Digital Commons Network^™

Steric Control Of The Rate-Limiting Step Of Udp-Galactopyranose Mutase, Gustavo Pierdominici-Sottile, Rodrigo Cossio-Pérez, Isabel Da Fonseca, Karina Kizjakina, John J. Tanner, Pablo Sobrado

Chemistry Faculty Research & Creative Works

Galactose is an abundant monosaccharide found exclusively in mammals as galactopyranose (Galp), the six-membered ring form of this sugar. In contrast, galactose appears in many pathogenic microorganisms as the five-membered ring form, galactofuranose (Galf). Galf biosynthesis begins with the conversion of UDP-Galp to UDP-Galf catalyzed by the flavoenzyme UDP-galactopyranose mutase (UGM). Because UGM is essential for the survival and proliferation of several pathogens, there is interest in understanding the catalytic mechanism to aid inhibitor development. Herein, we have used kinetic measurements and molecular dynamics simulations to explore the features of UGM that control the rate-limiting step (RLS). We show that …

A Series Of 4- And 5-Coordinate Ni(Ii) Complexes: Synthesis, Characterization, Spectroscopic, And Dft Studies, Jack Ghannam, Talal Al Assil, Trey C. Pankratz, Richard L. Lord, Matthias Zeller, Wei-Tsung Lee

Chemistry: Faculty Publications and Other Works

A series of four- and five-coordinate Ni(II) complexes Cz^tBu(Pyr^iPr)₂NiX (1–3 and 1·THF–3·THF), where X = Cl, Br, and I, were synthesized and fully characterized by NMR and UV–vis spectroscopy, X-ray crystallography, cyclic voltammetry, and density functional theory calculations. The solid-state structures of 1–3 reveal rare examples of seesaw Ni(II) complexes. In solution, 1–3 bind reversibly to a THF molecule to form five-coordinate adducts. The electronic transitions in the visible region (630–680 nm), attributed to LMCT bands, for 1 → 3 exhibit a …

Evaluation Of Oncolytic And Immunomodulatory Potential Of The Hsv-1 Live-Attenuated Vaccine Strain Vc2 In An Immunocompetent Murine Melanoma Model, Natalie Wall Fowlkes

LSU Doctoral Dissertations

Melanoma accounts for 90% of skin cancer-related deaths in humans. Treatment options for metastatic melanoma in people is very limited. Melanoma is considered to be an immunogenic tumor, spurring interest in development of immunotherapies for the treatment of metastatic melanoma. Oncolytic virotherapy has been widely investigated. The first ever oncolytic virotherapy to receive FDA-approval is an HSV-1-based virus (Talimogene Laherperavec (T-Vec) or Imlygic) containing a transgene for human GM-CSF to enhance anti-tumor immune responses after injection. Durable response rate in human patients was only 16% despite impressive efficacy in anti-tumor effects in vitro and in murine tumor models. Novel viruses …

The Effect Of Caregiver Feeding Education On Dementia Patient Weight, Elizabeth Marks Cortright

DNP and Student Works

Dementia is associated with deterioration in memory and cognition which can be severe enough to diminish a person's capacity to perform everyday activities including eating. Maintaining sufficient nutritional intake for dementia patients requires skilled knowledgeable caregivers. The focus of this project was to develop an evidence-based feeding protocol to assist caregivers in providing optimal nutrient intake of dementia patients, to evaluate changes in staff knowledge, and to determine the impact on dementia patients' meal intake percentage and weights through chart review. Dementia typically causes a decline in both cognitive and physical abilities leading to functionality and self-care limitations. Dorothea Orem's …

Design(Ing) And The Placebo Effect—A Productive Idea, Hannah Drayson

School of Art, Design and Architecture

No abstract provided.

Interrogation Of Protein Function With Peptidomimetics, Olapeju Bolarinwa

USF Tampa Graduate Theses and Dissertations

Proteins can be described as the “machineries” responsible for almost all tasks in the levels of organizational complexity in multi-cellular organisms namely: the cells, tissues, organs and systems. Any disorder in the function of a protein at any of these levels could result in disease, and a study of protein function is critical to understanding the pathological features of the disease at the molecular level. A quick glance at these abundantly present proteins reveals two striking features: large diversity of biological function, and the variations in structural complexity, which varies from simple random coils, to turns and helices, and on …

Tunable Silver-Functionalized Porous Frameworks For Antibacterial Applications, Mark A. Isaacs, Brunella Barbero, Lee J. Durndell, Anthony C. Hilton, Luca Olivi, Christopher M.A. Parlett, Karen Wilson, Adam F. Lee

School of Geography, Earth and Environmental Sciences

No abstract provided.

