Digital Commons Network^™

Profile Of Medical Care Costs In Patients With Amyotrophic Lateral Sclerosis In The Medicare Programme And Under Commercial Insurance, Lisa Meng, Amy Bian, Scott Jordan, Andrew Wolff, Jeremy M. Shefner, Jinsy Andrews

Neurology

Objective: To determine amyotrophic lateral sclerosis (ALS)-associated costs incurred by patients covered by Medicare and/or commercial insurance before, during and after diagnosis and provide cost details. Methods: Costs were calculated from the Medicare Standard Analytical File 5% sample claims data from Parts A and B from 2009, 2010 and 2011 for ALS Medicare patients aged ‰¥70 years (monthly costs) and ‰¥65 years (costs associated with disability milestones). Commercial insurance patients aged 18€“63 years were selected based on the data provided in the Coordination of Benefits field from Truven MarketScan® in 2008€“2010. Results: Monthly costs increased nine months before diagnosis, peaked …

Vitality-Als A Phase Iii Trial Of Tirasemtiv A Selective Fast Skeletal Muscle Troponin Activator As A Potential Treatment For Patients With Amyotrophic Lateral Sclerosis: Study Design And Baseline Characteristics, Jinsy A. Andrews, Merit E. Cudkowicz, Orla Hardiman, Lisa Meng, Amy Bian, Jacqueline Lee, Andrew A. Wolff, Fady I. Malik, Jeremy M. Shefner

Neurology

Objective: To assess the efficacy of tirasemtiv, a fast skeletal muscle troponin activator, vs. placebo on respiratory function and other functional measures in patients with amyotrophic lateral sclerosis (ALS). This study was designed to confirm and extend results from a large phase IIb trial and maximize tolerability with a slower dose escalation. Methods: VITALITY-ALS (NCT02496767) was a multinational, double-blind, randomized, placebo-controlled, parallel-group study in ALS patients. Participants who tolerated two weeks of open-label tirasemtiv (125 mg twice a day) were randomized 3:2:2:2 to placebo or one of three target total daily dose levels of tirasemtiv (250, 375, or 500 mg). …

Undergraduate Brochure 2018-2019, Southern Adventist University

Brochures & Flyers

Southern Adventist University's 2018-1019 undergraduate brochure.

Southern Adventist University Graduate Catalog 2018-2019, Southern Adventist University

Catalog, Graduate

Southern Adventist University's graduate catalog for the academic year 2018-2019.

Consideration For Care For Your Patient With Cerebral Palsy, Katlin R. Cannon, Melissa Stowe, Brooke Ryan

Dental Hygiene Student Scholarship

Cerebral palsy (CP) is a common developmental neurological disorder affecting about 2-3 children out of 1,000. CP is the result of infant brain damage or abnormal development resulting in impaired muscle control, coordination, tone, reflex, posture, and balance. These patients are unable to control motor movements of their muscles of mastication and facial expression, causing excessive drooling, clenching, bruxism, and other oral health-related issues. This lack of motor control affects their ability to swallow and often limits these patients to a liquid diet. This can lead to vitamin deficiencies and result in further developmental problems. As an example, a deficiency …

Got Caries? Breast Milk And Early Childhood Caries?, Megan L. Dean, Rebecca Fields, Hannah Fritz

Dental Hygiene Student Scholarship

Objective: To provide an analysis of the association between the longevity of breastfeeding and development of ECC. Determine the optimal time frame in which mothers should cease breastfeeding to reduce ECC development. Methods: Dr. Brickhouse, PubMed, Google Scholar and other scholarly databases were utilized to find current scientific evidence on the effects of breast milk on ECC. Relevant articles were summarized to write a review of literature. 16 articles published from 2015 to the present date were reviewed and cited. Results: From the studies, there is strong evidence to support breastfeeding beyond 12 months of age increases the prevalence …

An Overview Of Perinatal Health And Childhood Development In Honduras, Rose Margaret Carlson, Abigail D. Conrad, Alexandra Nicole Lothe, Caitlin M. O'Donnell, Cameron Svihla

All Electronic Theses and Dissertations

Honduras is a country with great healthcare needs. Within health care, the largest percentage of mortality is due to conditions occurring in the perinatal period, including prenatal and maternal health, delivery and postnatal care (PAHO, 2017a). Additionally, malnutrition continues to affect infants as they growth throughout their childhood (Gray, Cossman, & Powers, 2006). Education is shown to produce positive outcomes in low-income populations (Perkins, et al, 2011). The purpose of this project was to identify Honduran healthcare needs and provide effective and sustainable intervention. A needs assessment with a Honduran-Canadian health organization reiterated evidence found in the literature, illustrating the …

