Digital Commons Network^™

That Was Close! Reward Reporting Of Cybersecurity "Near Misses", Jonathan Bair, Steven M. Bellovin, Andrew Manley, Blake Reid, Adam Shostack

Colorado Technology Law Journal

No abstract provided.

Models Of Law, Christian Turner

Scholarly Works

The more we examine what is behind our most difficult legal questions, the more puzzling it can seem that we continue both to disagree strongly and, yet, to cooperate. If law is a reasoned enterprise, how is it that we are neither torn apart nor homogenized by our long social practice of it? I resolve this puzzle, and arrive at a richer understanding of law, using the idea of modeling familiar from the natural sciences and mathematics. I show (a) that theorists can model legal systems as abstract systems of institutions, information flows, and institutional processing or reasoning and (b) …

Design-Thinking, Making, And Innovating: Fresh Tools For The Physician's Toolbox, L. Albala, T. Bober, M. Mallozzi, L. Koeneke-Hernandez, B. Ku

Department of Emergency Medicine Faculty Papers

Medical school education should foster creativity by enabling students to become 'makers' who prototype and design. Healthcare professionals and students experience pain points on a daily basis, but are not given the tools, training, or opportunity to help solve them in new, potentially better ways. The student physician of the future will learn these skills through collaborative workshops and having dedicated 'innovation time.' This pre-clinical curriculum would incorporate skills centered on (1) Digital Technology and Small Electronics (DTSE), (2) Textiles and Medical Materials (TMM), and (3) Rapid Prototyping Technologies (RPT). Complemented by an on-campus makerspace, students will be able to …

Large Palaeophiid And Nigerophiid Snakes From Paleogene Trans-Saharan Seaway Deposits Of Mali, Jacob A. Mccartney, Eric M. Roberts, Leif Tapanila, Maureen A. O'Leary

Biology

The Paleogene was a time of high diversity for snakes, and was characterized by some of the largest species known to have existed. Among these snakes were pan-Tethyan marine species of Nigerophiidae and Palaeophiidae. The latter family included the largest sea snake, Palaeophis colossaeus, known from the Trans-Saharan Seaway of Mali during the Eocene. This paper describes new material collected from Malian Trans-Saharan Seaway deposits, including additional material of Palaeophis colossaeus, a new, large species of nigerophiid, Amananulam sanogoi gen. et sp. nov., and a medium-sized snake of indeterminate affinities. The material provides new information on the intracolumnar variation of …

Microbiology: A Laboratory Experience, Holly Ahern

Milne Open Textbooks

As a group of organisms that are too small to see and best known for being agents of disease and death, microbes are not always appreciated for the numerous supportive and positive contributions they make to the living world. Designed to support a course in microbiology, Microbiology: A Laboratory Experience permits a glimpse into both the good and the bad in the microscopic world. The laboratory experiences are designed to engage and support student interest in microbiology as a topic, field of study, and career.

This text provides a series of laboratory exercises compatible with a one-semester undergraduate microbiology or …

Monoamine Oxidases Inhibitors From Colvillea Racemosa: Isolation, Biological Evaluation, And Computational Study., Enas Mohamed, Mohamed A. Zaki, Narayan D. Chaurasiya, Asmaa I. Owis, Sameh Abouzid, Yan-Hong Wang, Bharathi Avula, Ahmed A. Seida, Babu L. Tekwani, Samir A. Ross

Faculty and Student Publications (Open Access)

Bioassay-guided fractionation and chemical investigation of Colvillea racemosa stems led to identification of two new α, β-dihydroxydihydrochalcones, colveol A (1) and colveol B (2) along with fifteen known compounds. The structures were elucidated via interpretation of spectroscopic data. The absolute configurations of the dihydrochalcones 1 and 2 were assigned by a combination of chemical modification and electronic circular dichroism data. The isolated compounds were evaluated for their inhibition activity toward recombinant human monoamine oxidases (rhMAO-A and -B). Compound 1 demonstrated preferential inhibition against hMAO-A isoenzyme (IC

A Matrix Population Model For Growth Of The Echinoid Skeleton, Louis Zachos

Faculty and Student Publications (Open Access)

No abstract provided.

