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Cultures: How Different Are They? A Nursing Perspective, Sanduni Silva

Senior Honors Theses and Projects

Chapter one will explore nursing models for culturally competent care and review three different theorists. First theorists, Campinha-Bacote (2008), will explain the model of cultural competence. Second theorist, Giger and Davidhizar talks about the model of transcultural nursing. Their theorist, Leininger, will explain cultural care diversity and universality theory/model. Chapter two will explain the differences between the first three cultures which include Muslim, Jewish, an Chinese. This will include the types of foods they may eat, religions they follow along with religious practices , and what each culture may find as social norms. When talking about social norms, with each …

Finding Myself Back Home In Botswana: Reflections On A Semester Abroad, Anne M. Odonnell

Capstones and Honors Theses

Anthropology aims to study people and their culture in order to understand the breadth of human experience. This paper examines the ways in which a semester of study abroad can supplement and aid in future work in anthropology. Primarily, it examines culture shock and how it can be managed and the connections between cultures that are separated across space. It also explores the ways in which the environment and wildlife of a new area can contribute to a person's experience of place.

Zwitterionic Polymer For Drug Delivery Applications, Yang Lu

Wayne State University Dissertations

This dissertation focuses on the applications of zwitterionic polymer materials in drug delivery. In one project, zwitterionic polymer was used to construct micelle surfactants. The zwitterionic micelles were found to have an ultralow critical micelle concentration (CMC). Potential mechanism for zwitterionic micelles achieving the ultralow CMC property has been studied. Based on the ultralow CMC feature, zwitterionic micelles were used to prepare a formulation of commercial antitumor drug docetaxel, and the resulting formulation showed excellent antitumor performance. In another project, zwitterionic polymer was used to modify protein drug insulin via conjugation reaction. Compared with current protein modification methods, such as …

Investigating Antibiotic Resistance In Urban Agricultural Environment Using Phenotypic, Genomic, And Metagenomic Tools, Abdullah Ibn Mafiz

Wayne State University Dissertations

Urban agricultural environment can be an important reservoir of antibiotic resistance and have great food safety and public health indications. This study was to investigate antibiotic-resistant bacteria and antibiotic resistance genes in urban agricultural environment using phenotypic, whole genome sequencing, and metagenomic tools. Three urban community gardens from metro Detroit were studied in two phases.

First phase of this study recovered a total of 207 soil bacteria from 41 soil samples collected from an urban agricultural garden. The most prevalent antibiotic resistance phenotypes demonstrated by Gram-negative bacteria was the resistance to ampicillin (94.2%), followed by chloramphenicol (80.0%), cefoxitin (79.5%), gentamicin …

Sexual Orientation Development, Acceptance, And Risk Behavior In Young Adult Gay Men, Erin Paige Smith

Wayne State University Dissertations

Research on sexual orientation development points to individual differences in developmental milestones (i.e., realization, identification, disclosure to friend, disclosure to parent, same-sex sexual behavior) that could be differentially related to adjustment. Additionally, differences in perceptions of acceptance from the self and important others, such as parents and friends, during adolescence and early adulthood may be related to both sexual orientation development and health risk behaviors (i.e., substance use, sexual risk). The goal of the current study was to advance our understanding of developmental processes among gay men by examining perceived acceptance of sexual orientation and its associations with individual differences …

Study Of Mri Signal In The Presence Of Discrete Spherical Magnetic Particles, Paul Kokeny

Wayne State University Dissertations

Simulating signal behavior in Magnetic Resonance imaging (MRI) is often a necessary step in being able to understand how signal relates to certain physiological parameters. One such parameter of interest in the body is magnetic susceptibility since it is related to iron content. The bulk magnetic susceptibility of an object is a property that describes how magnetized it becomes when placed in an external magnetic field. When the bulk susceptibility of an object arises from the presence of discrete magnetic inclusions, the MRI phase signal inside the object can no longer be determined analytically by assuming it has a continuous …

