Digital Commons Network^™

The Influence Of Protein Context On Polyglutamine Toxicity In Spinocerebellar Ataxia Type 3, Joanna Rae Sutton

Wayne State University Dissertations

The polyglutamine (polyQ) disease family is composed of nine neurodegenerative diseases caused by CAG trinucleotide repeat expansions in the associated genes. Although these diseases are caused by similar mutations, the polyQ proteins are otherwise structurally and functionally unique. Thus, the protein domains surrounding the polyQ tracts, as well as their interacting partners, are thought to be critical to the pathogenesis of these clinically distinct diseases. Spinocerebellar ataxia type 3 is caused by polyQ expansion of ataxin-3, a deubiquitinating enzyme implicated in protein quality control, transcriptional regulation, and DNA repair. Rad23 and VCP are two of ataxin-3’s protein quality control partners …

Validating Functional Mechanisms For Non-Coding Genetic Variants Associated With Complex Traits, Cynthia Ann Kalita

Wayne State University Dissertations

Genome-wide association studies (GWAS) have identified a large number of genetic variants associated with disease as well as normal phenotypic variation for complex traits. However challenges remain in determining the functional relevance of human DNA sequence variants. Even after fine mapping, most variants are located in non-coding regions making it difficult to infer mechanisms linking individual genetic variants with the disease trait. In addition, we do not know under which environmental conditions the sequence variants have a functional impact, and whether they become one of many factors involved in complex phenotypes at the organismal level.

Chapter 1 describes computational methods …

Uab Magazine - Spring 2018, University Of Alabama At Birmingham

UAB Magazine

No abstract provided.

Determinants Of Health Disparities Among African And Caucasian Americans With Chronic Kidney Disease, Renal Cell Carcinoma, And End-Stage Renal Disease, Kathleen Cosgrove

The Graduate Review

Many studies have confirmed the disparity that black patients have an increased prevalence of severely impaired kidney function compared to whites. Without dialysis, or a kidney transplant, chronic kidney disease will progress to a fatal prognosis of end-stage kidney failure. The most common type of kidney cancer, renal cell carcinoma, occurs most often in adult males, age 50-70. Diabetes and hypertension are two of the most determinant factors of end-stage renal disease (ESRD) in the United States, which most often develops following a chronic kidney disease (CKD) diagnosis. The poor are most susceptible to disease due to high risk community …

Breaking Barriers In Teaching And Learning: Using Student-Generated Questions To Promote Learning

National Collegiate Honors Council Monographs: Chapters

Faculty who teach gifted honors students often ask themselves, “How can I ask questions that foster higher-order thinking?” “How can I get more students to respond?” “How can I ensure that students are learning from question-based discussions?” Another key concern: “How can I get students to begin interacting with each other rather than conducting a discussion much like a ping-pong match where the rapid exchanges occur only between a single student and me and then another student and me?” This last question can lead faculty to a different model of questioning, one in which students generate questions that are then …

Indigenous Nations Studies Newsletter, Winter 2018, Portland State University. Indigenous Nations Studies

Indigenous Nations Studies Newsletter

Table of Contents:
-- Post-Traumatic Stress Disorder
-- Continuum Blood Quantum
-- Indian Education Blues
-- Faculty Spotlight: Sara Siestreem
-- Undergraduate Spotlight: Maiya Osife
-- UISHE Naimuma Pow-Wow
-- Cully Park: Native Gathering Garden
-- Other Futures Festival: Exploring New Perspectives Through Science Fiction
-- Native Wellness Brunch
-- Student Projects
-- Heritage High School Pow Wow

Gender And Decision-Making In The C-Suite, Trang Doan

Wayne State University Dissertations

This study empirically tests the implications of five theories on the importance of gender in the C-suite. Specifically, I examine the impact of the Chief Financial Officer (CFO) gender on the stock price response at the appointment of the executive and on post-hiring firm performance. The results from both tests are in support of the notion that female executives are less overconfident, but not less risk-averse, than their male counterparts. Particularly, I find that investors respond relatively less favorably to the appointment of female CFOs compared to that of male CFOs at firms characterized by high uncertainty. Further, the evidence …

