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Abortion: Drawing A Line Of Moral Permissibility In Fetal Development, Madison Elizabeth Nash

Honors Theses

The goals of this thesis are to first examine prominent arguments in philosophical and religious ethics regarding the morality of induced abortions, and then to create my own moral argument regarding induced abortion by drawing a line during fetal development. I will first discuss the biological stages of fetal development, the effects of pregnancy on a pregnant woman, and the mechanics of common induced abortion procedures. Next, I will present and analyze renowned philosophical arguments regarding the morality of abortion. Then, I will present and analyze arguments regarding the morality of induced abortions drawn from two religious traditions - Roman …

Purkinje Cell Morphology And Display Complexity In Manakins (Pipridae), Mary Harvey

Honors Theses

Manakins are a suboscine, lekking bird of the tropical and subtropical regions of South and Central America that perform complex mating displays shaped by sexual selection. The complexity of the mating display varies greatly across species of manakins. Some manakins only perform a limited number of different motor elements, whereas others have elaborate displays that consist of acrobatic movements and mechanical sound production. The complexity of these displays has been found to be positively related to brain weight, brain volume, arcopallium volume, body weight, and tarsus size but shows no relationship to the nucleus rotundus or nucleus taeniae. The volume …

Terrorism In The Time Of Schengen, Alaina Bierdz

Honors Theses

This paper investigates the relationship between the Schengen area in Europe and terrorism. The Schengen agreement was implemented in 1995; since then, internal borders between the contracting parties have been abolished. This paper emphasizes the rationale that Schengen made member-states more vulnerable to terrorist attacks because the agreement inherently involved less regulation. In order to test this rationale, this study uses James Q. Wilson's choice theory. This theory refers to the school of thought which maintains that rational wrongdoers act as if they weigh the possible benefits of criminal or delinquent activity against the expected costs of being apprehended. Specifically, …

Fabrication And Application Of Functional Polymer-Protein Coreshell Nanoparticles, Lin Lu

Theses and Dissertations

The study of polymer-protein nanoparticles is of increasing interest due to their various potential applications in biosensing, imaging, bioseparations, gene and drug delivery, etc. Synthetic polymers can be tailored with different functional groups and properties, therefore, they can serve as platforms to impart proteins with additional features and assist proteins to better perform biological functions. In this dissertation work, we were mainly focusing on the preparation of polymer-protein core-shell nanoparticles by synthesizing new functional polymers and assembling them with proteins for different applications. In chapter 1, a pyridine grafted diblock copolymer P(CL-g-Py)-b-PCL was prepared through ROP and CuAAC reactions. …

Enhancements In Alginate Microencapsulation Technology & Impacts On Cell Therapy Development, Marwa Belhaj

Theses and Dissertations

Biodegradable alginate microcapsules (MC) are recently becoming widely used in the biomedical field, and have shown effectiveness as a drug delivery system. Alginate has been used in microencapsulation due to its simple gelling process, biodegradability, excellent biocompatibility, and its stability under in-vivo conditions. Alginate polymer is a natural polysaccharide derived from brown seaweed and has the ability to polymerize rapidly in the presence of cations to form a porous matrix. In order to advance the previous system for efficient protein and peptide delivery, we further lyophilized the peptide-filled microcapsules and we were able to rehydrate, and test them for sustained …

The Impact Of Communication Deficits On Puberty And Sexual Development In Adolescents On The Autism Spectrum, Ashton Wolfe

Theses and Dissertations

Transitioning into a sexually mature adult is a challenging time for both an adolescent with autism spectrum disorder (ASD) and his or her family. Sexual development begets challenges due to the demands it places on the social and communication skills needed to explore developmental changes that are occurring physically, emotionally and hormonally. A diagnosis of ASD is largely established by quantifying impediments in social and communication skills through observation. With deficits in these skills, one can assume that social and communication difficulties can create obstacles in the sexual development of affected individuals. Our study used quantitative and qualitative measures to …

Environmental Impacts On Enterococcus In Shem Creek, South Carolina, And Characterization Of Changing Land Use, Maria Elizabeth Zubizarreta

