Digital Commons Network^™

Ole Miss Hall Of Famer Credited With 'Altering The Face Of Medicine', Tina Hahn

University of Mississippi News

Renowned immunologist Dr. Max Cooper wins Japan Prize

Discerning Novel Splice Junctions Derived From Rna-Seq Alignment: A Deep Learning Approach, Yi Zhang, Xinan Liu, James N. Macleod, Jinze Liu

Computer Science Faculty Publications

Background: Exon splicing is a regulated cellular process in the transcription of protein-coding genes. Technological advancements and cost reductions in RNA sequencing have made quantitative and qualitative assessments of the transcriptome both possible and widely available. RNA-seq provides unprecedented resolution to identify gene structures and resolve the diversity of splicing variants. However, currently available ab initio aligners are vulnerable to spurious alignments due to random sequence matches and sample-reference genome discordance. As a consequence, a significant set of false positive exon junction predictions would be introduced, which will further confuse downstream analyses of splice variant discovery and abundance estimation.

Results: …

Pengaruh Pemberian Susu Tinggi Protein Terhadap Tingkat Nafsu Makan Dan Kadar Glukosa Postprandial, Harna Harna, Clara M.Kusharto, Katrin Roosita, Andi Muh Asrul Irawan

Media Kesehatan Masyarakat Indonesia

High protein milk is a complex food that contains several potential bioactive compounds that might effect
on appetite control. However, the mechanism of high protein milk effect on appetite is still poorly understood in
underweight adults. This study aimed to analyze the effect of high protein milk on appetite level and postprandial
glucose. This study used experimental trial with design randomized controlled trial. The subjects were divided into
two groups, 24 subjects in the treatment group and 23 subjects in the control group. Treatment group was given
high protein milk and control group was given glucose. Subjective feelings including hunger, …

Diel Variability Of Pco 2 And Co 2 Outgassing From The Lower Mississippi River: Implications For Riverine Co 2 Outgassing Estimation, Jeremy H. Reiman, Y. Jun Xu

Faculty Publications

Carbon dioxide (CO 2 ) outgassing from river surface waters is an important component of the global carbon cycle currently not well constrained. To test the hypothesis that riverine partial pressure of CO 2 (pCO 2 ) and CO 2 outgassing rates differ between daylight and darkness, we conducted in-situ pCO 2 and ambient water measurements over four 24-h periods in the spring and summer of 2018 in the Lower Mississippi River under varying flow regimes. We hypothesized that diel pCO 2 variation will correlate inversely with solar radiation due to light-induced photosynthesis. Despite differing ambient conditions between seasons, we …

Using Physical Contact Heterogeneity And Frequency To Characterize Dynamics Of Human Exposure To Nonhuman Primate Bodily Fluids In Central Africa, Victor Narat, Mamdou Kampo, Thibut Heyer, Stephanie Rupp, Philippe Ambata, Richard Njouom, Tamara Giles-Vernick

Publications and Research

Emerging infectious diseases of zoonotic origin constitute a recurrent threat to global health. Nonhuman primates (NHPs) occupy an important place in zoonotic spillovers (pathogenic transmissions from animals to humans), serving as reservoirs or amplifiers of multiple neglected tropical diseases, including viral hemorrhagic fevers and arboviruses, parasites and bacteria, as well as retroviruses (simian foamy virus, PTLV) that are pathogenic in human beings. Hunting and butchering studies in Africa characterize at-risk human social groups, but overlook critical factors of contact heterogeneity and frequency, NHP species differences, and meat processing practices. In southeastern Cameroon, a region with a history of zoonotic emergence …

The Weekly Challenger, December 27, 2018, The Weekly Challenger, Et Al

Weekly Challenger Newspaper Collection

The December 27, 2018, issue of The Weekly Challenger.