Addressing The Threat Of Multidrug Resistant Infectious Diseases By Synthesis Of Novel Aminoglycoside Antibiotics, Girish Chandra Sati

Wayne State University Dissertations

The ever-growing increase in multidrug resistant infectious diseases is one of the major cause of human mortality, and there is an inherent need for the development of new antibiotics. Since the discovery of streptomycin, AGAs have been playing a very important role in human therapy as highly potent broad-spectrum antibiotics and are listed as one of the critically important antimicrobials by WHO. AGAs act by inhibiting the bacterial protein synthesis and by targeting the A-site present in the small subunit of bacterial ribosome. The clinical use of AGAs is somewhat restricted due to their toxic effects (ototoxicity and nephrotoxicity) and …

Proteolipid Protein 1 Regulates Inflammation In The Central Nervous System, Whitney Hoff

Wayne State University Theses

Pelizaeus-Merzbacher disease (PMD) results from mutations in the proteolipid protein 1 (PLP1) gene including PLP1 duplications and deletions. The absence of PLP is preferable to PLP1/Plp1 duplication in PMD patients and rodents as lifespan of PLP1/Plp1 null mammals is nearly normal. The reason for this is not entirely understood. However, because of this, less attention has been placed on Plp1 null mutations than on classical PMD mutations. However, data show that PLP levels must be properly titrated to ensure normal brain function. Specifically, changes in PLP1/Plp1 expression can result in massive microglia activation in animal models of PMD and likely …

The Effect Of Short-Term Supplementation Of Potato Starch And Vsl#3 On The Large Intestines Of Male C57bl/6 Mice, Kaitlyn R. Merz

Wayne State University Theses

The microbiome is extremely complex and presumed to be involved in several biological processes. Dysbiosis is associated with development of several diseases, therefore, eubiosis is essential for prevention and treatment, possibly achieved through prebiotic or probiotic supplementation. The objective of this study was to establish effects of short-term supplementation on large intestine microbiota, pH and inflammatory cytokines. Large intestines of 21 day old C57BL/6 male mice that were given a control diet or supplemented with 10% potato starch or VSL#3 short-term, were analyzed for shifts in bacteria, pH, and inflammatory cytokine concentration. Large intestine digesta bacteria concentration differed from feces …

Evaluating The Effectiveness Of Bioswales In Southeast Michigan, Grace Crowe

Research Opportunities for Engineering Undergraduates (ROEU) Program 2017-18

Bioswales are modern storm water management structures that utilize biological components in a traditional wale to more effectively filter out contaminants. Because of its modern nature the installation and management practices for bioswales is still developing. Perfecting the practices surrounding bioswales in southeast Michigan environment can aid in the advancement of green infrastructure in the state. Wayne State installed a bioswale in one its parking lots in New Center with the help of the Detroit Biodiversity Network (DBN). We wanted to monitor the progression of this existing bioswale throughout the year, observing the system components effecting overall bioswale performance. The …

Characterization Of Electroactive Nanofibers For Nerve Regeneration, Jean-Yves Azar

Research Opportunities for Engineering Undergraduates (ROEU) Program 2017-18

In the event of peripheral nerve injury, loss of function may occur as the result of a severed nerve. Hollow nerve gap conduits are used to provide a protected environment for nerves to reconnect and regain function, although therapies for nerve gaps larger than 3 cm lack a stable environment for nerves to reconnect. Development of a nerve guide conduit filler has been proposed to mimic the cell’s microenvironment. This would lead to increased functional regeneration. We are aiming to create a biomaterial to act as a filler for the hollow nerve gap conduits to promote functional regeneration of the …

Diversity And Ethics: Toward An Objective Business Compliance Function, Steven A. Ramirez

