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2018

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Alumni News | Romasco Moore's New Book Praised In New York Times, Ohio University College Of Arts & Sciences Dec 2018

Alumni News | Romasco Moore's New Book Praised In New York Times, Ohio University College Of Arts & Sciences

All Forum Articles

No abstract provided.


Find, Process, And Share: An Optimal Control In The Vidale-Wolfe Marketing Model, Michael C. Barg Dec 2018

Find, Process, And Share: An Optimal Control In The Vidale-Wolfe Marketing Model, Michael C. Barg

CODEE Journal

The Vidale-Wolfe marketing model is a first-order, linear, non-homogeneous ordinary differential equation (ODE) where the forcing term is proportional to advertising expenditure. With an initial response in sales as the initial condition, the solution of the initial value problem is straightforward for a first undergraduate ODE course. The model serves as an excellent example of many relevant topics for those students whose interests lie in economics, finance, or marketing. Its inclusion in the curriculum is particularly rewarding at an institution without a physics program. The model is not new, but it was novel to us when a group of students …


Preventing An Era Of "New Eugenics": An Argument For Federal Funding And Regulation Of Gene Editing Research In Human Embryos, Michael R. Dohn Dec 2018

Preventing An Era Of "New Eugenics": An Argument For Federal Funding And Regulation Of Gene Editing Research In Human Embryos, Michael R. Dohn

Richmond Journal of Law & Technology

The 1997 film Gattaca is set in a futuristic society in which its members are either “valid,” born with the aid of genetic engineering, or “invalid", conceived by traditional means. While valids qualify for high-level professional employment, in-valids are considered less desirable by society and are relegated to menial jobs. At the time of the film’s release, this type of dystopian society, dominated by genetic engineering, seemed far into the future; however, only twenty years later, the concept of manipulating the genes of human embryos is near reality. The last decade has seen tremendous progression in gene editing technology. In …


Post-Wildfire Recovery Of An Upland Oak-Pine Forest On The Cumberland Plateau, Kentucky, Usa, Devin E. Black, Zachary W. Poynter, Claudia A. Cotton, Suraj Upadhaya, David D. Taylor, Wendy Leuenberger, Beth A. Blankenship, Mary A. Arthur Dec 2018

Post-Wildfire Recovery Of An Upland Oak-Pine Forest On The Cumberland Plateau, Kentucky, Usa, Devin E. Black, Zachary W. Poynter, Claudia A. Cotton, Suraj Upadhaya, David D. Taylor, Wendy Leuenberger, Beth A. Blankenship, Mary A. Arthur

Forestry and Natural Resources Faculty Publications

Background: Many forests within the southern Appalachian region, USA, have experienced decades of fire exclusion, contributing to regeneration challenges for species such as oaks (Quercus spp. L.) and pines (Pinus spp. L.), and threatening the maintenance of oak-dominated forests in the future. While the use of prescribed fire as a forest management tool is increasing within this region, there remains a lack of information on the potential role of wildfire. A wildfire within the Daniel Boone National Forest, Kentucky, USA, provided an opportunity to investigate how wildfire affected forest vegetation response.

Results: We examined the effects of fire …


Biological Aspects Of Mountain Pine Beetle In Lodgepole Pine Stands Of Different Densities In Colorado, Usa, Jose Negron Dec 2018

Biological Aspects Of Mountain Pine Beetle In Lodgepole Pine Stands Of Different Densities In Colorado, Usa, Jose Negron

United States Department of Agriculture, Forest Service / University of Nebraska-Lincoln: Faculty Publications

Research Highlights: The biology of mountain pine beetle (MPB), Dendroctonus ponderosae Hopkins, in Colorado’s lodgepole pine forests exhibits similarities and differences to other parts of its range. Brood emergence was not influenced by stand density nor related to tree diameter. The probability of individual tree attack is influenced by stocking and tree size. Findings have implications for understanding MPB as a disturbance agent and for developing management strategies. Background and Objectives: MPB causes extensive tree mortality of lodgepole pine, Pinus contorta Douglas ex Loudon, across the western US and Canada and is probably the most studied bark beetle in North …


Usd President's Report 2018, University Of San Diego Dec 2018

Usd President's Report 2018, University Of San Diego

President's Reports (1985- )

Message from the President, 2018 Year in Review, Winter/Spring, Summer, Fall, Leadership, 2017-2018 Financial Operations, Giving to the University


