Dependence Of Nmr Chemical Shifts Upon Ch Bond Lengths Of A Methyl Group Involved In A Tetrel Bond, Steve Scheiner

Chemistry and Biochemistry Faculty Publications

Four different Lewis acids that might participate in a tetrel bond with a nucleophile (SEt₂Me⁺, NMe₄⁺, SMe₂, NMe₃) are examined. The NMR chemical shifts of the methyl C and H atoms are calculated as the CH bond lengths are systematically stretched and contracted, in the absence of a base. The C shielding diminishes by roughly 2 ppm for a stretch of 0.01 Å, while that of H drops by only 0.3 ppm. The deshieldings caused purely by the bond length changes are far too small to account for the …

Happy Beginnings: Francisco Tackles Recycling Composting With Greenest Region Corps, Ohio University College Of Arts & Sciences

All Forum Articles

No abstract provided.

Blame It On The Cortex, Sarah Press Dickerson

Erma Bombeck Writers' Workshop Blog

My sister, Judith, banged her toe on her coffee table yesterday. She told me all about it over the phone. She said it was so bad that not only was the toe bruised, but so was part of her foot. Of course I could empathize — everyone knows how painful it is to smash a piggy.

The Utah Statesman, October 30, 2018, Utah State University

The Utah Statesman

Weekly student newspaper of Utah State University in Logan.

Mitochondrial Replacement Therapy: How A Government For The People, Failed The People, Jeffery Mark Sauer

University of Miami Law Review

Despite having the potential to significantly reduce the passage of many lethal diseases and devastating birth defects, mitochondrial replacement therapy—a controversial medical procedure in which mitochondrial RNA from a healthy female replaces the mitochondrial RNA from the intended mother in vitro—will have no place in the United States anytime soon. Under the guise of purported safety concerns and ethical dilemmas, the Republican Congress used its “power of the purse” to halt any and all research furthering mitochondrial replacement therapy, notwithstanding the fact that many leaders in the medical community have advocated for further research. Several developed countries have already implemented …

Highly Potent 1h-1,2,3-Triazole-Tethered Isatin-Metronidazole Conjugates Against Anaerobic Foodborne, Waterborne, And Sexually-Transmitted Protozoal Parasites, Sumit Kumar, Trpta Bains, Ashley Sae Won Kim, Christina Tam, Jong Kim, Luisa W. Cheng, Kirkwood M. Land, Anjan Debnath, Vipan Kumar

College of the Pacific Faculty Articles

Parasitic infections like amebiasis, trichomoniasis, and giardiasis are major health threats in tropical and subtropical regions of the world. Metronidazole (MTZ) is the current drug of choice for amebiasis, giardiasis, and trichomoniasis but it has several adverse effects and potential resistance is a concern. In order to develop alternative antimicrobials, a library of 1H-1,2,3-triazole-tethered metronidazole-isatin conjugates was synthesized using Huisgen's azide-alkyne cycloaddition reaction and evaluated for their amebicidal, anti-trichomonal, and anti-giardial potential. Most of the synthesized conjugates exhibited activities against Trichomonas vaginalis, Tritrichomonas foetus, Entamoeba histolytica, and Giardia lamblia. While activities against T. vaginalis and T. foetus were comparable to …

Predominance Of Triple Wild-Type And Igf2r Mutations In Mucosal Melanomas., Yuuki Iida, Matthew P Salomon, Keisuke Hata, Kevin Tran, Shuichi Ohe, Chester Griffiths, Sandy C Hsu, Nellie Nelson, Dave S B Hoon

Articles, Abstracts, and Reports

BACKGROUND: Primary mucosal melanoma (MM) is a rare subtype of melanoma that arises from melanocytes in the mucosa. MM has not been well profiled for mutations and its etiology is not well understood, rendering current treatment strategies unsuccessful. Hence, we investigated mutational landscape for MM to understand its etiology and to clarify mutations that are potentially relevant for MM treatment.

