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A Nearly Complete Foot From Dikika, Ethiopia And Its Implications For The Ontogeny And Function Of Australopithecus Afarensis, Jeremy Desilva, Corey M. Gill, Thomas C. Prang, Miriam A. Bredella, Zeresenay Alemseged

Dartmouth Scholarship

The functional and evolutionary implications of primitive retentions in early hominin feet have been under debate since the discovery of Australopithecus afarensis. Ontogeny can provide insight into adult phenotypes, but juvenile early hominin foot fossils are exceptionally rare. We analyze a nearly complete, 3.32-million-year-old juvenile foot of A. afarensis (DIK-1-1f). We show that juvenile A. afarensis individuals already had many of the bipedal features found in adult specimens. However, they also had medial cuneiform traits associated with increased hallucal mobility and a more gracile calcaneal tuber, which is unexpected on the basis of known adult morphologies. Selection for traits …

Periodic Catatonia Marked By Hypercortisolemia And Exacerbated By The Menses: A Case Report And Literature Review, Samantha Zwiebel, Alejandro G. Villasante Tezanos, Jose De Leon

Psychiatry Faculty Publications

Kahlbaum first described catatonia; later Kraepelin, Gjessing, and Leonhard each defined periodic catatonia differently. A 48-year-old female with catatonia, whose grandmother probably died from it, was prospectively followed for >4 years in a US psychiatric state hospital. Through 4 catatonic episodes (one lasting 17 months) there were menstrual exacerbations of catatonia and increases in 4 biological variables: (1) creatine kinase (CK) up to 4,920 U/L, (2) lactate dehydrogenase (LDH) up to 424 U/L, (3) late afternoon cortisol levels up to 28.0 mcg/dL, and (4) white blood cell (WBC) counts up to 24,200/mm³ with neutrophilia without infections. Records from 17 …

The Effects Of A Self-Regulated Learning Music Practice Strategy Curriculum On Music Performance, Self-Regulation, Self-Efficacy, And Cognition, Kimberly N. Mieder

USF Tampa Graduate Theses and Dissertations

The purpose of this study was to evaluate the effects of a Self-Regulated Learning Music Practice Strategies Curriculum (SRL-MPSC) on Self-Efficacy in music practice, Self-Regulation in music practice, Music Performance Achievement, Processing Speed, and Meta-Cognitive Awareness for high school instrumentalists. The goal of the fifteen-day music training using the SRL-MPSC, was to teach adolescents how to practice more effectively, think meta-cognitively and develop musical independence while enhancing self-efficacy, performance achievement, processing speed and meta-cognitive awareness. Results of this study suggest that a 15-day music training intervention using the Self-Regulated Learning Music Practice Strategies Curriculum, significantly enhanced participant’s Music Performance Achievement, …

Texas Sour Orange Juice Used In Scaffolds For Tissue Engineering, Mandana Akia, Nataly Salinas, Cristobal Rodriguez, Robert Gilkerson, Luis A. Materon, Karen Lozano

Mechanical Engineering Faculty Publications

Fine fibers of polyhydroxybutyrate (PHB), a biopolymer, were developed via a centrifugal spinning technique. The developed fibers have an average diameter of 1.8 µm. Texas sour orange juice (SOJ) was applied as a natural antibacterial agent and infiltrated within the fibrous membranes. The antibacterial activity against common Gram-positive and Gram-negative bacteria (Staphylococcus aureus and Escherichia coli, respectively) was evaluated as well as cell adhesion and viability. The PHB/SOJ scaffolds showed antibacterial activity of up to 152% and 71% against S. aureus and E. coli, respectively. The cell studies revealed a suitable environment for cell growth and cell attachment. The outcome …

The Effects Of E-Cigarette Vapor Exposure, And The Role Of A7 Nicotinic Acetylcholine Receptors And Micro-Rna, On The Regeneration Potential Of Periodontal Ligament Derived Stem Cells, Carlos Miguel Carballosa