Social Support And Self-Management Behaviors Among Emerging Adults With Inflammatory Bowel Disease, Kendra Kamp

Sigma Foundation for Nursing Research Grant Reports

Self-management of chronic conditions is increasingly critical as individuals spend less time in healthcare systems and must learn how to manage their disease (through behaviors such as medication adherence and diet modification) at home instead (Grady & Gough, 2014). Factors that influence self-management, such as social support, are important for understanding how nurses can intervene to improve self-management among patients with chronic conditions (Gallant, 2003). While research demonstrates the importance of social support for self-management among older adults with chronic conditions, limited information is available on emerging adults with chronic conditions who experience developmental transitions which may influence social support …

A Temperate And Wholesome Beverage: The Defense Of The American Beer Industry, 1880-1920, Lyndsay Danielle Smith

Dissertations and Theses

For decades prior to National Prohibition, the "liquor question" received attention from various temperance, prohibition, and liquor interest groups. Between 1880 and 1920, these groups gained public interest in their own way. The liquor interests defended their industries against politicians, religious leaders, and social reformers, but ultimately failed. While current historical scholarship links the different liquor industries together, the beer industry constantly worked to distinguish itself from other alcoholic beverages.

To counter threats from anti-alcohol groups, beer industry advocates presented their drink as a wholesome, pure, socially and culturally rich, and economically significant beverage that stood apart from other alcoholic …

How Effective Is Intravenous Ketamine Compared To No Medication/Placebo In Reducing Suicidal Ideations In Adults?, Elena Kirilova Taneva-Cholakova

International Nursing Research Congress (INRC)

Suicide is a major public health problem with limited pharmacological options to treat acute risk. Every 40 seconds someone in the world commits suicide, WHO says. Lately, the dissociative anaesthetic Ketamine, has been studied as a potential short-acting treatment for suicidal ideations. Although promising, the available literature is still inconclusive.

Teamworks, Metro Edition, 1997 December 30, Advocate Aurora Health

Aurora Health Care Books, Documents, and Pamphlets

Aurora Health Care, Milwaukee, WI: December 30, 1997 Metro Edition of Teamworks, a newsletter for Aurora Health Care Metro Region employees and volunteers. Article topics include staff profiles and recognition, career in medical imaging, gift programs, the Annual Christmas Love-Lite Tree tribute, information service employees, community events and services, and nursing education classes.

A Documentary-Material Approach For Performance, Marc Kosciejew

Proceedings from the Document Academy

This article begins a conceptual discussion about the relationship between documentation, performance, and materiality. It argues that a documentary approach helps show the roles played by documents and practices with them in performance’s materialization and constitution. It presents the start of a documentary approach for analyzing performance by discussing some ways in which documentation helps provide a material basis for performance beyond its enactment whilst simultaneously materializing and constituting it in and for other diverse contexts.

Annual, Seasonal, And Diel Surface Energy Partitioning In The Semiarid Sand Hills Of Nebraska, Usa, Nathan C. Healey, Timothy J. Arkebauer, David P. Billesbach, John D. Lenters

School of Natural Resources: Faculty Publications

Study Region: The Nebraska Sand Hills consisting of four major land cover types: (1) lakes and wetlands (∼5% for both), (2) subirrigated meadows (∼10%), (3) dry valleys (∼20%), and (4) upland dunes (∼65%).

Study Focus: Examination of surface energy and water balances on multiple temporal scales with primary focus on latent heat flux (λE), and evapotranspiration (ET), to gain a better understanding of the annual, seasonal, and diel properties of surface energy partitioning among different Sand Hills ecosystems to improve regional water resource management. New Hydrological Insights for the Region: Based on surface energy and water balance measurements using Bowen …

Bhlhe40 Is An Essential Repressor Of Il-10 During Mycobacterium Tuberculosis Infection, Jeremy P Huynh, Chih-Chung Lin, Jacqueline M Kimmey, Nicholas N Jarjour, Elizabeth A Schwarzkopf, Tara R Bradstreet, Irina Shchukina, Oleg Shpynov, Casey T Weaver, Reshma Taneja, Maxim N Artyomov, Brian T Edelson, Christina L Stallings

2010-2019 OA Pubs

The cytokine IL-10 antagonizes pathways that control

Veggie Sales At Grover Atrium July 17 At Student Farm July 20, Ohio University College Of Arts & Sciences

All Forum Articles

No abstract provided.

Veggie Sales At Grover Atrium July 10 Student Farm July 13, Ohio University College Of Arts & Sciences

All Forum Articles

No abstract provided.

New Grant Will Fund Study Of Hagfish Slime, Sarah Schaier

UNH Today Archive

No abstract provided.