METHODS: Forty one MM and 48 cutaneous melanoma (CM) tissues were profiled for mutations using targeted deep next-generation sequencing (NGS) for 89 cancer-related genes. A total of 997 mutations within exons were analyzed for their mutational spectrum and prevalence of …

2018-October-30-Slow Road To Healing, University Marketing And Communication, East Tennessee State University

ETSU News

‘Slow Road to Healing’

JOHNSON CITY (Oct. 30, 2018) – “Slow Road to Healing” is the topic of a talk to be delivered by Dr. Victoria Sweet on Thursday, Nov. 1, at 6 p.m. in the Grand Soldiers Ballroom at the Carnegie Hotel on State of Franklin Road.

Sweet is a physician, Guggenheim Fellow of Medical History and author of two books, “God’s Hotel: A Doctor, a Hospital, and a Pilgrimage to the Heart of Medicine” and “Slow Medicine: The Way to Healing.”

Her free public talk, which will focus on the “slow medicine movement,” or “spending time to save …

Bp Gulf Science Data Reveals Ineffectual Subsea Dispersant Injection For The Macondo Blowout, Claire B. Paris-Limouzy, Igal Berenshtein, Marica L. Trillo, Robin Faillettaz, Maria J. Olascoaga, Zachary M. Aman, Michael Schlüter, Samantha B. Joye

C-IMAGE Publications

After the Deepwater Horizon oil platform explosion, an estimated 172.2 million gallons of gas-saturated oil was discharged uncontrollably into the Gulf of Mexico, causing the largest deep-sea blowout in history. In an attempt to keep the oil submerged, massive quantities of the chemical dispersant Corexit^® 9500 were deployed 1522 m deep at the gushing riser pipe of the Macondo prospect’s wellhead. Understanding the effectiveness of this unprecedented subsea dispersant injection (SSDI) is critical because deep-water drilling is increasing worldwide. Here we use the comprehensive BP Gulf Science Data (GSD) to quantify petroleum dynamics throughout the 87-day long blowout. The …

Forecast Or Fall: Prediction's Importance To Postural Control, Chris J. Dakin, David A.E. Bolton

Kinesiology and Health Science Faculty Publications

To interact successfully with an uncertain environment, organisms must be able to respond to both unanticipated and anticipated events. For unanticipated events, organisms have evolved stereotyped motor behaviors mapped to the statistical regularities of the environment, which can be trigged by specific sensory stimuli. These 'reflexive' responses are more or less hardwired to prevent falls and represent, maybe, the best available solution to maintaining posture given limited available time and information. With the gift of foresight, however, motor behaviors can be tuned or prepared in advance, improving the ability of the organism to compensate for, and interact with, the changing …

The Bring Your Own Tampon Policy: Why Menstrual Hygiene Products Should Be Provided For Free In Restrooms, Elizabeth Montano

University of Miami Law Review

Like toilet paper, menstrual hygiene products, such as tampons and pads, are necessities for managing natural and unavoidable bodily functions. However, menstrual hygiene products widely receive separate treatment in restrooms across the globe. While it would be absurd today to carry a roll of toilet paper at all times, it is considered necessary and common sense for all menstruators to carry menstrual hygiene products at all times, for approximately forty years, in case of an emergency. This is the “Bring Your Own Tampon” (“BYOT”) policy and it is a violation of human rights and equal protection.

This Note seeks to …

Daily Eastern News: October 30, 2018, Eastern Illinois University

October

No abstract provided.

Ban The Box: Outcomes Of Mandatory Disclosure And Predictors Of Voluntary Disclosure Of Criminal History In Job Applications, Ginevra Marta Scherini

Master's Theses

The present study was conducted in order to examine the outcomes of mandatory disclosure of criminal history on the individual during the job application process and predictors of the likelihood of voluntary disclosure. It was hypothesized that having to disclose criminal history would predict higher levels of self-identification with criminal history, higher levels of experienced discrimination, higher levels of perceived stigma, lower levels of attraction towards the organization, lower confidence in obtaining employment, and lower levels of likelihood of voluntary disclosure. It was also hypothesized that environmental support, employment self-efficacy, self-identification with criminal history, and less experienced discrimination would predict …

Supporting First-Generation Students’ Adjustment To College With High-Impact Practices, Theresa Conefrey