Loyola University Chicago Law Journal

This Article builds upon prior works which articulate an objective standard for corporate ethics and compliance that furthers shareholder wealth maximization: A firm should only engage in conduct that acclimates itself as optimally as possible to the full range of its constituencies, including investors, workers, consumers, and regulators. Further, because of the deep racial and social divisions within the United States today (and present in most business environments), a firm can achieve optimal acclimation only if it includes the full range of cultural diversity within its constituencies, as those diverse voices influence the behavior of the firm. This allows the …

A Mixed Methods Analysis Of Gender Differences In Symptom Progression And Trauma Narratives During Trauma-Focused Cognitive Behavioral Therapy, Sarah A. Ascienzo

Theses and Dissertations--Social Work

An alarming portion of youth experience traumatic events during childhood, and there is a robust body of literature documenting the adverse consequences of trauma exposure on the developing child. Fortunately, numerous empirically-supported phase-based interventions have been developed for youth that target the deleterious effects of trauma. While several of these interventions have demonstrated symptom reduction from the baseline to completion of treatment, much less is known regarding the trajectory of posttraumatic stress symptoms (PTSS) during the course of treatment. Information in this regard may have important implications for service delivery and help to illuminate the mechanisms of change responsible for …

Evaluation Of Microbially-Converted Soybean Meal As An Alternative To Fishmeal In Weaned Pig Diets, Sue Sinn

Electronic Theses and Dissertations

Digestibility values determined in growing pigs may not apply to nursery pigs; thus, standardized ileal digestibility (SID) of AA in MCSBM and fishmeal (FM) were determined using 30 ± 1.6 kg BW ileal-cannulated barrows (n = 6) and 9.8 ± 1.2 kg BW barrows (n = 37; serial slaughter). Experimental diets included MCSBM, FM, and nitrogen-free where FM and MCSBM were included as the sole protein source. The SID of AA was 3-5% lower in MCSBM than FM when fed to 30 kg pigs. The SID of Arg and Met was greater (P < 0.05) in MCSBM than FM when fed to 10 kg pigs. The SID of AA was 12-20% lower in FM when fed to 10 versus 30 kg pigs but only 3-9% lower in MCSBM. A total of 336 barrows and gilts were weaned at 21 d of age (initial BW 6.1 ± 0.8 kg) and used in a performance trial. Pens of pigs were assigned to one of 6 experimental diets (8 pens/diet in two blocks). Treatment diets were fed in Phase I (7 d) and Phase II (14 d) with all pigs fed a common Phase III diet (14 d). Experimental diets included: 1) negative control (NEG) containing corn, soybean meal and whey, 2) NEG + acidifier (NEGA), 3) NEG + FM (POS), 4) POS + acidifier (POSA), 5) NEG + MCSBM (MCSBM), and 6) MCSBM + acidifier (MCSBMA). The FM and MCSBM were included at 7.5% and 5.0% in Phase I and II diets, respectively. Diets were formulated to meet the standard nutrient requirements for weaned pigs. Pig BW and feed disappearance was measured weekly and fecal scores were measured daily for the first 14 d postweaning as an indicator of PWDS. Performance (BW, ADG, ADFI, and G/F) was not significantly different among treatments. Treatment for PWDS occurred on different days in each block. Analysis of fecal score was completed separately by block. Pigs fed the NEG diets had higher (P = 0.02) fecal scores than pigs fed the POS diets on d 2 and 3 (block 1) and higher (P < 0.05) than pigs fed MCSBM or POS diets and diets with dietary acidifier on d 6 and 3 (block 2). At the end of Phase I and II, one pig/pen was humanely euthanized for digesta and tissue collection. Digesta pH was measured in the pyloric region of the stomach, duodenum, middle jejunum, ileum, cecum, and middle colon. There was an effect of location (P < 0.0001), where the pH was lowest in the stomach and increased until the ileum with a slight dip in the cecum and increased in the colon. There was no effect of ingredient, dietary acid, or their interaction within the gastrointestinal tract. At the end of Phase I, pigs fed NEG and POSA diets had similar pH (P > 0.10) from the stomach to the duodenum, …