Open Access Dissertations

The electronic cigarette (EC) has recently been deemed as a “safer alternative” to cigarette smoking; however, EC are still believed to cause major health concerns due to the concentrated delivery of toxic chemicals. ECs have not been fully regulated by the FDA and the long-term effects of EC vapor exposure have yet to be identified, yet according to the 2016 Surgeon General Report, EC use among young adults has grown by more than 900% within the last 5 years and is currently the most popular form of tobacco use among this group. The proposed research will investigate how EC use …

Gsu View, July 3, 2018, Office Of Marketing And Communications

GSU View

Professor of History Weighs In on Supreme Court Labor Union Decision (David Golland), Division of Student Affairs and Enrollment Management awards,

Advances In Aquatic Insect Systematics And Biodiversity In The Neotropics: Introduction, David E. Bowles, Gregory W. Courtney

College of Natural and Applied Sciences

The Neotropical Region or Neotropics, contains vast expanses of rain forest and river systems representing some of the most biologically diverse ecosystems on Earth, but much of its resident biota remains undescribed and undocumented, and some of it is at risk of extirpation and extinction. Anthropogenic disturbances, especially deforestation, urbanization, and climate change, threaten the integrity of the Neotropics and its biodiversity. In the Neotropics, freshwater habitats are particularly susceptible to environmental stressors and freshwater species throughout the Neotropics have experienced marked declines greater than those of other groups when compared to marine and terrestrial systems. Advances in taxonomic descriptions, …

Brief Of Amici Curiae Environmental Law Professors In Support Of Federal Respondents And Intervenor-Respondents, Weyerhaeuser Company V. United States Fish And Wildlife Service, No. 17-71 (U.S. July 3, 2018), Hope M. Babcock

U.S. Supreme Court Briefs

The Fifth Circuit correctly upheld the Secretary’s designation of the St. Tammany Parish tract (Unit 1) as critical habitat for the dusky gopher frog. To advance the ESA’s goals of species survival and recovery, Congress explicitly gave the Secretary broad discretion to designate as critical habitat areas that are unoccupied where the Secretary determines “that such areas are essential for the conservation” of the species. 16 U.S.C. § 1532(5)(A)(ii). The question whether designation of such habitat has the potential to serve the recovery goals for a particular species is a matter within the sound expertise of the Secretary.

Here, the …

Coupling Toxicokinetic–Toxicodynamic And Population Models For Assessing Aquatic Ecological Risks To Time-Varying Pesticide Exposures, Glen Thursby, Keith Sappington, Matthew Etterson

United States Environmental Protection Agency: Publications

Population modeling evaluations of pesticide exposure time series were compared with aspects of a currently used risk assessment process. The US Environmental Protection Agency’s Office of Pesticide Programs models daily aquatic 30-yr pesticide exposure distributions in its risk assessments, but does not routinely make full use of the information in such time series.We used mysid shrimp Americamysis bahia toxicity and demographic data to demonstrate the value of a toxicokinetic– toxicodynamic model coupled with a series of matrix population models in risk assessment refinements. This species is a small epibenthic marine crustacean routinely used in regulatory toxicity tests. We demonstrate how …

Application Of Fraser’S “Practical” Ethic In Veterinary Practice, And Its Compatibility With A “One Welfare” Framework, Anne Fawcett, Siobhan Mullan, Paul Mcgreevy

Professional Veterinary Ethics Collection

Ethically challenging situations are common in veterinary practice, and they may be a source of moral stress, which may in turn impact the welfare of veterinarians. Despite recognition of the importance of ethical reasoning, some veterinary students may struggle to apply theoretical ethical frameworks. Fraser developed a “practical” ethic consisting of four principles that can be applied to ethically challenging situations. We apply Fraser’s “practical” ethic to three cases that veterinarians may encounter: animal hoarding, animal neglect, and treatment of wildlife. We argue that Fraser’s “practical” ethic is consistent with a One Welfare framework, and may have increasing currency for …