English

This qualitative case study describes some of the issues faced by incoming first-generation college students at a private, 4-year institution in the northwest. Using constructs drawn from social cognitive theory and social cognitive career theory, it explores how high-impact practices such as learning communities, writing-intensive courses, and ePortfolios might impact first-generation students’ adjustment during their first year of college. The findings of the research on students’ writing in their first-year composition course suggest that the cumulative impact of engaging in multiple high-impact practices improves students’ literacy and study skills. In addition, these educational practices appear to increase students’ self-appraisal of …

A Biochemical Study Of The Autocatalytic Nature Of A Serine Protease (Early Trypsin) From The Aedes Aegypti Female Mosquito, Rachael Marie Lucero

Master's Theses

The female Aedes aegypti mosquito requires specific midgut proteases to digest

blood meals in a biphasic manner for completion of the gonotrophic cycle. The anautogenous nature of the female mosquito has led to the mosquito in becoming an efficient vector in transmitting several bloodborne pathogens: Chikungunya, Yellow Fever, Dengue and the Zika virus. With the many flaws associated with current vector control strategies, our research lab is focused on the development of a potential novel vector control strategy by targeting midgut proteases involved in blood meal digestion. The role of one of the four most abundantly expressed proteases, AaET, an …

Um Professor Part Of Upcoming American Chemical Society Webinar, Shea Stewart

University of Mississippi News

Presentation puts astrochemistry research program in spotlight

Evaluasi Kebutuhan Modul Bioteknologi Berbasis Problem Based Learning Untuk Mahasiswa Jurusan Biologi, Novia Sigma Amalina, Mohamad Amin, Betty Lukiati

Jurnal Pendidikan: Teori, Penelitian, dan Pengembangan

This study aims to evaluate the needs of module based Biotechnology with Problem Based Learning for students majoring in Biology Universitas Negeri Malang. Data collection techniques using a questionnaire aimed at 60 students of Biology Department FMIPA UM who have taken the course of Biotechnology with cluster sampling design. Questionnaires are used to evaluate the curriculum, learning process, teaching materials, bioinformatics knowledge, and the need for PBL-based teaching materials. The questionnaire results show that the development of PBL-based biotechnology modules for students in biotechnology courses is essential.

Computational Models Exploring The Role Of Flexibility In Binding Tat Peptide To Tar Rna, Thanh Quoc Le

Master's Theses

Viral-encoded regulatory proteins interacting with RNA target sequences control the gene expression of lentiviruses, notably the human immunodeficiency virus (HIV) and bovine immunodeficiency virus (BIV). The latter provides a simpler interaction model between the viral trans-activator protein (Tat) and trans-activation response RNA element (TAR), including Tat peptides binding to TAR RNA fragments. This model may offer insights into clinical approaches for treatment, initially through theoretical consideration of the role of peptide flexibility in binding as evidenced by literature-based binding assays and NMR. It has more recently been suggested that DNA-protein binding may also be enhanced by increases in conformational entropy. …

Characterization Of Four Type-C Silica Columns Using Resveratrol Analogues, Joshua Topete

Master's Theses

High performance liquid chromatography (HPLC) is an analytical technique used to separate, identify and quantify components in a solution based on the affinities between analyte, mobile phase and stationary phase. The main goal of my research is to characterize four Type-C silica columns by comparing the retention of resveratrol analogues. The four columns included are functionalized with either Diamond Bidentate C18 (DBC18), Bidentate C18 (BC18), phenyl hydride or diol groups. Retention maps displaying mobile phase composition compared to compound retention times were compared between columns. In addition to this, two organic solvents (acetonitrile and methanol) were compared. Considering that the …

Changes In The Elasmobranch Assemblage In A California Estuary, Catarina Pien

Master's Theses

Elkhorn Slough is an estuarine system that provides habitat for several elasmobranch species. During the past century, the hydrography and habitat of Elkhorn Slough have dramatically changed. Previous studies suggest shifts in the species composition and habitat usage patterns of elasmobranchs. This study characterizes the elasmobranch species composition, and examines the abiotic conditions associated with differences in distribution by sex and life stage. Elasmobranchs were sampled from 2015 –2016 by longline and gillnet. Bat rays (Myliobatis californicus), leopard sharks (Triakis semifasciata), and thornback rays (Platyrhinoidis triseriata) were most commonly observed, and were generally more abundant during the dry seasons and …

Canavalia Gladiata And Dolichos Lablab Extracts For Sustainable Pest Biocontrol And Plant Nutrition Improvement In El Salvador, Carlos Martinez

