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In Vitro Growth Of Human Ovarian Follicles For Fertility Preservation, Diego Marin, Min Yang, Tianren Wang

Department of Biochemistry and Molecular Biology Faculty Papers

Young female cancer survival rates significantly increased due to the great progress of cancer therapy. In fact, cryostorage and transplantation of ovarian tissue have already resulted in the birth of healthy babies. Follicle in vitro growth (IVG) has the great potential of restoring fertility by achieving functional oocytes from the most immature stages to maturation. This is suitable for a wide range of patients, from pubertal to perimenopause women. Notable achievements have been achieved in human follicle IVG in the past decade. Mature oocytes have been successfully collected from long-term sequential follicle IVG. However, it is still a major challenge …

Simulating Detection-Censored Movement Records For Home Range Analysis Planning, Lyndsie S. Wszola, Victoria L. Simonsen, Lucía Corral, Christopher J. Chizinski, Joseph J. Fontaine

Nebraska Cooperative Fish and Wildlife Research Unit: Staff Publications

Home range estimation is an important analytical method in applied spatial ecology, yet best practices for addressing the effects of spatial variation in detection probability on home range estimates remain elusive. We introduce the R package “DiagnoseHR,” simulation tools for assessing how variation in detection probability arising from landscape, animal behavior, and methodological processes affects home range inference. We demonstrate the utility of simulation methods for home range analysis planning by comparing bias arising from three home range estimation methods under multiple detection scenarios. We simulated correlated random walks in three landscapes that varied in detection probability and constructed home …

The Current Understanding Of Microrna's Therapeutic, Diagnostic, And Prognostic Role In Chordomas: A Review Of The Literature., Paul J Choi, Rod J Oskouian, R Shane Tubbs

Articles, Abstracts, and Reports

Chordomas are primary low-grade bone tumors derived from the embryonic notochord that make up less than 5% of all osseous malignancies and commonly affect the spine at its vertebral body and at its two ends i.e., skull base and the sacrum. Although histologically defined to be low-grade, chordoma is locally destructive, metastatic, and has a serious recurrence rate, which all contribute to the dismal median survival rate of six years. Its locally destructive nature places the adjacent vital neurovascular structures at risk, making an en-bloc resection a challenge. This tumor is also known to show high resistance to currently available …

Determining The Amsr-E Sst Footprint From Co-Located Modis Ssts, Brahim Boussidi, Peter Cornillon, Gavino Puggioni, Chelle Gentemann

Graduate School of Oceanography Faculty Publications

This study was undertaken to derive and analyze the Advanced Microwave Scanning Radiometer - EOS (AMSR-E) sea surface temperature (SST) footprint associated with the Remote Sensing Systems (RSS) Level-2 (L2) product. The footprint, in this case, is characterized by the weight attributed to each 4x4 km square contributing to the SST value of a given AMSR-E pixel. High-resolution L2 SST fields obtained from the MODerate-resolution Imaging Spectroradiometer (MODIS), carried on the same spacecraft as AMSR-E, are used as the sub-resolution “ground truth“ from which the AMSR-E footprint is determined. Mathematically, the approach is equivalent to a linear inversion problem, and …

The Heart Of A Zombie: Dominican Literature's Sentient Undead, Emily A. Maguire

Alambique. Revista académica de ciencia ficción y fantasía / Jornal acadêmico de ficção científica e fantasía

A formerly human being that has been separated from its human consciousness, the has always been marked as more dead than alive. Yet in recent cultural production, another kind of zombie has emerged, what we might call the “sentient undead.” In these recent narratives, the undead protagonist is conscious of his or her inhumanity/non-humanness, along with the marginality of this position, and his or her potential “redemption” or return to humanity is often what drives the plot. Although the sentient zombie’s outsider position can function as a meditation on the social mores that make up human behavior, it also allows …

Overview Of Boron Neutron Capture Therapy: A Medical Aspect, Bangun Alan Anderson, Poedjomartono Bagaswoto

