Digital Commons Network^™

The Role Of D1/Dda1 And D5/Damb Dopamine Receptors In Ethanol Induced Behavioral Disinhibition, Ivan Mercado

Open Access Theses & Dissertations

Alcohol drinking causes changes in behaviors by acting on various neurotransmitters (e.g. GABA, acetyl choline and glutamate) (Kumar et al., 2009), neuromodulators (e.g. dopamine, and serotonin) (Banerjee, 2014) and ion channels (e.g. Ca2+ and K channels) (Harris and Hood, 1980). Behaviors associated with alcohol consumption include loss of motor coordination, impaired decision-making, altered circadian rhythm, and disinhibited behaviors (NIH-NIAAA, Bethesda, MD). Behavioral disinhibition is defined as having poor judgment and acting in a manner that one would not usually behave (Greenspan and Ferveur, 2000) and commonly caused by substance abuse such as alcohol consumption and cocaine use. Excessive alcohol intake …

Association Of Opioid Metabolism With Aberrant Drug-Related Behaviors Among Non-Malignant Chronic Pain Patients, Eduardo Aguila

Open Access Theses & Dissertations

An estimated 100 million Americans suffer from some form of chronic pain. Chronic opioid therapy (COT) use in non-malignant chronic pain patients (NMCPP) has markedly increased over the past two decades due to growing consensus that COT is suitable for the treatment of moderate-to-severe non-malignant chronic pain. Yet, COT for NMCPP has been widely associated with multiple aberrant drug-related behaviors (ADRB) such as misuse, abuse, diversion, addiction, and pseudoaddiction. One reason for the relative high incidence of ADRB among NMCPP on COT may be genetics-induced medication response variability, which, can result in pharmacotherapy failure and/or toxicity

The present study evaluated …

Biologically Available Phosphorus In Biocrust-Dominated Soils Of The Chihuahuan Desert, Grace Margaret Crain

Open Access Theses & Dissertations

In desert soils, phosphorus (P) is an important limiting nutrient and its cycling characteristics are less understood compared to nitrogen and carbon. Phosphorus cycling is controlled by both geochemical and biological factors. Traditionally, P availability has been characterized via sequential extraction analyses such as Hedley fractionation, but newly developed extraction methods allow for the examination of more biologically relevant P fractions, providing insight on mechanisms of P acquisition by plants and microbes. We examined these P cycling features in the context of biological soil crusts (biocrusts), which have been found to be important drivers of nutrient cycling and have the …

Fluoxetine Exposure Results In Decreased Sensitivity To Cocaine And Sucrose Later In Life: A Study In Female C57bl/6 Mice, Francisco Javier Flores Ramirez

Open Access Theses & Dissertations

Preclinical evidence indicates that exposure to psychotropic medications, during early development, results in long-lasting altered responses to stress- and reward-related stimuli. However, these animal studies have been conducted, primarily, using male subjects. This is surprising, given that clinical data suggests that females have a higher likelihood, than their male counterparts, to be diagnosed with mood-related illnesses, and thus, be prescribed with psychotropic medications, mostly antidepressants. Therefore, to examine whether enduring reward-related alterations are exhibited as a result of antidepressant exposure, in female subjects specifically, we exposed C57BL/6 female mice to fluoxetine (FLX; 250 mg/l in their drinking water). Specifically, separate …

Evaluating Fold And Thrust Systems Within An Inverted Basin: Indio Mounntains, West Texas, Myra Guerrero

Open Access Theses & Dissertations

Fold and thrust belts often are complicated by out of sequence thrust faulting and inverted basins display these structures particularly often due to reactivation of original normal faults as well as complex topographic evolution. The Indio Mountains lie along the northern margin of the Chihuahua trough which formed as a mid-Cretaceous extensional basin and was subsequently shortened during the Laramide orogeny, making the Indio Mountains an exceptional site for studies of structures produced by large scale basin inversion. This study focuses on the subsurface structures in a complexly imbricated thrust window developed along the paleo rift basin margin.