Department of Agronomy and Horticulture: Dissertations, Theses, and Student Research

Botanical repellents and pesticides are now being rediscovered as new tools for integrated pest management in order to reduce the use of toxic chemicals in crop production. Canavalia gladiata and Dolichos lablab are two Fabaceae very well adapted to farmlands of El Salvador, effective as living barriers and mostly as cover crops, however, they are not yet very well disseminated. This document describes the potential for using the liquid extracts and the dry flour of raw seeds of those plants for economic benefit and practical convenience for pest management in Salvadorian agriculture under field conditions. Seed extracts were useful when …

Innovation In Pedagogy And Technology Symposium: University Of Nebraska, May 8, 2018, University Of Nebraska

Zea E-Books Collection

Selected Conference Proceedings, Presented by University of Nebraska Online and University of Nebraska Information Technology Services.

University of Nebraska Information Technology Services (NU ITS) and University of Nebraska Online (NU Online) present an education and technology symposium each spring. The Innovation in Pedagogy and Technology Symposium provides University of Nebraska (NU) faculty and staff the opportunity to learn from nationally recognized experts, share their experiences and learn from the initiatives of colleagues from across the system. This event is offered free to NU administrators, faculty and staff free of charge. Tuesday, May 8, 2018 The Cornhusker Marriott, Lincoln, NE

Technology …

Effect Of Operational Parameters, Characterization And Antibacterial Studies Of Green Synthesis Of Silver Nanoparticles Using Tithonia Diversifolia, Adewumi Dada, Adejumoke A. Inyinbor, Ebiega Idu, Oluwasesan M. Bello, Abimbola Peter Oluyori, Tabitha A. Adelani‐Akande, Abiodun A. Okunola, Olarewaju Dada

Faculty and Student Publications (Open Access)

No abstract provided.

Functional Assessment Of 2,177 U.S. And International Drugs Identifies The Quinoline Nitroxoline As A Potent Amoebicidal Agent Against The Pathogen Balamuthia Mandrillaris, Matthew T. Laurie, Corin V. White, Hanna Retallack, Wesley Wu, Matthew S. Moser, Judy A. Sakanari, Kenny Ang, Christopher Wilson, Michelle R. Arkin, Joseph L. Derisi

UROC Staff Publications and Presentations

Balamuthia mandrillaris is a pathogenic free-living amoeba that causes a rare but almost always fatal infection of the central nervous system called granulomatous amoebic encephalitis (GAE). Two distinct forms of B. mandrillaris—a proliferative trophozoite form and a nonproliferative cyst form, which is highly resistant to harsh physical and chemical conditions—have been isolated from environmental samples worldwide and are both observed in infected tissue. Patients suffering from GAE are typically treated with aggressive and prolonged multidrug regimens that often include the antimicrobial agents miltefosine and pentamidine isethionate. However, survival rates remain low, and studies evaluating the susceptibility of B. mandrillaris to …

California Island Rediscovery: Building An Archive To Improve Conservation Today And Equip The Historical Ecologist Of Tomorrow, Scott A. Morrison, T. Scott Sillett, W. Chris Funk, Cameron K. Ghalambor, Torben C. Rick

Western North American Naturalist

An understanding of how past conditions have shaped present-day ecological patterns and trends is critical to science-based conservation management. Unfortunately, the records, specimens, and objects historical ecologists need to help generate that understanding are often lacking. And because of a general underinvestment by society in systematic collection and museum curation, future historical ecologists may be similarly limited in their ability to investigate conditions regarding our present day. Given the importance of historical data and materials in contemporary conservation decision-making, we suggest it is incumbent upon resource managers and scientists to ask whether additional research efforts are needed to document past …

Pengaruh Model Pembelajaran Inkuiri Terbimbing Terhadap Keterampilan Proses Sains Dan Hasil Belajar Muatan Ipa Di Kelas Iv, Sarah Nurhabibah, Arif Hidayat, Alif Mudiono

Jurnal Pendidikan: Teori, Penelitian, dan Pengembangan

This study aims to determine the effect of guided inquiry learning model on the science process skills and cognitive learning outcomes of natural science in 4th grade of elementary school. Quasi experiments were used in the study with a pretest-posttest design control group. Science process skills hypothesis test and cognitive learning outcomes of natural science using ANACOVA. The results showed that (1) there is the effect of application of guided inquiry learning model on Keterampilan Proses Sains with sig <0.05 and (2) there is the effect of application of guided inquiry learning model on cognitive learning outcomes of natural science with sig <0.05.

