Digital Commons Network^™

Nlrx1 Modulates Differentially Nlrp3 Inflammasome Activation And Nf-Κb Signaling During Fusobacterium Nucleatum Infection, Shu Chen Hung, Pei Rong Huang, Cassio Luiz Coutinho Almeida-Da-Silva, Kalina R. Atanasova, Ozlem Yilmaz, David M. Ojcius

All Dugoni School of Dentistry Faculty Articles

NOD-like receptors (NLRs) play a large role in regulation of host innate immunity, yet their role in periodontitis remains to be defined. NLRX1, a member of the NLR family that localizes to mitochondria, enhances mitochondrial ROS (mROS) generation. mROS can activate the NLRP3 inflammasome, yet the role of NLRX1 in NLRP3 inflammasome activation has not been examined. In this study, we revealed the mechanism by which NLRX1 positively regulates ATP-induced NLRP3 inflammasome activation through mROS in gingival epithelial cells (GECs). We found that depletion of NLRX1 by shRNA attenuated ATP-induced mROS generation and redistribution of the NLRP3 inflammasome adaptor protein, …

Polymicrobial Sepsis Influences Nk-Cell-Mediated Immunity By Diminishing Nk-Cell-Intrinsic Receptor-Mediated Effector Responses To Viral Ligands Or Infections., Isaac J. Jensen, Christina S. Winborn, Micaela G. Fosdick, Peng Shao, Mikaela M. Tremblay, Qiang Shan, Sandeep Kumar Tripathy, Christopher M. Snyder, Hai-Hui Xue, Thomas S. Griffith, Jon C. Houtman, Vladimir P. Badovinac

Department of Microbiology and Immunology Faculty Papers

The sepsis-induced cytokine storm leads to severe lymphopenia and reduced effector capacity of remaining/surviving cells. This results in a prolonged state of immunoparalysis, that contributes to enhanced morbidity/mortality of sepsis survivors upon secondary infection. The impact of sepsis on several lymphoid subsets has been characterized, yet its impact on NK-cells remains underappreciated-despite their critical role in controlling infection(s). Here, we observed numerical loss of NK-cells in multiple tissues after cecal-ligation-and-puncture (CLP)-induced sepsis. To elucidate the sepsis-induced lesions in surviving NK-cells, transcriptional profiles were evaluated and indicated changes consistent with impaired effector functionality. A corresponding deficit in NK-cell capacity to produce …

Emerging Best Practices For The Management And Treatment Of Lesbian, Gay, Bisexual, Transgender, Questioning, And Intersex Youth In Juvenile Justice Settings, Brenda V. Smith, Hayley Gorenberg, J. Rhodes Perry, Lisa Belmarsh, Shaena Johnson, Steven Jett, Rebecca Walters, Macarena Saez, Dana Shoenberg, Terry Schuster, Josh Delaney, Karen Bachar, Mykel Selph, Mark Seymour, Sharita Gruberg, Chris Daley, Mark Yarhouse

Research Reports & White Papers

In 2016 according to the U.S. Department of Justice, 856,130 youth were arrested and 45,567 juveniles were held in 1,772 residential juvenile facilities across the country. Detained and confined youth share many characteristics: most are from poor communities and lack access to quality health care. Mental illness and sexually transmitted infections are prevalent. Compared to their non-confined counterparts, incarcerated youth also experience higher rates of substance abuse and homelessness, are educationally behind their peers, are disproportionately identified as needing special education services, and are more likely to have had traumatic experiences (including sexual and emotional abuse) and injuries including traumatic …

Neoliberalism And Human Rights: The Brandt Commission And The Struggle For A New World, Umut Özsu

Law and Contemporary Problems

No abstract provided.

Chairs Of Excellence Annual Report 2018, Tennessee. Higher Education Commission.

Academic Programs and Workforce Reports

No abstract provided.

