Digital Commons Network^™

Gut Microbiota And Cardiovascular Uremic Toxicities, Manuel T. Velasquez, Patricia Centron, Ian Barrows, Rama Dwivedi, Dominic S. Raj

Medicine Faculty Publications

Cardiovascular disease (CVD) remains a major cause of high morbidity and mortality in patients with chronic kidney disease (CKD). Numerous CVD risk factors in CKD patients have been described, but these do not fully explain the high pervasiveness of CVD or increased mortality rates in CKD patients. In CKD the loss of urinary excretory function results in the retention of various substances referred to as “uremic retention solutes”. Many of these molecules have been found to exert toxicity on virtually all organ systems of the human body, leading to the clinical syndrome of uremia. In recent years, an increasing body …

Profile Of Dupilumab And Its Potential In The Treatment Of Inadequately Controlled Moderate-To-Severe Atopic Dermatitis., Olabola Awosika, Lori Kim, Momina Mazhar, Monica Rengifo-Pardo, Alison Ehrlich

Dermatology Faculty Publications

Atopic dermatitis (AD) is a common inflammatory skin disorder that manifests as eczematous lesions, often associated with allergic rhinitis and asthma. Historically, moderate-to-severe disease has been managed with systemic immunosuppression, such as oral corticosteroids, which result in relapse and limiting side effects. Due to recent advancements in the identification of interleukin (IL)-4 and IL-13 as key mediators in AD, new biological agents have been developed for treatment. Dupilumab is a recently approved monoclonal antibody that targets the alpha subunit of the IL-4 receptor and, thus, downregulates activity of IL-4 and IL-13. This review discusses the profile of dupilumab and its …

Association Of Two Foxp3 Polymorphisms With Breast Cancer In Chinese Han Women, Wenge Zhu, +Several Additional Authors

Biochemistry and Molecular Medicine Faculty Publications

Background

Forkhead box P3 (FOXP3) is a key gene in the immune system which also plays a role in tumor development. This study aims to explore the association of two FOXP3 polymorphisms (rs3761548 and rs3761549) with susceptibility to breast cancer (BC).

Method

A case–control study was conducted, involving 560 patients and 583 healthy individuals from the Chinese Han population. The genotypes of FOXP3 polymorphisms were detected using the Sequenom MassARRAY method. The association between FOXP3 polymorphisms and BC risk was evaluated using a χ2 test with an odds ratio (OR) and 95% confidence intervals (95% CIs) under six …

The Neurodevelopmental Perspective Of Surgical Necrotizing Enterocolitis: The Role Of The Gut-Brain Axis., Chariton Moschopoulos, Panagiotis Kratimenos, Ioannis Koutroulis, Bhairav V Shah, Anja Mowes, Vineet Bhandari

Pediatrics Faculty Publications

This state-of-the-art review article aims to highlight the most recent evidence about the therapeutic options of surgical necrotizing enterocolitis, focusing on the molecular basis of the gut-brain axis in relevance to the neurodevelopmental outcomes of primary peritoneal drainage and primary laparotomy. Current evidence favors primary laparotomy over primary peritoneal drainage as regards neurodevelopment in the surgical treatment of necrotizing enterocolitis. The added exposure to inhalational anesthesia in infants undergoing primary laparotomy is an additional confounding variable but requires further study. The concept of the gut-brain axis suggests that bowel injury initiates systemic inflammation potentially affecting the developing central nervous system. …

The Pathology Workforce And Clinical Licensure, Robin Lorenz, Donald S. Karcher, Michael Gautreaux, Melvin Limson, Dani Zander

Pathology Faculty Publications

There has been a recent recognition of the need to prepare PhD-trained scientists for increasingly diverse careers in academia, industry, and health care. The PhD Data Task Force was formed to better understand the current state of PhD scientists in the clinical laboratory workforce and collect up-to-date information on the training and certification of these laboratorians. In this report, we summarize the findings of the PhD Data Task Force and discuss the relevance of the data collected to the future supply of and demand for PhD clinical laboratory scientists. It is clear that there are multiple career opportunities for PhD …

How Household Healthcare Expenditures Redistribute Disposable Income? An Analysis Using Bangladesh Household Income And Expenditure Survey, 2010., Azahar Molla Md, Phd, Mph, Msc, Chunhuei Chi Mph, Sc.D.