Potensi Pembelajaran Ricosre Pada Peningkatan Hasil Belajar Kognitif Siswa Kelas Xi, Ika Dewi Sumiati, Susriyati Mahanal, Siti Zubaidah

Jurnal Pendidikan: Teori, Penelitian, dan Pengembangan

The aim of this research is to determine the influence of learning model RICOSRE (Reading, Identifying Problem, Constructing Solution, Solving Problem, Reviewing Problem Solving, and Extending Problem Solving) toward XIth grade students’ Biology cognitive learning outcomes in SMAN 4 and SMAN 10 Malang. This research type is a quasi-experimental research with non-equivalent pretest posttest control group design. The sample used is the students in two classes each schools. Data collected in the form of pretest score and postes score. Data analysis using ancova technique and continued with LSD test that showed RICOSRE learning model significantly influenced the XIth grade students' …

Landscape Genetics Reveal Broad And Fine‐Scale Population Structure Due To Landscape Features And Climate History In The Northern Leopard Frog (Rana Pipiens) In North Dakota, Justin M. Waraniak, Justin D. L. Fisher, Kevin Purcell, David M. Mushet, Craig A. Stockwell

United States Geological Survey, Northern Prairie Wildlife Research Center: Publications

Prehistoric climate and landscape features play large roles structuring wildlife populations. The amphibians of the northern Great Plains of North America present an opportunity to investigate how these factors affect colonization, migration, and current population genetic structure. This study used 11 microsatellite loci to genotype 1,230 northern leopard frogs (Rana pipiens) from 41 wetlands (30 samples/wetland) across North Dakota. Genetic structure of the sampled frogs was evaluated using Bayesian and multivariate clustering methods. All analyses produced concordant results, identifying a major east–west split between two R. pipiens population clusters separated by the Missouri River. Substructuring within the two major identified …

Landscape Genetics Reveal Broad And Fine‐Scale Population Structure Due To Landscape Features And Climate History In The Northern Leopard Frog (Rana Pipiens) In North Dakota, Justin M. Waraniak, Justin D.L. Fisher, Kevin Purcell, David M. Mushet, Craig A. Stockwell

United States Geological Survey, Northern Prairie Wildlife Research Center: Publications

Prehistoric climate and landscape features play large roles structuring wildlife populations. The amphibians of the northern Great Plains of North America present an opportunity to investigate how these factors affect colonization, migration, and current population genetic structure. This study used 11 microsatellite loci to genotype 1,230 northern leopard frogs (Rana pipiens) from 41 wetlands (30 samples/wetland) across North Dakota. Genetic structure of the sampled frogs was evaluated using Bayesian and multivariate clustering methods. All analyses produced concordant results, identifying a major east–west split between two R. pipiens population clusters separated by the Missouri River. Substructuring within the two major identified …

Kaposi’S Sarcoma-Associated Herpesvirus Seropositivity Is Associated With Type 2 Diabetes Mellitus: A Case–Control Study In Xinjiang, China, Meng Cui, Qiwen Fang, Jun Zheng, Zhanjun Shu, Yin Chen, Yage Fan, Juan Zhao, Charles Wood, Tiejun Zhang, Yan Zeng

Nebraska Center for Virology: Faculty Publications

Objective: To assess the potential relationship between Kaposi’s sarcoma-associated herpesvirus (KSHV) infection and type 2 diabetes mellitus (DM-2) in Xinjiang, China.

Methods: A case–control study of consecutively included DM-2 patients and normal controls was conducted among the Uygur and Han populations in Xinjiang Uygur Autonomous Region, China. Blood samples were collected and KSHV seroprevalence, antibody titers, and viral load were investigated. Logistic regression analysis and multiple linear regression analysis were applied to explore determinants of the main outcome measures.

Results: A total of 324 patients with DM-2 and 376 normal controls were included. The seroprevalence of KSHV was 49.1% (95% …