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Clearance Concepts: Fundamentals And Application To Pharmacokinetic Behavior Of Drugs, Reza Mehvar

Pharmacy Faculty Articles and Research

Clearance concepts were introduced into the pharmacokinetics discipline in the 1970s and since then have played a major role in characterization of the pharmacokinetic behavior of drugs. These concepts are based on the relationship between organ extraction ratio or clearance and physiologic parameters such as the organ blood flow and the intrinsic capability of the eliminating organ to remove the free (unbound) drug from the body. Several theoretical models have been developed, which define these relationships and may be used to predict the effects of changes in the physiological parameters on various pharmacokinetic parameters of drugs, such as drug clearance. …

Design And Evaluation Of Gemini Surfactant-Based Lipoplexes Modified With Cell-Binding Peptide For Targeted Gene Therapy, Waleed Mohammed-Saeid, Rania Soudy, Richa Tikoo, Kamaljit Kaur, Ronald E. Verrall, Ildiko Badea

Pharmacy Faculty Articles and Research

Purpose Achieving successful gene therapy requires delivery of a gene vector specifically to the targeted tissue with efficient expression and a good safety profile. The objective of this work was to develop, characterize and determine if a novel gemini surfactant-based lipoplex systems, modified with a cancer-targeting peptide p18-4, could serve this role. Methods The targeting peptide p18-4 was either chemically coupled to a gemini surfactant backbone or physically co-formulated with the lipoplexes. The influence of targeting ligand and formulation strategies on essential physicochemical properties of the lipoplexes was evaluated by dynamic light scattering and small angle X-ray scattering techniques. In …

Mindfulness Training For Judges: Mind Wandering And The Development Of Cognitive Resilience, Scott L. Rogers, Chris Mcaliley, Amishi P. Jha

Court Review: Journal of the American Judges Association

The benefits of mindfulness practices for lawyers have been the subject of broad discussion within the profession for a number of years. Increasingly, this discussion has expanded to include judges and the work of the judiciary. In this article we explore more deeply the relevance of mindfulness to judges, and in particular, how it can support their resilience, health, and well-being, as well as their cognitive functioning.

We hope to educate and support judges who would like to gain greater mastery over their cognitive capacity and emotional well-being. Recognizing that the full breadth of this subject is beyond an article …

2017-2018 Annual Report On Philanthropy/Impact Report: Star Power

Annual Report on Philanthropy

No abstract provided.

Revision Of The Taxonomic Status Of Aphis Floridanae Tissot (Hemiptera: Aphididae) Using Morphological And Molecular Insight, Doris Lagos-Kutz, Susan E. Halbert, David J. Voegtlin, Glen L. Hartman

Insecta Mundi

Morphological and cytochrome oxidase 1 (Cox1) data show that Aphis floridanae Tissot (Hemiptera: Aphididae) is not synonymous with A. nasturtii Kaltenbach. Instead, A. floridanae matches the morphological characters of A. impatientis Thomas. Additionally, the range of cytochrome oxidase 1 (Cox1) pair-wise distance of the multiple collections of A. impatientis on Cornus spp., Impatiens spp. and Erechtites hieraciifolius (L.) Raf. ex DC. is 0–0.39%. Therefore, we conclude that A. floridanae Tissot, 1933 is a junior synonym of A. impatientis Thomas, 1878, new synonymy. In addition, A. impatientis is re-described, including first descriptions of the ovipara and alate …

Description Of Two New Bolivian Cerambycidae And A Costa Rican Record For An African Prionine (Coleoptera), James E. Wappes, Antonio Santos-Silva, Maria Helena M. Galileo

Insecta Mundi

Two new species of Cerambycidae (Coleoptera) are described from Bolivia: Compsibidion woodleyi Wappes, Santos-Silva and Galileo (Cerambycinae: Neoibidionina): and Drycothaea dozieri Wappes, Santos-Silva and Galileo (Lamiinae: Calliini). Illustrations of the new species are included. Mallodon downesii Hope, 1843 (Prioninae: Macrotomini) is reported for the first time in Costa Rica.