In Situ Gel Of Triamcinolone Acetonide-Loaded Solid Lipid Nanoparticles For Improved Topical Ocular Delivery: Tear Kinetics And Ocular Disposition Studies, Akshaya Tatke, Narendar Dudhipala, Karthik Yadav Janga, Sai Prachetan Balguri, Bharathi Avula, Monica M. Jablonski, Soumyajit Majumdar

Faculty and Student Publications (Open Access)

Triamcinolone acetonide (TA), an intermediate acting corticosteroid, is used in the treatment of posterior ocular diseases, such as inflammation, posterior uveitis, and diabetic macular edema. The objective of this investigation was to prepare TA-loaded solid lipid nanoparticles (TA-SLNs) and in situ gel (TA-SLN-IG) formulations for delivery into the deeper ocular tissues through the topical route. TA-SLNs were prepared by hot homogenization and ultrasonication method using glyceryl monostearate and Compritol® 888ATO as solid lipids and Tween®80 and Pluronic® F-68 as surfactants. TA-SLNs were optimized and converted to TA-SLN-IG by the inclusion of gellan gum and evaluated for their rheological properties. In …

Small Rna Mgrr Regulates Sensitivity Of Escherichia Fergusonii To Oxidative Stress, Austin Paul Wright

Dissertations and Theses

Non-coding small RNAs (sRNAs) are integral to post-transcriptional gene regulation in bacteria. The function of an sRNA is dependent on both secondary structure and the sequence of its unstructured seed region. The sRNA seed region typically base-pairs with target mRNAs to down-regulate the expression of target genes by blocking the ribosome-binding site or by promoting RNase-mediated degradation of the sRNA-mRNA complex. sRNAs have also been shown to increase expression of target genes by releasing RNA secondary structures that block ribosome-binding sites. Selective pressure to maintain sRNA function conserves the sequence of the sRNA seed region, but mutations in mRNA sequences …

The Addition Of Simvastatin Administration To Cold Storage Solution Of Explanted Whole Liver Grafts For Facing Ischemia/Reperfusion Injury In An Area With A Low Rate Of Deceased Donation: A Monocentric Randomized Controlled Double-Blinded Phase 2 Study., Duilio Pagano, Elisabetta Oliva, Simone Khouzam, Fabio Tuzzolino, Davide Cintorino, Sergio Li Petri, Fabrizio Di Francesco, Calogero Ricotta, Pasquale Bonsignore, Alessandro Tropea, Sergio Calamia, Federico Costanzo, Angelo Luca, Salvatore Gruttadauria

Student Papers, Posters & Projects

BACKGROUND: Liver transplantation is the best treatment for end-stage liver disease. The interruption of the blood supply to the donor liver during cold storage damages the liver, affecting how well the liver will function after transplant. The drug Simvastatin may help to protect donor livers against this damage and improve outcomes for transplant recipients. The aim of this study is to evaluate the benefits of treating the donor liver with Simvastatin compared with the standard transplant procedure.

PATIENT AND METHODS: We propose a prospective, double-blinded, randomized phase 2 study of 2 parallel groups of eligible adult patients. We will compare …

Capsule Integrated Polypeptide Multilayer Films For Effective Ph-Responsive Multiple Drug Co-Delivery, Shichao Zhang, Malcolm Xing, Bingyun Li

Clinical and Translational Science Institute

Many applications using drug-carrying biomedical materials require on-demand, localized delivery of multiple therapeutic agents in precisely controlled and patient-specific time sequences, especially after assembly of the delivery vehicles; however, creating such materials has proven extremely challenging. Here, we report a novel strategy to create polypeptide multilayer films integrated with capsules as vehicles for co-delivery of multiple drugs using layer-bylayer self-assembly technology. Our approach allows the multilayered polypeptide nanofilms and preimpregnated capsules to assemble into innovative biomedical materials with high and controllable loading of multiple drugs at any time postpreparation and to achieve pH-responsive and sustained release. The resulting capsule-integrated polypeptide …

Effects Of Soil Nitrogen On Diploid Advantage In Fireweed, Chamerion Angustifolium (Onagraceae), Alex L. Bales, Erika Hersch-Green