Isolation And Biological Evaluation Of Prenylated Flavonoids From Maclura Pomifera, Yerkebulan Orazbekov, Mohamed A. Ibrahim, Serjan Mombekov, Radhakrishnan Srivedavyasasri, Ubaidilla Datkhayev, Bauyrzhan Makhatov, Narayan D. Chaurasiya, Babu L. Tekwani, Samir A. Ross

Faculty and Student Publications (Open Access)

No abstract provided.

Role Of Natural Antioxidants From Functional Foods In Neurodegenerative And Metabolic Disorders, José Carvalho, Caio P. Fernandes, Júlio Beltrame Daleprane, Maria Silvana Alves, Didier Stien, N. P. Dhammika Nanayakkara

Faculty and Student Publications (Open Access)

No abstract provided.

Effects Of 5-Hydroxymethylcytosine Epigenetic Modification On The Stability And Molecular Recognition Of Vegf I-Motif And G-Quadruplex Structures, Rhianna Morgan, Michael M. Molnar, Harshul Batra, Bethany Summerford, Randy M. Wadkins, Tracy A. Brooks

Faculty and Student Publications (Open Access)

No abstract provided.

India-United States Dialogue On Traditional Medicine: Toward Collaborative Research And Generation Of An Evidence Base, Jeffrey White, Barry R. O’Keefe, Jitendra Sharma, Ghazala Javed, Vid Nukala, Aniruddha Ganguly, Ikhlas A. Khan, Nagi B. Kumar, Hasan Mukhtar, Guido F. Pauli, Larry Walker, Sudha Sivaram, Preetha Rajaraman, Edward L. Trimble

Faculty and Student Publications (Open Access)

Therapies originating from traditional medical systems are widely used by patients in both India and the United States. The first India-US Workshop on Traditional Medicine was held in New Delhi, India, on March 3 and 4, 2016, as a collaboration between the Ministry of Ayurveda, Yoga and Naturopathy, Unani, Siddha, and Homoeopathy (AYUSH) of the Government of India, the US National Cancer Institute (NCI), National Institutes of Health, and the Office of Global Affairs, U.S. Department of Health and Human Services. It was attended by Indian and US policymakers, scientists, academics, and medical practitioners from various disciplines. The workshop provided …

Short Term (24 Hours) And Long Term (1 Year) Assessments Of Reliability In Older Adults: Can One Replace The Other?, Tsutomu Abe, Scott J. Dankel, Samuel L. Buckner, Matthew B. Jessee, Kevin T. Mattocks, J. Grant Mouser, Zachary W. Bell, Jeremy P. Loenneke

Faculty and Student Publications (Open Access)

No abstract provided.

Bioassay-Guided Isolation And Identification Of Aedes Aegypti Larvicidal And Biting Deterrent Compounds From Veratrum Lobelianum, Nurhayat Tabanca, Zulfıqar Ali, Ulrich R. Bernier, Nancy D. Epsky, Ayşe Nalbantsoy, Ikhlas A. Khan, Abbas Alı

Faculty and Student Publications (Open Access)

No abstract provided.

Wave Erosion Of Cohesive And Non-Cohesive Embankments: Laboratory Experiments, Yavuz Ozeren, Daniel G. Wren

Faculty and Student Publications (Open Access)

No abstract provided.

Phytochemical And Biological Studies On Ziziphora Bungeana, S. Radhakrishnan, Karlygash Zhaparkulova, Zuriyadda Sakipova, Liliya Ibragimova, Samir A. Ross

Faculty and Student Publications (Open Access)

No abstract provided.

Marine Natural Product Peptides With Therapeutic Potential: Chemistry, Biosynthesis, And Pharmacology., Vedanjali Gogineni, Mark T. Hamann

Faculty and Student Publications (Open Access)

The oceans are a uniquely rich source of bioactive metabolites, of which sponges have been shown to be among the most prolific producers of diverse bioactive secondary metabolites with valuable therapeutic potential. Much attention has been focused on marine bioactive peptides due to their novel chemistry and diverse biological properties. As summarized in this review, marine peptides are known to exhibit various biological activities such as antiviral, anti-proliferative, antioxidant, anti-coagulant, anti-hypertensive, anti-cancer, antidiabetic, antiobesity, and calcium-binding activities. This review focuses on the chemistry and biology of peptides isolated from sponges, bacteria, cyanobacteria, fungi, ascidians, and other marine sources. The role …

(Un)Frozen Spaces: Exploring The Role Of Sea Ice In The Marine Socio-Legal Spaces Of The Bering And Beaufort Seas, Kristen L. Shake, Karen E. Frey, Deborah G. Martin, Philip E. Steinberg