Revision Of The Obesus Species Group Of The Stag Beetle Genus Nigidius Macleay (Coleoptera: Lucanidae: Lucaninae: Figulini), M. J. Paulsen

Insecta Mundi

This paper contains nomenclatural acts concerning the genus Nigidius MacLeay in the stag beetle tribe Figulini Burmeister (Coleoptera: Lucanidae: Lucaninae). A revision of species in the obesus group results in the correction of multiple nomenclatural problems. A lectotype is designated for N. obesus Parry, and the identity of N. helleri Boileau is corrected. A new species, Nigidius gravelyi Paulsen, is described from Borneo. The synonymy of Nigidius larssoni de Lisle is transferred from N. obesus to N. dawnae Gravely.

Descriptions Of Two New Species Of False Click Beetles (Coleoptera: Eucnemidae) From The Bahamas, Robert L. Otto

Insecta Mundi

Specimens of Eucnemidae collected in the Bahamas were re-evaluated following initial identifications completed in 2007. Two new species of false click beetle (Coleoptera: Eucnemidae) are described from several islands in the Bahamas. These new species are: Golbachia rufa sp. nov. and Fornax bahamiensis sp. nov. Diagnostic differences are noted for each species and compared with similar species found in both Cuba and the United States.

New Synonymies Sensu Barr For The Checkered Beetle Subfamily Hydnocerinae (Coleoptera: Cleroidea: Cleridae), William F. Barr

Insecta Mundi

Eleven new synonymies involving the checkered beetle subfamily Hydnocerinae (Coleoptera: Cleridae) are proposed.

Phyllium (Phyllium) Letiranti Sp. Nov. (Phasmida: Phylliidae) A New Leaf Insect From Peleng Island, Indonesia, Royce T. Cumming

Insecta Mundi

A new species of leaf insect, Phyllium (Phyllium) letiranti Cumming and Teemsma, new species (Phasmida: Phylliidae), is described from a series of males, females, and eggs from Peleng Island, Indonesia. This new species is the first record of the family Phylliidae on the island and is here differentiated from congeners. Keys to males, females, and eggs of the Phyllium species of Sulawesi and Peleng islands are included within.

First Records Of Hippodamia Variegata (Goeze) (Coleoptera: Coccinellidae) For Iowa, U.S.A., Louis S. Hesler, M. J. Hatfield

Insecta Mundi

Hippodamia variegata (Goeze) (Coleoptera: Coccinellidae), a Palearctic lady beetle that has become established in North America, is reported for the first time from the state of Iowa, U.S.A. The earliest specimen of H. variegata from Iowa was collected in 2009, with two subsequent specimens in 2012. Collection records of an advancing, non-native species like H. variegata are important for determining comparative rates of geographic spread across various regions and understanding its invasion dynamics.

A Review Of Three Species-Level Taxa Of The Anthocharis Sara Complex (Lepidoptera: Pieridae: Pierinae: Anthocharidini), Todd L. Stout

Insecta Mundi

A combination of five characters supports the arrangement of three species in the Anthocharis sara complex (Lepidoptera: Pieridae: Pierinae: Anthocharidini) consisting of Anthocharis sara Lucas, 1852 (Sara orangetip), Anthocharis thoosa Scudder, 1878 (southwestern orangetip), and Anthocharis julia W.H. Edwards, 1872 (Julia orangetip). These five characters include adult phenotypes, fifth instar larval coloration, pupal cone curvature and color, number of overwintering cycles, and interspecific contact zone behavior. This taxonomic treatment is generated from extensive life history studies from 12 western U.S. states through most of the sara complex distribution.

New Species Of The Scarabaeus Subgenus Scarabaeolus Balthasar, With A Review Of The Subgenus (Scarabaeidae: Scarabaeinae: Scarabaeini), Jiri Zídek, Svatopluk Pokorny

Insecta Mundi

The Scarabaeus subgenus Scarabaeolus Balthasar, 1965 (Scarabaeidae: Scarabaeinae: Scarabaeini) is defined and nine new species are described, six from the Republic of South Africa [S. (S.) fragilis sp. n., S. (S.) krugeri sp. n., S. (S.) lizleri sp. n., S. (S.) orientalis sp. n., S. (S.) rugosipennis sp. n., S. (S.) similis sp. n.] and one each from Angola [S. (S.) cunene sp. n.], Namibia [S. (S.) namibensis sp. n.] and Kenya [ …

Description Of A New Species Of Toumeyella Cockerell (Hemiptera: Coccomorpha: Coccidae) On Crataegus Mexicana Moc. And Sessé Ex Dc. (Rosaceae), Takumasa Kondo, Héctor González

Insecta Mundi

A new species of soft scale from Mexico, Toumeyella crataegi Kondo and González sp. nov., (Hemiptera: Coccomorpha: Coccidae) collected on Crataegus mexicana DC. (Rosaceae), is described and illustrated based on the adult female. An updated taxonomic key to the soft scale insects of the genus Toumeyella Cockerell known from Mexico is provided. The specific epithet of Toumeyella martinezi Kondo and González is here emended to T. martinezae. A checklist with information on geographical distribution, host plants and brief notes of all 18 currently known species of Toumeyella is provided.

