Digital Commons Network^™

Redox-Sensitive, Cholesterol-Bearing Pegylated Poly(Propyleneimine)-Based Dendrimersomes For Drug And Gene Delivery To Cancer Cells, Partha Laskar, Sukrut Somani, Najla Altwaijry, Margaret Mullin, Deborah Bowering, Monika Warzecha, Patricia Keating, Rothwelle J. Tate, Hing Y. Leung, Christine Dufès

School of Medicine Publications

Stimuli-responsive nanocarriers have attracted increased attention as materials that can facilitate drug and gene delivery in cancer therapy. The present study reports the development of redox-sensitive dendrimersomes comprising disulfide-linked cholesterol-bearing PEGylated dendrimers, which can be used as drug and gene delivery systems. Two disulfide-linked cholesterol-bearing PEGylated generation 3 diaminobutyric polypropylenimine dendrimers have been successfully synthesized via an in situ two-step reaction. They were able to spontaneously self-assemble into stable, cationic, nanosized vesicles (or dendrimersomes) with lower critical aggregation concentration values for high-cholesterol-bearing vesicles. These dendrimersomes were able to entrap both hydrophilic and hydrophobic dyes, and they also showed a redox-responsive …

The Continuing Relevance Of C. Wright Mills: His Approach To Research And What We Can Learn From It, John E. Miller

Studies in Midwestern History

C. Wright Mills (1916-1962), remembered primarily for his 1956 book, The Power Elite, and for his 1960 essay “Letter to the New Left,” which helped launch the rising New Left in the America of the 1960s, was a major American sociologist, but he also had much to teach historians. Although he focused his research on national and global subjects, students and scholars of regionalism can also learn much from his wide-ranging, critical approach. Like all good sociologists, Mills always assumed that historical context was an essential element of any adequate analysis of society, economics, and politics. Born in Texas, …

Context For Confusion: Understanding Babel In The Book Of Beginnings, Douglas R. Osselaer

Fidei et Veritatis: The Liberty University Journal of Graduate Research

The meaning of the Tower of Babel episode in Genesis 11 proves to be continually elusive for both biblical scholars and pastors. While the results of this momentous event in world history seem obvious, owing to the racial and linguistic diversity present in the world today, the reason for God's judgment over the unified peoples who attempted to build together is far less clear. This has even led some to question the justice and wisdom of God, considering the challenges posed by racial division throughout history. As with most questions of biblical interpretation, however, the key to interpretation lies within …

Orotic Aciduria, Aliah L. Fonteh

Fidei et Veritatis: The Liberty University Journal of Graduate Research

Orotic acid is an intermediate found in the pathway for pyrimidine synthesis. The mitochondrial enzyme dihydroorotate dehydrogenase (DHODH) catalyzes the production of orotic acid by the conversion of the compound dihydroorotate to orotic acid. Orotic acid is commonly produced by this reaction in erythrocytes, hepatocytes, and kidney cells. Chemical modification of orotic acid in the pyrimidine pathway will generate nucleotides involved in DNA and RNA synthesis. Orotic aciduria can occur as a secondary manifestation due to a defect in an enzyme or transporter within the urea cycle, due to competitive inhibition by anti-cancer drugs such as allopurinol and 6-azauridine, or …

Dual-Display Laparoscopic Laser Speckle Contrast Imaging For Real-Time Surgical Assistance, Jaepyeong Cha, Corey Zheng, Lung Wai Lau

Pediatrics Faculty Publications

Laser speckle contrast imaging (LSCI) utilizes the speckle pattern of a laser to determine the blood flow in tissues. The current approaches for its use in a clinical setting require a camera system with a laser source on a separate optical axis making it unsuitable for minimally invasive surgery (MIS). With blood flow visualization, bowel viability, for example, can be determined. Thus, LSCI can be a valuable tool in gastrointestinal surgery. In this work, we develop the first-of-its-kind dual-display laparoscopic vision system integrating LSCI with a commercially available 10mm rigid laparoscope where the laser has the same optical axis as …

Faculty Senate Agenda And Minutes, November 5, 2018

Faculty Senate Minutes and Agendas

Agenda and minutes from the Wright State University Faculty Senate Meeting held on November 5, 2018.

