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Simulation And Optimization Of A Sheathless Size-Based Acoustic Particle Separator, Shivaraman Asoda

USF Tampa Graduate Theses and Dissertations

Standing surface acoustic waves (SSAW) have been widely used for sorting of cells and particles. However, the major challenges faced with the acoustic driven separation process is the need for an optimized setup to achieve effective separation and the range of particles that can be separated. In this thesis, a custom simulation model is studied to investigate and optimize the separation of varying size particles in a sheathless acoustic separation platform that was developed in our research lab. Specifically, the effect of flowrate, pressure amplitude, wavelength and interdigitated transducers (IDTs) physical parameters on the separation efficiency is explored. We also …

Enzyme Kinetics From Circular Dichroism Of Insulin Reveals Mechanistic Insights Into The Regulation Of Insulin-Degrading Enzyme, Valerie A. Ivancic, Claire A. Krasinski, Qiuchen Zheng, Rebecca J. Meservier, Donald E. Spratt, Noel D. Lazo

Chemistry

Insulin-degrading enzyme (IDE) is a zinc metalloprotease that selectively degrades biologically important substrates associated with type 2 diabetes and Alzheimer's disease (AD). As such, IDE is an attractive target for therapeutic innovations. Amajor requirement is an understanding of how other molecules present in cells regulate the activity of the enzyme toward insulin, IDE's most important physiologically relevant substrate. Previous kinetic studies of the IDE-dependent degradation of insulin in the presence of potential regulators have used iodinated insulin, a chemical modification that has been shown to alter the biological and biochemical properties of insulin. Here, we present a novel kinetic assay …

Patients Educating Health Care Providers On Lynch Syndrome, Kelsey Hennig, Barry Decoster, Rebecca Chu, Wendy Parker, Lisa Campo-Engelstein, Allison M. Burton-Chase

Patient Experience Journal

Objective: Lynch syndrome (LS) patients are at an elevated risk for early-onset cancers, including endometrial and colorectal (CRC). Prior research has shown a deficit in provider knowledge of LS, which may affect patient satisfaction and adherence to recommended screening and surveillance regimens. Studies suggest patients with LS may educate providers perceived as lacking LS knowledge; however, little is known about these interactions. The goal of this study is to assess patient-reported outcomes from clinical interactions where LS patients educate their providers.

Methods: Participants (n=55) were asked to complete an in-depth telephone interview.

Results: Out of 55 participants, …

Racial/Ethnic And Geographic Differences In Access To A Usual Source Of Care That Follows The Patient-Centered Medical Home Model: Analyses From The Medical Expenditure Panel Survey Data, Zo Ramamonjiarivelo, Delawnia Comer-Hagans, Shamly Austin, Karriem Watson, Alicia Kaye Matthews

Patient Experience Journal

This study examined racial and geographic differences in access to a usual source of care (USC) and it further explored these differences among individuals who had a USC that followed the patient-centered medical home (PCMH) model. Using cross-sectional data from the Household Component of the Medical Expenditure Panel Survey (2008-2013), our sample consisted of non-institutionalized US civilians ages 18-85 (n= 146,233; weighted n = 229,487,016). Our analysis included weighted descriptive statistics and weighted logistic regressions. Although 76% of the respondents had a USC, only 11% of them had a USC that followed the PCMH model. Among respondents who had a …

Unlv Innovation: The Research Magazine Of The University Of Nevada, Las Vegas

UNLV Innovation

From health disparities to social injustices, UNLV researchers are tackling some of the toughest challenges our community faces.

Up From Poverty: A Narrative Non-Fiction Study Of Three Female Superintendents From Poverty, Stephanie Johnson

School Leadership Review

This study focused on three female superintendents from poverty and how they elevated out of poverty to become successful superintendents in their school districts and help students living in poverty.

Seasonality Of Life History Events And Behavior Patterns In The Island Endemic Hawaiian Duck (Anas Wyvilliana), Christopher P. Malachowski, Bruce D. Dugger, Kimberly J. Uyehara

United States Fish and Wildlife Service: Publications

Year-round behavioral observations and surveys were used to investigate the temporal dynamics of life history events and associated variation in behavioral activities of the endangered, island-endemic Hawaiian Duck (Anas wyvilliana) on Kaua‘i, Hawai‘i, USA. Although breeding activity occurred throughout the year, backdated brood observations (n = 67) revealed that birds initiated 94% of nests during the 9-month period from September through May, their peak nesting season. A greater proportion of females (n = 149) were paired during the peak nesting season (75%) than the off-peak season (48%). Behavioral patterns (n = 984; 329 hr) differed between seasons for males but …