Growth Characteristics Of Newly Isolated Indonesian Microalgae Under Different Salinity, Wa Iba, Michael A. Rice, Lucie Maranda, Gary H. Wikfors Dec 2018

Growth Characteristics Of Newly Isolated Indonesian Microalgae Under Different Salinity, Wa Iba, Michael A. Rice, Lucie Maranda, Gary H. Wikfors

Fisheries, Animal and Veterinary Sciences Faculty Publications

The aim of this study was to investigate the growth characteristics of microalgae strains isolated from Kendari Bay and the Wanggu River estuary, Indonesia. The growth of the isolates, denoted as Kb1-2, Kb1-3, Kb1-5, and Kb2-6, were evaluated under controlled conditions. A batch culture experiment of these strains except Kb2-6 was conducted for 15 days under salinity levels of 20, 25, 30 and 35 gL-1. Tetraselmis chui, Tisochrysis lutea and Chaetocero sneogracile were also culture and used as the growth references. Cell density was measured every day and cell size was measured from 50 live cells during the logarithmic …


Implantable Biomaterials To Provide Local Immunotherapy Following Surgical Resection., Michael J Gough, Jason R Baird, R Bryan Bell Dec 2018

Implantable Biomaterials To Provide Local Immunotherapy Following Surgical Resection., Michael J Gough, Jason R Baird, R Bryan Bell

Articles, Abstracts, and Reports

No abstract provided.


Origins And Risk Assessment Of Thiocyanate In Raw Milk From 21 Farming Village Of Hebei Province, Sheng Qinghai, Tian Tingting, X Uli Dec 2018

Origins And Risk Assessment Of Thiocyanate In Raw Milk From 21 Farming Village Of Hebei Province, Sheng Qinghai, Tian Tingting, X Uli

Food and Machinery

In order to investigate the content of thiocyanate in raw milk, tracked the content of thiocyanate in 930 milk samples from 21 cattle-raising areas in Hebei Province in the past two years from 2014 to 2015. The results showed that the content of thiocyanate in those 930 milk samples ranged from 1.86 to 11.92 mg/L, and the detection rate was 100%. The results suggested that the thiocyanate in raw milk was all originated from the background, and there was no artificial addition. It was also found that the seasonal distribution of thiocyanate content in raw milk had no significant difference. …


Effects Of Microwave On Free Radical Production And Oxidative Properties Of Model Protein, Wang Tingting, Yuan Jiangfeng, Wang Lunji, Zhang Bin, Qiu Zhijun, Gong Minggui, Yin Qihang Dec 2018

Effects Of Microwave On Free Radical Production And Oxidative Properties Of Model Protein, Wang Tingting, Yuan Jiangfeng, Wang Lunji, Zhang Bin, Qiu Zhijun, Gong Minggui, Yin Qihang

Food and Machinery

Bovine Serum Albumin (BSA), a model protein, was used to study the relationship between the free radical production and oxidative properties in the microwave field. Electron paramagnetic resonance (EPR) trapping with 5,5-dimethyl-l-pyrrolin N-oxide (DMPO) was used for the detection of free radical produced by BSA under different microwave treatment conditions. The signal intensity of free radicals arose from BSA solution via the increasing of power, temperature, and time after microwave irradiation. By measuring the carbonyl, thiol and surface hydrophobic oxidative properties of BSA under different microwave temperatures. It was showed that the carbonyl content increased, the thiol content decreased, and …


Variations Of Size Distribution Of Tobacco Strips Separated From Different Threshing And Pneumatic Separation Unit, Liang Miao, Liu Maolin, Yang Yongfeng, Wang Genfa, Yang Zongcan, Zhang Junsong, Xiao Jinzhe, Lu Minrui, Liu Xiangzhen Dec 2018

Variations Of Size Distribution Of Tobacco Strips Separated From Different Threshing And Pneumatic Separation Unit, Liang Miao, Liu Maolin, Yang Yongfeng, Wang Genfa, Yang Zongcan, Zhang Junsong, Xiao Jinzhe, Lu Minrui, Liu Xiangzhen

Food and Machinery

In order to study the variation of size distribution of tobacco strips from different threshing and separation unit, an upper blend tobacco formula was introduced into threshing machine with five stages of threshing unit and eleven pneumatic separators. The results showed that the size proportion of tobacco strips separated from different pneumatic separators exhibited a similar change trend. Moreover, in the first and second stage threshing unit, the large and middle size particle content could reach more than 94% with good stability. Meanwhile, the characteristic size tobacco strips and the proportion of tobacco strips with size bigger than 44.5 mm …