Kinetic Characterization Of The Shigella Type Three Secretion System Atpase Spa47 Using Α-32p Atp, Heather B. Case, Nicholas E. Dickenson

Chemistry and Biochemistry Faculty Publications

ATPases represent a diverse class of enzymes that utilize ATP hydrolysis to support critical biological functions such as driving ion pumps, providing mechanical work, unfolding/folding proteins, and supporting otherwise thermodynamically unfavorable chemical reactions. We have recently shown that the Shigella protein Spa47 is an ATPase that supports protein secretion through its specialized type three secretion apparatus (T3SA), supporting infection of human host cells. Characterizing ATPases, such as Spa47, requires a means to accurately determine enzyme activity (ATP hydrolysis) as a function of time, reaction conditions, and potential cofactors, regulators, inhibitors, etc. Here, we describe a detailed protocol for characterizing …

The Statesman, V. 62, I. 10, Stony Brook University

Stony Brook Statesman-Sucolian

v. 62, i. 10;

Hlc Accreditation Final Report - November 2018, University Of Missouri-St. Louis

UMSL Accreditation

No abstract provided.

Sediment Dynamics In The Bear River-Mud Lake-Bear Lake System, Patrick Belmont, Mitchell Donovan, Janice Brahney, Lindsay Capito, Zach Burgert

Watershed Sciences Faculty Publications

The overarching goal of this project was to compile and analyze a variety of existing datasets, and generate several new datasets, to advance our understanding of how the Bear River Mud Lake-Bear Lake system functions, how it has, or is expected to change, identify which components are degraded or vulnerable to degradation, and determine if/where critical data and/or knowledge gaps exist. We conducted a series of analyses to evaluate changes in hydrology and suspended sediment, collected sediment cores from nine locations in Mud Lake to evaluate how sedimentation rates, sediment sources and water quality have changed over time, and utilized …

Sjsu Erfa Board Minutes, November 5, 2018, San Jose State University, Emeritus And Retired Faculty Association

SJSU ERFA Minutes

SJSU ERFA Executive Board Minutes, November 5, 2018. Final Draft: November 19, 2018.

Application Of Click Chemistry In The Development Of Peptide Based Hiv Fusion Inhibitors, Mukesh Madan Mudgal, Nagaraju Birudukota

Chemistry and Physics Faculty Articles

Human Immunodeficiency Virus (HIV) continues to be a major global public health issue. Inhibition of HIV envelope fusion with the CD4 cell membrane prevents the entry of HIV into the CD4 cells providing a novel approach to the treatment of HIV infection. Thus, interference in the fusion of the virus with the co-receptor substrate appears to be a specific and potential way to fight HIV infection and replication. Applications of click chemistry are spreading in the field of drug discovery and it became a powerful tool for the synthesis of medicinally important compounds.

Remarkably, the Cu (I)-Catalyzed Azide-Alkyne Cycloaddition (CuAAC) …

Impact Of Precision Medicine On Drug Repositioning And Pricing: A Too Small To Thrive Crisis, Venkataswarup Tiriveedhi

Biology Faculty Research

The pricing of targeted medicines continues to be a major area of contention in healthcare economics. This issue is further complicated by redefining the role of molecular testing in precision medicine. Currently, whilst pricing of clinical laboratory diagnostics is cost-based, drug pricing is value-based. The pricing for molecular testing is under pressure to change the traditional business model, for it has a critical subsidiary role in determining the final value of targeted medicines. The market size for drugs is reduced by molecular testing when patients with the same disease are stratified based on their genetics, it is critical to determine …

Busy Uab Corner Has Housed Faculty, Students And Patients For Decades, Haley Herfurth

Browse All News

No abstract provided.

Rotunda - Vol 97, No. 10 - Nov 5, 2018, Longwood University

Rotunda

No abstract provided.

Pyronaridine Exerts Potent Cytotoxicity On Human Breast And Hematological Cancer Cells Through Induction Of Apoptosis, Paulina J. Villanueva, Alberto Martinez, Sarah T. Baca, Rebecca E. Dejesus, Manuel Larragoity, Lisett Contreras, Denisse A. Gutierrez, Armando Varela-Ramirez, Renato J. Aguilera

Publications and Research

The potent antimalarial drug pyronaridine (PND) was tested for its potential as an anticancer drug. After exposing cancerous (17) and non-cancerous (2) cells to PND for 72 hr, PND was found to exhibit consistent and potent cytotoxic activity at low micromolar (μM) concentrations that ranged from 1.6 μM to 9.4 μM. Moreover, PND exerted a significant selective cytotoxicity index (SCI) on five out of seven breast cancer cell lines tested, with favorable values of 2.5 to 4.4, as compared with the non-cancerous breast MCF-10A cell line. By using the same comparison, PND exhibited a significant SCI on three out of …

The Daily Gamecock, Monday, November 5, 2018, University Of South Carolina, Office Of Student Media

November

No abstract provided.

The Rider (2018-11-05), Victor G. Ramirez

The Rider Archives

Vol.4 No.11

After A Cystic Fibrosis 'Miracle,' Researchers Are Exploring Ways To Reach Millions More, Staff

Browse All News

No abstract provided.