Faculty & Staff Research and Creative Activity

Essential healthcare is a civil right. Payments toward healthcare is a moral compulsion, and no less strong than legal compulsion like income tax. Healthcare payments can redistribute disposable income. Redistribution may be vertical (from rich to poor or opposite) and horizontal (from men to women or from households without children to households with children). Health planners are interested in degrees to which redistribution occurs. In this paper, we aim to analyze how well different forms of healthcare payments in Bangladesh redistribute disposable income. Our data comes from Bangladesh Household Income and Expenditure Survey, 2010. Using the methods developed by Aronson …

Clinical Oral Health Recommended Care And Oral Health Self-Report, Nhanes, 2013-2014, R Constance Wiener, Nilanjana Dwibedi, Chan Shen, Patricia A. Findley, Usha Sambamoorthi

Faculty & Staff Scholarship

Purpose. The purpose of this study was to determine the concordance of self-reported responses to oral health questions versus clinically evaluated recommended need for oral healthcare by calibrated dentists to determine usefulness of the questions for epidemiological studies. We additionally examined other factors associated with concordant self-reports versus clinical evaluations. Materials and Methods. We used a cross-sectional study design with 4,205 participants, ages 30 years and above, who had complete oral health self-perception data and dental referral data in the NHANES 2013-14. Calibrated dentists completed clinical oral healthcare assessments. The assessments were dichotomized to (1) recommendation for immediate care and …

Personal Oral Infection Control, Low Birthweight, And Preterm Births In Appalachia West Virginia: A Cross-Sectional Study, R Constance Wiener, Christopher Waters

Faculty & Staff Scholarship

Appalachia West Virginia has a higher prevalence of preterm and low birthweight babies than the US national prevalence. Many factors have been studied which are known to influence preterm births and low birthweight babies. There are limited interventions that are available to decrease the likelihood of preterm and low birthweight babies; however oral health and personal oral infection control may be helpful. The purpose of this study was to evaluate the association of limited personal oral infection control among pregnant West Virginia Appalachian women and poor birth outcomes (preterm and low birthweight babies). Methods. A secondary data analysis of data …

Project Anacostia, Lapoldeon Williams, Abenezer Lemma, Janae Thomas, Kafoued Ouedraogo

DC Health and Academic Prep Program (DC HAPP)

Objectives Project Anacostia aims to [1] help meet the Healthy People 2020 goal of reducing the disease burden of diabetes mellitus (DM) and improving the quality of life for all persons who have, or are at risk for, DM as outlined by the U.S. Department of Health and Human Services. [2] To increase community awareness of the social determinants of health related to obesity and diabetes. [3] Increase access to recreational facilities and healthy food options in Wards 7 &8 and [4] promote healthy lifestyle choices among youth in the Anacostia community.

Methods Our intervention is comprised of three progressive …

Review Of A Medical Pre-Clinical Curriculum For Competencies In Caring For Patients Who Are Lgbt, Gender Nonconforming, Or Born With Dsd, Nina Abon, Mandi L. Pratt-Chapman

GW Research Days 2016 - 2020

This review aimed to assess whether the George Washington University medical, pre-clinical curriculum met any of the Association of American Medical College’s (AAMC) 30 professional competencies to improve health care for people who are lesbian, gay, bisexual, transgender (LGBT), gender nonconforming, or born with disorders of sex development (DSD).

Methods:

Relevant sessions were reviewed based on instructors’ PowerPoint slides, audio recording of sessions (when available), assigned pre-session material, and notes taken by a student. Content and objectives from each session were mapped to corresponding AAMC competencies, and each competency was qualitatively graded as completely met, partially met, or unmet.

Results: …

Himmelfarb Library Annual Report 2018, George Washington University, Himmelfarb Health Sciences Library

Himmelfarb Library Annual Report

No abstract provided.

Overview Of Big-Data-Intensive Storage And Its Technologies, Richard S. Segall, Jeffrey S. Cook

Faculty Publications

This chapter deals with a detailed discussion on the storage systems for data-intensive computing using Big Data. The chapter begins with a brief introduction about data-intensive computing and types of parallel processing approaches. It also highlights the points that display how data-intensive computing systems differ from other forms of computing. A discussion on the importance of Big Data computing is put forth. The current and future challenges of storage in genomics are discussed in detail. Also, storage and data management strategies are given. The chapter's focus is then on the software challenges for storage. Storage use cases are provided like …

A Preliminary Study Of The Influence Of Breeding Area Density On Sandhill Crane Habitat Selection In South-Central Wisconsin, Sara A. Prussing, Hillary L. Thompson

Proceedings of the North American Crane Workshop

We hypothesized that territorial sandhill cranes (Grus canadensis) in densely populated breeding areas occupy smaller home ranges that are richer in optimal habitat than those in less densely populated breeding areas. We analyzed satellite telemetry data collected from 2012 to 2016 for 3 and 2 sandhill cranes from dense and less dense breeding areas, respectively. Tracked sandhill cranes in a dense breeding area tended to have smaller home ranges (0.37-14.25 km²) with higher concentrations of wetlands (27%) and row crops (40%) than tracked sandhill cranes in the less dense breeding area (8.80-48.81 km², 14% …