ASEAN Journal on Science and Technology for Development

Cancer is an abnormal growth of a cell due to the cell’s inability to control and maintain its proliferation, differentiation and apoptosis cycle. There are several methods to treat cancer; one of which is boron neutron capture therapy (BNCT). BNCT is a radiation modality by which a high radiation dose is delivered to tumor cells with lower damage to surrounding normal tissue. This modality has been used widely as a treatment for several cancer cases, such as head and neck cancer, breast cancer, and liver cancer. BNCT uses sodium borocaptate (BSH) or boronophenylalanine (BPA) as the delivery agent. Then, the …

Dosimetry Of In Vivo Experiment For Lung Cancer Based On Boron Neutron Capture Therapy On Radial Piercing Beam Port Kartini Nuclear Reactor By Mcnpx Simulation Method, Maysaroh Atika, Kusminarto Kusminarto, Palupi Dwi Satya, Sardjono Yohannes

ASEAN Journal on Science and Technology for Development

Cancer is one of the leading causes of death globally, with lung cancer being among the most prevalent. Boron Neutron Capture Therapy (BNCT) is a cancer therapy method that uses the interaction between thermal neutrons and boron-10 which produces a decaying boron-11 particle and emits alpha, lithium 7 and gamma particles. A study was carried out to model an in vivo experiment of rat organisms that have lung cancer. Dimensions of a rat’s body were used in Konijnenberg research. Modeling lung cancer type, non-small cell lung cancer, was used in Monte Carlo N Particle-X. Lung cancer was modeled with a …

Analysis Of Radiation Interactions And Biological Effects For Boron Neutron Capture Therapy, Chiang Ren-Tai

ASEAN Journal on Science and Technology for Development

The direct and indirect ionizing radiation sources for boron neutron capture therapy (BNCT)are identi?ed. The mechanisms of physical, chemical and biological radiation interactions for BNCT are systematically described and analyzed. The relationship between the effect of biological radiation and radiation dose are illustrated and analyzed for BNCT. If the DNAs in chromosomes are damaged by ion- izing radiations, the instructions that control the cell function and reproduction are also damaged. This radiation damage may be reparable, irreparable, or incorrectly repaired. The irreparable damage can result in cell death at next mitosis while incorrectly repaired damage can result in mutation. Cell …

Dose Analysis Of In Vitro And In Vivo Test For Boron Neutron Capture Therapy (Bnct), Faqqiyyah Hamidatul, Sunarno Sunarno, Akhlis Isa, Sardjono Yohannes

ASEAN Journal on Science and Technology for Development

The purpose of this study was to determine the in vitro and in vivo doses of boron neutron capture cancer therapy (BNCT) using the SHIELD-HIT12A program. To be able to determine the recoil energy, the research was conducted using the Monte Carlo method. Running data obtained the value of ionization activity and recoil lost. The results showed that in vitro and in vivo doses of BNCT for soft tissue irradiation had a value of 0.312 × 10-2 Sv, which is safe and does not harm healthy body tissue around the cancer cells because it is below the threshold of 1.5 …

Differential Expression Of Genes Related To Innate Immune Responses In Ex Vivo Spinal Cord And Cerebellar Slice Cultures Infected With West Nile Virus, Parminder J.S. Vig, Deyin Lu, Amber M. Paul, Ram Kuwar, Maria Lopez, Dobrivoje S. Stokic, A. Arturo Leis, Michael R. Garrett, Fengwei Bai

Faculty Publications

West Nile virus (WNV) infection results in a spectrum of neurological symptoms, ranging from a benign fever to severe WNV neuroinvasive disease with high mortality. Many who recover from WNV neuroinvasive infection present with long-term deficits, including weakness, fatigue, and cognitive problems. While neurons are a main target of WNV, other cell types, especially astrocytes, play an important role in promoting WNV-mediated central nervous system (CNS) damage. Conversely, it has been shown that cultured primary astrocytes secrete high levels of interferons (IFNs) immediately after WNV exposure to protect neighboring astrocytes, as well as neurons. However, how intrinsic responses to WNV …

Ne Stem 4u Afterschool Intervention Leads To Gains In Stem Content Knowledge For Middle School Youth, Christine E. Cutucache, Taylor Boham, Jamie Luhr, Amie Sommers, Nikolaus Stevenson, Erkko Sointu, Kati Mäkitalo‐Siegl, Sirpa Kärkkäinen, Teemu Valtonen, Neal Grandgenett, William Tapprich