Cockroaches, Cows And "Canines Of The Hebrew Faith": Exploring Animal Imagery In Graphic Novels About Genocide, Deborah Mayersen

Genocide Studies and Prevention: An International Journal

Graphic novels about genocide feature a surprisingly rich array of animal imagery. While there has been substantial analysis of the anthropomorphic animals in Maus, the roles and functions of non-anthropomorphised animals have received scant attention. In this article, I conduct a comparative analysis of ten graphic novels about genocide to identify and elucidate the archetypical functions of non-anthropomorphised animals. These animals can play a symbolic role, providing insight into the human condition. More commonly, they provide crucial emotional cues to the reader. Animal imagery can be a powerful technique for creating an affective context, communicating both simple and complex …

Membrane Associated Collagen Xiii Promotes Cancer Metastasis And Enhances Anoikis Resistance, Hui Zhang, Tricia Fredericks, Gaofeng Xiong, Yifei Qi, Piotr G. Rychahou, Jia-Da Li, Taina Pihlajaniemi, Wei Xu, Ren Xu

Markey Cancer Center Faculty Publications

Background: Increased collagen expression and deposition are associated with cancer progression and poor prognosis in breast cancer patients. However, function and regulation of membrane-associated collagen in breast cancer have not been determined. Collagen XIII is a type II transmembrane protein within the collagen superfamily. Experiments in tissue culture and knockout mouse models show that collagen XIII is involved in cell adhesion and differentiation of certain cell types. In the present study, we determined roles of collagen XIII in breast cancer progression and metastasis.

Methods: We analyzed the association of collagen XIII expression with breast cancer development and metastasis using published …

Comparative Venom-Gland Transcriptomics And Venom Proteomics Of Four Sidewinder Rattlesnake (Crotalus Cerastes) Lineages Reveal Little Differential Expression Despite Individual Variation, Erich Hofmann, Rhett M. Rautsaw, Jason L. Strickland, Matthew L. Holding, Michael P. Hogan, Andrew J. Mason, Darin R. Rokyta, Christopher L. Parkinson

Publications

Changes in gene expression can rapidly influence adaptive traits in the early stages of lineage diversification. Venom is an adaptive trait comprised of numerous toxins used for prey capture and defense. Snake venoms can vary widely between conspecific populations, but the influence of lineage diversification on such compositional differences are unknown. To explore venom differentiation in the early stages of lineage diversification, we used RNA-seq and mass spectrometry to characterize Sidewinder Rattlesnake (Crotalus cerastes) venom. We generated the first venom-gland transcriptomes and complementary venom proteomes for eight individuals collected across the United States and tested for expression differences …

Glucose Signaling Is Important For Nutrient Adaptation During Differentiation Of Pleomorphic African Trypanosomes, Yijian Qiu, Jillian E. Milanes, Jessica A. Jones, Rooksana E. Noorai, Vijay Shankar, James C. Morris

Publications

The African trypanosome has evolved mechanisms to adapt to changes in nutrient availability that occur during its life cycle. During transition from mammalian blood to insect vector gut, parasites experience a rapid reduction in environmental glucose. Here we describe how pleomorphic parasites respond to glucose depletion with a focus on parasite changes in energy metabolism and growth. Long slender bloodstream form parasites were rapidly killed as glucose concentrations fell, while short stumpy bloodstream form parasites persisted to differentiate into the insect-stage procyclic form parasite. The rate of differentiation was lower than that triggered by other cues but reached physiological rates …

Mind The Gaps: How Can Food Safety Gaps Be Addressed In Developing Nations?, Jessie L. Vipham, Byron D. Chaves, Valentina Trinetta

Department of Food Science and Technology: Faculty Publications

As global food systems integrate, to meet the demands of a growing global population, safe and healthy agriculture value-chains will be essential to maintaining public health worldwide. In many ways, the current global food production landscape is made up of “mice and men.” Meaning that the food sector within and across most countries includes both large-scale corporate agriculture production and varying degrees of small-scale agriculture production; the variation being the interpretation of small scale, which is highly dependent upon the country. This structure presents challenges for the creation of effective food safety systems in many countries, and can contribute to …

Deciphering The Role Of The Barr Body In Malignancy: An Insight Into Head And Neck Cancer, Deepti Sharma, George Koshy, Shruti Sharma, Bhushan, Sonal Grover