This study …

Deep Learning Models For Scoring Protein-Ligand Interaction Energies, Md Mahmudulla Hassan

Open Access Theses & Dissertations

In recent years, the cheminformatics community has seen an increased success with machine learning-based scoring functions for estimating binding affinities. The prediction of protein-ligand binding affinities is crucial for drug discovery research. Many physics-based scoring functions have been developed over the years. Lately, machine learning approaches are proven to boost the performance of traditional scoring functions. In this study, two scoring functions were developed; one is based on the Convolutional Neural Networks and the other one, called DLSCORE, is based on an ensemble of fully connected neural networks. Both the models were trained on the refined PDBbind (v.2016) dataset using …

A Mexican American's Passage: An Autoethnographic Exploration Of Identity And Self-Empowerment, Corina Lerma

Open Access Theses & Dissertations

This Thesis presents a critical autoethnography that explores how an understanding of political and cultural events have contributed to my conflicted sense of identity. The purpose of the study was to identify genealogical and historical patterns that manifest in the traumas that have influenced and problematized the construction of my reality and to discover if personal traumas and conflicted senses of identity as a Mexican American in the United States finds any source in the social and political events that took place during the Mexican Repatriation of the 1930s. The autoethnography was conducted both through research of Mexican American history, …

Crispr/Cas9-Induced Genetic Disruption And Characterization Of Udp-Galactopyranose Mutase In Trypanosoma Cruzi, Claudia Manriquez

Open Access Theses & Dissertations

The protozoan parasite, Trypanosoma cruzi, is the causative agent of Chagas disease (ChD), or American trypanosomiasis, which affects 6-8 million people in Latin America. It is estimated that 2-3 million people will develop severe lifelong cardiac and/or digestive disorders. ChD has become a life threat not only to endemic regions but most recently also to nonendemic regions, including the United States, owing to extensive worldwide migration in recent years. The lack of a vaccine and the limited efficacy of the two drug treatments available make it urgent to develop novel therapies to treat such a threatening disease. UDP-Galactopyranose mutase (UGM) …

Characterization Of 3d Printed Polylactic Acid/ Polycaprolactone/Titanium Dioxide Composites For Bone Replacement And Grafting, Sandra Elena Najera Beltran

Open Access Theses & Dissertations

A material that mimics the properties of bones was developed by optimizing the ratio of polymer composites of polylactic acid (PLA) and poly-ε-caprolactone (PCL), containing small amounts of titanium oxide (TiO2). Although titanium-based alloys have commonly been used for bone replacement procedures due to their biocompatibility with the human body and their mechanical properties, stress shielding continues to be a problem. The structure of a bone has a porosity which permits the flow of nutrients, blood, oxygen and minerals, and is an issue at the time of creating bone replacements using conventional methods. PLA and PCL have been used in …

Trends In Antibiotic Resistance And Correlations Of Antibiotic Use And Antibiotic Resistance In A Small Hospital In El Paso, Texas 2013-2015, Christopher Olivas

Open Access Theses & Dissertations

Antibiotic resistance is a serious public health threat, primarily, resulting from the excess and inappropriate use of antibiotics. Antibiotic resistance and antibiotic consumption trends may differ along the U.S-Mexico border from the rest of the U.S. due to geographical and cultural differences unique to the border region. The objectives of this study were: 1.) To examine the trends in antibiotic resistance among E. coli, ESBL producing E. coli, P. aeruginosa, S. aureus, and MRSA over a 3-year period (2013, 2014, 2015) in a U.S.-Mexico border area hospital; 2.) To examine the trends in antibiotic consumption among aztreonam, cefazolin, cefepime, ceftriaxone, …

Multi-Antigen-Chemiluminescent-Elisa For The Diagnosis Of Trypanosoma Cruzi Infection In Chihuahua, Mexico., Jose Andrei Orozco

Open Access Theses & Dissertations

No abstract provided.