Identification Of Novel Δnp63Α-Regulated Mirnas Using An Optimized Small Rna-Seq Analysis Pipeline, Suraj Sakaram, Michael P. Craig, Natasha T. Hill, Amjad Aljiagthmi, Christian Garrido, Oleg Paliy, Michael Bottomley, Michael L. Raymer, Madhavi Kadakia

Biochemistry and Molecular Biology Faculty Publications

Advances in high-throughput sequencing have enabled profiling of microRNAs (miRNAs), however, a consensus pipeline for sequencing of small RNAs has not been established. We built and optimized an analysis pipeline using Partek Flow, circumventing the need for analyzing data via scripting languages. Our analysis assessed the effect of alignment reference, normalization method, and statistical model choice on biological data. The pipeline was evaluated using sequencing data from HaCaT cells transfected with either a non-silencing control or siRNA against ΔNp63α, a p53 family member protein which is highly expressed in non-melanoma skin cancer and shown to regulate a number of miRNAs. …

High-And Low-Temperature Pyrolysis Profiles Describe Volatile Organic Compound Emissions From Western Us Wildfire Fuels, Kanako Sekimoto, Abigail R. Koss, Jessica B. Gilman, Vanessa Selimovic, Matthew M. Coggon, Kyle J. Zarzana, Bin Yuan, Brian M. Lerner, Steven S. Brown, Carsten Warneke, Robert J. Yokelson, James M. Roberts, Joost De Gouw

Chemistry and Biochemistry Faculty Publications

Biomass burning is a large source of volatile organic compounds (VOCs) and many other trace species to the atmosphere, which can act as precursors to secondary pollutants such as ozone and fine particles. Measurements performed with a proton-transfer-reaction time-of-flight mass spectrometer during the FIREX 2016 laboratory intensive were analyzed with positive matrix factorization (PMF), in order to understand the instantaneous variability in VOC emissions from biomass burning, and to simplify the description of these types of emissions. Despite the complexity and variability of emissions, we found that a solution including just two emission profiles, which are mass spectral representations of …

Genetic And Developmental Origins Of A Unique Foraging Adaptation In A Lake Malawi Cichlid Genus, Moira R. Conith, Yinan Hu, Andrew J. Conith, Maura A. Maginnis, Jacqueline F. Webb, R. Craig Albertson

Biological Sciences Faculty Publications

Phenotypic novelties are an important but poorly understood category of morphological diversity. They can provide insights into the origins of phenotypic variation, but we know relatively little about their genetic origins. Cichlid fishes display remarkable diversity in craniofacial anatomy, including several novelties. One aspect of this variation is a conspicuous, exaggerated snout that has evolved in a single Malawi cichlid lineage and is associated with foraging specialization and increased ecological success. We examined the developmental and genetic origins for this phenotype and found that the snout is composed of two hypertrophied tissues: the intermaxillary ligament (IML), which connects the right …

Identification Of Erosional Terraces On Seamounts: Implications For Interisland Connectivity And Subsidence In The Galápagos Archipelago, Darin M. Schwartz, S. Adam Soule, V. Dorsey Wanless, Meghan R. Jones

Geosciences Faculty Publications and Presentations

Shallow seamounts at ocean island hotspots and in other settings may record emergence histories in the form of submarine erosional terraces. Exposure histories are valuable for constraining paleo-elevations and sea levels in the absence of more traditional markers, such as drowned coral reefs. However, similar features can also be produced through primary volcanic processes, which complicate the use of terraced seamounts as an indicator of paleo-shorelines. In the western Galápagos Archipelago, we utilize newly collected bathymetry along with seafloor observations from human-occupied submersibles to document the location and depth of erosional terraces on seamounts near the islands of Santiago, Santa …