Geography

Sea ice is a dynamic physical element of the greater Arctic marine system, one that has myriad connections to human systems on a variety of spatial and temporal scales. Changes to the spatial extent of sea ice simultaneously permits and endangers maritime operations, as well as impacts current debates over maritime boundaries, presenting an interesting challenge for international law. Sea ice is not a stationary object; it moves through time and space in response to the physical forces of wind, ocean currents, and heating. It has a tangible, material and substantive role in contestations over territory, resources and marine boundaries …

Aguilar V. Aguilar And Third-Party Custody Determinations: Examining The Definition Of Parent From The Eyes Of The Child, Rachel E. Mairose

South Dakota Law Review

No abstract provided.

Wnt Secretion Proteins Modulate Rankl-Induced Expression Of Aire In Thymic Epithelial Cells, Daniel Pollack

Dissertations and Theses

Thymic epithelial cells (TEC) are essential for a proper adaptive immune response by regulating thymocyte development and establishing central tolerance. In the thymus, TECs differentially express Wnt proteins, which activate canonical and non-canonical Wnt signaling pathways. Wnt signaling is thought to regulate cell survival, proliferation, and development although the direct molecular mechanisms in TECs have yet to be elucidated. The inducible inhibition of canonical Wnt signaling with Dkk1 leads to a rapid loss of TEC progenitors as well as a decline in mature Aire-expressing mTECs. Therefore, we explore the role of Wnt ligands potentially responsible for stimulating and/or regulating Wnt …

Towards A Queer Aesthetic: Biographical Readings Of Oscar Wilde, Herman Melville And Walt Whitman, Vanessa J. Ragusa

Dissertations and Theses

No abstract provided.

Evolution Of Floral Morphology And Symmetry In The Miconieae (Melastomataceae), Maria Gavrutenko

Dissertations and Theses

Analyses of evolution of floral morphology and symmetry broaden our understanding of the drivers of angiosperm diversification. Integrated within a flower, labile floral characters produce different phenotypes that promote variable interactions with pollinators. Thus, investigation of floral evolution may help infer potential historic transitions in pollinator modes and ecological pressures that generated present diversity. This study aims to explore morphological evolution of flowers in Miconieae, a species-rich Neotropical tribe within family Melastomataceae. Despite a constrained floral plan, Melastomataceae manage to achieve a variety of floral traits appealing to diverse pollinator types, with majority of the species requiring specialized “buzz pollination” …

Writing Indigenous Identity In Herman Melville And Joseph Conrad's Polynesian And Malay Archipelago Novels, Catherine L. Black

Dissertations and Theses

The thesis of this paper is that cross-cultural writing can be done with the right methods of communication, such as engaging narrator and education—or simply sensitive, imaginative writing. Herman Melville and Joseph Conrad’s five books set in the Polynesian and Malay Archipelagos—Typee and Omoo and the Malay Trilogy (Almayer’s Folly, An Outcast of the Islands, and The Rescue)— are used as master models of how to write indigenous characters with rich characterization in pivotal roles, even circa 1846 and 1896. The unique perspective and technique by which they did this is explored, a technique and perspective not …

The Famished Road: Oil Dependency And Socioeconomic Underdevelopment In The Niger Delta, Nelson Caban

Dissertations and Theses

This thesis examines the social and political relationships between indigenous communities within the Nigerian Delta region and the Federal government regarding the management of petroleum resources and its implication for the general socioeconomic development of the Nigerian State. It investigates the correlation between the broader issues of sociocultural sovereignty, representation of ethnic minorities in the body politic and infrastructural development of the country. Furthermore, the thesis explores trends such as the development of native-led cultural institutions that foster the continuation of cultural praxis through the theoretical tropes of Globalization and Modernization.

