults Age 50 And Over, Anna M. Muraco, Jennifer Putney, Chengshi Shiu, Karen I. Fredriksen-Goldsen

Sociology Faculty Works

This study uses mixed-methods data and a life-course perspective to explore the role of pets in the lives of lesbian, gay, bisexual, and transgender (LGBT) adults age 50 and over and addresses the following research questions: (1) How does having a pet relate to perceived social support and social network size? and (2) how do LGBT older adults describe the meaning of pets in their lives? The qualitative data (N = 59) were collected from face-to-face interviews, and the quantitative data (N = 2,560) were collected via surveys from a sample across the United States. Qualitative findings show that pets …

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Era Of Direct Acting Anti-Viral Agents For The Treatment Of Hepatitis C., Monjur Ahmed Oct 2018

Era Of Direct Acting Anti-Viral Agents For The Treatment Of Hepatitis C., Monjur Ahmed

Division of Gastroenterology and Hepatology Faculty Papers

Hepatitis C infection is universal and the most common indication of liver transplantation in the United States. The period of less effective interferon therapy with intolerable side effects has gone. Now we have stepped into the era of direct acting anti-viral agents (DAAs) against hepatitis C virus. Treatment of hepatitis C is now extremely effective, tolerable and requires a short duration of intake of oral agents. Less monitoring is required with the current therapy and drug-drug interactions are less than the previous regimen. The current treatment options of chronic hepatitis C with various DAAs are discussed in this article.

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