A Pre-Registered Multi-Replication Examination Of The Independent And Interdependent Effects Of Big Five Traits And Facets In Predicting Physical Activity Via A Cybernetic Framework, Phuong Vo

Wayne State University Dissertations

Personality traits are important and reliable predictors of health outcomes and health-related behaviors, yet examining only main effects does not allow an examination of possible synergistic effects of traits (and their related lower-order facets) on health behaviors (Hampson & Friedman, 2008). Guided by Cybernetic Big Five Theory (CB5T; DeYoung, 2015), the present study examined three samples of U.S. adults recruited through Amazon Mechanical Turk (total N = 2879) to test main and moderated effects of broad Big Five traits and trait facets on physical activity while accounting relevant background factors such as age, sex, education, income, body mass index, health …

Tumor Mutational Burden Is A Determinant Of Immune-Mediated Survival In Breast Cancer., Alexandra Thomas, Eric D Routh, Ashok Pullikuth, Guangxu Jin, Jing Su, Jeff W Chou, Katherine A Hoadley, Cristin Print, Nick Knowlton, Michael A Black, Sandra Demaria, Ena Wang, Davide Bedognetti, Wendell D Jones, Gaurav A Mehta, Michael L Gatza, Charles M Perou, David B Page, Pierre Triozzi, Lance D Miller

Articles, Abstracts, and Reports

Mounting evidence supports a role for the immune system in breast cancer outcomes. The ability to distinguish highly immunogenic tumors susceptible to anti-tumor immunity from weakly immunogenic or inherently immune-resistant tumors would guide development of therapeutic strategies in breast cancer. Genomic, transcriptomic and clinical data from The Cancer Genome Atlas (TCGA) and Molecular Taxonomy of Breast Cancer International Consortium (METABRIC) breast cancer cohorts were used to examine statistical associations between tumor mutational burden (TMB) and the survival of patients whose tumors were assigned to previously-described prognostic immune subclasses reflecting favorable, weak or poor immune-infiltrate dispositions (FID, WID or PID, respectively). …

Repeat Associated Mechanisms Of Genome Evolution And Function Revealed By The Mus Caroli And Mus Pahari Genomes, David Thybert, Maša Roller, Fábio C.P. Navarro, Ian Fiddes, Ian Streeter, Christine Feig, David Martin-Galvez, Mikhail Kolmogorov, Václav Janoušek, Wasiu Akanni, Bronwen Aken, Sarah Aldridge, Varshith Chakrapani, William Chow, Laura Clarke, Carla Cummins, Anthony Doran, Matthew Dunn, Leo Goodstadt, Kerstin Howe, Matthew Howell, Ambre-Aurore Josselin, Robert C. Karn, Christina M. Laukaitis, Lilue Jingtao, Fergal Martin, Matthieu Muffato, Stefanie Nachtweide, Michael A. Quail, Cristina Sisu, Mario Stanke, Klara Stefflova, Cock Van Oosterhout, Frederic Veyrunes, Ben Ward, Fengtang Yang, Golbahar Yazdanifar, Amonida Zadissa, David J. Adams, Alvis Brazma, Mark Gerstein, Benedict Paten, Son Pham, Thomas M. Keane, Duncan T. Odom, Paul Flicek

Scholarship and Professional Work - LAS

Understanding the mechanisms driving lineage-specific evolution in both primates and rodents has been hindered by the lack of sister clades with a similar phylogenetic structure having high-quality genome assemblies. Here, we have created chromosome-level assemblies of the Mus caroli and Mus pahari genomes. Together with the Mus musculus and Rattus norvegicus genomes, this set of rodent genomes is similar in divergence times to the Hominidae (human-chimpanzee-gorilla-orangutan). By comparing the evolutionary dynamics between the Muridae and Hominidae, we identified punctate events of chromosome reshuffling that shaped the ancestral karyotype of Mus musculus and Mus caroli between 3 and 6 million yr …

Initiating Language In Lida: Learning The Meaning Of Vervet Alarm Calls, N. Khayi, S. Franklin

CCRG Papers

No abstract provided.