Theses and Dissertations

Zoning and land-use practices have a direct influence on hydrologic systems and can impact water resources. Linkages between change in land uses and degradation of water quality in stream and watershed environments have been well established. Shem Creek, located in Mount Pleasant, SC, has a history of fecal indicator bacteria levels that exceed the Environmental Protection Agency’s recreational water quality standards. With recent coastal population and development trends, proper management and the sustainability of beach and estuary environments are a rising public health concern. The objective of this study is to determine what climatic and water quality parameters are associated …

Matrix Stiffness Modulates Mesenchymal Stem Cell Sensitivity To Geometric Asymmetry Signals, Maria Eugenia Piroli

Theses and Dissertations

Human stem cells hold significant potential for the treatment of various diseases. However, their use as a therapy is hampered by the limited understanding of the mechanisms by which stem cells respond to environmental stimuli. Efforts to understand extracellular biophysical cues have demonstrated the critical roles of geometric and mechanical signals in determining the fate of stem cells. The goal of this study was to explore the interplay between cell polarity and matrix stiffness in stem cell lineage specification. We hypothesize that confining cells to asymmetric extracellular matrix (ECM) islands will impart polarity at a single-cell level and result in …

Plants As Biofactories To Produce Mammalian Tumor Suppressor Micrornas, John Lachlan Macarthur

Theses and Dissertations

MicroRNAs (miRNAs) are small noncoding single stranded RNAs that are considered master regulators of gene expression. They are also an emerging class of therapeutic agents with significant potential for the prevention and treatment of many diseases, including cancer. Many different forms of cancer are associated with loss or reduced accumulation of one or more miRNAs that function as tumor suppressors. In animal models, restoration of missing tumor suppressor miRNAs prevents the initiation, progression and/or spread of the disease. However, the current absence of an efficient method for delivery of therapeutic miRNAs is a critical barrier to their use. The research …

Linking Microbial Phylogenetic And Functional Gene Diversity To Microbial Mat Ecosystem Function Following Environmental Disturbance, Eva Christine Preisner

Theses and Dissertations

The ability of ecosystems to adapt to environmental perturbations depends on the duration and intensity of change and the overall biological diversity of the system. In this study, a microbial mat ecosystem located on San Salvador Island, the Bahamas was used as a model to examine how environmental disturbance affects microbial community resistance, their protein synthesis potential (PSP), ecosystem function as measured by biogeochemical cycling, community stability, and resilience. This ecosystem experienced a large shift in salinity (230 to 65 g kg-1) during 2011–2012 following the landfall of Hurricane Irene on San Salvador Island. High throughput sequencing and analysis of …

Comparison Of The Performance Of Simple Linear Regression And Quantile Regression With Non-Normal Data: A Simulation Study, Marjorie Howard

Theses and Dissertations

Linear regression is a widely used method for analysis that is well understood across a wide variety of disciplines. In order to use linear regression, a number of assumptions must be met. These assumptions, specifically normality and homoscedasticity of the error distribution can at best be met only approximately with real data. Quantile regression requires fewer assumptions, which offers a potential advantage over linear regression. In this simulation study, we compare the performance of linear (least squares) regression to quantile regression when these assumptions are violated, in order to investigate under what conditions quantile regression becomes the more advantageous method …

Family And School Impact On Psychological Functioning From Childhood To Late Adolescence: A Longitudinal Study Of Rural Chinese Youth, Yang Yue

Theses and Dissertations

The transition from childhood to adolescence can be a significant stressor for youth, leading to increases in internalizing problems for those who are vulnerable. Compared to the mounting research conducted on U.S. youth, children and adolescents in China have received less attention on their psychological adjustment. As Chinese youth constitute roughly 15% of the world’s population (World Health Organization, 2010), and the disproportionate quantity of longitudinal investigation on Chinese youth psychological functioning, understanding the influence of risk and protective factors, and their interactive effects on internalizing problems among Chinese youth is critical.