Sultan Qaboos University Medical Journal

X chromosome inactivation is the epitome of epigenetic regulation and long non-coding ribonucleic acid function. The differentiation status of cells has been ascribed to X chromosome activity, with two active X chromosomes generally only observed in undifferentiated or poorly differentiated cells. Recently, several studies have indicated that the reactivation of an inactive X chromosome or X chromosome multiplication correlates with the development of malignancy; however, this concept is still controversial. This review sought to shed light on the role of the X chromosome in cancer development. In particular, there is a need for further exploration of the expression patterns of …

Purification And Characterization Of Naturally Occurring Post-Translationally Cleaved Ara H 6, An Allergen That Contributes Substantially To The Allergenic Potency Of Peanut, Govardus A. H. De Jong, Shyamali Jayasena, Philip Johnson, Justin Marsh, Danijela Apostolovic, Marianne Van Hage, Julie A. Nordlee, Joe Baumert, Steve L. Taylor, Camille Roucairol, Harmen De Jongh, Stef J. Koppelman

Department of Food Science and Technology: Faculty Publications

The 2S albumin Ara h 6 is one of the most important peanut allergens. A post-translationally cleaved Ara h 6 (pAra h 6) was purified from Virginia type peanuts, and the cleavage site was mapped using high-resolution mass spectrometry. Compared to intact Ara h 6, pAra h 6 lacks a 5-amino acid stretch, resembling amino acids 43−47 (UniProt accession number Q647G9) in the nonstructured loop. Consequently, pAra h 6 consists of two chains: an N-terminal chain of approximately 5 kDa and a C-terminal chain of approximately 9 kDa, held together by disulfide bonds. Intermediate post-translationally cleaved products, in which this …

Fueling Defense: Effects Of Resources On The Ecology And Evolution Of Tolerance To Parasite Infection, Sarah A. Budischak, Clayton E. Cressler

School of Biological Sciences: Faculty Publications

Resource availability is a key environmental constraint affecting the ecology and evolution of species. Resources have strong effects on disease resistance, but they can also affect the othermain parasite defense strategy, tolerance. A small but growing number of animal studies are beginning to investigate the effects of resources on tolerance phenotypes. Here, we review how resources affect tolerance strategies across animal taxa ranging from fruit flies to frogs to mice. Surprisingly, resources (quality and quantity) can increase or reduce tolerance, dependent upon the particular host-parasite system. To explore this seeming contradiction, we recast predictions of models of sterility tolerance and …

Comparison Of Maternal Beliefs About Causes Of Autism Spectrum Disorder And Association With Utilization Of Services And Treatments, Virginia Chaidez, Erik Fernandez Y Garcia, Lulu W. Wang, Kathleen Angkustsiri, Paula Krakowiak, Irva Hertz-Picciotto, Robin L. Hansen

Department of Nutrition and Health Sciences: Faculty Publications

Background: This study aimed to describe parental perceptions of the causes of autism spectrum disorder (ASD) in an ethnically diverse sample and explore whether these perceptions relate to treatment choices.

Methods: The sample consisted of White (n=224), Hispanic (n=85) and Asian (n=21) mothers of a child with ASD. A mixed methods approach was used in this secondary analysis focusing on parental perceptions about the causes of ASD and the relationship of these to utilization of services and treatment.

Results: Environmental and genetic factors were most often believed to be the cause or one of the causes of ASD by mothers …

Acquired Resilience: An Evolved System Of Tissue Protection In Mammals., Jonathan Stone, John Mitrofanis, Daniel M Johnstone, Benedetto Falsini, Silvia Bisti, Paul Adam, Arturo Bravo Nuevo, Mindy George-Weinstein, Rebecca Mason, Janis Eells