Exploring The Effects Of Zinc Nanoparticle Concentration, Antioxidant, And Media On Cilantro (Coriandrum Sativum), And Radish (Raphanus Sativus) Plants Growth, Venkata Laxma Reddy Pullagurala

Open Access Theses & Dissertations

Engineered nanomaterials (ENMs) have proven to be one of the emerging chemicals of concern in the contemporary times. Soil acts as one of the major sinks of these ENMs. Reports have shown that ENMs have varied effects on soil biota. Particularly, their effects on plants are inconsistent. Amongst these ENMs, ZnO nanoparticles (nZnO) are the fourth largest raw materials in the nanotechnology industry. Globally, it is estimated that around 34,000 tons of n ZnO are utilized per year. The nZnO exposure on terrestrial plants yielded both beneficial as well as detrimental effects. Recently, there is an emerging evidence about the …

Geant4 Study Of A Gamma Ray Collimator For Proton Therapy, Selim Romero

Open Access Theses & Dissertations

This Thesis presents the results of an investigation of the use of collimators in proton therapy. The problem to solve is that in the proton therapy, we do not have the certainty if the target-tumor is receiving all the energy to destroy it or if we are really shooting at this one, so the remaining question is: where the beam is hitting? How to know it? to answer those questions our work has the propose of study proton therapy to determine where the proton interactions occur, these kinds of interactions usually produce gamma rays, and we simulated in GEANT4 the …

Glycoconjugate-Based Vaccines For Chagas Disease, Brenda Guadalupe Zepeda

Open Access Theses & Dissertations

Chagas disease is caused by the protozoan parasite Trypanosoma cruzi. About 6–8 million people are estimated to be infected worldwide. It is a blood borne pathogen and transmitted to humans by the insect vector (kissing bug), blood transfusion, organ transplant, contaminated foods and juices, and by congenital contagion. The chemotherapy is partially effective in chronic phase of the disease, and the drugs cause several side effects. There is no vaccine to prevent or treat Chagas disease. The great majority of experimental vaccines have employed whole parasite extracts, purified or recombinant proteins, synthetic peptides, or DNA; however, most of them provide …

Undergraduate Course Catalog Of The University Of San Diego 2018-2019, University Of San Diego

Undergraduate Course Catalogs (1973- )

352 pages. Includes information about academics, campus and the college, the 2018-2019 academic calendar, and school policies.

An Integrated Machine Learning Geological Field Tool In The Age Of Big Data And Drones, Guillermo Vargas

Open Access Theses & Dissertations

Unmanned aerial vehicles (UAVs) and machine learning are relatively new research tools in the geosciences that can be used to collect and analyze large data sets rapidly. We combine the power of rapid data collection using unmanned aerial vehicles with machine learning algorithms to develop a field-based system to identify targeted geological features. For data collection, we have used a commercial-grade UAV which carried visible-wavelength and multispectral (visible- infrared) cameras. We analyzed the data with machine learning and machine vision algorithms that can classify rock units exposed in a field area. We have identified algorithms that in previous literature have …

Electrocatalysts Based On Organic Macrocycles For Electrochemical Water Splitting, Yanyu Wu

Open Access Theses & Dissertations

Water splitting, which is the dissociation of water into hydrogen and oxygen gases, can be separated into two half reactions corresponding to the hydrogen evolution reaction and oxygen evolution reaction (HER and OER, respectively). Both reactions offer a promising way for storing energy into the form of chemical bonds, which is an important strategy for the development of clean-energy technologies. A main area of interest while studying HER and OER is to design effective and robust electrocatalysts made from earth-abundant materials. This dissertation describes several homogeneous and heterogeneous systems for the electrocatalytic generation of hydrogen and oxygen gases.

In Chapter …

Geostatistical And Geospatial Distribution Of Multiple Metallic Elements In Agricultural Regions Of The Mid-Continental Usa, Najwah Alssaeidi Ahmed Almesleh

Open Access Theses & Dissertations

Regional geochemical mapping constitute the chemistry of the surface of the earth in a large scale and relatively low sample density. It is widely accepted scientific activity and man uses some cases to identify contamination. In the present study, data present in national geochemical survey database was used to investigate the chemical loading loading of the agricultural soil. In the mid-continent region of the United States. Several traditional parameters were used mainly the enrichment factor (EF), and geoaccumulation index (I geo). Total chemical influence (TCI) maps were used to guide sampling. In addition, regional trace element chemistry of bedrock was …

Integrated Statistical And Machine Learning Algorithms For Predicting And Classifying G Protein-Coupled Receptors, Fredrick Ayivor