Impacts: Annual Report Fy2018 (July 1, 2017 To June 30, 2018), Robert B. Daugherty Water For Food Global Institute

Daugherty Water for Food Global Institute: Administrative Materials

One in nine people goes to bed hungry each night, according to the U.N. World Food Program. That’s 795 million people on the planet who do not have access to enough nutritious food. The challenge is growing. Global drivers like climate change, urbanization and increasing demand for water-intensive agricultural products are altering landscapes, increasing soil erosion, and degrading water resources and soils in important food producing regions around the world. We must figure out how to feed a global population projected to reach 10 billion by 2050, with the same amount of water and arable land – and quickly. This …

2017-2018 Lynn University Common Data Set, Lynn University

Lynn University Common Data Set

2017-2018 Lynn University Common Data Set (CDS), prepared by Lynn University Office of Institutional Research, Planning and Assessment (AY2018)

Clowning Around With Final Agency Action, Beau J. Baumann, Greg Mina

Cornell Journal of Law and Public Policy

While Chevron and Auer deference dominate the administrative law literature, another doctrine—the final agency action requirement—has been perverted by the lower federal courts. Several circuits have developed an undergrowth of formalistic rules that tighten the Supreme Court’s standard, as it was laid out in Bennett v. Spear. This development ignores the Court’s decades-old refrain that the final agency action requirement should be flexible. Unfortunately, this development comes at the worst possible time. The interconnectedness of federal and state agencies has led to a sort of division of labor. Data collection, designations, and enforcement are increasingly divided across different agencies. Because …

Custody, Visitation, And Parental Rights Under Scrutiny, Mark Strasser

Cornell Journal of Law and Public Policy

The Supreme Court recognized long ago that the United States Constitution protects parental rights, even though those rights are not expressly mentioned anywhere in that document. However, in many of the relevant cases, the Court recognizes the importance of parental rights on the one hand and undercuts the breadth or robustness of those very rights on the other. The Court’s parental rights jurisprudence has consistently sent mixed messages, which has exacerbated the degree to which states differ with respect to how readily those rights may be overridden.

Part I of this Article discusses the Court’s parental rights jurisprudence, noting how …

Parental Broad Autism Phenotype And The Language Skills Of Children With Autism Spectrum Disorder, Michelle Flippin, Linda R. Watson

Communicative Disorders Faculty Publications

Father–child and mother–child interactions were examined in order to investigate concurrent associations between three characteristics of parental broad autism phenotype (i.e., aloofness, rigidity, pragmatic language deficits), parental verbal responsiveness, and language skills of children with ASD. Results for mothers indicated that aloofness and rigidity were negatively associated with both child-initiated engagement and child language skills. Maternal aloofness was also negatively correlated with verbal responsiveness to their children, but rigidity was not. Results suggest that the association between aloofness and child language are potentially mediated by maternal use of responsive verbal behaviors. Maternal pragmatic language deficits were not concurrently related to …

2022 Using Father-Mediated Intervention To Increase Responsive Parental Behaviors And Child Communication In Children With Autism Spectrum Disorder: A Pilot Study, Michelle Flippin

Communicative Disorders Faculty Publications

OBJECTIVES/SPECIFIC AIMS: Although parent involvement is recognized as an integral autism intervention component, and two-thirds of children are currently raised in 2-parent families, the majority of ASD parent research to date has focused on mother-implemented interventions, and fathers have been largely overlooked. However, fathers use interaction styles and language models that are different from mothers and may benefit children with ASD in unique ways. Thus there is a critical need in the field to expand our understanding of the potential contributions of various caregivers to communication outcomes. This investigation aimed to address this void in the research literature and contribute …

Reflections On Fake News, Librarians And Undergraduate Research, Lisa Madeleine Rose-Wiles

Library Publications

The recent explosion of “fake news” highlights the need for academic libraries to provide access to reliable information resources and for librarians to instruct students in using them effectively. Providing reliable resources with minimal barriers to access involves cooperation between librarians, publishers and vendors. However, I suggest that there is tension between our mutual desire to satisfy student demands for instant and perfect results and encouraging them to become persistent and critical information seekers. Many tools exist to assist students in gaining background information and limiting search results, but ultimately none replace the need to develop and explore questions and …

What Do Chemists Cite? A Five-Year Analysis Of References Cited In American Chemical Society Journal Articles, Lisa Madeleine Rose-Wiles, Cecilia Marzabadi

Library Publications

This study analyzes references cited by articles published in ten American Chemical Society journals between 2011 and 2015. The median age of references was 6 years. On average, 44% of the references were five years old or younger, and only 11% were more than 20 years old. There appears to be a modest increase in references to older sources, possibly due to the increased availability of older articles online. References tended to be concentrated on a small core of journals. Overall, 20% of the journals cited accounted for 80% of the references. However, there was considerable variation among subdisciplines.