“Dignity In Living And In Dying”: The Henry H. H. Remak Memorial Lecture, George P. Smith Ii

Scholarly Articles

Dignity is seen commonly as an ethical obligation owed to human persons. The dimensions of this obligation in today's post secular society are, however, subject to wide discussion and debate; for the term, human dignity, and its preservation, defies universal agreement. Yet, its preservation, together with the prevention of indignity, is a guiding principle or at least a vector of force in a wide range of issues ranging from recognizing and protecting the civil rights of the citizen members of the LGBTQ community throughout the nation to the care of the disabled and to the dying.

In clinical medicine, safeguarding …

On Hygiene In A Modern Peripheral City, Diego Armus

History Faculty Works

This chapter discusses hygiene in the making of modern Buenos Aires focusing on the hygienic imagination, the construction of a hygienic consensus, and the limits of hygiene discourses in daily life. The arrival of modern hygiene in Buenos Aires took place during a time of profound, rapid changes that were evident in almost every aspect of urban life, from social geography to politics to culture. The triumph of hygiene culture as a catalog of detailed indications for people's daily behavior was part and parcel of the medicalization process that gave shape to a new consensus about normalized urban manners. The …

Shoreline Characterization For Northern Indian River Lagoon And Mosquito Lagoon, Melinda J. Donnelly, Linda Walters, Michelle Shaffer

CEELAB Research Data

The purpose of this project was to evaluate the current conditions of estuarine shorelines in Mosquito Lagoon and northern Indian River. The shoreline assessment is the first phase in the development of a shoreline restoration suitability model for the northernmost section of the Indian River Lagoon system, in order to better conserve and restore shorelines and promote sustainable use of natural resources. The shoreline survey methodology was developed by St. Johns River Water Management for northeastern Florida and was adapted for applications in Brevard and Volusia Counties. Between November 2017 through June 2018, shoreline evaluations were completed at transects located …

Oyster Storytelling Yoga, Linda Walters, Violette Gibbs, Roel Fleuren

CEELAB Outreach Materials

No abstract provided.

Touch Dna And Chemical Analysis Of Skin Trace Evidence: Protecting Privacy While Advancing Investigations, Mary Graw Leary

Scholarly Articles

Forensic science transforms criminal investigations by resolving previously unsolvable cases and bringing an increased sense of justice to communities. This application of scientific disciplines to legal questions aids investigators in solving crimes. While many sciences can be utilized—such as physics (pattern evidence), chemistry (toxicology), or biology (cause of death), to name a few—two aspects of scientific advancement have played an outsized role in responding to crime. Trace evidence analysis—specifically, deoxyribonucleic acid (DNA) analysis—is an essential component to an effective and accurate criminal justice system. DNA evidence has emerged as a powerful tool to identify perpetrators of unspeakable crimes and to …

Group Defamation, Power, And A New Test For Determining Plaintiff Eligibility, Jeffrey Greenwood

Fordham Intellectual Property, Media and Entertainment Law Journal

In the fall of 2014, Rolling Stone Magazine published an article describing the rape of a woman at a University of Virginia fraternity house. The story turned out to be false, and members of the fraternity sued for defamation. The suit raises an interesting question: under what circumstances may anonymous individual members of the fraternity recover? This Note describes the case, related common and constitutional law, as well as differences in group defamation doctrine across jurisdictions. After detailing problems with the existing paradigm, the Note proposes a new method for performing the analysis.