According to Life Course Theory, Ecological Systems Theory, …

Role Of Mir-489 In Her2 Positive Breast Cancer, Yogin Patel

Theses and Dissertations

Human epidermal growth factor receptor 2 (HER2 or ErBb2) is a receptor tyrosine kinase overexpressed in 20-30% of breast cancers and associated with poor prognosis and outcome. Dysregulation of several micro RNAs (miRs) plays a key role in breast cancer progression and metastasis. In this study, we screened and identified miRs dysregulated in HER2-positive breast cancer cells. Molecular study demonstrated that miR-489 was specifically downregulated by the HER2-downstream signaling, especially the MAPK pathway. Restoration or overexpression of miR-489 in HER2-positive breast cancer cells significantly inhibited cell growth in vitro and decreased the tumorigenicity and tumor growth in xenograft mice. Mechanistically, …

Environmental Links To Ectopic Kidney Diseases, Firas Alhasson

Theses and Dissertations

Nonalcoholic fatty liver disease (NAFLD) is the most common liver disease in the western culture and worldwide. Its morbidity has been raising and it has become a burden on the public health. NAFLD is associated with other metabolic diseases such as Diabetic Mellitus and hypertension. NAFLD is a wide spectrum of symptoms, from an accumulation of fat in the liver (cirrhosis) to production of scar tissue (Fibrosis). The liver along with other distal organs such as the kidney and cardiovascular system can be damaged as ectopic manifestations of NAFLD. Contamination of drinking water with Cyanobacterium toxin (Microcystin) and water disinfection …

Interactive Effects Of Domoic Acid Allelopathy, Salinity, And Eutrophication On Estuarine Phytoplankton Community Structure, Elise Van Meerssche

Theses and Dissertations

Coastal regions and estuaries are particularly sensitive to the increase in nutrient loading and river runoff, threatening the ecosystems with possible spreads in harmful algal blooms (HABs). As an example, blooms of toxic Pseudo-nitzschia species can release acute concentrations of the neurotoxin domoic acid (DA) in the water column. When ingested at concentrations higher than 20 ppm, DA can cause the death of marine birds, marine mammals and even humans. The main objectives of my research were to determine the drivers of Pseudo-nitzschia abundance and toxicity and to assess how these drivers influenced the phytoplankton community structure and DA allelopathy. …

Two-Electrode Measurements Of Electrostatic Double Layer Potentials With Atomic Force Microscopy, Jason Giamberardino

Theses and Dissertations

In this dissertation, I provide a thorough description of my development of theoretical, analytical, and experimental techniques pertaining to novel measurements of the electrostatic double layer (EDL) using atomic force microscopy (AFM), among other techniques. The EDL refers to the structure formed by ions that exists at the interface between a solid and a liquid. The EDL is an important physical element of many systems and its behavior has been of interest to scientists for many decades. Because many areas of science and engineering are moving to test, build, and understand systems at smaller and smaller scales, this work focuses …

Mechanisms Of Rad51d-Dependent Repair Of Dna And Telomere Damage Induced By Interstrand Crosslinking Agents And Thiopurines, Nicole M. Reilly

Theses and Dissertations

Mutations in homologous recombination (HR) genes increase genomic instability, an enabling characteristic of cancer. However, the status of these same genes can also determine chemotherapy outcomes. RAD51D is a breast and ovarian cancer susceptibility gene that is an important component of HR. Mammalian cells defective for RAD51D have extensive chromosomal aberrations and are more sensitive to the interstrand crosslink-inducing agent mitomycin C (MMC) and the thiopurine 6-thioguanine (6TG). Previously, the RNF138 E3 ubiquitin ligase was identified to promote RAD51D ubiquitination, and loss of RNF138 also increased cellular sensitivity to MMC. Ubiquitination assays were used to show that a 3-ubiquitin modification …

Modulation Of Amyloid-Β Aggregation Via Small Molecules And Glycine Zipper Alterations, Steven Zebulon Vance

Theses and Dissertations

Alzheimer’s disease (AD) is the most common form of neurodegenerative disease. Nationally, AD is the 6th leading cause of death and the only top 10 killer of Americans that cannot be slowed, cured, or prevented. AD is characterized by the deposition of extracellular plaques of aggregated amyloid-β protein (Aβ). Aβ originates from the amyloid precursor protein (APP), a transmembrane protein that is cleaved to form a short and inert protein fragment called Aβ. However, Aβ undergoes a nucleation process wherein aggregates from soluble oligomers to insoluble fibrils are formed. While uncertainty remains as to the exact mechanism, studies have associated …

Evaluation Of Sonocatalytic Degradation Of Ibuprofen And Sulfamethoxazole In The Presence Of Various Catalysts, Yasir Alhamadani