A Pan-Cancer Analysis Of Driver Gene Mutations, Dna Methylation And Gene Expressions Reveals That Chromatin Remodeling Is A Major Mechanism Inducing Global Changes In Cancer Epigenomes., Ahrim Youn, Kyung In Kim, Raul Rabadan, Benjamin Tycko, Yufeng Shen, Shuang Wang

Faculty Research 2018

BACKGROUND: Recent large-scale cancer sequencing studies have discovered many novel cancer driver genes (CDGs) in human cancers. Some studies also suggest that CDG mutations contribute to cancer-associated epigenomic and transcriptomic alterations across many cancer types. Here we aim to improve our understanding of the connections between CDG mutations and altered cancer cell epigenomes and transcriptomes on pan-cancer level and how these connections contribute to the known association between epigenome and transcriptome.

METHOD: Using multi-omics data including somatic mutation, DNA methylation, and gene expression data of 20 cancer types from The Cancer Genome Atlas (TCGA) project, we conducted a pan-cancer analysis …

Improving Ecological Restoration To Curb Biotic Invasion—A Practical Guide, Qinfeng Guo, Dale G. Brockway, Diane L. Larson, Deli Wang, Hai Ren

United States Department of Agriculture, Forest Service / University of Nebraska-Lincoln: Faculty Publications

Common practices for invasive species control and management include physical, chemical, and biological approaches. The first two approaches have clear limitations and may lead to unintended (negative) consequences, unless carefully planned and implemented. For example, physical removal rarely completely eradicates the targeted invasive species and can cause disturbances that facilitate new invasions by nonnative species from nearby habitats. Chemical treatments can harm native, and especially rare, species through unanticipated side effects. Biological methods may be classified as biocontrol and the ecological approach. Similar to physical and chemical methods, biocontrol also has limitations and sometimes leads to unintended consequences. Therefore, a …

Local Adaptation In Mainland Anole Lizards: Integrating Population History And Genome–Environment Associations, Ivan Prates, Anna Penna, Miguel Trefaut Rodrigues, Ana Carolina Carnaval

Publications and Research

Environmental gradients constrain physiological performance and thus species’ ranges, suggesting that species occurrence in diverse environments may be associated with local adaptation. Genome–environment association analyses (GEAA) have become central for studies of local adaptation, yet they are sensitive to the spatial orientation of historical range expansions relative to landscape gradients. To test whether potentially adaptive genotypes occur in varied climates in wide‐ranged species, we implemented GEAA on the basis of genomewide data from the anole lizards Anolis ortonii and Anolis punctatus, which expanded from Amazonia, presently dominated by warm and wet settings, into the cooler and less rainy Atlantic …

Opinion: Bipartisanship In Our Genes, Staff

Browse All News

No abstract provided.

Herbicide Metabolism: Crop Selectivity, Bioactivation, Weed Resistance, And Regulation, Vijay K. Nandula, Dean E. Riechers, Yurdagul Ferhatoglu, Michael Barrett, Stephen O. Duke, Franck E. Dayan, Alina Goldberg-Cavalleri, Catherine Tétard-Jones, David J. Wortley, Nawaporn Onkokesung, Melissa Brazier-Hicks, Robert Edwards, Todd Gaines, Satoshi Iwakami, Mithila Jugulam, Rong Ma

United States Department of Agriculture-Agricultural Research Service / University of Nebraska-Lincoln: Faculty Publications

Several grass and broadleaf weed species around the world have evolved multiple-herbicide resistance at alarmingly increasing rates. Research on the biochemical and molecular resistance mechanisms of multiple-resistant weed populations indicate a prevalence of herbicide metabolism catalyzed by enzyme systems such as cytochrome P450 monooxygenases and glutathione S-transferases and, to a lesser extent, by glucosyl transferases. A symposium was conducted to gain an understanding of the current state of research on metabolic resistance mechanisms in weed species that pose major management problems around the world. These topics, as well as future directions of investigations that were identified in the symposium, are …

Epigenetic Profiling For The Molecular Classification Of Metastatic Brain Tumors., Javier I Orozco, Theo A Knijnenburg, Ayla O Manughian-Peter, Matthew P Salomon, Garni Barkhoudarian, John R Jalas, James S Wilmott, Parvinder Hothi, Xiaowen Wang, Yuki Takasumi, Michael E Buckland, John F Thompson, Georgina V Long, Charles S Cobbs, Ilya Shmulevich, Daniel F Kelly, Richard A Scolyer, Dave S B Hoon, Diego M Marzese