The Effect On The Postharvest Qualities Of ‘Lianhong’ Citrus Fruit By Using Heat Shock Combined With Ozone Fumigation, Jiang Jing, Zhu Xiangrong, Su Donglin, Fu Fuhua, Zhang Juhua, Li Gaoyang, Shan Yang Dec 2018

The Effect On The Postharvest Qualities Of ‘Lianhong’ Citrus Fruit By Using Heat Shock Combined With Ozone Fumigation, Jiang Jing, Zhu Xiangrong, Su Donglin, Fu Fuhua, Zhang Juhua, Li Gaoyang, Shan Yang

Food and Machinery

Effects of heat shock combined with ozone fumigation at low temperature atmosphere were investigated on the storage quality and fruit physiological index of citrus processing varieties (‘Lianhong’ citrus fruit). The fruit was stored in cold storage at 4 ℃ and 90% relative humidity (RH), after treated with hot water (52 ℃, 3 min) and 6.0 mg/m3 of ozone for 15 min. Respiratory intensity, water loss rate, total soluble solids content (SSC), titratable acid (TA), ascorbic acid (VC), superoxide dismutase (SOD), peroxidase (POD) and catalase (CAT) activity were determined. The result showed that the combined treatment could enhance …


Effect Of Compound Preservative Solution On Freshness-Retaining Of Fresh-Cut Chufa, Wang Jinxin, Yang Fuxin, Si Wanfang Dec 2018

Effect Of Compound Preservative Solution On Freshness-Retaining Of Fresh-Cut Chufa, Wang Jinxin, Yang Fuxin, Si Wanfang

Food and Machinery

According to the phenomenon that fresh cut water chestnut was easily oxidized and degraded during storage, a kind of compound preservative solution was studied to preserve fresh-cut chufa. The fresh-cut chufa were pretreated with salt, white sugar, white vinegar and other solutions, and then stored at room temperature (25 ℃). The color, hardness, weight loss, electrical conductivity, polyphenol oxidase activity, soluble solids and total phenol content, odor and bagging were then evaluated in specific period of time. Orthogonal test was carried out on the basis of single factor experiment. The results showed that the best preservative solution was 80 g/L+ …


Studies On Curcumin And Cftr: Refutation And Recognition, Luan Jian, Cao Huanhuan, Zhou Xiaofu Dec 2018

Studies On Curcumin And Cftr: Refutation And Recognition, Luan Jian, Cao Huanhuan, Zhou Xiaofu

Food and Machinery

The research progress of curcumin stimulates mutant CFTR chloride channel since 2004 is summarizes in this review, and the process from discovery to refutation, from resistance to recognition of this theory are also discussed. Scientists prove that curcumin is a natural molecular activator of CFTR chloride channel, and plays an important role in the treatment of cystic fibrosis and the drug development, according the investigation of the experiment methods, mechanisms and pharmacokinetics. This review reveals the potential problems such as safe dose, and aims to provide references for cystic fibrosis drug research and development.


Research Progress Of Polyphenolic Compounds In Artichoke, Shi Mingyue, Cao Qingming, Zhong Wenhui, Yi Yingjian, Fang Yi, Zhang Zhikun, Zhou Wenhua Dec 2018

Research Progress Of Polyphenolic Compounds In Artichoke, Shi Mingyue, Cao Qingming, Zhong Wenhui, Yi Yingjian, Fang Yi, Zhang Zhikun, Zhou Wenhua

Food and Machinery

Artichoke has important nutritional and medicinal value and great development potential in the application of health food. In this review, the recent research results on extraction methods, analytical methods of artichoke, its chemical components and biological activities of polyphenols were summarized. It is hoped that national and international research results, can be popularized and utilized. The recognition of artichoke medicinal value in modern medicine and the promotion of artichoke products will bring great benefits to people's health and longevity.