Drug Delivery Strategies For The Treatment Of Advanced Lung Cancer And Various Lung Metastases, Elizabeth Bielski

Wayne State University Dissertations

Lung cancer remains the leading cause of cancer-related deaths in the United States. Secondary lung tumors metastasized from other cancer sites also remains highly prevalent, in which most metastatic tumors cannot be cured with existing therapies. Chemoresistance (multi drug resistance – MDR) that develops intrinsically or acquired is one of the key factors leading to fatality in these patients. MDR develops form a variety of resistance mechanisms that can occur consecutively or concurrently, therefore, making most current treatments unsuccessful. Current therapies have known to slow tumor growth, but rarely provide a cure. Immunotherapy has seen some promise, including the use …

Coin Doctrine For The 21st Century Gwot: Improvements For Battling Al Qaeda In The Western Sahel, Caleb Archuleta

Honors Program Theses

This paper takes an interdisciplinary approach in examining the United States role in the conflict in Mali and Niger. As a strategic locale in a region that is plagued with conflict, the U.S. is faced with increasing involvement across Africa, specifically the Western Sahel. With an Al Qaeda that continues to shift, change, and grow, the U.S. is faced with a War on Terror that is increasingly difficult to contain or succeed in. In an effort to shift the narrative to one from counterterrorism to one of counterinsurgency, this paper takes an in depth look at the political, geographical, sociocultural, …

Let’S Escape Into The Music: A Cross-Generational Oral History Of Orlando Lgbtq+ Spaces, Hannah Powell

Honors Program Theses

Since Orlando’s first gay bar, The Palace Club, opened in 1969, LGBTQ+ spaces have played an essential role in the Orlando queer community. They have acted as loci of gathering, solidarity, identity-formation, recreation, and even healing. There is an absence of literature on the LGBTQ+ community in Orlando and, more generally, in Central Florida as a whole. The legacy of LGBTQ+ spaces in Orlando is worthy of study due both to the city’s rich queer history and Orlando’s singular experience of the deadliest act of hate-motivated violence against the LGBTQ+ community in the history of the United States. Through documenting …

Uni Today, V101n3, Winter 2018, University Of Northern Iowa Alumni Association

UNI Today

Inside This Issue:
-- North to Alaska ••• 2
-- Saving UNI Art ••• 6
-- Defying the Odds ••• 10
-- Emerging Programs ••• 14
-- UNI ALUMNI: Brent Dahlstrom ••• 16
-- Clinically Speaking ••• 18
-- Campus ••• 21
-- Panther Polaroids ••• 22
-- Heritage Honours Awards & Distinguished Awards ••• 24
-- Class Notes ••• 26
-- Alumni Travel Program ••• 31
-- Webinars ••• 32
-- Alumni Clubs and Calendar of Events ••• 33

Ath 2500 I Introduction To Cultural Anthropology For Health Care Professionals Core General Education Assessment, 2017-2018, College Of Liberal Arts, Wright State University

Core General Education Assessments - All

This report assesses Wright State University's course ATH 2500, I Introduction to Cultural Anthropology for Health Care Professionals, as part of the institution’s ongoing general education Core assessment plan.

Ath 2500 Iii Introduction To Cultural Anthropology For Health Care Professionals Core General Education Assessment, 2017-2018, College Of Liberal Arts, Wright State University

Core General Education Assessments - All

This report assesses Wright State University's course ATH 2500, III Introduction to Cultural Anthropology for Health Care Professionals, as part of the institution’s ongoing general education Core assessment plan.

Language Politics And The Constitution Of Racialized Subjects In The Corinthian Church, Ekaputra Tupamahu

Faculty Publications - Portland Seminary

This study examines the phenomenon of speaking in tongue(s) in the Corinthian church from the point of view of the politics of language. Instead of seeing tongue(s) as a problem of unintelligible-ecstatic speech, it reconsiders this phenomenon as a linguistic struggle. Tongue(s), in this sense, is a multilingual social dynamic that Paul perceives as chaotic. Special attention is given to the role of language as one of the crucial markers of the ancient Greeks’ collective identity. The barbarians are their imaginative and discursive ‘others’ who do not share their language. It is within this sociopolitical context that the employment of …

Biology In Your World Agriculture In Africa America, Jan 27, Ohio University College Of Arts & Sciences

All Forum Articles

No abstract provided.

Pbio Colloquium | Advances In The Systematics Of Charophytes Synthesizing Biological Data In The Genomic Era, Jan 26, Ohio University College Of Arts & Sciences

All Forum Articles

No abstract provided.