Daily Eastern News: November 05, 2018, Eastern Illinois University

November

No abstract provided.

Ohio Honors Excellence In Faculty Research And Teaching At Recognition Ceremony [Photos] (November 5, 2018), University Communications And Marketing

OHIO News Articles Archive

No abstract provided.

Legacy Scholarship Recipients Continue Proud Bobcat Tradition (November 5, 2018), University Communications And Marketing

OHIO News Articles Archive

No abstract provided.

Um Diversity, Community Engagement Division Welcomes New Leaders, Shea Stewart

University of Mississippi News

Shawnboda Mead, Cade Smith join unit as assistant vice chancellors

Mcsa Forum Minutes 11/5/2018, Morris Campus Student Association

Morris Campus Student Association

No abstract provided.

Sanctuary Networks And Integrative Enforcement, Ming Hsu Chen

Washington and Lee Law Review

My intended focus is on the widespread response—in cities, churches, campuses, and corporations that together comprise “sanctuary networks”1—to the Trump Administration’s Executive Order 13768 Enhancing Public Safety in the Interior of the United States2 as an instance of the changing relationship between federal, local, and private organizations in the regulation of immigration. After briefly covering the legal background of the Trump Interior E.O., the focus of the Article shifts to the institutional dynamics arising in communities. These institutional dynamics exemplify the beginnings of a reimagined immigration enforcement policy with a more integrative flavor.

In Defense Of Hearth And [Foster] Home: Determining The Constitutionality Of State Regulation Of Firearm Storage In Foster Homes, Joseph G. Duchane

Washington and Lee Law Review

No abstract provided.

The Guardian, Week Of November 5, 2018, Wright State University Student Body

The Guardian Student Newspaper

News articles from The Guardian for the week of November 5, 2018. The Guardian is the official student-run newspaper for Wright State University. It has been published regularly since March of 1965.

Applying Pattern Oriented Sampling In Current Fieldwork Practice To Enable More Effective Model Evaluation In Fluvial Landscape Evolution Research, Rebecca M. Briant, Kim M. Cohen, Stephane Cordier, Alain J.A.G. Demoulin, Mark G. Macklin, Anne E. Mather, Gilles Rixhon, Tom Veldkamp, John Wainwright, Alex Whittaker, Hella Wittmann

School of Geography, Earth and Environmental Sciences

No abstract provided.

Anti-Leishmanial And Cytotoxic Activities Of A Series Of Maleimides: Synthesis, Biological Evaluation And Structure-Activity Relationship, Yongxian Fan, Yuele Lu, Xiaolong Chen, Babu Tekwani, Xing-Cong Li, Yinchu Shen

Faculty and Student Publications (Open Access)

In the present study, 45 maleimides have been synthesized and evaluated for anti-leishmanial activities against L. donovani in vitro and cytotoxicity toward THP1 cells. All compounds exhibited obvious anti-leishmanial activities. Among the tested compounds, there were 10 maleimides with superior anti-leishmanial activities to standard drug amphotericin B, and 32 maleimides with superior anti-leishmanial activities to standard drug pentamidine, especially compounds 16 (IC50 < 0.0128 μg/mL) and 42 (IC50 < 0.0128 μg/mL), which showed extraordinary efficacy in an in vitro test and low cytotoxicities (CC50 > 10 μg/mL). The anti-leishmanial activities of 16 and 42 were 10 times better than that of amphotericin B. The structure and activity relationship (SAR) studies revealed that 3,4-non-substituted maleimides displayed the strongest anti-leishmanial activities compared to those for …

A Multiscale Approach To Balance Trade-Offs Among Dam Infrastructure, River Restoration, And Cost, Samuel G. Roy, Emi Uchida, Simone P. De Souza, Ben Blachly, Emma Fox, Kevin H. Gardner, Arthur J. Gold, Jessica Jansujwicz, Sharon Klein, Bridie Mcgreavy, Weiwei Mo, Sean M. C. Smith, Emily Vogler, Karen Wilson, Joseph Zydlewski, David Hart

New Hampshire EPSCoR

Aging infrastructure and growing interests in river restoration have led to a substantial rise in dam removals in the United States. However, the decision to remove a dam involves many complex trade-offs. The benefits of dam removal for hazard reduction and ecological restoration are potentially offset by the loss of hydroelectricity production, water supply, and other important services. We use a multiobjective approach to examine a wide array of trade-offs and synergies involved with strategic dam removal at three spatial scales in New England. We find that increasing the scale of decision-making improves the efficiency of trade-offs among ecosystem services, …