Jefferson Digital Commons Quarterly Report: April-June 2018, Kelsey Duinkerken, Msi, James Copeland, Libt

Jefferson Digital Commons Reports

This quarterly report includes:

• New Feature: PlumX Metrics
• New Feature: CrossRef DOIs
• College Restructuring
• Articles
• CREATE Day Presentations
• Department of Surgery Resident Research Day
• Dissertations
• From the Archives
• Grand Rounds and Lectures
• Master of Public Health Capstones
• Newsletters
• Pathology Honors Program Student Research Symposium
• Posters
• What People are Saying About the JDC

Eleven Years Of Mountain Weather, Snow, Soil Moisture And Streamflow Data From The Rain–Snow Transition Zone – The Johnston Draw Catchment, Reynolds Creek Experimental Watershed And Critical Zone Observatory, Usa, James P. Mcnamara

Geosciences Faculty Publications and Presentations

Detailed hydrometeorological data from the rain-to-snow transition zone in mountain regions are limited. As the climate warms, the transition from rain to snow is moving to higher elevations, and these changes are altering the timing of downslope water delivery. To understand how these changes impact hydrological and biological processes in this climatologically sensitive region, detailed observations from the rain-to-snow transition zone are required. We present a complete hydrometeorological dataset for water years 2004 through 2014 for a watershed that spans the rain-to-snow transition zone (https://doi.org/10.15482/usda.adc/1402076). The Johnston Draw watershed (1.8km²), ranging from 1497 to 1869m in elevation, is …

Removal Of Total Dissolved Solids From Reverse Osmosis Concentrates From A Municipal Wastewater Reclamation Plant By Aerobic Granular Sludge, Do-Hyung Kim, Sangjin Park, Yeomin Yoon, Chang Min Park

Faculty Publications

Reverse osmosis (RO) has been widely utilized in water reclamation plants and produces a concentrated brine (or reject) stream as a by-product. RO concentrates (ROC) contain vast quantities of salts and dissolved organic matter, such as biomass and humic-like substances, which hinder biological wastewater treatment (such as biological nitrogen removal). In this study, we cultivated granular sludge in an aerobic sequencing batch reactor to treat municipal wastewater with an organic loading rate of 2.1–4.3 kgCOD/m³ day at room temperature (25 °C), and remove total dissolved solids (TDS) from ROC by biosorption, with aerobic granular sludge as a novel biosorbent. …

Mary Kenton, University Honors Program, Wright State University, Dan Abrahamowicz, Mary Kenton

Wright State University Retirees Association Oral History Project

On July 2, 2018, Dan Abrahamowicz interviewed Mary Kenton about her years as a student and longtime staff member in Wright State University’s Honors Program . Kenton discusses the early development of the Honors Program, scholarship expansion, campus governance, and her work on Title IX and gender equity in athletics. The interview highlights the university’s growth, faculty culture, and changing student life from the late 1960s through 2010.

Robust Estimation And Inference On Current Status Data With Applications To Phase Iv Cancer Trial, Deo Kumar Srivastava, Liang Zhu, Melissa M. Hudson, Jianmin Pan, Shesh N. Rai

Journal of Modern Applied Statistical Methods

The use of piecewise exponential distributions was proposed by Rai et al. (2013) for analyzing cardiotoxicity data. Some parametric models are proposed, but the focus is on the Weibull distribution, which overcomes the limitation of piecewise exponential.

Meet Your Pals Series: Mamady Sankoh '21, Kassidy Taylor

UNH Today Archive

No abstract provided.

Generation Of Knockout Cell Lines To Investigate The Roles Of Cklf And Cry2 In The Regulation Of Circadian Clock, Thanuja Ramanna

Electronic Theses and Dissertations Archive

Many physiological parameters such as body temperature, circulating hormone levels, blood pressure and metabolic activity are rhythmic, and their rhythmicity is governed by the circadian clock. This is a self-sustained ̃24-hour cycle, which at the molecular level is determined by negative transcriptional and translational feedback loops controlled by the products of core clock genes. There are at least 10 core clock genes namely Bmal1, Bmal2, Clock, Npas2, Per1, Per2, Per3, Cry1, Cry2, Nr1d1 and Nr1d2. In addition to these core clock genes, clock modifier genes exist that modulate the molecular clock by integrating synchronous and asynchronous clues from signal transduction …

Artificial Neural Network And Finite Element Modeling Of Nanoindentation Tests On Silica, Kianoosh Koocheki

Department of Civil and Environmental Engineering: Dissertations, Theses, and Student Research

Two major forms of Silica include the crystalline form named Quartz which consist of the sand grains in nature, and amorphous form named Silica Glass or Fused Silica which is commonly known as glass. Fused Silica is an amorphous crystal that can show plastic behavior at micro-scale despite its brittle behavior in large scales. Due to the amorphous and ductile nature of Fused Silica, this behavior may not be explained well using the traditional dislocation-based mechanism of plasticity for crystalline solids. The crystal plasticity happens due to shear stress and stored energy in the material as dislocations which does not …

An Interdisciplinary Approach To Understanding Predator-Prey Relationships In A Changing Ocean: From System Design To Education, Ileana M. Freytes-Ortiz

USF Tampa Graduate Theses and Dissertations

Climate change is ecologically and socially complex, deemed the most important issue of our generation. Through this dissertation I have approached climate change research through an interdisciplinary perspective, investigating how this phenomenon will affect marine ecological systems, how we can better develop experimental systems to answer ecological questions, and how we can effectively educate about this issue.