The Influence Of Pressure On Crude Oil Biodegradation In Shallow And Deep Gulf Of Mexico Sediments, Uyen T. Nguyen, Sara A. Lincoln, Ana Gabriela Valladares Juárez, Martina Schedler, Jennifer L. Macalady, Rudolf Müller, Katherine H. Freeman

C-IMAGE Publications

A significant portion of oil released during the Deepwater Horizon disaster reached the Gulf of Mexico (GOM) seafloor. Predicting the long-term fate of this oil is hindered by a lack of data about the combined influences of pressure, temperature, and sediment composition on microbial hydrocarbon remineralization in deep-sea sediments. To investigate crude oil biodegradation by native GOM microbial communities, we incubated core-top sediments from 13 GOM sites at water depths from 60–1500 m with crude oil under simulated aerobic seafloor conditions. Biodegradation occurred in all samples and followed a predictable compound class sequence dictated by molecular weight and structure. 45 …

Hyperpolarization By Activation Of Halorhodopsin Results In Enhanced Synaptic Transmission: Neuromuscular Junction And Cns Circuit, Matthew Mattingly, Kristin Weineck, Jennifer Costa, Robin L. Cooper

Biology Faculty Publications

Optogenetics offers a unique method to regulate the activity of select neural circuits. However, the electrophysiological consequences of targeted optogenetic manipulation upon the entire circuit remain poorly understood. Analysis of the sensory-CNS-motor circuit in Drosophila larvae expressing eHpHR and ChR2-XXL revealed unexpected patterns of excitability. Optical stimulation of motor neurons targeted to express eNpHR resulted in inhibition followed by excitation of body wall contraction with repetitive stimulation in intact larvae. In situ preparations with direct electrophysiological measures showed an increased responsiveness to excitatory synaptic activity induced by sensory stimulation within a functional neural circuit. To ensure proper function of eNpHR …

A Bayesian Phase I/Ii Trial Design For Immunotherapy, Suyu Liu, Beibei Guo, Ying Yuan

Faculty Publications

Immunotherapy is an innovative treatment approach that stimulates a patient’s immune system to fight cancer. It demonstrates characteristics distinct from conventional chemotherapy and stands to revolutionize cancer treatment. We propose a Bayesian phase I/II dose-finding design that incorporates the unique features of immunotherapy by simultaneously considering three outcomes: immune response, toxicity, and efficacy. The objective is to identify the biologically optimal dose, defined as the dose with the highest desirability in the risk–benefit tradeoff. An Emax model is utilized to describe the marginal distribution of the immune response. Conditional on the immune response, we jointly model toxicity and efficacy using …

Elnec Core Module 1: Palliative Nursing Care, Betty Rolling Ferrell, Pamela Malloy, Polly M. Mazanec, Judith Ann Paice, Patrick Coyne

General Submissions: Presentations (Oral and Poster)

Describe the role of the nurse in providing quality palliative care for patients across the lifespan. Identify the need for collaborating with interdisciplinary team members while implementing the nursing role in palliative care. Recognize changes in population demographics, healthcare economics, and service delivery that necessitate improved professional preparation for palliative care. Describe the philosophy and principles of hospice and palliative care that can be integrated across settings to affect quality care at the end of life. Discuss aspects of assembling physiological, psychological, spiritual, and social domains of quality of life for patients and families facing a life‐threatening illness or event.

Factors Related To Hearing Aid Use Among Older Adults From Hispanic/Latino Backgrounds: Findings From The Hispanic Community Health Study/Study Of Latinos, Michelle L. Arnold

USF Tampa Graduate Theses and Dissertations

The purpose of this dissertation was to understand perceived hearing loss and hearing health care use among older adults from Hispanic/Latino backgrounds using the Andersen model of health care utilization as a framework. A cross sectional analysis of audiometric and survey data from the Hispanic Community Health Study/Study of Latinos was used to estimate factors that characterize perceived hearing handicap and hearing aid use, and to determine hearing aid use rates in a large group of older Hispanic/Latino adults. Data came from 6970 adults aged 45 to 76. Results revealed that self-perceived hearing handicap is significantly correlated to measured hearing …