Biology Faculty Publications

Afterschool interventions in STEM are linked to learning gains during the school day. These opportunities engage and excite students about STEM concepts since they observe a more hands-on, project-oriented approach. Often these opportunities for afterschool interventions are infrequent in nature and leave gaps for students in their maturation and understanding. Herein we describe the first report of an afterschool intervention, named NE STEM 4U, targeting socioeconomically disadvantaged middle school youth via a twice weekly, year-long intervention, studied across two years. We assessed the impact of this program on i.) short-term, individual student gains in STEM content knowledge and ii.) delivery …

Many Labs 2: Investigating Variation In Replicability Across Samples And Settings, Richard A. Klein, Michelangelo Vianello, Susan L. O'Donnell, Et Al

Faculty Publications - Psychology Department

We conducted preregistered replications of 28 classic and contemporary published findings, with protocols that were peer reviewed in advance, to examine variation in effect magnitudes across samples and settings. Each protocol was administered to approximately half of 125 samples that comprised 15,305 participants from 36 countries and territories. Using the conventional criterion of statistical significance (p < .05), we found that 15 (54%) of the replications provided evidence of a statistically significant effect in the same direction as the original finding. With a strict significance criterion (p < .0001), 14 (50%) of the replications still provided such evidence, a reflection of the extremely highpowered design. Seven (25%) of the replications yielded effect sizes larger than the original ones, and 21 (75%) yielded effect sizes smaller than the original ones. The median comparable Cohen’s ds were 0.60 for the original findings and 0.15 for the replications. The effect sizes were small (< 0.20) in 16 of the replications (57%), and 9 effects (32%) were in the direction opposite the direction of the original effect. Across settings, the Q statistic indicated significant heterogeneity in 11 (39%) of the replication effects, and most of those were among the findings with the largest overall effect sizes; only 1 effect that was near zero in the aggregate showed significant heterogeneity according to this measure. Only 1 effect had a tau value greater than .20, an indication of moderate heterogeneity. Eight others had tau values near or slightly above .10, an indication of slight heterogeneity. Moderation tests indicated that very little heterogeneity was attributable to the order in which the tasks were performed or whether the tasks were administered in lab versus online. Exploratory comparisons revealed little heterogeneity between Western, educated, industrialized, rich, and democratic (WEIRD) cultures and less WEIRD cultures (i.e., cultures with relatively high and low WEIRDness scores, respectively). Cumulatively, variability in the observed effect sizes was attributable more to the effect being studied than to the sample or setting in which it was studied.

Comparative Transcriptome Analysis Reveals An Efficient Mechanism For Α-Linolenic Acid Synthesis In Tree Peony Seeds, Qingyu Zhang, Rui Yu, Daoyang Sun, Mahbubur Rahman, Lihang Xie, Jiayuan Hu, Lixia He, Aruna Kilaru, Lixin Niu, Yanlong Zhang

ETSU Faculty Works

Tree peony (Paeonia section Moutan DC.) species are woody oil crops with high unsaturated fatty acid content, including α-linolenic acid (ALA/18:3; >40% of the total fatty acid). Comparative transcriptome analyses were carried out to uncover the underlying mechanisms responsible for high and low ALA content in the developing seeds of P. rockii and P. lutea, respectively. Expression analysis of acyl lipid metabolism genes revealed upregulation of select genes involved in plastidial fatty acid synthesis, acyl editing, desaturation, and triacylglycerol assembly in seeds of P. rockiirelative to P. lutea. Also, in association with ALA content in seeds, …

Week Of December 24, 2018, New York Medical College

InTouch

• Department of Surgery Hosts 15th Annual Louis R.M. DelGuercio Distinguished Visiting Professorship and Research Day
• SHSP Hosts Winter Meet and Greet
• GSA Sponsors Third Annual Snowman Project

Differential Expression Of Genes Related To Innate Immune Responses In Ex Vivo Spinal Cord And Cerebellar Slice Cultures Infected With West Nile Virus, Amber M. Paul, Parminder J.S. Vig, Deyin Lu, Ram Kuwar, Maria Lopez, Dobrivoje S. Stokic, A. Arturo Leis, Michael R. Garrett, Fengwei Bai