Theses and Dissertations

Over the last two decades, large quantities of products, such as medicines, disinfectants, and personal care products, have been released into surface waters and wastewater treatment facilities by the pharmaceutical and chemical industries which have come to the attention of scientists with regard to their impacts on life in lakes, rivers, and groundwater. Among various types of treatment processes, ultrasonic (US) treatment process was used in this study to investigate the effect catalysts and removal of selected pharmaceutical’s (PhACs) compounds (ibuprofen (IBP) and sulfamethoxazole (SMX)). Carbon nanomaterials (CNMs) have become candidates for numerous applications in nanocomposites, microelectric devices, sensors, energy …

What Makes Killing For Organs Wrong? A Philosophical Defense Of The ‘Dead Donor’ Rule, Adam Omelianchuk

Theses and Dissertations

The purpose of my dissertation is to give a philosophic defense of the so-called “dead donor” rule (DDR) in transplant ethics, something that is sorely lacking in the current literature on the topic. Part of my project is concerned with the rule’s correct formulation: What exactly does it forbid? I answer that it is primarily concerned with prohibiting the killing of the donor for his or her organs, and that it need not be concerned with requiring that the donor be dead before surgery begins (as important as that might be). What is morally important is that surgery not be …

The Effect Of A Compassion Fatigue Awareness And Self-Care Skills Educational Program On Retention Among Certified Nursing Assistants Working In A Veterans Nursing Home, Michele M. Dreher

Theses and Dissertations

Background: Compassion fatigue is defined as the emotional and physical exhaustion that can affect helping professionals and caregivers over time. Certified nursing assistants (CNAs) are at high-risk for compassion fatigue due to their daily exposure to those who are suffering from a myriad of chronic medical and behavioral illnesses along with repeated workplace stressors. If not addressed early, compassion fatigue can adversely impact a CNA’s wellbeing and quality of resident care. Compassion fatigue is associated with high absenteeism, high turnover, and low retention rates. Despite these challenges, there is no published research on the effects of a workplace compassion …

Exploring Alternative Therapeutic Interventions For The Treatment Of Leigh Syndrome, Stephanie Martin

Theses and Dissertations

Leigh syndrome is the most common mitochondrial disease, affecting 1:40,000 live births. It manifests with symptoms including ataxia, cognitive impairment, motor difficulties, and stroke. Leigh syndrome is a genetic condition caused by mutations in either the nuclear DNA or mitochondrial DNA that affects the assembly of the electron transport chains. Death typically occurs around 2-3 years of age, due to respiratory failure, as the body cannot produce sufficient ATP for survival. The genetic basis of Leigh syndrome means that there is no cure, and current treatments of the symptoms have proven ineffective. This thesis proposes two different therapeutic approaches for …

Association Of Objective Measures Of Sleep And Inflammation Markers On Police Officers: A Cross-Sectional Analysis, Megan R. Buss

Theses and Dissertations

Police officers are a unique occupational group due to the fact that they have more health problems than many other occupations. These health problems could be a result of elevated inflammation markers caused by poor sleep. Sleep influences circadian rhythms, which thereby influences the function of the immune system. The immune system is responsible for the body’s inflammatory response using pro-inflammatory cytokines such as IL-6, CRP, Fibrinogen, and TNF-a. These cytokines can become elevated if disruption of the sleep cycle occurs. Elevated levels of inflammatory markers are associated with increased risk of cardiovascular disease. Police officers also work shifts and …

Teaching Musically: Incorporating Dalcroze Pedagogy Into Flute Instruction For The Elementary-Age Student, Emily M. Stumpf

Theses and Dissertations

The current practice of flute pedagogy for the elementary-age student is often focused on skill-building: finger technique, tone development, and note-reading and rhythm skills. Often the teacher will delve into concepts of musicianship only after the student develops a high level of technical skill. I have found it is possible to include musical concepts such as expressive playing, developing an internal sense of rhythm, and improvisation at all stages of the learning process. When the flute teacher functions as the initiator of an aesthetic experience, the development of musicianship becomes just as important as skill-building.

