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Counterterrorism And Human Rights: A Comparative Analysis Of United States And European Laws, And Suggestions For Turkish Law Reform, Gulen Soyaslan

SJD Dissertations

This dissertation examines whether Turkish law could be amended in order to address the concerns of counterterrorism officials without unnecessarily infringing on individual rights. It differs from other research conducted on counterterrorism law in a number of ways. First, it provides general information on the concept of terrorism and the history and evolution of terrorism in Turkey. It further compares terrorism in Turkey with Europe and the United States. Second, it compares relevant counterterrorism laws of the United States, the United Kingdom, France, Germany, and Turkey. Third, it shows the approaches of the European and United States highest courts to …

Wall Fellows Newsletter, Volume 7, Issue 2, Fall 2018, Coastal Carolina University

Wall Fellows Newsletter

Newsletter of the Wall Fellows Program in the E. Craig Wall Sr. College of Business Administration.

Ecosystem Based Fisheries Management (Ebfm) Risk Assessment Of The Western Australian Sea Cucumber Fishery, F J. Webster, Anthony M. Hart

WA Marine Stewardship Council report series

This report provides a comprehensive overview of the commercial Western Australian Sea Cucumber Fishery (SCF) and the outcomes from the 2016 ecological risk assessment for this fishery. Two key species, sandfish (Holothuria scabra) and redfish (Actinopyga echinites), are targeted by the commercial SCF through hand collection by diving and wading primarily in shallow waters of northern WA.

Climate Change Implications For Irrigation And Groundwater In The Republican River Basin, Usa, Gengxin Ou, Francisco Munoz-Arriola, Daniel R. Uden, Derrel Martin, Craig R. Allen, Nancy Shank

School of Natural Resources: Faculty Publications

This study investigates the influence of climate change on groundwater availability, and thereby, irrigation across political boundaries within the US High Plains aquifer. A regression model is developed to predict changes in irrigation according to predicted changes in precipitation and temperature from a downscaled dataset of 32 general circulation models (GCMs). Precipitation recharge changes are calculated with precipitation recharge curves developed for prognostic representations of precipitation across the Nebraska-Colorado-Kansas area and within the Republican River Basin focal landscape. Irrigation-recharge changes are scaled with changes in irrigation. The groundwater responses to climate forcings are then simulated under new pumping and recharge …

Cariogenic Pathogens: One Less Thing To Wine About, Jordan White, Kathleen Kersey, Jessica Darcy

Dental Hygiene Student Research Posters

Recently, studies have explored how biologically active compounds in wine benefit human teeth. Dietary polyphenols, in particular wine polyphenols, seem to balance the composition of the oral microbiota, thus leading to potentially more effective anti-carious effects on the individual. Recent research has discussed the main action mechanisms of polyphenols against oral microbial diseases and highlighted the antiadhesive capacity of caffeic and p-coumaric acids as well as grape seed and red wine extracts. It has been found that polyphenols increased their inhibition potential against S. mutans adhesion when combined with S. dentisani.¹ Other research regarding polyphenols, specifically resveratrol, discussed the anti-inflammatory …

Relieving Low Back Pain And Improving Mobility For An Adult Patient With Progressive Multifocal Leukoencephalopathy: A Case Report, Derek Schwaiger, Matthew Somma

Case Report Posters

Progressive Multifocal Leukoencephalopathy (PML) is a progressive demyelinating disease caused by the John Cunningham Virus (JCV). There is no FDA approved JCV- specific treatment. This case report examines interventions administered to address low back pain (LBP) and functional mobility deficits.

Chanticleer | November 1, 2018, Jacksonville State University

Chanticleer

No abstract provided.

Getting Their Fix: Doctor's Dependency On Big Pharma, Larissa Tiller

The Business, Entrepreneurship & Tax Law Review

Section 6002 of the Affordable Care Act, also known as the “Sunshine Act,” was intended to stop corrupt practices within the medical community by requiring pharmaceutical and medical device manufacturers to disclose all transfers of value of a certain amount made between them and physicians. This article suggests that the better solution to stopping corrupt practices is to ban some transfers all together.