The Satisfactory Growth And Development At 2 Years Of Age Of The Intergrowth-21st Fetal Growth Standards Cohort Support Its Appropriateness For Constructing International Standards., José Villar, Leila Cheikh Ismail, Eleonora Staines Urias, Francesca Giuliani, Sikolia Wanyonyi

Obstetrics and Gynaecology, East Africa

Background: The World Health Organization recommends that human growth should be monitored with the use of international standards. However, in obstetric practice, we continue to monitor fetal growth using numerous local charts or equations that are based on different populations for each body structure. Consistent with World Health Organization recommendations, the INTERGROWTH-21st Project has produced the first set of international standards to date pregnancies; to monitor fetal growth, estimated fetal weight, Doppler measures, and brain structures; to measure uterine growth, maternal nutrition, newborn infant size, and body composition; and to assess the postnatal growth of preterm babies. All these standards …

"Class Of One" Dismissed: A Proposal To Relax The Similarly Situated Test In Cases Of Obvious Government Animus, Kyle C. Sproul

University of the Pacific Law Review

No abstract provided.

Personhood Seeking New Life With Republican Control, Jonathan Will, I. Glenn Cohen, Eli Y. Adashi

Journal Articles

Just three days prior to the inauguration of Donald J. Trump as President of the United States, Representative Jody B. Hice (R-GA) introduced the Sanctity of Human Life Act (H R. 586), which, if enacted, would provide that the rights associated with legal personhood begin at fertilization. Then, in October 2017, the Department of Health and Human Services released its draft strategic plan, which identifies a core policy of protecting Americans at every stage of life, beginning at conception. While often touted as a means to outlaw abortion, protecting the "lives" of single-celled zygotes may also have implications for the …

2018-19 Uni Wrestling, University Of Northern Iowa

Athletics Media Guides

Contents:

--2018-19 Schedule
--UNI Panthers
--Big 12 Conference
--Head Coach Doug Schwab - 9th Season
--8 All-Americans
--41 NCAA Qualifiers
--Coaches
--2018-19 Dual Opponents
--UNI's Bill Smith First Panther Wrestler to be Inducted into MVC Hall of Fame
--2018-19 Roster/Career Stats
--2017-18 Stats
--UNI Results 2017-18
--Big 12 Championship Results 2018
--UNI at 2018 NCAA Division I Wrestling Championships
--Career and Season Leaders of Panther Wrestling
--Year by Year Results

Analytical High-Resolution Electron Microscopy Reveals Organ-Specific Nanoceria Bioprocessing, Uschi M. Graham, Robert A. Yokel, Alan K. Dozier, Lawrence Drummy, Krishnamurthy Mahalingam, Michael T. Tseng, Eileen Birch, Joseph Fernback

Pharmaceutical Sciences Faculty Publications

This is the first utilization of advanced analytical electron microscopy methods, including high-resolution transmission electron microscopy, high-angle annular dark field scanning transmission electron microscopy, electron energy loss spectroscopy, and energy-dispersive X-ray spectroscopy mapping to characterize the organ-specific bioprocessing of a relatively inert nanomaterial (nanoceria). Liver and spleen samples from rats given a single intravenous infusion of nanoceria were obtained after prolonged (90 days) in vivo exposure. These advanced analytical electron microscopy methods were applied to elucidate the organ-specific cellular and subcellular fate of nanoceria after its uptake. Nanoceria is bioprocessed differently in the spleen than in the liver.

Mandating Meaningful Forensic Discovery: A Proposal To Fuel The Engine Of Truthfulness, Marjorie Mcdiarmid

Faculty & Staff Scholarship

No abstract provided.

The Believing Scientist: Essays On Science And Religion, Hyrum Lewis

BYU Studies

Stephen M. Barr. The Believing Scientist: Essays on Science and Religion.

Grand Rapids, Mich: William B. Eerdmans Publishing, 2016.