PCOM Scholarly Works

This review brings together observations on the stress-induced regulation of resilience mechanisms in body tissues. It is argued that the stresses that induce tissue resilience in mammals arise from everyday sources: sunlight, food, lack of food, hypoxia and physical stresses. At low levels, these stresses induce an organised protective response in probably all tissues; and, at some higher level, cause tissue destruction. This pattern of response to stress is well known to toxicologists, who have termed it hormesis. The phenotypes of resilience are diverse and reports of stress-induced resilience are to be found in journals of neuroscience, sports medicine, cancer, …

Literature Of Pediatric Nursing: A Bibliometric Analysis (2013 – 2017), Jagannathan Ramakrishnan, Jayaraman Selvamani

Library Philosophy and Practice (e-journal)

Presents a bibliometric analysis of the literature in the field of Pediatric Nursing as indexed the MEDLINE data which covered in the Pubmed for the period 2013-2017. It is observed that a total of 5853 records in the MEDLINE data covered by Pubmed on ‘Pediatric Nursing’. Maximum numbers of records were published during 2016, followed by the years 2015 and 2017. It was found that majority of records covered by Journal Article; followed by Research Support, Non-U.S. Gov't, Review, Research Support, N.I.H., Extramural, Editorial, Randomized Controlled Trial, News etc. Relative Growth Rate (RGR) has shown decreasing trend and the Doubling …

Exogenous Application Of Methyl Jasmonate Alters Pinus Resinosa Seedling Response To Simulated Frost, Brian M. Connolly, John L. Orrock

Biology Faculty Scholarship

Physical stresses, such as exposure to cold, can affect plant recruitment, survival, and demography. The ability of plants to tolerate physical stress, however, may depend upon the co-occurrence of other stresses. For example, although plants undergo physiological changes to increase defense against herbivores, it is unknown whether chemical signaling associated with herbivory can alter plant tolerance to cold. We tested the hypothesis that both tissue removal and chemical induction (via exogenous application of 1 mmol/L methyl jasmonate [MeJA]) would alter cold tolerance of seedlings of Pinus resinosa Aiton. Application of MeJA resulted in 18% less foliar tissue damage compared with …

School Deans, Department Chairpersons, And Program Directors 2018-2019, Saint Mary's College Of California

Chairs and Program Directors lists

No abstract provided.

The Impact Of Social Desirability On An Individual’S Scale Of Accurate Personality Prediction (Sapp) Score, Alexander James Kiss

Theses and Dissertations

The Scale of Accurate Personality Prediction (SAPP), developed by Miller (2000), was derived from the 16PF and purports to measure an individual’s ability to accurately assess his or her own self-knowledge. The scores from the SAPP are derived from calculating the absolute value of the difference between the individuals predicted scores on the 16PF, and the individual’s actual scores on the 16PF. The present study aimed to determine if individuals with lower SAPP scores were influenced by social desirability, and if social desirability perception differs by gender. Archival data of 607 individuals was organized into 150 low scoring SAPP individuals …

October 2018 News Releases, University Of Montana--Missoula. Office Of University Relations

University of Montana News Releases, 1928, 1956-present

No abstract provided.

Elucidating The Mechanisms Of Apoptosis Induced By A Novel Geranylgeranyl Diphosphate Synthase Inhibitor In T-Cell Acute Lymphoblastic Leukemia, Sherry Agabiti

Doctoral Dissertations

Archival abstract submitted

Time Sensitive Functionals Of Marked Random Measures In Real Time, Kizza M. Nandyose Frisbee

Theses and Dissertations

In this dissertation, we study marked random measures that model stochastic networks (under attacks), status of queueing systems during vacation modes, responses to cancer treatments (such as chemotherapy and radiation), hostile actions in economics and warfare. We extend the recently developed time sensitivity technique for investigating the processes’ behavior about a fixed threshold to a novel time sensitive technique in three important directions: (1) real-time monotone stochastic processes; (2) two-dimensional signed random measures; and (3) antagonistic stochastic games with two active players and one passive player. The need for the time sensitive feature in our study (i.e., an analytical association …

A Healthy Balance, Une Applied Nutrition Program

All Student-Created Educational Resources

This handout focuses on four different factors attributed to maintaining a healthy lifestyle for adolescents and families based on four separate articles and research.