Department of Biological Sciences Publications

In many ecosystems, plant growth and reproduction are nitrogen limited. Current and predicted increases of global reactive nitrogen could alter the ecological and evolutionary trajectories of plant populations. Nitrogen is a major component of nucleic acids and cell structures, and it has been predicted that organisms with larger genomes should require more nitrogen for growth and reproduction and be more negatively affected by nitrogen scarcities than organisms with smaller genomes. In a greenhouse experiment, we tested this hypothesis by examining whether the amount of soil nitrogen supplied differentially influenced the performance (fitness, growth, and resource allocation strategies) of diploid and …

A Closer Look At The Items Within Three Measures Of Evolution Acceptance: Analysis Of The Mate, I-Sea, And Gaene As A Single Corpus Of Items, William L. Romine, Amber Todd, Emily M. Walter

Medical Education Faculty Publications

Background: Current direct Likert measures for evolution acceptance include the MATE, GAENE, and I-SEA. Pros and cons of each of these instruments have been debated, and yet there is a dearth of research teasing out their similarities and differences when they are used together in a single context beyond the fact that their measures tend to be highly correlated. We administered these to 452 college students in non-major biology classes at two research-intensive universities from the Midwestern and Western United States to investigate the measurement properties of the items within these instruments when combined as a single corpus.Results: Factor analysis …

Engineering Researchers Hit Record With 17 Payloads On The International Space Station, Staff

Browse All News

No abstract provided.

Resource Extraction And Infrastructure Threaten Forest Cover And Community Rights, Anthony Bebbington, Denise Humphreys Bebbington, Laura Sauls, John Rogan, Sumali Agrawal, César Gamboa, Aviva Imhof, Kimberly Johnson, Herman Rosa, Antoinette Royo, Tessa Toumbourou, Ricardo Verdum

Sustainability and Social Justice

Mineral and hydrocarbon extraction and infrastructure are increasingly significant drivers of forest loss, greenhouse gas emissions, and threats to the rights of forest communities in forested areas of Amazonia, Indonesia, and Mesoamerica. Projected investments in these sectors suggest that future threats to forests and rights are substantial, particularly because resource extraction and infrastructure reinforce each other and enable population movements and agricultural expansion further into the forest. In each region, governments have made framework policy commitments to national and cross-border infrastructure integration, increased energy production, and growth strategies based on further exploitation of natural resources. This reflects political settlements among …

Hematopoietic Stem And Progenitor Cells Are A Distinct Hiv Reservoir That Contributes To Persistent Viremia In Suppressed Patients, Thomas D. Zaikos, Valeri H. Terry, Nadia T. Sebastian Kettinger, Jay Lubow, Mark M. Painter, Maria C. Virgilio, Andrew Neevel, Frances Taschuk, Adewunmi Onafuwa-Nuga, Lucy A. Mcnamara, James Riddell, Dale Bixby, Norman Markowitz, Kathleen L. Collins

Infectious Diseases Articles

Long-lived reservoirs of persistent HIV are a major barrier to a cure. CD4+ hematopoietic stem and progenitor cells (HSPCs) have the capacity for lifelong survival, self-renewal, and the generation of daughter cells. Recent evidence shows that they are also susceptible to HIV infection in vitro and in vivo. Whether HSPCs harbor infectious virus or contribute to plasma virus (PV) is unknown. Here, we provide strong evidence that clusters of identical proviruses from HSPCs and their likely progeny often match residual PV. A higher proportion of these sequences match residual PV than proviral genomes from bone marrow and peripheral blood mononuclear …

State V. Joslin Appellant's Brief Dckt. 45629

Idaho Supreme Court Records & Briefs, All

No abstract provided.

Phenotypic And Transcriptomic Characterization Of Colonial Phase Variation In The Cholera Pathogen Reveals A Novel Smooth Biofilm-Defective Form, Bliss Nicole Lambert

LSU Doctoral Dissertations

Biofilm formation, through the production of Vibrio polysaccharide (VPS), greatly enhances the environmental fitness and pathogenic success of Vibrio cholerae. As a result of phase variation, V. cholerae can switch from a smooth form to rugose, whose cells produce excess VPS, resulting in highly structured biofilms and greater resistance to stress. To further characterize the reversible process of phase variation, we isolated three colonial lineages. Each lineage began with a smooth parent, N16961, and contained a rugose variant derived from the parent, N16961R, as well as a smooth revertant of the rugose, N16961SD. We found clear phenotypic and transcriptomic …