Technology And Grieving: A Relationship, James Nichols

Biology

No abstract provided.

Departmental Action Teams: A Five-Year Update On A Model For Sustainable Change, Daniel Reinholz, Mary Pilgrim, Karen Falkenberg, Courtney Ngai, Gina Quan, Sarah Wise, Chris Geanious, Joel Corbo, Noah Finkelstein

Faculty Publications

Fostering sustainable improvements in undergraduate education remains a formidable challenge. To address this challenge, our team has developed the Departmental Action Team (DAT) model. DATs are small working groups of faculty, students, and staff, that work collaboratively to envision, plan, develop, and build sustainable structures in their department. To support the uptake of such structures, DATs collect and analyze data to reflect on the root causes of an issue, which they use to shift beliefs, values, and practices within their context. This paper provides a five-year status report on the DAT project. We describe the history of the model, its …

Stem Cell Generated Β-Cells: A Possible Solution To The Growing Problem Of Type 1 Diabetes, Danielle Rae Steffen

Biology: Student Scholarship & Creative Works

Type 1 diabetes is a growing problem throughout the world. At this time, there is no functional cure, only various treatment options. However, in recent years there has been a significant increase in both the quantity and quality of research into potential cures for type 1 diabetes. This has led to a variety of new possibilities, the most promising of which are β-cells generated from the patient’s own stem cells.

Rebel Research: Real Results, University Of Mississippi. Office Of Research And Sponsored Programs

Publications of the ORSP

The fall semester at the University of Mississippi is quickly coming to a close, but talented UM researchers, scientists and professors are busy working on projects with potential transformative effects for Mississippi and the world.

Feasibility Of Dose Escalation Using Intraoperative Radiotherapy Following Resection Of Large Brain Metastases Compared To Post-Operative Stereotactic Radiosurgery, John A. Vargo, Kristie M. Sparks, Rahul Singh, Geraldine M. Jacobson, Joshua D. Hack, Christopher P. Cifarelli

Clinical and Translational Science Institute

Background and purpose Post-operative SRS (stereotactic radiosurgery) for large brain metastases is challenged by risks of radiation necrosis that limit SRS dose. Intraoperative radiotherapy (IORT) is a potential alternative, however standard dose recommendations are lacking. Methods and materials Twenty consecutive brain metastases treated with post-operative SRS were retrospectively compared to IORT plans generated for 10–30 Gy in 1 fraction to 0–5 mm by estimating the applicator size and distance from critical organs using pre-operative and post-operative MRI. Additionally, 7 consecutive patients treated with IORT 30 Gy to surface were compared to retrospectively generated SRS plans using the post-operative MRI to …

Mesenchymal Cox2-Pg Secretome Engages Nr4a-Wnt Signalling Axis In Haematopoietic Progenitors To Suppress Anti-Leukaemia Immunity, Limei Wu, Surya Amarachintha, Jian Xu, Frank Oley Jr., Wei Du

Clinical and Translational Science Institute

The bone marrow (BM) microenvironment (niche) plays important roles in supporting normal/abnormal haematopoiesis. We investigated the interaction between leukaemic mesenchymal niche and haematopoietic stem and progenitor cells (HSPCs) using the model of Fanconi anaemia (FA), a genetic disorder characterized by BM failure and leukaemia. Healthy donor HSPCs co‐cultured on mesenchymal stromal cells (MSCs) derived from FA patients with acute myeloid leukaemia (AML) exhibited higher human engraftment and myeloid expansion in Non‐obese diabetic severe combined immunodeficiency IL‐2γ−/−/SGM3 recipients. Untargeted metabolomics analysis revealed the progressively elevated prostaglandins (PGs) in the MSCs of FA patients with myelodysplastic syndromes (MDS) and AML. Reduced secretion …