Publications

West Nile virus (WNV) infection results in a spectrum of neurological symptoms, ranging from a benign fever to severe WNV neuroinvasive disease with high mortality. Many who recover from WNV neuroinvasive infection present with long-term deficits, including weakness, fatigue, and cognitive problems. While neurons are a main target of WNV, other cell types, especially astrocytes, play an important role in promoting WNV-mediated central nervous system (CNS) damage. Conversely, it has been shown that cultured primary astrocytes secrete high levels of interferons (IFNs) immediately after WNV exposure to protect neighboring astrocytes, as well as neurons. However, how intrinsic responses to WNV …

Male And Female Mice Exhibit Divergent Responses Of The Cortical Vasculature To Traumatic Brain Injury, Amandine Jullienne, Arjang Salehi, Bethann M. Affeldt, Mohsen Baghchechi, Elizabeth Haddad, Angela Avitua, Mark Walsworth, Isabelle Enhalric, Mary Hamer, Sonali Bhakta, Jiping Tang, John Zhang, William Pearce, Andrea Obenaus

Loma Linda University Student Journal

Traumatic brain injuries (TBI) occur in 1.7 million people each year in the USA. Little is known about how the cerebrovasculature is altered after TBI. We previously reported that TBI elicits acute decrements in cerebral vessels near the injury site in rats followed by revascularization over the subsequent 2 weeks. Sexual dimorphism of the brain is well documented and different hormonal levels in males and females differentially modify the recovery process after injury. However, the effects of biological sex on the temporal evolution of revascularization following TBI are understudied. Using a model of controlled cortical impact in male and female …

Factors Associated With Access To Immunotherapy And Its Impact On Survival In Mucosal Melanoma, Joanne Jee Yeon Lee, Donovan Kearns, Medora Rodrigues, Blake Babcock, Naveenraj L. Solomon Md, Maheswari Senthil Md, Mark E. Reeves Md, Phd, Carlos A. Garberoglio Md, Jukes P. Namm Md

Loma Linda University Student Journal

Mucosal melanoma is rare, comprising only 1.4% of all melanomas in the United States. Yet it is associated with a worse prognosis compared to cutaneous melanoma due to aggressive biology and advanced stage at diagnosis with a reported 5-year survival rate of less than 30%. Although there are no established guidelines for the treatment of mucosal melanoma, immunotherapy has been increasingly used for the management of advanced mucosal melanoma.

A Mindful Model Of Sexual Health: A Review And Implications Of The Model For The Treatment Of Individuals With Compulsive Sexual Behavior Disorder, Gretchen R. Blycker, Marc N. Potenza

College of Nursing Faculty Publications

Background and aims: Mindfulness-based approaches, derived from centuries of eastern philosophy and practice, have been increasingly incorporated into western medicine. For example, data support the efficacy of mindfulness-based therapies to reduce stress and promote mental health. Methods: In this study, we briefly review models and approaches to sexual health in the context of considering compulsive sexual behavior disorder, describe mindfulness-based approaches to stress, addiction, and compulsive sexual behaviors, and present a Mindful Model of Sexual Health (MMSH) that incorporates elements of eastern and western philosophies. We further illustrate the clinical utility of the MMSH in a clinical case …

Bovine Mammary Gland Biopsy Techniques, Veridiana L. Daley, Charles Dye, Sophie H. Bogers, R. Michael Akers, Francisco C. Rodriguez, John P. Cant, John Doelman, Peter Yoder, Karan Kumar, Dane Webster, Mark D. Hanigan

Animal and Food Sciences Faculty Publications

Bovine mammary gland biopsies allow researchers to collect tissue samples to study cell biology including gene expression, histological analysis, signaling pathways, and protein translation. This article describes two techniques for biopsy of the bovine mammary gland (MG). Three healthy Holstein dairy cows were the subjects. Before biopsies, cows were milked and subsequently restrained in a cattle chute. An analgesic (flunixin meglumine, 1.1 to 2.2 mg/kg of body weight) was administered via jugular intravenous [IV] injection 15-20 min prior to biopsy. For standing sedation, xylazine hydrochloride (0.01-0.05 mg/kg of body weight) was injected via the coccygeal vessels 5-10 min before the …