Best Health Tips For Teenage Girls, Une Applied Nutrition Program

All Student-Created Educational Resources

The handout provides basic nutrition tips on how to implement small changes towards a healthier lifestyle.

Millennial Male Associate Degree Of Nursing Students: Perceived Motivators, Benefits And Barriers, Daniela Brink

All Theses And Dissertations

There is a severe nursing shortage in the United States which affects the delivery of healthcare. The reasons for the nursing shortage are many and complex including the national movement toward healthcare reform, an aging population making greater demands on an already stressed healthcare system, and stereotypical attitudes about the work of nursing in general. While men comprise approximately half of the population, men represent only 9.6% of the nursing profession. As millennials are the current emerging workforce, this problem of a nursing shortage could be addressed by increasing the diversity of the nursing workforce to include more men from …

Understanding The Relationship Between Cultural Wellness And Academic Achievement On Standing Rock Reservation, Derek A. Stewart

All Theses And Dissertations

Academic achievement concerns are common among reservation schools in North and South Dakota and elicit numerous questions regarding how to address these concerns to improve educational outcomes for Native American students. This study examined the relationship between cultural wellness integration, based on the Medicine Wheel model, and the following academic achievement measures: standardized achievement tests, attendance, graduation rates, and behavioral disciplinary referrals. The specific research questions that guided this study are: 1) Using a Medicine Wheel model, how are schools on Standing Rock Reservation integrating cultural wellness? 2) How do cultural wellness integration practices relate to academic achievement in schools …

Identification Of Chst9 As A Candidate Gene For Schizophrenia From Whole Genome Sequencing, Christopher Sharp, Jingchun Chen, Marvi Moreno, Mahtab Hamid, Francisco Servin, Bita Bashy, Travis Mize

LSAMP Poster Presentations

Recent results imply that rare variants contribute to the risk of schizophrenia. We conducted whole genome sequencing for 99 subjects from 20 Chinese families (parents and at least two siblings with a schizophrenia diagnosis and one unaffected sibling). Of the 9 frameshift mutations identified in more than 2 families, one was at chromosome 10:125780762 on the Carbohydrate Sulfotransferase 15 (CHST15) gene and another at chromosome 18:24722723 on the Carbohydrate Sulfotransferase 9 (CHST9) gene. We observed these deletions in 4 affected persons of two families from whole. At least two types of mutations (one or three bases insertion) have been identified …

Unlv Magazine, Marta Meana, Tiffany Pereira, Juliet V. Casey, Jason Scavone, Keyonna Summers

UNLV Magazine

No abstract provided.

Impact, Office For The Advancement Of Research, Cuny John Jay College

Reports and Publications from John Jay College

[John Jay College’s research magazine.] Welcome to the inaugural issue of Impact, a celebration of the extraordinary work of the scholars and artists at John Jay College. John Jay has been on an incredible journey. Our grant portfolio has grown by more than 70 percent in just five years, and the scholarship produced by our faculty has increased by over 50 percent in this same period. In this issue, we share with you just a few of these incredible projects. Like the work of Christopher Herrmann, Eric Piza, Preeti Chauhan and Phil Goff on the practices and policies of policing. …

Pseudomyxoma Pleurii And Peritonei Secondary To Sigmoid Colon Adenocarcinoma: A Rare Clinico-Pathologico-Radiological Presentation, Casmir Wambura

Internal Medicine, East Africa

Pseudomyxoma peritonei (PMP) is a rare condition resulting from mucin-producing tumors that have disseminated into intraperitoneal implants and mucinous ascites. The extra-abdominal spread of PMP is exceptionally rare, with few reported cases in the medical literature. Pseudomyxoma pleurii is an infrequently encountered clinical syndrome characterized by transdiaphragmatic pleural extension and spread of PMP. The disease is highly fatal. We hereby report a case of 58 years old woman who presented with an abdominal distension and shortness of breath of 2 months duration. Histopathology confirmed the diagnosis of large mucin-producing rectosigmoid adenomatous polypoid lesion with malignant transformation and PMP that had …