The Dalcroze philosophy of music …

Effect Of Environmental Factors On The Aggregation Behavior Of Silver Nanoparticles In The Aquatic Environment, Kamelia Afshinnia

Theses and Dissertations

Understanding the environmental factors that affect the fate and effects of engineered nanoparticles (ENPs) in the environment is crucial for NP risk assessment. Silver nanoparticles (Ag NPs) readily transform in the environment, which alters their properties and subsequently their transport, fate, and toxicity. The overall aim of this dissertation was to evaluate the effects of Ag NPs physicochemical properties (e.g., size, surface charge, surface coating) and water chemistry (e.g., buffer concentration, organic ligands, natural organic matter) in controlling Ag NPs colloidal stability. This aim was achieved by systematically 1) review and rationalize many studies that investigated the aggregation kinetics of …

Enhance Flow Boiling In Microchannels By Regulating Two-Phase Transport Patterns, Wenming Li

Theses and Dissertations

Flow boiling in microchannels is one of the most promising cooling techniques for microelectronics. Using latent heat by vaporization can significantly improve heat dissipation of high power density electronic devices. Most of the failure of electronic devices is induced by the occurrence of critical heat flux (CHF), which defines the maximum operating conditions. However, the vigorous rapid generation of vapor through phase change leads to chaotic two-phase flows in microchannels, resulting in flowinstability in terms of severe flow, temperature and pressure drop fluctuations. Particularly, the very well-known bubble confinement exacerbates the two-phase flow instabilities and greatly deteriorates heat transfer performance …

Probing Solvent Effects In Aromatic Interactions Using Molecular Balances, Josef M. Maier

Theses and Dissertations

Aromatic interactions play a key role in many important processes, such as the formation and stability of biological and synthetic assemblies, facilitation of molecular recognition processes, and catalysis of chemical reactions. One of the key factors determining the strength of aromatic interaction is the solvent environment. Therefore, developing model systems that can accurately measure the influence or effects of solvents on non-polar interaction strengths is a task of great importance. Over the years, we have been approaching this challenge via designing and analyzing molecular devices that can quantitatively report aromatic interaction energies under various solvent and chemical environments. With this …

Assessing The Strengths And Difficulties Of Typically Developing Siblings Of Persons Born With Lifelong Disabilities, Joseph Joseph Wofford

Theses and Dissertations

In this study, strengths and difficulties of siblings of persons born with disabilities were quantitatively assessed, based on parental perception, in comparison to national norms. Answers of 148 parents to the Strengths and Difficulties Questionnaire (SDQ; Goodman, 1997; Youthinmind, n.d.a.) for children four to seven years old who are siblings of persons born with lifelong disabilities (SPBDs) were gathered and analyzed. The causal-comparative design compared each subscale of the SDQ for SBPDs against their respective norms in the USA for females or males. SPBDs were found to have no statistically significant difference from the norm group on emotional problems, and …

Mechanisms Of Decarboxylation In The Cyp152 Family Of Cytochrome P450s, José Armando Amaya

Theses and Dissertations

Intense interest has focused on the development of enzymes as next-generation catalysts for the production of molecules with biotechnological potential. OleTJE, a member of the cytochrome P450 CYP152 family is an excellent candidate for the generation of advanced biofuels. OleTJE catalyzes the hydrogen peroxide-dependent decarboxylation of Cn fatty acids to produce Cn-1 terminal alkenes. Despite the ability of this enzyme to yield long chain alkenes with nearly exclusive chemoselectivity, its reactivity towards shorter chain length substrates results in undesired levels of hydroxylated side-products, limiting its industrial potential. Previous transient kinetic studies have demonstrated that, despite its unusual chemistry, the reaction …

Effect Of Resveratrol On The Development Of Eczema, Christopher Carlucci

Theses and Dissertations

Atopic dermatitis is a type of eczema characterized by chronic inflammation of the skin, affecting millions of people worldwide. Resveratrol, a naturally occurring stilbenoid, is widely believed to exhibit beneficial effects on a host of chronic diseases. Although some previous studies have aimed to evaluate the effects of resveratrol on the pathogenesis of atopic dermatitis, this relationship remains ill-defined. We have previously established that mast cell activation, remodeling, and cellular infiltration in the hypodermis all begin prior to the IgE-mediated immune response in an atopic dermatitis mouse model, and that this early pathogenesis is directly related to an increase in …