Terrorism In The Middle East: Implications On Egyptian Travel And Tourism, Tamer Z.F Mohamed, Tamer S. Elseyoufi

International Journal of Religious Tourism and Pilgrimage

This paper attempts to shed the light on challenging issues affecting travel and tourism industry especially in the Middle East such as political, socio-economic and security instability. Due to its geopolitical and historical importance, the paper focuses on the situation in Egypt as a descriptive case study. The methodology relies on historical review and impact assessment to understand the roots and extended branches of instability in the Middle East that led to the Arab Spring, by focusing on the Egyptian case in the last half century. The assessment explains the negative effect of Western and Egyptian policy on extending the …

The New Natural Distribution Area Of Aspen (Populus Tremula L.) Marginal Populations In Pasinler In The Erzurum Province, Turkey, And Its Stand Characteristics, Halil Bariş Özel, Sezgin Ayan, Serdar Erpay, Bojan Simovski

Aspen Bibliography

Background and Purpose: Genetic diversity is the basis for adaptation and survival of tree species under changing environmental conditions, representing the key issue of stability and productivity of forest ecosystems. This paper studies the marginal population characteristics and stand dynamics of aspen tree (Populus tremula L.) in natural, pure and mixed forest stands with Scots pine (Pinus sylvestris L.). These populations were observed on founding sites between Timarli Valley and Timan Plateau located in Pasinler in the Erzurum Province in Turkey.
Materials and Methods: Three replicated sample sites were established according to a randomised block design …

Profit Efficiency And Smallholder Sugarcane Out-Growers Under Contract Farming In Tanzania: Does Location Matter?, Thobias Nsindagi, Jennifer K. Sesabo

Journal of Humanities and Social Sciences

Tanzania is among countries that value the sugarcane sector as one of the potential crops for poverty alleviation. The sector provides direct employment to about 14,000 people, and it is an outlet for the produce of over 30,000 farming households (Nkonya & Barreiro Hurle, 2012). Likewise, it provides direct earnings and savings amounting to about US$28m annually (Sugar Board of Tanzania (SBT), 2007). However, sugarcane out-growers in Tanzania have been getting low prices relative to unit costs (Matango, 2006). This has generated substantial debate about the need and level of government support. Like other developing countries, contract farming (CF) has …

Non-Pharmacological Solutions To Sleep And Circadian Rhythm Disruption: Voiced Bedside Experiences Of Hospice And End-Oflife Staff Caregivers, Rana Sagha Zadeh, Elizabeth Capezuti, Paul Eshelman, Nicole Woody, Jennifer Tiffany, Ana C. Krieger

Publications and Research

Background: Sleep disturbance is a significant issue, particularly for patients with advanced terminal illness. Currently, there are no practice-based recommended approaches for managing sleep and circadian disruptions in this population. To address this gap, a cross-sectional focus group study was performed engaging 32 staff members at four hospices/end-of-life programs in three demographically diverse counties in New York State.

Methods: Participants responded to structured open-ended questions. Responses were transcribed and subjected to qualitative content analysis. The themes and recommendations for improved practice that emerged were tabulated using Atlas TI qualitative software.

Results: This report details the experiences of hospice and end-of-life …

Potential Applications Of Functional Magnetic Resonance Imaging (Fmri) To Organizational Research: A Primer And Sample Study, Allen I. Huffcutt, Wen-Ching Liu, Lori A. Russell-Chapin

Personnel Assessment and Decisions

The first purpose of this manuscript is to provide a primer for organizational researchers on both fMRI and brain physiology because few are likely to have encountered an in-depth treatment of either previously. The second purpose is to present the results of an actual fMRI study on an organizational topic (structured employment interviews) as a sample to help illustrate the potential of this type of research. Results of the sample study enhanced understanding of the brain processes behind responding to situational (SI) and behavior description (BDI) interviews, and offered several promising directions for follow-up research. To illustrate the latter, there …

From Biopolitics To Biopoetics: A Hypothesis On The Relationship Between Life And Writing, Julieta Yelin

CLCWeb: Comparative Literature and Culture

The objective of this article is to examine the theoretical potential of the dialogues between literary critique and biopolitical thought, with an analysis centered on a reconsideration of the concept of interpretation. In order to accomplish this, we analyze the shift in Michel Foucault’s thought around the beginning of the 1970s, a time during which the notion of life took prominence over the study of literature as a specific discipline. From this transformation, a particular way of approaching both literary and, generally speaking, artistic creations can be derived that would give rise to a biopoetics perspective.