Out Of The Basement And Into The Classroom: Pathways For Expanding The Role Of Radiation Oncologists In Medical Student Education, Malcolm D. Mattes, William Small Jr., Neha Vapiwala

Clinical and Translational Science Institute

Purpose To characterize radiation oncologist involvement in undergraduate medical education at US academic medical centers and to incorporate these findings into practical pathways for greater and broader integration of radiation oncology (RO) into medical curricula. Methods Chairpersons and residency program directors at RO departments directly affiliated with a medical school were asked to describe all the ways in which radiation oncologists in their department are involved in medical student education, excluding their elective clerkship. Results Of 75 eligible departments, 49 responded (response rate 65.3%). Twenty departments (40.8%) reported that at least one faculty member participates in a curricular educational session …

Scholarworks Usage Report, 11-2018, Maura Valentino

ScholarWorks Reports

No abstract provided.

Illuminator, Volume 2, Issue 3, Batten College Of Engineering & Technology, Old Dominion University

College of Engineering & Technology Newsletter

November 2018 issue of Illuminator, a monthly publication of ODU's Batten College of Engineering and Technology.

Environmental Water Transactions In The Colorado River Basin: A Closer Look, Leon Szeptycki, David Pilz, Rachel O'Connor, Beatrice Gordon

All In-stream Flows Material

Over the last 30 years, the voluntary transfer of water and water rights for environmental uses has become a recognized strategy for restoring streamflow in the Western United States.¹ Historically, taking water out of a stream was a legally required element of an appropriative water right. Water rights holders who left all or a portion of their right instream to enhance fish populations, riparian habitat or recreation, risked forfeiture or diminishment of their water right. Beginning in the 1980’s, state laws began to recognize both the appropriation of new water rights for instream use and to allow the transfer …

Genetic And Environmental Influences On Stomates Of Big Bluestem (Andropogon Gerardii), Nick A. Varvel, Christina J. Hilt, Loretta C. Johnson, Matthew Galliart, Sara G. Baer, Brian R. Maricle Ph.D.

Biological Sciences Faculty Publications

Big bluestem (Andropogon gerardii) is a dominant C4 prairie grass that has wide distribution and several genetically distinct ecotypes. Many of the ecotypic adaptations are related to water availability in the native environment. Stomates facilitate photosynthetic gas exchange and regulate water loss from the plant. As such, stomatal size and density represent possible adaptations to conserve water. We hypothesized drought-tolerant ecotypes of big bluestem would have fewer or smaller stomates compared to more mesic ecotypes. Five ecotypes of big bluestem were planted in four common gardens from western Kansas to southern Illinois, USA to determine genetic and environmental influences on …

Preliminary Evaluation Of A Novel Whole Slide Multispectral Assessment Of Seven Markers: Potential To Minimize Bias In The Characterization Of The Tumor Immune Environment, Carmen Ballesteros Merino, Shawn Jensen, Carla Coltharp, Kristin Roman, Chichung Wang, Nikhil Lonberg, Sebastian Marwitz, Tarsem Moudgil, William Miller, William Redmond, Yoshinobu Koguchi, Carlo Bifulco, Clifford Hoyt, Bernard A. Fox

Society for Immunotherapy of Cancer 2018 Annual Meeting Posters

Background: PD-L1 expression and tumor-mutational burden enrich for patients that respond to checkpoint blockade, but these evaluations are only a component of the entire story. Recently, our lab reported that evaluation of specific cell-cell relationships provided a powerful biomarker for overall survival in patients with HPV- head and neck cancer (HNSCC). However, the areas selected for analysis were operator selected “hot spots”. This approach introduces the potential for unconscious bias in the selection process. To address this, we have sought to perform whole slide evaluations of sections to compare with hot spot analysis. This study is a preliminary report applying …