Advacnes On Biological And Farming Technology For The Prevention And Treatment Of Cadmium In Rice, Shen Junjun, Lin Qinlu, Luo Feijun Dec 2018

Advacnes On Biological And Farming Technology For The Prevention And Treatment Of Cadmium In Rice, Shen Junjun, Lin Qinlu, Luo Feijun

Food and Machinery

In this paper, on account of the current situation that some rice have high cadmium content or even exceeds the national standard, the severity and regional distribution currently at home and abroad are analyzed. The necessity of controlling cadmium pollution of rice was revealed, and the methods of biotechnology and farming at home and abroad were systematically integrated,such as screening low cadmium enriched rice varieties using biological technology, hybrid technology and genetic engineering technology that includes transgene technology, gene knockout and gene silencing to improve rice traits. The microbial adsorption method and fermentation technology to reduce the cadmium content in …


Research Progress On The Improvement Of Edible Quality Of Brown Rice, Chen Bingjie, Qiao Yongjin, Liu Chenxia Dec 2018

Research Progress On The Improvement Of Edible Quality Of Brown Rice, Chen Bingjie, Qiao Yongjin, Liu Chenxia

Food and Machinery

From the physical and biological perspective, the methods, principles and characteristics of technologies of improving the quality of brown rice were introduced in the article. Present status and advance of studies on technologies of edible quality improvement for brown rice were overviewed. Synergy technology is also proposed to apply to the improvement of edible quality of brown rice. Combining other technologies and germination technology would become the development tendency. At the same time, the existing problems in the quality improvement of brown rice are also pointed out.


Research Progress On Functional Composition Andcomprehensive Utilization Of Passion Fruit, Zhu Wenxian, Xia Bibang, Liao Hongmei Dec 2018

Research Progress On Functional Composition Andcomprehensive Utilization Of Passion Fruit, Zhu Wenxian, Xia Bibang, Liao Hongmei

Food and Machinery

Summarizes the extraction of functional composition, pharmacological activities, processing and comprehensive utilization of passion fruit. Simultaneously, corresponding problems in research process of passion fruit have also been expounded. Theoretical references for subsequent research and product development would be provided.


Inhibition Of Heat-Induced Aggregation Of Tilapia Myosin By Dextran Sulfate At Low Ionic Strength, Li Ting, Zhou Chunxia, Feng Rui, Hong Pengzhi Dec 2018

Inhibition Of Heat-Induced Aggregation Of Tilapia Myosin By Dextran Sulfate At Low Ionic Strength, Li Ting, Zhou Chunxia, Feng Rui, Hong Pengzhi

Food and Machinery

Studied, the inhibitory effect of DS on thermal aggregation of tilapia myosin (2.0 mg/mL) in low ionic strength (1, 50, 150 mmol/L KCl) during the heat treatment (40~80 ℃, 1 ℃/min). The result showed that the myosin had poor solubility in 1 mmol/L KCl. While, with the icreased of ionic strengths, myosin fibrils could dissociate in 50 and 150 mmol/L KCl. After heating, the myosin filaments disappeared, and the heads and tails of myosin aggregated seriously, resulting in the solubility and the content of α-helix decreased significantly. After adding 0.4 mg/mL DS, the change of turbidity, solubility and α-helix content …


Evidence For Terahertz Acoustic Phonon Parametric Oscillator Based On Acousto-Optic Degenerate Four-Wave Mixing In A Silicon Doping Superlattice, Thomas E. Wilson Dec 2018

Evidence For Terahertz Acoustic Phonon Parametric Oscillator Based On Acousto-Optic Degenerate Four-Wave Mixing In A Silicon Doping Superlattice, Thomas E. Wilson

Physics Faculty Research

We report evidence for a 1.0-THz self-starting mirrorless acoustic phonon parametric oscillator (MAPPO) produced from acousto-optic phase-conjugate degenerate four-wave (D4WM) mixing in a THz laser-pumped silicon doping superlattice (DSL). The DSL was grown by molecular beam epitaxy on a (100) boron-doped silicon substrate. A superconducting NbTiN subwavelength grating was used to couple the THz laser radiation into the DSL. Superconducting granular aluminum bolometric detection, coupled with Si:B piezophonon spectroscopy, revealed excitation of THz coherent compressional and shear waves, along the ⟨111⟩ direction only. The Bragg scattering condition for distributed feedback, and the energy conservation requirement for the D4WM process, were …


Dynamic Responses And Implications To Coastal Wetlands And The Surrounding Regions Under Sea Level Rise, Karim Alizad, Scott C. Hagen, Stephen C. Medeiros, Matthew V. Bilskie, James T. Morris, Len Balthis, Christine A. Buckel Dec 2018

Dynamic Responses And Implications To Coastal Wetlands And The Surrounding Regions Under Sea Level Rise, Karim Alizad, Scott C. Hagen, Stephen C. Medeiros, Matthew V. Bilskie, James T. Morris, Len Balthis, Christine A. Buckel