Failed Anti-Activist Legislation: The Curious Case Of The Brokaw Act, Alon Brav, J.B. Heaton, Jonathan Zandberg

The Journal of Business, Entrepreneurship & the Law

The Brokaw Act was proposed legislation aimed at “financial abuses being carried out by activist hedge funds who promote short-term gains at the expense of long-term growth . . . .” Sponsoring Senators named it after a small town in Wisconsin that, according to the Act’s sponsors, was decimated by the actions of a hedge fund activist in shutting down the local paper mill with a loss of hundreds of jobs. The Brokaw Act represented the first attempt at federal legislation aimed at restricting hedge fund activism. Since then, new and similar bipartisan proposals have appeared as have threats of …

Lessons Of Resilience From Our Founding Mothers: An Examination Of Women From 1776 To 1830, Jody A. Kunk-Czaplicki

Journal of Research, Assessment, and Practice in Higher Education

The role of women in American society during its first 50 years (1776-1830) varied. Women, however, built and maintained the Republic but were not granted access to the Academy (Nash, 2005, Kerber, 1997). At the threshold of the Revolutionary War, women served not only their home, family, and husbands, they began to serve the broader country. In the first third of the 19^th century, white women of wealth engaged in political acts of service and in acts of disruption (Kerber, 1997). The rest of this paper examines how women leaders of early America laid the foundation for women’s access …

Unmasking Of Impostor Syndrome, Aishwarya Joshi, Haley Mangette

Journal of Research, Assessment, and Practice in Higher Education

Members of minority populations are forced to hide behind a mask of stereotypes others associate to them. Individuals who feel fraudulent when they fulfill certain stereotypes, associate their success to external forces, define the problem as impostor syndrome (IS). The paper focuses on the prevalence and relevance of IS on college campuses. The session will explore the affect and effect of IS from different cultural lenses and discuss possible preventive and coping strategies for academic and mental health professionals. The purpose is to ‘unmask’ the impostor syndrome caused by stereotypes and stereotype threats that prevents individuals from reaching ‘new heights’ …

Climate Evolution Across The Mid-Brunhes Transition, Aaron M. Barth, Peter U. Clark, Nicholas S. Bill, Feng He, Nicklas G. Pisias

School of Earth & Environment Departmental Research

The Mid-Brunhes Transition (MBT) began ∼ 430 ka with an increase in the amplitude of the 100 kyr climate cycles of the past 800 000 years. The MBT has been identified in ice-core records, which indicate interglaciations became warmer with higher atmospheric CO2 levels after the MBT, and benthic oxygen isotope (δ18O) records, which suggest that post-MBT interglaciations had higher sea levels and warmer temperatures than pre-MBT interglaciations. It remains unclear, however, whether the MBT was a globally synchronous phenomenon that included other components of the climate system. Here, we further characterize changes in the climate system across the MBT …

Performance Of Riverbank Filtration Under Hydrogeologic Conditions Along The Upper Krishna River In Southern India, Thomas B. Boving, K. Patil, F. D’Souza, S. F. Barker, S. L. Mcguinness, J. O’Toole, M. Sinclair, A. B. Forbes, K. Leder

Geosciences Faculty Publications

Riverbank filtration (RBF) systems were installed in four rural villages along a 64 km stretch of the upper Krishna River in southern India; with each one designed to supply approximately 2500 people. Site selection criteria included hydrogeological suitability, land availability and access, proximity to villages and their population sizes, and electric power supply. Water samples were collected from the river and the RBF wells over more than one year (November 2015 to December 2017) and were analyzed for Escherichia coli bacteria, major ions, and a range of other physicochemical and chemical parameters. The shallow groundwater at the study sites was …