In Chapter 2, I provided accessible alternatives for researching the effects of climate change (elevated temperatures and pCO2) on marine ecosystems. I designed, built, and troubleshooted two accurate and inexpensive climate-controlled experimental systems capable of maintaining target conditions: a temperature-controlled system and an …

Residual Effects Of Termiticides On Mortality Of Formosan Subterranean Termites, Coptotermes Formosanus Shiraki, In Substrates Subjected To Flooding, Rajani Sapkota

LSU Master's Theses

Formosan subterranean termites (Coptotermes formosanus Shiraki) are one of the most important economic insects in the Southern US since they cause severe and costly damage to properties. Soil treatment with termiticides is the most widely used and reliable method for termite prevention, but their efficacy after a home floods, an all too common event for a homeowner in recent years, has prompted many pest control companies to suggest a new treatment is necessary. This can be expensive and possibly unnecessary. However, several factors such as termiticide water solubility and binding properties, soil type and soil leachability and the inherent …

Groundwater And Thermal Legacy Of A Large Paleolake In Taylor Valley, East Antarctica As Evidenced By Airborne Electromagnetic And Sedimentological Techniques, Krista Falcon Myers

LSU Master's Theses

During the Last Glacial Maximum, grounded ice in the Ross Sea extended into the otherwise ice-free McMurdo Dry Valleys, creating a series of large ice dammed paleolakes. Grounded ice within the mouth of Taylor Valley allowed for lake levels to reach elevations not possible at modern day and formed what is known as Glacial Lake Washburn (GLW). GLW extended from the eastern portion of Taylor Valley roughly 20 km west to a level ~300 m higher than modern day Lake Fryxell. The formation and existence of GLW has been debated, though previous studies correlate the timing of GLW with early …

Curve Tracking Control Under State Constraints And Uncertainties, Robert Kelly Sizemore

LSU Doctoral Dissertations

We study a class of steering control problems for free-moving particles tracking a curve in the plane and also in a three-dimensional environment, which are central problems in robotics. In the two-dimensional case, we provide adaptive controllers for curve tracking under unknown curvatures and control uncertainty. The system dynamics include a nonlinear dependence on the curvature, and are coupled with an estimator for the unknown curvature to form the augmented error dynamics. This nonlinear dependence puts our curvature identification objective outside the scope of existing adaptive tracking and parameter identification results that were limited to cases where the unknown parameters …

Fern Genomes Elucidate Land Plant Evolution And Cyanobacterial Symbioses, Fay-Wei Li, Paul Brouwer, Lorenzo Carretero-Paulet, Shifeng Cheng, Jan De Vries, Pierre-Marc Delaux, Ariana Eily, Nils Koppers, Li-Yaung Kuo, Zheng Li, Mathew Simenc, Ian Small, Eric Wafula, Stephany Angarita, Michael S. Barker, Andrea Bräutigam, Claude Depamphilis, Sven Gould, Prashant S. Hosmani, Yao-Moan Huang, Bruno Huettel, Yoichiro Kato, Xin Liu, Steven Maere, Rose Mcdowell, Lukas A. Mueller, Klaas G. J. Nierop, Stefan A. Rensing, Tanner A. Robison, Carl J. Rothfels, Erin M. Sigel, Yue Song, Prakash R. Timilsena, Yves Van De Peer, Hongli Wang, Per K. I. Wilhelmsson, Paul G. Wolf, Xun Xu, Joshua P. Der, Henriette Schluepmann, Gane K.-S. Wong, Kathleen M. Pryer

Biology Faculty Publications

Ferns are the closest sister group to all seed plants, yet little is known about their genomes other than that they are generally colossal. Here, we report on the genomes of Azolla filiculoides and Salvinia cucullata (Salviniales) and present evidence for episodic whole-genome duplication in ferns—one at the base of ‘core leptosporangiates’ and one specific to Azolla. One fern-specific gene that we identified, recently shown to confer high insect resistance, seems to have been derived from bacteria through horizontal gene transfer. Azolla coexists in a unique symbiosis with N2-fixing cyanobacteria, and we demonstrate a clear pattern of cospeciation between …