Newsroom, Georgia Southern University

Newsroom (2006-2023)

• Carl L. Reiber, Ph.D., begins role as Georgia Southern's new provost and vice president for Academic Affairs

Lacustrine Spawning By Mountain Suckers (Catostomus Platyrhynchus) On Boulder Mountain, Utah, Martin C. Arostegui

Western North American Naturalist

Facultative spawning in lakes is an uncommon and notable behavior among catostomids and other fish species that typically spawn in streams. I describe what may be the first documented case of lake-spawning behavior by mountain suckers (Catostomus platyrhynchus).


El desove facultativo en los lagos es un comportamiento poco común y notable entre los catostomidos y otras especies de peces que típicamente desovan en los arroyos. Describo cuál puede ser el primer caso documentado del comportamiento de desove en un lago por los matalotes del montaña (Catostomus platyrhynchus).

New Records Of Tricolored Bats (Perimyotis Subflavus) In Colorado, With First Evidence Of Reproduction, Rick A. Adams, Burton Stoner, Donna Nespoli, Sarah M. Bexell

Western North American Naturalist

The tricolored bat (Perimyotis subflavus) is widely distributed throughout eastern North America. However, this species has also undergone severe population declines in areas where white-nose syndrome has taken hold. Previous records in Colorado showed what appeared to be vagrant individuals with no evidence of established populations. Herein we provide new records for Boulder and Weld Counties, Colorado. We also provide evidence of reproduction supporting the hypothesis of westward expansion of this species. Because the tricolored bat has been significantly impacted by white-nose syndrome in eastern North America, the Rocky Mountain West may provide at least a temporary refugium …

Analysis-Suitable Geometry From Discrete Point Sets Using A Mesh-Free Method, Daniel Craig Simkins, Jr., Joseph Bradley Alford

USF Patents

The present invention includes a method of creating analysis suitable models from discrete point sets. The proposed methodology is completely automated, requiring no human intervention, as compared to traditional mesh-based methods that often require manual input. The present invention is directly applicable to engineering approaches in medicine where the object to be analyzed is described by discrete medical images, such as MM or CT scans. Moreover, the present invention is useful in any application where the object of interest is created from digitized imaging technology.

Antibiotic Compositions And Methods Of Use, Edward Turos, Biplob Bhattacharya

USF Patents

Embodiments of the present disclosure provide for compositions including an antibiotic containing a N-thiolated beta-lactam moiety, pharmaceutical compositions including the antibiotic, methods of treatment of a condition (e.g., bacterial infection), methods of treatment using compositions or pharmaceutical compositions, and the like.

Consensus On Molecular Subtypes Of High-Grade Serous Ovarian Carcinoma, Gregory M. Chen, Lavanya Kannan, Ludwig Geistlinger, Victor Kofia, Zhaleh Safikhani, Deena Ma Gendoo, Giovanni Parmigiani, Michael Birrar, Benjamin Haibe-Kains, Levi Waldron

Publications and Research

Purpose: The majority of ovarian carcinomas are of high-grade serous histology, which is associated with poor prognosis. Surgery and chemotherapy are the mainstay of treatment, and molecular characterization is necessary to lead the way to targeted therapeutic options. To this end, various computational methods for gene expression-based subtyping of high-grade serous ovarian carcinoma (HGSOC) have been proposed, but their overlap and robustness remain unknown.