Articles, Abstracts, and Reports

Optimal treatment of brain metastases is often hindered by limitations in diagnostic capabilities. To meet this challenge, here we profile DNA methylomes of the three most frequent types of brain metastases: melanoma, breast, and lung cancers (n = 96). Using supervised machine learning and integration of DNA methylomes from normal, primary, and metastatic tumor specimens (n = 1860), we unravel epigenetic signatures specific to each type of metastatic brain tumor and constructed a three-step DNA methylation-based classifier (BrainMETH) that categorizes brain metastases according to the tissue of origin and therapeutically relevant subtypes. BrainMETH predictions are supported by routine histopathologic evaluation. …

College Voice Vol. 42 No. 4 [November 6, 2018], Connecticut College

2018-2019

No abstract provided.

Brain Metastasis Dna Methylomes, A Novel Resource For The Identification Of Biological And Clinical Features., Matthew P Salomon, Javier I J Orozco, James S Wilmott, Parvinder Hothi, Ayla O Manughian-Peter, C Cobbs, Richard A Scolyer, Dave S B Hoon, Diego M Marzese

Articles, Abstracts, and Reports

Brain metastases (BM) are one the most lethal and poorly managed clinical complications in cancer patients. These secondary tumors represent the most common intracranial neoplasm in adults, most frequently originating from lung cancer, breast cancer, and cutaneous melanoma. In primary brain tumors, such as gliomas, recent advances in DNA methylation profiling have allowed for a comprehensive molecular classification. Such data provide prognostic information, in addition to helping predict patient response to specific systemic therapies. However, epigenetic alterations of metastatic brain tumors with specific biological and translational relevance still require much further exploration. Using the widely employed Illumina Infinium HumanMethylation 450K …

11-06-2018 Swosu Bull Pup Camps Planned Saturday Morning For Area Youth, Southwestern Oklahoma State University

THE BARK ARCHIVE 2018

As part of Homecoming activities this weekend at Southwestern Oklahoma State University, several academic departments are planning fun, free activities for youngsters ages 8-12.

Intranasal Rapamycin Ameliorates Alzheimer-Like Cognitive Decline In A Mouse Model Of Down Syndrome, Antonella Tramutola, Chiara Lanzillotta, Eugenio Barone, Andrea Arena, Ilaria Zuliani, Luciana Mosca, Carla Blarzino, D. Allan Butterfield, Marzia Perluigi, Fabio Di Domenico

Chemistry Faculty Publications

Background: Down syndrome (DS) individuals, by the age of 40s, are at increased risk to develop Alzheimer-like dementia, with deposition in brain of senile plaques and neurofibrillary tangles. Our laboratory recently demonstrated the disturbance of PI3K/AKT/mTOR axis in DS brain, prior and after the development of Alzheimer Disease (AD). The aberrant modulation of the mTOR signalling in DS and AD age-related cognitive decline affects crucial neuronal pathways, including insulin signaling and autophagy, involved in pathology onset and progression. Within this context, the therapeutic use of mTOR-inhibitors may prevent/attenuate the neurodegenerative phenomena. By our work we aimed to rescue mTOR signalling …

Toll-Like Receptor 2 Ligands And Methods Of Making And Using Thereof, David L. Morse, Josef Vagner, Mark Mclaughlin, Robert Gillies, Amanda Huynh, Michael Doligalski

USF Patents

Disclosed are monoacylated Toll-like receptor 2 ligands which can be used in both the development of targeted agents for the imaging and treatment of pancreatic cancer as well as other cancers, and as an adjuvant for cancer immunotherapy. The monoacylated compounds disclosed herein have a higher binding affinity for TLR2 relative to a known potent diacylated agonists, but only −½ the bioactivity. Competition of the monoacylated compound with the diacylated compound for binding TLR2 was confirmed. Hence, the reported monoacylated compounds are inhibitors/antagonists of TLR2 activation.

Agenda, November 6, 2018, Programs Committee

Programs Committee (PC)

No abstract provided.