Integral Feedback Control Is At The Core Of Task Allocation And Resilience Of Insect Societies, Thomas Schmickl, Istvan Karsai

ETSU Faculty Works

Homeostatic self-regulation is a fundamental aspect of open dissipative systems. Integral feedback has been found to be important for homeostatic control on both the cellular and molecular levels of biological organization and in engineered systems. Analyzing the task allocation mechanisms of three insect societies, we identified a model of integral control residing at colony level. We characterized a general functional core mechanism, called the “common stomach,” where a crucial shared substance for colony function self-regulates its own quantity via reallocating the colony’s workforce, which collects and uses this substance. The central component in a redundant feedback network is the saturation …

Online Learning Checkpoints: Exploring The Role Of Mandatory Student And Ta Interaction And Perceptions Of Satisfaction And Usefulness, Carolyn Andrews

Instructional Psychology and Technology Graduate Student Projects

With the rapid growth of online learning, there is considerable attention focused on student interaction and satisfaction in online courses. Instructors are instrumental in orchestrating interaction. When interaction is dissected, three distinct functions are identified. Researchers have identified T.A.’s as capable of fulfilling some of these instructor functions. TA’s from Brigham Young University’s online program conduct 3 predetermined checkpoints with each of their students. Checkpoints are used to monitor the progress and to ensure its timely advancement. The purpose of this study is to understand the nature and effectiveness of T.A. - student checkpoint interactions. Specifically, this research seeks to …

High Affinity Binding Of H3k14ac Through Collaboration Of Bromodomains 2, 4 And 5 Is Critical For The Molecular And Tumor Suppressor Functions Of Pbrm1., Lili Liao, Nilda L. Alicea-Velázquez, Lauren Langbein, Xiaohua Niu, Weijia Cai, Eun-Ah Cho, Meiling Zhang, Celeste B. Greer, Qin Yan, Michael S. Cosgrove, Haifeng Yang

Department of Pathology, Anatomy, and Cell Biology Faculty Papers

Polybromo-1 (PBRM1) is an important tumor suppressor in kidney cancer. It contains six tandem bromodomains (BDs), which are specialized structures that recognize acetyl-lysine residues. While BD2 has been found to bind acetylated histone H3 lysine 14 (H3K14ac), it is not known whether other BDs collaborate with BD2 to generate strong binding to H3K14ac, and the importance of H3K14ac recognition for the molecular and tumor suppressor function of PBRM1 is also unknown. We discovered that full-length PBRM1, but not its individual BDs, strongly binds H3K14ac. BDs 2, 4, and 5 were found to collaborate to facilitate strong binding to H3K14ac. Quantitative …

Proteomic Analysis Discovers The Differential Expression Of Novel Proteins And Phosphoproteins In Meningioma Including Nek9, Hk2 And Set And Deregulation Of Rna Metabolism., Jemma Dunn, Sara Ferluga, Vikram Sharma, Matthias Futschik, David A. Hilton, Claire L. Adams, Edwin Lasonder, C. Oliver Hanemann

School of Biomedical Sciences

BACKGROUND: Meningioma is the most frequent primary intracranial tumour. Surgical resection remains the main therapeutic option as pharmacological intervention is hampered by poor knowledge of their proteomic signature. There is an urgent need to identify new therapeutic targets and biomarkers of meningioma. METHODS: We performed proteomic profiling of grade I, II and III frozen meningioma specimens and three normal healthy human meninges using LC-MS/MS to analyse global proteins, enriched phosphoproteins and phosphopeptides. Differential expression and functional annotation of proteins was completed using Perseus, IPA® and DAVID. We validated differential expression of proteins and phosphoproteins by Western blot on a meningioma …

Mutants Of Cocaine Esterase, Donald Landry, Chang-Guo Zhan

Pharmaceutical Sciences Faculty Patents

Provided are mutant cocaine esterase polypeptides and PEGylated formulations thereof.