Open Access Theses & Dissertations

G protein-coupled receptors (GPCRs) are transmembrane proteins with important functions in signal transduction and often serve as drug targets. With increasing availability of protein sequence information, there is much interest in computationally predicting GPCRs and classifying them according to their biological roles. Such predictions are cost-efficient and can be valuable guides for designing wet lab experiments to help elucidate signaling pathways and expedite drug discovery. There are existing computational tools of GPCR prediction that involve principal component analysis (PCA), intimate sorting (IS), support vector machine, and random forest (RF) techniques using various sequence derived features. While accuracies of over 90\% …

Seeking Health Information In The Diabetes Online Community (Doc); The Role Of Health Literacy, Social Support And Community Interaction On Treatment Adherence, Allyson Hughes

Open Access Theses & Dissertations

Social support, being valued and cared for by others (Wills, 1991), is a critical construct for disease management and often includes providing advice and information to peers online. Approximately 83% of individuals with chronic disease search for health information online and there are more than 500,000 active social media users in the Diabetes Online Community (DOC) who have varying levels of disease management expertise. Due to the strenuous nature of Type 1 Diabetes (T1D), members of the DOC are continuously asking for and receiving anecdotal health information, yet very few studies have evaluated the impact of the DOC on treatment …

"Wommanly Noblesse:" Female Gender Dynamics In Medieval Romance, Mary Elizabeth Shaner

Open Access Theses & Dissertations

Exploring systemic, gendered power dynamics and inequalities for women within medieval Matters of Rome, France, and Britain Romances is essential to understanding real-world sociopolitical power structures and female gender roles. Diverging from most previous scholarship in my use of critics as well as in my interpretation of Criseyde and Guinevere as protagonists, my argument examines how scholars would laud the heroic bravery of Geoffrey Chaucer's Criseyde and Sir Thomas Malory's Guinevere if they were male heroes, yet because of the narrative conventions of medieval Romance, Courtly Love, Chivalry, and the Antifeminist Traditions, these fictive women are seen as the destroyers …

Electrochemical Investigation Of The Kinetics Of Chloride Substitution Upon Reduction Of [Ru(Porphyrin)(No)Cl] Complexes In Thf., Jeremy R. Zink, E G. Abucayon, Anthony R. Ramuglia, Arghavan Fadamin, James E. Eilers, George B. Richter-Addo, Michael J. Shaw

SIUE Faculty Research, Scholarship, and Creative Activity

The electrochemistry of several ruthenium porphyrin nitrosyl chloride complexes [Ru(por)(NO)Cl] have been examined in tetrahydrofuran. The complexes undergo 1-electron irreversible reductions which result in the diffusion-limited substitutions of the chloride ligands for THF. This chloride metathesis is reversible in the presence of added NBu₄Cl, and equilibrium constants and rate constants for chloride loss have been estimated. These parameters correlate with the NO stretching frequencies of the parent complexes, with more electron-donating porphyrin ligands favouring chloride loss from the reduced complexes. The [Ru(por)(NO)(THF)] products of the reductions can be detected by IR, EPR and visible spectroscopies. These species undergo …

Avian Habitat Use In A Chronosequence Of Bottomland Hardwood Forest Restoration Sites, Paul T. Le, Lindley B. Ballen, Richard Essner, Peter R. Minchin

SIUE Faculty Research, Scholarship, and Creative Activity

Since the 1950s, anthropogenic activity has caused the loss of millions of hectares of bottomland hardwood forest in the Upper Mississippi River Valley, causing population declines in bird populations. Restoration of these forest stands has been ongoing for the past 2 decades. We assessed bird species presence on sites in the Upper Mississippi River Valley to quantify diversity and relate presence to habitat conditions and sites’ age since restoration. We observed higher mean diversities at mature bottomland-forest sites during the spring and autumn, but nested ANOVAs indicated no significant differences among restoration-age categories during spring. During the autumn, the 15–23-y …