Una nueva especie de escama blanda de México, Toumeyella crataegi …

New Records And Diagnostic Notes On Large Carpenter Bees (Hymenoptera: Apidae: Genus Xylocopa Latreille), From The Amazon River Basin Of South America, Jonathan R. Mawdsley

Insecta Mundi

Previously unpublished museum specimen records are presented for 23 species of the genus Xylocopa Latreille (Hymenoptera: Apidae) collected in portions of the countries of Bolivia, Brazil, Peru, and Venezuela within the Amazon River basin of South America. Dichotomous keys and dorsal habitus photographs are provided for the identification of females of the 13 species of Xylocopa subgenus Neoxylocopa Michener, and females of the 10 species of Xylocopa subgenus Schonnherria Lepeletier, that have been recorded to date from the Amazon River basin.

A New Species Of Honduran Strongylaspis (Coleoptera: Cerambycidae: Prioninae), Maria Helena M. Galileo, Antonio Santos-Silva

Insecta Mundi

Strongylaspis antonkozlovi Galileo and Santos-Silva sp. nov. (Coleoptera: Cerambycidae: Prioninae) is described from Cusuco National Park in Honduras, becoming the second species of the genus known in that country. The new species is compared to S. bullata Bates, 1872, the most similar species.

Notes On The Amydetinae (Coleoptera: Lampyridae) In Mcdermott’S 1966 Catalogue Of Lampyridae, Oliver Keller, Marc A. Branham

Insecta Mundi

Nomenclatural changes are proposed and herein implemented for several beetles in the family Lampyridae (Coleoptera). Corrections of authorship are proposed for Psilocladus marginatus (Lewis), Psilocladus ruficollis (Kiesenwetter), and Dryptelytra fulvipennis E. Olivier. Dates of publication are corrected for Magnoculus marginatus (Guérin-Méneville), Psilocladus calvus Kirsch, Psilocladus peruvianus Kirsch, and Vesta vitellinothorax (Perty) a synonym of Vesta thoracica (G. A. Olivier). “Dodacles grandjeani E. Olivier” is found to be a nomen nudum, which actually refers to Dryptelytra grandjeani (E. Olivier).

Canthidium Alvarezi Martínez And Halffter, 1986: A Remarkable Ateuchus Weber, 1801 (Coleoptera: Scarabaeidae: Scarabaeinae), Francois Genier, Mario Cupello

Insecta Mundi

The species Canthidium alvarezi Martínez and Halffter, 1986 (Coleoptera: Scarabaeidae: Scarabaeinae) is transferred to the genus Ateuchus Weber, 1801, becoming Ateuchus alvarezi (Martínez and Halffter), new combination. Its relationship with other species in the genus is briefly discussed. The validity and ranking of the genus Lobidion Génier, 2010, originally described from a single female, is discussed based on the discovery of male specimens, which lead us to reclassify it as a monotypic subgenus of Ateuchus, becoming Ateuchus (Lobidion), new rank, with the only included species becoming Ateuchus (Lobidion) punctatissimus (Génier, 2010) new combination …

Melipona Beecheii Bennett (Hymenoptera: Apidae): Origen, Estudios Y Meliponicultura En Cuba, Julio A. Genaro, Walberto Loriga

Insecta Mundi

Melipona beecheii Bennett is a common bee, native to Mexico and some parts of Central America. There has been much speculation about his presence in Cuba and Jamaica. The origin, the studies carried out, and the development of meliponiculture in Cuba are reviewed. The main diagnostic characteristics between M. beecheii and Apis mellifera Linnaeus, the only two highly social and domesticated species in Cuba, are presented. The historical trend has been the independent capture of colonies of M. beecheii, in the wild, by untrained farmers. These colonies are kept inside the trunks or branches of the trees that the …