Integrative Spatially-Resolved, High-Plex Digital Profiling Enables Characterization Of Complex Immune Biology In The Tumor Microenvironment Of Mesothelioma, Carmen Ballesteros-Merino, Moritz Widmaier, Sarah Church, Thomas Herz, Alexei Budco, Das Medrikova, Ivan Kanchev, Andrew White, Douglas Hinerfeld, Shawn Jensen, John Handy, Rachel Sanborn, Carlo Bifulco, Sarah Warren, Joseph Beechem, Bernard .. Fox

Society for Immunotherapy of Cancer 2018 Annual Meeting Posters

Background: Malignant mesothelioma is an aggressive cancer with poor prognosis and few effective therapies. Since mesothelioma is derived from the mesothelium of the lung, we hypothesize that immune cells in the tumor microenvironment (TME) may behave differently than other solid tumors. In our previous studies, utilizing multi-plexed immunofluorescence, we did not find immune phenotypes associated with improved patient survival. Here we describe a novel combination of two technologies to spatially characterize the interface between mesothelioma cells, stroma and immune cells in the TME in a high-plex capacity.

Methods: Ten FFPE mesothelioma tumors were characterized by Definiens’ Immune-Oncology Profiling (IOP) and …

Ethical Implications Of Treatment For Gender Dysphoria In Youth, Kelsey Hayes

Journal of Health Ethics

This manuscript explores ethical implications on treatment for youth with diagnosed gender dysphoria. The ethical considerations outlined and analyzed in this essay involve illuminating an understanding of whether the administration of pubertal suppression with GnRH agonists, and cross-sex hormones to children with gender dysphoria is morally justified as treatment to manage their psychological distress, or if safer more understood alternatives exist. This essay emphasizes that as health care professionals we must ensure youth with gender dysphoria receive adequate medical treatment and care however, this essay concludes through extensive literature review, that the use of inconclusive and under researched methods to …

Exponentially-Modified Logistic Distribution With Application To Mining And Nutrition Data, Jimmy Reyes, Osvaldo Venegas, Hector W. Gomez

Applied Mathematics & Information Sciences

In this work we introduce a modification of the exponentially-modified Gaussian distribution. This new distribution is obtained by combining a logistic distribution with an exponential distribution, and is more flexible than other similar distributions. We provide a closed expression for the density function and obtain some important properties useful for making inferences, such as moment estimators and maximum likelihood estimators. By way of illustration, and using real data to show the effectiveness of the new model, we compare it with known related models, showing that the new model achieves a better fit.

Ostrowski Type Inequalities For Functions Whose Second Derivatives Are Convex Generalized., Yenny Rangel-Oliveros, Miguel Vivas-Cortez

Applied Mathematics & Information Sciences

In this paper we introduce the notion of s−j−convex functions as generalization of convex functions. Some basic results under various conditions for the function j are investigated. Moreover, we establish Ostrowski type inequalities for twice differentiable mappings which are s−j−convex.

The Effect Of Immigration On The Persistence And Ergodicity Of A Stochastic Sis Model For Transmission Of Disease, Youness El Ansari, Ali El Myr, Lahcen Omari, Aadil Lahrouz

Applied Mathematics & Information Sciences

This paper aims to study the dynamic behavior of a stochastic SIS (Susceptible-Infected-Susceptible) epidemic model with varying population size and constant flow of new members of whom a specified fraction is infective. First, we show that the solution is stochastically ultimately bounded and permanent. Then, we investigate the persistence in the mean of the variable I(t) (the number of infected members). Next, we use the Markov semigroups theory to investigate the ergodicity of the solution. Mainly, we show that a stationary distribution for the solution always exists for all values of the parameters in this model. Finally, Numerical simulations are …

Optimal Control And Cost-Effectiveness Analysis For Dysentery Epidemic Model, Hailay Weldegiorgis Berhe, Oluwole Daniel Makinde, David Mwangi Theuri

Applied Mathematics & Information Sciences

In this paper, optimal control theory is applied to a system of ordinary differential equations representing a dysentery diarrhea epidemic. Optimal control strategies are proposed to reduce the number of infected humans and the cost of interventions. The Pontryagin’s maximum principle is employed to find the necessary conditions for the existence of the optimal controls. Runge- Kutta forward-backward sweep numerical approximation method is used to solve the optimal control system. The incremental costeffectiveness analysis technique is used to determine the most cost-effective strategy.We observe that the control measure implementing sanitation and education campaign is the most efficient and cost-effective.