What's Intent Got To Do With It? Interpreting "Peaceful Purpose" In Article Iv.1 Of The Npt, David S. Jonas, Ariel E. Braunstein

Emory International Law Review

The Treaty on the Non-Proliferation of Nuclear Weapons features many ambiguous provisions. Arguably its most controversial provision'Part 1 of Article IV'address states' rights to nuclear energy for 'peaceful purposes.' Non-Nuclear Weapon States argue that they have an inalienable right to develop nuclear technology for peaceful purposes, while Nuclear Weapon States emphasize that the rights of Non-Nuclear Weapon States to nuclear technology does not entitle them to all materials and technologies. The subsequent 'nuclear apartheid''with Non-Nuclear Weapon States claiming that Nuclear Weapon States are denying access to certain nuclear materials and technologies to maintain the current state of nuclear hierarchy'has intensified …

Assessing Assisted Reproductive Technology, Raymond C. O'Brien

Scholarly Articles

Technological innovation possesses both opportunity and challenge. Because assisted reproductive technology (ART) involves sexual intimacy, parenthood, personhood, gender identity, privacy, legacy, and a plethora of religious, historical, sociological, and ethical underpinnings, the challenges presented in such technological innovation are substantial. Nonetheless, the opportunities are significant and progressive. Because of in vitro fertilization, gestational and genetic surrogacy, posthumous conception, and mitochondrial replacement therapy, humans now have the opportunity to overcome infertility, gender obstacles to parentage, dynastic limitations, and diseases that have long plagued mothers and infants. However, challenges include the exploitation of surrogates, unequal access to ART services, possibilities of cloning …

An Epidemiological Study Of Pediatric Sports And Recreational Injuries Reporting To The Emergency Room In Grand Forks, Nd, Carly Bertsch, Lucas Dolan

Physical Therapy Scholarly Projects

PROBLEM: The purpose of this research study is to evaluate the emergency room records from Altru Health System in Grand Forks, ND from 2011-2015 to find trends in pediatric injuries from the ages of 0-19. The justification for the study is to provide Grand Forks with information about the frequency and distribution of pediatric sports and recreational injuries. No injury surveillance system has been implemented to monitor youth injuries, but his study is a continuation of a previous 10-year study and the combining of the two time frames would result in a 15-year compilation of data. By using descriptive data …

Characterizing The Information Needs Of Rural Healthcare Practitioners With Language Agnostic Automated Text Analysis, Melissa Resnick

Dissertations and Theses (Open Access)

Objectives – Previous research has characterized urban healthcare providers' information needs, using various qualitative methods. However, little is known about the needs of rural primary care practitioners in Brazil. Communication exchanged during tele-consultations presents a unique data source for the study of these information needs. In this study, I characterize rural healthcare providers' information needs expressed electronically, using automated methods.

Methods – I applied automated methods to categorize messages obtained from the telehealth system from two regions in Brazil. A subset of these messages, annotated with top-level categories in the DeCS terminology (the regional equivalent of MeSH), was used to …

Human Anatomy Lab Manual, Malgosia Wilk-Blaszczak

Mavs Open Press Open Educational Resources - Archive

This is a lab manual for a college-level human anatomy course. Mastery of anatomy requires a fair amount of memorization and recall skills. The activities in this manual encourage students to engage with new vocabulary in many ways, including grouping key terms, matching terms to structures, recalling definitions, and written exercises. Most of the activities in this manual utilize anatomical models, and several dissections of animal tissues and histological examinations are also included. Each unit includes both pre- and post-lab questions and six lab exercises designed for a classroom where students move from station to station. The vocabulary terms used …

Identification Of Mental States And Interpersonal Functioning In Borderline Personality Disorder, Kathy R. Berenson, Cara L. Dochat, Christiana G. Martin, Xiao Yang, Eshkol Rafaeli, Geraldine Downey

Psychology Faculty Publications

Atypical identification of mental states in the self and others has been proposed to underlie interpersonal difficulties in borderline personality disorder (BPD), yet no previous empirical research has directly examined associations between these constructs. We examine 3 mental state identification measures and their associations with experience-sampling measures of interpersonal functioning in participants with BPD relative to a healthy comparison (HC) group. We also included a clinical comparison group diagnosed with avoidant personality disorder (APD) to test the specificity of this constellation of difficulties to BPD. When categorizing blended emotional expressions, the BPD group identified anger at a lower threshold than …

Ancestral Dependence On Breast Stemness And Nucleotide Excision Repair In Breast Cancer Stem Cells In Novel Human Model Systems, Omar Ibrahim