The Dung Beetle Fauna Of The Big Bend Region Of Texas (Coleoptera: Scarabaeidae: Scarabaeinae), William D. Edmonds

Insecta Mundi

This paper reports the results of a 2001–2009 field study of the scarabaeine dung beetle fauna (Coleoptera: Scarabaeidae) of the Big Bend region of Texas, a three-county area of the Trans-Pecos portion of the Chihuahuan Desert. The observed fauna comprises 10 native species, Canthon blumei Halffter and Halffter, C. imitator Brown, C. praticola LeConte, and C. mixtus Robinson; Onthophagus browni Howden and Cartwright, O. knausi Brown, O. velutinus Horn and O. brevifrons Horn; Copris arizonensis Schaeffer and Phanaeus texensis Edmonds; as well as two exotic species introduced in the 1970s, Digitonthophagus gazella (Fabricius) and Euoniticellus intermedius (Reiche). The existing native …

Forty New Records Of Aleocharine Beetles, And Two New Species In The Genera Acrotona Thomson And Atheta Thomson, For The Province Of Manitoba, Canada (Coleoptera: Staphylinidae: Aleocharinae), Jan Klimaszewski, Benoit Godin, Anthony Davies, Caroline Bourdon, Denise Horwood

Insecta Mundi

Forty new provincial records, including two new aleocharine species for the province of Manitoba (Coleoptera: Staphylinidae) are provided. The two new species, Acrotona manitobensis Klimaszewski and Godin, new species, and Atheta manitobae Klimaszewski and Godin, new species, are described and illustrated. Habitat information and new locality records are provided for the newly recorded species. The current number of Aleocharinae in Manitoba stands at 120 species, including 40 new records and two new species described here. A checklist of all currently recorded species from the province, with their distribution records in Canada and USA, is included.

New Genus And Species Of Yponomeutidae (Lepidoptera: Yponomeutoidea) Associated With Maytenus Boaria Molina (Celastraceae) From Chile, With Descriptions Of Immature Stages And Natural History Observations, Danilo E. Cepeda

Insecta Mundi

A new genus and species of Yponomeutidae (Lepidoptera: Yponomeutoidea) from Chile, Chileporter huemeri n. gen. and n. sp., is described based on adults, larvae and pupae. This is the second record of a specific herbivore associated with Maytenus boaria Molina.

Se describe un nuevo género y especie de Yponomeutidae (Lepidoptera: Yponomeutoidea) de Chile, Chileporter huemeri n. gen. y n. sp., basado en caracteres morfológicos del adulto, larva y pupa. Este corresponde al segundo registro de un herbívoro específico asociado a Maytenus boaria Molina.

Contribution To The Knowledge Of Chilean Phycitinae (Lepidoptera: Pyralidae): New Species Of Passadena Hulst, 1900, And Ragonotia Grote, 1888, From Northern Chile, Danilo E. Cepeda

Insecta Mundi

Two new species of Phycitinae (Lepidoptera: Pyralidae) from Chile are described: Passadena mistralae Cepeda, n. sp., and Ragonotia campodonicoi Cepeda, n. sp. Adult external morphological characters, as well as male and female genitalia, are described and illustrated for both taxa.

Se describen dos nuevas especies de Phycitinae (Lepidoptera: Pyralidae) de Chile: Passadena mistralae Cepeda, n. sp., y Ragonotia campodonicoi Cepeda, n. sp. Para ambos taxa, se entregan caracteres morfológicos externos del adulto y se describen e ilustran la genitalia masculina y femenina.

New Species Of Elaphidiini From Central America (Coleoptera: Cerambycidae: Cerambycinae), James E. Wappes, Juan Pablo Botero, Antonio Santos-Silva

Insecta Mundi

Four new species of Elaphidiini (Coleoptera: Cerambycidae: Cerambycinae) are described: Psyrassa vandenberghei Wappes, Botero and Santos-Silva, from Nicaragua; Psyrassa androwi Wappes, Botero and Santos-Silva, from Belize, Costa Rica, Nicaragua and Panama; Psyrassa vandevenderi Wappes, Botero and Santos-Silva, from Mexico; and Aneflomorpha monzoni Wappes, Botero and Santos-Silva, from Guatemala.