Global-Change Effects On Early-Stage Decomposition Processes In Tidal Wetlands – Implications From A Global Survey Using Standardized Litter, Peter Mueller, Lisa M. Schile-Beers, Thomas J. Mozdzer, Gail L. Chmura, Thomas Dinter, Yakov Kuzyakov, Alma V. De Groot, Peter Esselink, Christian Smit, Andrea D'Alpaos, Carles Ibáñez, Magdalena Lazarus, Urs Neumeier, Beverly J. Johnson, Andrew H. Baldwin, Stephanie A, Yarwood, Diana I. Montemayor, Zaichao Yang, Jihua Wu, Kai Jensen, Stefanie Nolte

Biology Faculty Research and Scholarship

Tidal wetlands, such as tidal marshes and mangroves, are hotspots for carbon sequestration. The preservation of organic matter (OM) is a critical process by which tidal wetlands exert influence over the global carbon cycle and at the same time gain elevation to keep pace with sea-level rise (SLR). The present study assessed the effects of temperature and relative sea level on the decomposition rate and stabilization of OM in tidal wetlands worldwide, utilizing commercially available standardized litter. While effects on decomposition rate per se were minor, we show strong negative effects of temperature and relative sea level on stabilization, as …

Structural Features And Domain Movements Controlling Substrate Binding And Cofactor Specificity In Class Ii Hmg-Coa Reductase, Bradley R. Miller, Yan Kung

Chemistry Faculty Research and Scholarship

The key mevalonate pathway enzyme 3-hydroxy-3-methylglutaryl coenzyme A (HMG-CoA) reductase (HMGR) uses the cofactor NAD(P)H to reduce HMG-CoA to mevalonate in the production of countless metabolites and natural products. Although inhibition of HMGR by statin drugs is well-understood, several mechanistic details of HMGR catalysis remain unresolved, and the structural basis for the wide range of cofactor specificity for either NADH or NADPH among HMGRs from different organisms is also unknown. Here, we present crystal structures of HMGR from Streptococcus pneumoniae (SpHMGR) alongside kinetic data of the enzyme’s cofactor preferences. Our structure of SpHMGR bound with its kinetically preferred NADPH cofactor …

The Immediate Early Gene Egr3 Is Required For Hippocampal Induction Of Bdnf By Electroconvulsive Stimulation, Kimberly T. Meyers, Ketan K. Marballi, Samuel J. Brunwasser, Briana Renda, Milad Charbel, Diano F. Marrone, Amelia L. Gallitano

Open Access Publications

No abstract provided.

Positron Emission Tomography (Pet) For Prediction Of Glioma Histology: Protocol For An Individual-Level Data Meta-Analysis Of Test Performance, Nikolaos A. Trikalinos, Takashi Nihashi, Evangelos Evangelou, Teruhiko Terasawa

Open Access Publications

No abstract provided.

Characterization Of Small Molecules Inhibiting The Pro-Angiogenic Activity Of The Zinc Finger Transcription Factor Vezf1, Ming He, Qianyi Yang, Allison B. Norvil, David Sherris, Humaira Gowher

Open Access Publications

No abstract provided.

The Presentation Of The Mind-Brain Problem In Leading Psychiatry Journals, Alexander Moreira-Almeida, Saulo De F. Araujo, C. Robert Cloninger

Open Access Publications

No abstract provided.

An Integrated Clinical Program And Crowdsourcing Strategy For Genomic Sequencing And Mendelian Disease Gene Discovery, Nathan O. Stitziel, Et Al

Open Access Publications

No abstract provided.

New Insights Into The Role Of Trem2 In Alzheimer’S Disease, Maud Gratuze, Cheryl E.G. Leyns, David M. Holtzman

Open Access Publications

No abstract provided.

Systemic Activation Of Activin A Signaling Causes Chronic Kidney Disease-Mineral Bone Disorder, Toshifumi Sugatani

Open Access Publications

No abstract provided.