Student Theses, Dissertations and Capstones

Precocious puberty, measured by thelarche or menarche, is a well-established breast cancer risk factor. Using a unique and patented tissue engineering system we established cell lines from 48 primary cultures of normal breast tissue from reduction mammoplasties and used them as an in vitro model of thelarche, quantifying episphere formation and ductal differentiation. Differential ductal formation was observed based on ancestry. In light of African American (AA) precocious thelarche both in vivo and as we observed in vitro, we hypothesized that AA women would exhibit an increased proportion of breast stem cells, with greater potency for differentiation. Five AA cell …

Analysis Of Molecular Changes In 2 Types Of Non-Tumor Adjacent Breast Identified By Nucleotide Excision Repair In Early Stage Breast Cancer, Manasi Ramesh Pimpley

Student Theses, Dissertations and Capstones

NER plays an important role in remediating DNA damage. Latimer et al., have previously shown nucleotideexcision repair (NER) to be intrinsically deficient in stage I sporadic BC by function and gene expression. Previous work performed on 12 isogenically matched stage I tumors and non-tumor adjacent (NTA) samples identified 2 types of NTA tissue with regard to functional NER. One type that represented 75% ofthe samples, had lower NER capacity, similar to the tumor (Low: Low pair). The other type had high NER relative to the tumor (High: Low pair). Two isogenic NTA/tumor cell line pairs representing these 2 types ofNTA …

The Endangered Species Act As Applied To Captive Animals: Sea Shepherd Legal's Amicus Brief In Peta V. Miami Seaquarium, Sea Shepherd Legal

Animal Law Review

This Article contains Sea Shepherd Legal’s (SSL) amicus brief in the matter of People for the Ethical Treatment of Animals v. Miami Seaquarium, an ongoing litigation concerning the captive orca known as “Lolita.” SSL filed this brief for two reasons. First, the conditions under which Lolita is held are at once particularly illegal and immoral. Lolita’s conditions of captivity violate both the Endangered Species Act (ESA) and the Animal Welfare Act (AWA), all while imposing continuous harm on a highly intelligent being in the name of entertainment. Second, the decision in this case frustrates the logic of the underlying laws. …

2017 International Review, Ashlyn Whitbeck

Animal Law Review

No abstract provided.

Montanan, Winter 2018, University Of Montana--Missoula

Montanan Magazine, 1969-2024

This is the magazine of the University of Montana with news about the University for UM alumni as well as current faculty, students, staff, and administrators. This is volume 35, number 1.

2018-Meet Dr. David Roane, Bill Gatton College Of Pharmacy, East Tennessee State University, University Marketing And Communication, East Tennessee State University

ETSU News

Dr. David Roane, from Ruston, Louisiana, joined Gatton College of Pharmacy in 2006 as the founding chair of the department of Pharmaceutical Sciences. His initial goals focused on hiring superior faculty and guiding the de novo development of the department. Previously, Dr. Roane served on faculty in the College of Pharmacy and chaired the Department of Biology as the DeGree endowed professor from 1989 to 2006 at the University of Louisiana at Monroe. Since arriving at ETSU, Dr. Roane has spent most of his time on administration, program development, and teaching. He relishes the opportunity to promote the empowerment of …

2018-Meet Dr. David Stewart, Bill Gatton College Of Pharmacy, East Tennessee State University, University Marketing And Communication, East Tennessee State University

ETSU News

Dr. David Stewart, from Roan Mountain, Tennessee, joined the faculty of the department of pharmacy practice in 2007. Prior to his appointment of Assistant Professor at ETSU he served as an Assistant Clinical Professor at the Auburn University Harrison School of Pharmacy. Dr. Stewart was promoted to Associate Professor of Pharmacy Practice in 2012 and Professor in 2018. He also serves as Vice Chair for the Department of Pharmacy Practice, Residency Program Director for the college’s PGY2 Internal Medicine Pharmacy Residency Program, and Post-graduate Training Coordinator for the Department of Pharmacy Practice. Over his tenure at the BGCOP he …