Faculty Publications

Two distinct microtidal estuarine systems were assessed to advance the understanding of the coastal dynamics of sea level rise in salt marshes. A coupled hydrodynamic-marsh model (Hydro-MEM) was applied to both a marine-dominated (Grand Bay, Mississippi) and a mixed fluvial/marine (Weeks Bay, Alabama) system to compute marsh productivity, marsh migration, and potential tidal inundation from the year 2000 to 2100 under four sea level rise scenarios. Characteristics of the estuaries such as geometry, sediment availability, and topography, were compared to understand their role in the dynamic response to sea level rise. The results show that the low sea level rise …


Identitas Sosial Remaja Suku Mandar Dalam Pappasang: Implikasi Bagi Penyusunan Bahan Bimbingan, Andy Wahyu Irawan, Andi Mappiare-At, Muslihati Muslihati Dec 2018

Identitas Sosial Remaja Suku Mandar Dalam Pappasang: Implikasi Bagi Penyusunan Bahan Bimbingan, Andy Wahyu Irawan, Andi Mappiare-At, Muslihati Muslihati

Jurnal Kajian Bimbingan dan Konseling

Pappasang is a Mandar Tribe cultural product which contains advice. This advice has a characteristic describes the tribe identity of Mandar Tribe. This study aimed to examine the social identity of the Mandar Tribe adolescents in Pappasang as well as the foundation of guidance material. The qualitative study of gadamerian hermeneutics interpreted the social identity of Mandar Tribe adolescents in Pappasang. The findings showed the social identity are: empathy; remind each other; mutual help; solidarity; keep the disgrace on a secret; obedient; generous; democratic. Then, the social identity in Pappasang constructed to be material for guidance and counseling.


Palladium Adatoms On Gold Nanoparticles As Electrocatalysts For Ethanol Electro-Oxidation In Alkaline Solutions, Hui-Mei Chen, Shang-Qian Zhu, Jia-Le Huang, Min-Hua Shao Dec 2018

Palladium Adatoms On Gold Nanoparticles As Electrocatalysts For Ethanol Electro-Oxidation In Alkaline Solutions, Hui-Mei Chen, Shang-Qian Zhu, Jia-Le Huang, Min-Hua Shao

Journal of Electrochemistry

Palladium (Pd) is a good catalyst for ethanol electro-oxidation in alkaline solutions. The activity of Pd is further improved in this study by modifying the gold (Au) nanoparticles with Pd adatoms using a simple spontaneous deposition process. The Pd overlayer on the Au core (Au@Pd) is un-uniform with some Au atoms exposed to the electrolyte. The activity of Au@Pd/C toward ethanol oxidation reaction (EOR) is much higher than that of Pd/C in an alkaline solution. The peak current density of Au@Pd/C is 4.6 times higher than that of Pd/C with a 100 mV lower onset potential. The enhanced activity may …


A Study Of Adiponectin/Leptin Ratio In Adult Males With Metabolic Syndrome, Ann Khazaal Yaseen, Yousra Ahmed Abdulateef Dec 2018

A Study Of Adiponectin/Leptin Ratio In Adult Males With Metabolic Syndrome, Ann Khazaal Yaseen, Yousra Ahmed Abdulateef

Iraqi Postgraduate Medical Journal

BACKGROUND: Metabolic syndrome is a disorder of energy utilization and storage. It is a multi-component disease brought on by a combination of life style and environmental factors, with some populations exhibiting a genetic predisposition and type 2 diabetes. It is marked by abdominal obesity, elevated levels of triglyceride, low levels of HDL (good) cholesterol, high blood pressure and high blood sugar levels. Metabolic syndrome is a significant risk factor for the development of both type 2 diabetes and heart disease, also associated with fatty liver, and polycystic ovary syndrome. Recently two adipocytokines secreted from visceral adipose tissue leptin and adiponectin, …


Meral Spot Total Reflectance Signals Weapon Performance In The Mantis Shrimp Neogonodactylus Oerstedii (Stomatopoda), Amanda M. Franklin, Cassandra M. Donatelli, Casey R. Culligan, Eric D. Tytell Dec 2018

Meral Spot Total Reflectance Signals Weapon Performance In The Mantis Shrimp Neogonodactylus Oerstedii (Stomatopoda), Amanda M. Franklin, Cassandra M. Donatelli, Casey R. Culligan, Eric D. Tytell