Smith And Hume On Animal Minds, Richard Fry

SIUE Faculty Research, Scholarship, and Creative Activity

This paper situates Hume’s views on animals in the context of the Scottish Enlightenment by contrasting them with the views of Adam Smith. While Smith is more central to the philosophical establishment of the Scottish Enlightenment, their views on morals resemble each other greatly and both think that the analogies between humans and non-human animals are useful for thinking about morals. Their estimation of the nature and extent of those analogies, however, differ widely from one another. This has been historically obscured by the fact that in no single work does Smith precisely detail what he thinks non-human animals are …

What Is Sexual Orientation?, Mary Ziegler

Kentucky Law Journal

At a time when the Supreme Court seems closer than ever before to treating sexual orientation as a suspect classification, consideration of the legal definition of sexual orientation is both timely and important. The Court’s 2015 decision in Obergefell recognizes two guideposts for defining sexual orientation: its immutability and normalcy. While other scholars offer rich and nuanced accounts of the fight for gay, lesbian, transgender, and bisexual rights, they do not fully analyze the history of sexual orientation as a legal category. This Article closes that gap, illuminating the hidden costs of the definition of sexual orientation that Obergefell endorses. …

Comparative Analysis Of Low Molecular Weight Fraction Of Conditioned Media Derived From Starvation-Dormant And Anaerobically-Dormant Mycobacterium Avium Subsp. Paratuberculosis, Marina Buciuc

All Graduate Theses, Dissertations, and Other Capstone Projects

Johne's disease (JD) caused by Mycobacterium avium subsp. paratuberculosis (MAP) is a contagious chronic enteritis affecting all ruminants and causing economic loss of at least $250 million annually in the US dairy industry. One of the major limitations in the diagnosis of JD is the low sensitivity of fecal culture in animals with no clinical signs of the disease, but who are actively shedding MAP. Persistence of MAP in the host with no apparent signs of infection is attributed to its ability to enter a dormant state wherein the bacterium is viable, but is not able to replicate until conditions …

Congress Considering Legislation Intended To Reverse The Recent Trend Toward Devaluation Of The Us Patent Right, Christopher M. Holman

Faculty Works

Decisions of the United States Supreme Court spanning the last quarter of a century that have, in the aggregate, substantially devalued the patent right. The Court’s four decisions reinvigorating and substantially raising the patent eligibility bar have probably resulted in the most critical commentary, but a host of other decisions have also served to erode the patent right in multiple dimensions, including the scope of potentially patent-able subject matter as well as the strength and enforce-ability of issued patents. In 2011 Congress joined in when it enacted the America Invents Act (AIA), which includes multiple provisions tending to devalue patents, …

Morals In The United States Of America: Are They In Their Death Throes?, John A. Cook

Communication Faculty Publications

This article explores the ethics of large complex systems in the United States of America in three major case studies: the food industry, the pharmaceutical industry and the political/governmental institutions. Using the simple Aristotelian heuristic of good sense, good character and good will, the conclusion is that ethics is not a high priority due in large part to the relentless pursuit of large sums of money at any cost.

The Divine Collaborative Effort: Agency As A Tool For Examining Power And Relationship In The Exodus Narrative, Harley Burgess

Undergraduate Honors Theses

Excerpt from Introduction

The character of Moses as seen within the Old Testament is perhaps the most dynamic and powerful character within the biblical text. Continually throughout the Exodus narrative, Moses faces opportunities for growth and development that lead him toward becoming the archetype for leadership. Moses’ journey is rife with choice. Though many would place Yahweh at the forefront of the narrative, it is truly Moses whom the audience witnesses generating change, making decisions, and even influencing the decisions of his God.

Regeneration Of Teeth And Periodental Tissues Using Stem Cells, Joshua A. Mckoy

Undergraduate Honors Theses

The purpose of this thesis is to serve as systematic literature review that provides a background on regenerative therapy in dentistry, as well as proposing the need for continued research. Regenerative dentistry has great potential for stem cell use. Stem cells of many types have the capability of self-renewal and differentiation into multiple cell types. With stem cell-based regeneration, dentistry can grow exponentially with the implementation whole-tooth replacement, pulp regeneration, periodontium regeneration, enamel regeneration, and dentin regeneration. Furthermore, utilizing various biomaterial scaffolds and inducing growth factor activity has been demonstrated to aid in regenerative efforts. Issues of regenerative therapies must …