Assessing The Legal Base For Gender Neutral Society In Uzbekistan Using Un Sustainable Development Goals Framework, R. Arslonova

Review of law sciences

This article critically analyzes existing legal framework with respect to protecting women’s right; substantiating their equal status in society; creating new opportunities to promote better equality between men and women. Author researches UN Sustainable Development Goals framework with the intention of compiling a roadmap to further the agenda on women’s rights in Uzbekistan with global perspective.

The Role Of The World Food Security, A.B. Khodjaeva

Review of law sciences

This article outlines the general recommendation, key features of FAO and the World Food Program, compliance with specific international standards, as well as the importance of food security and analysis of Uzbekistan's measures and their further improvement. The Food and Agriculture Organization of the United Nations (FAO), as a specialized UN agency for nutrition, food and agriculture, has been striving for more than 60 years to expand its main goals: to improve the quality of food and the standard of living of people all over the world; ensuring the growth of efficiency of production and distribution of all food and …

Development Of Ziyarah Tourism In The Republic Of Uzbekistan Within The Organization Of Islamic Cooperation, S.B. Usmanova

Review of law sciences

This paper examines cooperation of the Republic of Uzbekistan for development of pilgrimage (Muslim) tourism in the framework of the Organization of Islamic Cooperation. The author analyzes functioning of the OIC in the sphere of tourism by proposing implementation of organization’s member states’ practices for perspective development of pilgrimage tourism in Uzbekistan. Therefore, the article highlights the signing of a special Memorandum of understanding between the members of the OIC for the development of Islamic tourism in the Republic of Uzbekistan.

Analysis Of Terminological Concept Of Information Technologies In Domestic And Foreign Literature, A.R. Davronov

Review of law sciences

In this article, the conceptual and terminological apparatus of information technologies in domestic and foreign literature has been studied and the concept of “Information technologies” has been analyzed using a comparative method. In addition, proposals are made to improve legislation in the field of information technology.

Targeted Therapies For Advanced Non-Small Cell Lung Cancer, Xiaojuan Ai, Xialing Guo, Jun Wang, Andreea L Stancu, Patrick M N Joslin, Dianzheng Zhang, Shudong Zhu

PCOM Scholarly Works

Lung cancer is a serious health problem and the leading cause of cancer death worldwide, due to its high incidence and mortality. 85% of lung cancers are represented by the non-small cell lung cancer (NSCLC). Traditional chemotherapy has been the main treatment option in NSCLC. However, it is often associated with limited efficacy and overall poor patient survival. In recent years, molecular targeting has achieved great progress in therapeutic treatment of cancer and plays a crucial role in the current clinical treatment of NSCLC, due to enhanced efficacy on cancer tissues and reduced toxicity for normal tissues. In this review, …

His 34 History And Contemporary Issues In Science And Technology, William Dejong-Lambert

Open Educational Resources

No abstract provided.

Predicting Post-Procedural Complications Using Neural Networks On Mimic-Iii Data, Namratha Mohan

LSU Master's Theses

The primary focus of this paper is the creation of a Machine Learning based algorithm for the analysis of large health based data sets. Our input was extracted from MIMIC-III, a large Health Record database of more than 40,000 patients. The main question was to predict if a patient will have complications during certain specified procedures performed in the hospital. These events are denoted by the icd9 code 996 in the individuals' health record. The output of our predictive model is a binary variable which outputs the value 1 if the patient is diagnosed with the specific complication or 0 …

Medicine Research In India: A Scientometric Assessment Of Publications During 2009 – 2018, Chaman Sab M, Dharani Kumar P, Biradar B. S

Library Philosophy and Practice (e-journal)

The purpose of this paper is to qualitative analyse of medicine research output using select scientometric indicators with the aim of identifying top preparing countries, subject subthemes, organisations, authors and journals in the area. The present study has examined 29153 publications in medicine research, the present study deals with the Assessment of Indian medicine research output as reflected in Web of Science (WOS) database for the period 2009 to 2018 for identifying the research output in the field of medicine literature. It also provides a comparative evaluation and performance of different types of scientometric indicators, such as number of publications, …