A Systematic Investigation Of Condensation Heat Transfer Using Asymmetric Micro-Scale Surfaces, Emily Brown

LSU Master's Theses

Asymmetric surfaces been shown to inducing unidirectional motion in the Leidenfrost regime; however, very minimal research has been conducted to investigate whether these surface can enhance condensation through the same means. The investigation of heat transfer of ratchets in condensation is a relatively untapped area of study, specifically ratchets with superhydrophobic properties. Anticipated difficulty lies in creating surfaces features or coatings that retain the ratchets and can adequately sustain optimal wetting state of Cassie-Baxter required to improve heat transfer performance during condensation. This study serves to investigate whether ratchets are a feasible surface feature to enhance condensation heat transfer. First, …

Two Honors College Students Named Marshall Scholar Finalists, Edwin B. Smith

University of Mississippi News

Jaz Brisack or Marisa Kutchma could be Britain-bound as university's third recipient

James Beasley, November 6, 2018, Rachel Burns, Matt Jones

Oral Histories

James Beasley graduated from Eastern Michigan University in 1977 and was an active member of the Student Senate and other associations on campus. Not on campus for the 1969 takeover of Pierce Hall, Beasley was a member of the next generation of student activists on campus, witness to the implementation of many of the changes demanded by earlier activists.

Transforming Lives In Coastal Communities Through Economic Development: Breeding Crassostrea Virginica For Alternative Oyster Culture, Brian Randall Callam

LSU Doctoral Dissertations

This dissertation helped address the commercialization of triploid Crassostrea virginica production and develop tetraploid C. virginica broodstock in Louisiana by addressing triploid commercialization and tetraploid broodstock development. This was done by: 1) developing regional breeding plans for diploid and tetraploid C. virginica targeted at the Gulf Coastal Region, 2) assessing the effect of chromosome set manipulation on gonadal development in diploid, triploid, and tetraploid C. virginica, 3) quantifying the variation of commercially important hatchery traits in triploid C. virginica larvae from different tetraploid parents, 4) developing an up-to-date remote setting manual for the Gulf Coastal Region for industry use, …

Lindenwood Digest, November 6, 2018, Lindenwood University

Lindenwood Digest

The Lindenwood Digest has been a digital employee newsletter since 2009.

Isolation Of A 300 Kda, Au∼1400 Gold Compound, The Standard 3.6 Nm Capstone To A Series Of Plasmonic Nanocrystals Protected By Aliphatic-Like Thiolates, Chanaka Kumara, M. Mozammel Hoque, Xiaobing Zuo, David A. Cullen, Robert L. Whetten, Amala Dass

Faculty and Student Publications (Open Access)

No abstract provided.

Exceptional Points Of Degeneracy And Branch Points For Coupled Transmission Lines—Linear-Algebra And Bifurcation Theory Perspectives, George Hanson, Alexander B. Yakovlev, Mohamed A. K. Othman, Filippo Capolino

Faculty and Student Publications (Open Access)

No abstract provided.

A Neurobiologically Constrained Cortex Model Of Semantic Grounding With Spiking Neurons And Brain-Like Connectivity, Rosario Tomasello, Max Garagnani, Thomas Wennekers, F Pulvermueller

School of Engineering, Computing and Mathematics

No abstract provided.

Spartan Daily, November 6, 2018, San Jose State University, School Of Journalism And Mass Communications

Spartan Daily, 2018

Volume 151, Issue 33

Developmental Parameters Of A Southern Mountain Pine Beetle (Coleoptera: Curculionidae) Population Reveal Potential Source Of Latitudinal Differences In Generation Time, Anne E. Mcmanis, James A. Powell, Barbara J. Bentz

Mathematics and Statistics Faculty Publications

Mountain pine beetle (Dendroctonus ponderosae, Hopkins) is a major disturbance agent in pine ecosystems of western North America. Adaptation to local climates has resulted in primarily univoltine generation time across a thermally diverse latitudinal gradient. We hypothesized that voltinism patterns have been shaped by selection for slower developmental rates in southern populations inhabiting warmer climates. To investigate traits responsible for latitudinal differences we measured lifestage-specific development of southern mountain pine beetle eggs, larvae and pupae across a range of temperatures. Developmental rate curves were fit using maximum posterior likelihood estimation with a Bayesian prior to improve fit stability. …

Development Of A New Piezoelectric-Based Energy Harvesting Pavement System, Lukai Guo

USF Tampa Graduate Theses and Dissertations

A novel design of a piezoelectric-based energy harvesting pavement system (PZ-EHPS) is introduced in this dissertation work. The design concept of this PZ-EHPS is to transform asphalt layers into a piezoelectric energy harvester to collect dissipated vehicle kinetic energy in a large-scale system, relying on two conductive asphalt layers and one piezoelectric material layer. To verify the feasibility of the above design concept, this dissertation work practically fabricated and tested a series of PZ-EHPS specimens under the loads from a Material Testing System (MTS) in the laboratory, and theoretically analyzed one typical PZ-EHPS specimen via a three-degree-of-freedom electromechanical model and …