Improved Bandwidth And Gain In Ultra-Wideband Staircase Antipodal Bowtie Antenna With Rounded Edge For Microwave Imaging Applications, J. Vijayalakshmi, G. Murugesan

Applied Mathematics & Information Sciences

We propose the ultra-wideband antipodal bowtie antenna with staircase steps at the corners of the antipodal bowtie patch with a rounded edge and a reflector is placed at the bottom part of the antenna. The modified design of the bowtie antenna of a step cut is made to improve the bandwidth. Furthermore, in the bottom side of an antenna, the reflector is united with the feed to improve the gain. This antenna operates over for the frequency between 3.1 to 10.6 GHz, with a directive radiation pattern of peak gain 4.29 dB with the bandwidth of 3.17 GHz. This improvement …

Spacelike Curves In The Lightlike Cone, Nemat Abazari, Martin Bohner, Ilgın Sager, Alireza Sedaghatdoost

Applied Mathematics & Information Sciences

In this paper, we study curves in the lightlike cone. First, we show that any curves in the lightlike cone are spacelike or lightlike, and then we characterize some curves with special cone curvature function in the 4, 5, and 6-dimensional lightlike cone. Finally, we consider the relationship between Frenet curvature functions and cone curvature functions for a spacelike curve on the lightlike cone.

Graphene Quantum Dots Potently Block Copper-Mediated Oxidative Dna Damage: Implications For Cancer Intervention, Rachel E. Li, Y R. Li, Hong Zhu, Zhenquan Jia

Osteopathic Medicine, Jerry M. Wallace School of

Our early work suggested that graphene quantum dots (GQDs) block Cu(II)/Cu(I) redox cycle in biological systems. Here we report that GQDs could also potently protect against copper redox-mediated oxidative DNA damage. Using Cu(II)/hydrogen peroxide, Cu(II)/hydroquinone, and Cu(II)/ascorbic acid as three biologically relevant systems for inducing oxidative DNA damage, we demonstrated that GQDs protected against the above system-induced DNA strand breaks in ϕx-174 plasmid DNA in a concentration-dependent manner. Notably, a significant protection was observed with GQDs at 1 μg/ml, and a nearly complete protection was shown with 10 and 100 μg/ml of GQDs. Using electron paramagnetic resonance (EPR) spectrometry in …

Preliminary Results From A First-In-Human Phase 1 Study Of The Cd40 Agonist Monoclonal Antibody (Mab) Cdx-1140, Rachel Sanborn, Michael S. Gordon, Mark O'Hara, Nina Bhardwaj, Yi He, Tracey Rawls, Tibor Keler, Michael Yellin

Society for Immunotherapy of Cancer 2018 Annual Meeting Posters

Background: Agonist CD40 mAbs can mediate antitumor immunity through multiple mechanisms, including enhancing tumor antigen presentation, activation of tumoricidal macrophages, and direct growth inhibition/killing of CD40- expressing tumor cells. To fully exploit these mechanisms may require the mAb to be dosed at levels that provide significant tumor and tissue penetration, without dose-limiting-toxicities (DLT) from systemic CD40 activation. Our agonist CD40 mAb, CDX-1140, was selected based on its unique and linear dose-dependent in vitro and in vivo activity and is postulated will achieve maximum agonist activity at dose levels associated with good systemic exposure. CDX-1140 is a fully human IgG2 agonist …