Engineering Faculty Articles and Research

During animal contests over resources, opponents often signal their fighting ability in an attempt to avoid escalating to physical attack. A reliable signal is beneficial to receivers because it allows them to avoid injuries from engaging in contests they are unlikely to win. However, a signaler could benefit from deceiving an opponent by signaling greater fighting ability or greater aggressive intent than the signaler possesses. Therefore, the reliability of agonistic signals has long intrigued researchers. We investigated whether a colored patch, the meral spot, signals weapon performance in the stomatopod Neogonodactylus oerstedii. During fights over possession of refuges, stomatopods can …


Affordances On Facebook, Stress, And Emotional Support, Caitlin Rose Rethwish Dec 2018

Affordances On Facebook, Stress, And Emotional Support, Caitlin Rose Rethwish

Dissertations and Theses

This study discusses Facebook as a social network site and a social media application. It compares perceived emotional support, general life stress, and media affordance-based stress from two participant samples - one that reported using the Facebook desktop site most frequently to reach out for emotional support, and one that reported using the mobile application.

The media affordance measure asked participants if perceiving a media affordance was more likely to increase or decrease their stress. In both samples, persistence was more likely to decrease stress, and personalization was more likely to increase stress. On the Facebook Desktop site, searchability was …


A New Insight Into Underlying Disease Mechanism Through Semi-Parametric Latent Differential Network Model, Yong He, Jiadong Ji, Lei Xie, Xinsheng Zhang, Fuzhong Xue Dec 2018

A New Insight Into Underlying Disease Mechanism Through Semi-Parametric Latent Differential Network Model, Yong He, Jiadong Ji, Lei Xie, Xinsheng Zhang, Fuzhong Xue

Publications and Research

Background

In genomic studies, to investigate how the structure of a genetic network differs between two experiment conditions is a very interesting but challenging problem, especially in high-dimensional setting. Existing literatures mostly focus on differential network modelling for continuous data. However, in real application, we may encounter discrete data or mixed data, which urges us to propose a unified differential network modelling for various data types.

Results

We propose a unified latent Gaussian copula differential network model which provides deeper understanding of the unknown mechanism than that among the observed variables. Adaptive rank-based estimation approaches are proposed with the assumption …


The International Conference On Intelligent Biology And Medicine (Icibm) 2018: Bioinformatics Towards Translational Applications, Xiaoming Liu, Lei Xie, Zhijin Wu, Kai Wang, Zhongming Zhao, Jianhuan Ruan, Degui Zhi Dec 2018

The International Conference On Intelligent Biology And Medicine (Icibm) 2018: Bioinformatics Towards Translational Applications, Xiaoming Liu, Lei Xie, Zhijin Wu, Kai Wang, Zhongming Zhao, Jianhuan Ruan, Degui Zhi

Publications and Research

The 2018 International Conference on Intelligent Biology and Medicine (ICIBM 2018) was held on June 10–12, 2018, in Los Angeles, California, USA. The conference consisted of a total of eleven scientific sessions, four tutorials, one poster session, four keynote talks and four eminent scholar talks, which covered a wild range of aspects of bioinformatics, medical informatics, systems biology and intelligent computing. Here, we summarize nine research articles selected for publishing in BMC Bioinformatics.


The Court’S Undue Burden: A Look At Jespersen And Its Inconsistencies, Alessandro Botta Blondet Dec 2018

The Court’S Undue Burden: A Look At Jespersen And Its Inconsistencies, Alessandro Botta Blondet

University of Cincinnati Law Review

No abstract provided.


Lifestyle Modifications: Coordinating The Trna Epitranscriptome With Codon Bias To Adapt Translation During Stress Responses, Cheryl Chan, Phuong Pham, Peter C. Dedon, Thomas J. Begley Dec 2018

Lifestyle Modifications: Coordinating The Trna Epitranscriptome With Codon Bias To Adapt Translation During Stress Responses, Cheryl Chan, Phuong Pham, Peter C. Dedon, Thomas J. Begley

Biological Sciences Faculty Scholarship

Cells adapt to stress by altering gene expression at multiple levels. Here, we propose a new mechanism regulating stress-dependent gene expression at the level of translation, with coordinated interplay between the tRNA epitranscriptome and biased codon usage in families of stress-response genes. In this model, auxiliary genetic information contained in synonymous codon usage enables regulation of codon-biased and functionally related transcripts by dynamic changes in the tRNA epitranscriptome. This model partly explains the association between synchronous stress-dependent epitranscriptomic marks and significant multi-codon usage skewing in families of translationally regulated transcripts. The model also predicts translational adaptation during viral infections.