The Effect Of Stress Induced Premature Senescence On The Expression Of Heterogeneous Ribonucleoieoprotein, Yuriy Pechenyy

Dissertations and Theses

The role of heterogeneous nuclear ribonucleoproteins (hnRNP) in cellular senescence is yet to be defined. Cellular senescence is a terminal growth arrest in somatic cells. It is thought to be the consequence of telomeric shortening that acts as a DNA damage signal. Conversely, cells induced into premature senescence (SIPS) by oxidative stress, is independent of telomere attrition. Premature senescence has been proposed to be physiologically relevant as it can be induced by treatment with chemotherapeutic agents. In particular, we are studying the roles of hnRNP A1 and A2 in the maintenance of the senescence phenotype. hnRNPs are a family of …

Mexican Technoscientific Arts, 2000-2015: Art And Science, Machine Inventions, And Political Ecologies, Carlos R. Guzman

Dissertations and Theses

In the last decades, several artists have engaged directly with emerging digital technologies and science, the so-called new media arts. For the past fifteen or twenty years, such practices have experienced a paradigmatic transformation in Mexico, particularly in the capital. They have shifted from peripheral to mainstream, from contingent to ubiquitous, and from underground/experimental to official and governmentally funded.

This thesis explores the development of technoscientific arts in Mexico, its evolution, main artists, and institutions. It focuses on specific technoscientific artistic projects developed in Mexico between 2000 and 2015 by artists like Tania Candiani, Gilberto Esparza, Iván Puig, and Ale …

Mild Traumatic Brain Injuries And Their Implications On Changes In Event Related Potentials: A Look Into Visual Gating (P50), Katelynn M. Kozak

Dissertations and Theses

Concussions are a prevalent injury that affect a wide range of individuals. Commonly seen amongst individuals who play contact sports, there are many underlying factors that doctors and clinicians have yet to understand which include properties such as proper diagnosis standards or lasting impacts. In this study, we look at those impacts by using electroencephalographic (EEG) measures to study the changes in event related potentials (ERPs) associated with sensory gating and how this cognitive property is affected in those who have a self-reported concussion. Here we show that a visual attention and gating mechanism exists in both populations (control and …

The Geographic Mosaic Of Wolbachia Infection In Melanitis Leda Butterfly Populations, Brandon E. Latorre

Dissertations and Theses

Insects are the most species-rich multicellular taxon on the planet, and it is estimated that more than half of all insect species are infected with the endosymbiont Wolbachia. This bacterium can manipulate the reproduction of its host and potentially affect host evolution. Most surveys investigating patterns of Wolbachia infection in nature sample limited numbers of individuals; population-level investigations into geographic differences in infection status that might affect host evolution are few. To investigate geographic variability among populations of a single species, we assayed 133 Melanitis leda butterflies (Lepidoptera: Nymphalidae: Satyrinae) for Wolbachia infection collected throughout its range in the …

Bone Marrow Derived Progenitor Cells And Their Contributions To The Thymic Stroma, Mohammed Hoque

Dissertations and Theses

The thymus serves as the primary lymphoid organ responsible for the development and selection of a self-tolerant T cell repertoire. In paradox to its critical functions for the adaptive immune response, the thymus undergoes a profound age associated decline beginning in early adult life resulting in significant decline in T-cell function.Thymic epithelial cells (TECs) are the most critical component of the thymic microenvironment and undergo rapid turn-over, so understanding the cellular mechanisms responsible for the maintenance of TEC number and organization will be critical in counteracting age associated involution, particularly in cancer patients, due to enhanced degeneration in response to …

Wood Trait Preferences Of Neotropical Xylophagous Beetles (Coleoptera: Cerambycidae), Christina Torres

Dissertations and Theses

Tree life history strategies are correlated with functional plant traits, such as wood density (WD), moisture content (MC), bark thickness (BT), and nitrogen content (N); these traits affect the nutrients available to xylophagous insects. Cerambycid beetles feed on substrates that vary in these traits, but little is known about how they affect community composition. The goal of this project is to document the abundance of two cerambycid subfamilies (Cerambycinae and Lamiinae) and the WD, MC, BT, and N content in the wood they eat. In a salvage project conducted adjacent to the Panama Canal, trees were felled and exposed to …

A Role For A Predicted E. Coli Inner Membrane Lipoprotein In Cell Envelope Integrity, Charlie Chung

Dissertations and Theses

One of the distinct characteristics of Gram-negative bacteria such as Escherichia coli is the possession of a double-membraned cell envelope. The outer membrane provides an additional layer of protection against hydrophobic molecules including antibiotics, contributing to the multidrug resistance crisis. The Gram-negative membrane is composed of phospholipids, glycolipids, and proteins. A large portion of the bacterial cellular proteome is composed of membrane proteins. Despite this, the functions of several membrane proteins are as yet undefined. Therefore, defining the physiological roles of uncharacterized membrane proteins is expected to provide us with insights into the biology of the Gram-negative cell envelope and …