Experimental Design: We assess three major subtype classifiers by meta-analysis of publicly available expression data, and assess statistical criteria of subtype robustness and classifier concordance. We develop a consensus classifier that represents the subtype classifications of …

Global Phosphoproteomics Of Ccr5-Tropic Hiv-1 Signaling Reveals Reprogramming Of Cellular Protein Production Pathways And Identifies P70-S6k1 And Mk2 As Hiv-Responsive Kinases Required For Optimal Infection Of Cd4+ T Cells, Danica D. Wiredja, Caroline O. Tabler, Daniela M. Schlatzer, Ming Li, Mark R. Chance, John C. Tilton

Faculty Scholarship

Background: Viral reprogramming of host cells enhances replication and is initiated by viral interaction with the cell surface. Upon human immunodeficiency virus (HIV) binding to CD4+ T cells, a signal transduction cascade is initiated that reorganizes the actin cytoskeleton, activates transcription factors, and alters mRNA splicing pathways. Methods: We used a quantitative mass spectrometry-based phosphoproteomic approach to investigate signal transduction cascades initiated by CCR5-tropic HIV, which accounts for virtually all transmitted viruses and the vast majority of viruses worldwide. Results: CCR5-HIV signaling induced significant reprogramming of the actin cytoskeleton and mRNA splicing pathways, as previously described. In addition, CCR5-HIV signaling …

Diversity Of Warning Signal And Social Interaction Influences The Evolution Of Imperfect Mimicry, Renan Bosque, J. P. Lawrence, Richard Buchholz, Guarino Rinaldi Colli, Jessica M. Heppard, Brice P. Noonan

Faculty and Student Publications (Open Access)

No abstract provided.

Spatial And Temporal Distributions Of Pelagic Sargassum In The Intra-Americas Sea And Atlantic Ocean, Mengqiu Wang

USF Tampa Graduate Theses and Dissertations

Pelagic Sargassum is one type of marine macroalgae that is known to be abundant in the Gulf of Mexico and Sargasso Sea. It is also known to serve as a critical habitat for many marine animals. In the past few years, large amounts of Sargassum have been reported in the Tropical Atlantic and Caribbean Sea (CS), causing significant environmental and economic problems. The goal of this study is to improve the understanding of Sargassum distributions, quantity, transport pathways, and bloom mechanisms in the CS and Tropic Atlantic through combining a variety of techniques including satellite remote sensing, field and laboratory …

Future Ozone-Related Acute Excess Mortality Under Climate And Population Change Scenarios In China: A Modeling Study, Kai Chen, Arlene M. Fiore, Renjie Chen, Leiwen Jiang, Bryan Jones, Alexandra Schneider, Annette Peters, Jun Bi, Haidong Kan, Patrick L. Kinney

Publications and Research

Background Climate change is likely to further worsen ozone pollution in already heavily polluted areas, leading to increased ozone-related health burdens. However, little evidence exists in China, the world's largest greenhouse gas emitter and most populated country. As China is embracing an aging population with changing population size and falling age-standardized mortality rates, the potential impact of population change on ozone-related health burdens is unclear. Moreover, little is known about the seasonal variation of ozone-related health burdens under climate change. We aimed to assess near-term (mid-21st century) future annual and seasonal excess mortality from short-term exposure to ambient ozone in …

Viral Entry Properties Required For Fitness In Humans Are Lost Through Rapid Genomic Change During Viral Isolation, Sho Iketani, Ryan C. Shean, Marion Ferren, Negar Makhsous, Dolly B. Aquino, Amedee Des Georges, Bert Rima, Cyrille Mathieu, Matteo Porotto, Anne Moscona, Alexander L. Greninger

Advanced Science Research Center

Human parainfluenza viruses cause a large burden of human respiratory illness. While much research relies upon viruses grown in cultured immortalized cells, human parainfluenza virus 3 (HPIV-3) evolves in culture. Cultured viruses differ in their properties compared to clinical strains. We present a genome-wide survey of HPIV-3 adaptations to culture using metagenomic next-generation sequencing of matched pairs of clinical samples and primary culture isolates (zero passage virus). Nonsynonymous changes arose during primary viral isolation, almost entirely in the genes encoding the two surface glycoproteins—the receptor binding protein hemagglutinin-neuraminidase (HN) or the fusion protein (F). We recovered genomes from 95 HPIV-3 …