Erratum To Cano (2018): A New Anomiopus Westwood (Coleoptera: Scarabaeidae: Scarabaeinae) From The Mayan Biosphere Reserve, Petén, Guatemala, Enio B. Cano

Insecta Mundi

After publication of Cano (2018), it was noticed that the wrong holotype photographs of Anomiopus cirulito Cano were included in Figure 3, resulting in images that did not correspond to the captions. The author and the Insecta Mundi editorial staff apologize for this error. The intended version of Figure 3 is reproduced here. Insecta Mundi has also released a revised version of the Cano (2018) manuscript, with this error corrected. However, the revised version is not an official peer-reviewed article, and anyone wishing to reference the findings of Cano (2018) should cite the original manuscript or this erratum.

A New Species Of Philacelota Heller (Scarabaeidae: Melolonthinae: Melolonthini) From Flores Island, Indonesia, Jiri Zidek

Insecta Mundi

Philacelota jakli sp. n. (Scarabaeidae: Melolonthinae: Melolonthini) is described, illustrated and compared with the other two known congeners, P. submaculata Heller and P. sulana Heller. Philacelota sub maculata is here designated the type species for the genus.

New Species And Records Of Elateridae (Coleoptera) From Cuatrociénegas, Coahuila, Mexico, Paul J. Johnson, David C. Lightfoot

Insecta Mundi

Eleven species of Elateridae (Coleoptera) were collected during a two-year arthropod inventory survey at the Cuatrociénegas Natural Protected Area, Coahuila, Mexico. Aeolus cuatro new species, Horistonotus coahuila new species, and Megapenthes cienegas new species are described for the first time. Additionally reported as new state records are Conoderus athoides (LeConte), C. lividus (De Geer), Deilelater mexicanus (Champion), Esthesopus parcus Horn, and Dipropus rufulus (Candèze). Sixteen species of click beetle are now recorded from Coahuila. The sampled habitats and the environmental setting are briefly described with images of each sampling site.

Once especies de Elateridae (Coleoptera) fueron recolectadas durante …

Remarks On The Subgenus Cylinderina Rivalier (Coleoptera: Cicindelidae: Cylindera) From The Philippines With Description Of A New Species 144. Contribution Towards The Knowledge Of The Cicindelidae, Jürgen Wiesner, Charles Dheurle

Insecta Mundi

Cylindera (Cylinderina) sierramadrensis Wiesner and Dheurle, new species (Coleoptera: Cicindelidae) is described from Luzon. Re-descriptions of the other seven species of this subgenus (C. (C.) nanula (Horn, 1937), C. (C.) nana (Schaum, 1862), C. (C.) pseudonana (Horn, 1924), C. (C.) werneri Wiesner, 1988, C. (C.) rothschildi (Horn, 1896), C. (C.) genieri Cassola and Werner, 2003, C. (C.) vandenberghei Dheurle, 2016) are provided together with a key and pictures of their habitus, labrum and aedeagus.

Toward Learning And Justice, Through Love, Isis Artze-Vega

To Improve the Academy: A Journal of Educational Development

This chapter responds to the call for educational developers to isolate the one perspective that guides our work. It retraces the author’s career steps, seeking the origin of love as a guiding principle, and describes its evolution and application during her career. To do so, the piece includes a theoretical perspective on love and argues that its utility as a characterizing perspective for our profession stems from its significance to learning and justice. It suggests the timeliness and urgency of elevating the role of love in our field, notes associated risks and rewards, and suggests resources for doing so.

“Once A Scientist…”: Disciplinary Approaches And Intellectual Dexterity In Educational Development, Katherine Kearns, Molly Hatcher, Mara Bollard, Michele Dipietro, Devon Donohue-Bergeler, Leslie E. Drane, Elizabeth Luoma, Andrew E. Phuong, Laura Thain, Mary C. Wright

To Improve the Academy: A Journal of Educational Development

The authors claim that disciplinary epistemologies—disciplinary habits of mind and ways of thinking—offer productive lenses for observing teaching practices. Furthermore, they argue that educational developers who draw from multiple epistemologies in combination provide rich evidence with regard to teaching and learning and can speak to academic colleagues from an array of disciplines. Clarity is provided for career paths in educational development for colleagues from academic disciplines who are contemplating part- or full-time work in a teaching center. The authors hope that this opening collection develops into a toolkit and area of inquiry about disciplinary approaches to the practice of educational …