The Antioxidant Potential Of The Mediterranean Diet In Patients At High Cardiovascular Risk: An In-Depth Review Of The Predimed, Hayley E. Billingsley, Salvatore Carbone

Kinesiology and Health Sciences Publications

Cardiovascular disease (CVD) is the leading global cause of death. Diet is known to be important in the prevention of CVD. The PREDIMED trial tested a relatively low-fat diet versus a high-fat Mediterranean diet (MedDiet) for the primary prevention of CVD. The resulting reduction of the CV composite outcome resulted in a paradigm shift in CV nutrition. Though many dietary factors likely contributed to this effect, this review focuses on the influence of the MedDiet on endogenous antioxidant systems and the effect of dietary polyphenols. Subgroup analysis of the PREDIMED trial revealed increased endogenous antioxidant and decreased pro-oxidant activity in …

Characterizing Glucose Metabolism And Insulin Resistance In Adult Lew.1wr1. Rats, Sharifa T. Love-Rutledge

Summer Community of Scholars (RCEU and HCR) Project Proposals

No abstract provided.

An Examination Of A Mindfulness-Based Intervention For Older Adults, Morgan Levy

Theses and Dissertations

Mindfulness-based interventions use meditation and other learning exercises to help individuals become more aware of their current physiological and emotional experiences. Benefits of practicing mindfulness include an increase in positive psychological outcomes (e.g., psychological well-being, emotion regulation) and a decrease in negative psychological outcomes (e.g., anxiety, depression). The vast majority of studies focus on younger rather than older adults—setting the stage for the current study, which involved delivering a five-session mindfulness-based intervention to older adults (i.e., 60 and older). The smaller literature focused on older adults is promising but generally lacks methodological rigor (e.g., lack of no-treatment control groups). The …

Intensive Archeological Survey Of The Willrae Tract City Of Florence, Williamson County, Texas, Caitlin Gulihur, Beth Valenzuela, Ann M. Scott

Index of Texas Archaeology: Open Access Gray Literature from the Lone Star State

Georgetown Independent School District (GISD) has proposed the Willrae Tract project where school facilities will be constructed south of Florence, Williamson County, Texas. GISD retained Terracon Consultants, Inc. to conduct a systematic, intensive pedestrian survey of the approximate 100-acre project area. Because GISD, a political subdivision of the State of Texas, sponsored the project, the proposed undertaking is subject to compliance with the Antiquities Code of Texas and oversight from the Texas Historical Commission. In addition, the survey meets the standards for compliance under Section 106 of the National Historic Preservation Act of 1966, as amended, should a US Army …

Archaeological Investigations For The Proposed Mission County Park Tree Planting Project, San Antonio, Bexar County, Texas, Antonio E. Padilla

Index of Texas Archaeology: Open Access Gray Literature from the Lone Star State

Raba Kistner Environmental, Inc. (RKEI), was contracted by the Bexar Heritage Program (CLIENT) to conduct archaeological investigations of two areas of Mission County Park in anticipation of the planting of 22 trees. The Mission County Park Tree Planting Project will be funded and managed by Bexar County, an entity of the State of Texas. As such, the project falls under the jurisdiction of Chapter 35 of the City of San Antonio Unified Development Code, as well as the Antiquities Code of Texas (Texas Natural Resource Code, Title 9, Chapter 191), by virtue of it representing a public undertaking.

The investigations …

18 Annual Report, Tennessee. Department Of Human Services

Annual Reports

This annual report highlights the accomplishments of the Department of Human Services for the fiscal year.

Ethnohistoric Records Of Hunter-Gatherer Diet Of The Texas/Mexico Borderlands: Implications For Staple Foods Of The Lower Pecos Canyonlands During The Holocene, Tim Riley

Index of Texas Archaeology: Open Access Gray Literature from the Lone Star State

Hinds Cave (41VV456) and other rockshelters excavated in the Lower Pecos Canyonlands have yielded thousands of coprolites spanning the Holocene. To date, several hundred specimens have been analyzed, providing a detailed record of meals consumed by hunter-gatherers who called this landscape home. This article compares the paleodietary records derived from these specimens with the foodways documented in the ethnohistoric records available for the Lower Pecos Canyonlands and adjacent landscapes. This comparison confirms the deep temporal roots of the foodways recorded in the earliest written records of the Texas/Mexico borderlands. Coprolite data corroborate the strong dependence on the seasonal staples of …

Forgotten Soldiers: Burials On The Texas Frontier And Shifting Perceptions Of Military Interment, Anthony Schienschang Ii

Index of Texas Archaeology: Open Access Gray Literature from the Lone Star State

This research examines the interrelation between civilian and military burials on the Texas frontier in the 1850s with further discussion about the drivers for changing military burial practices. A soldier’s life on the Texas frontier is briefly outlined along with some of the difficulties facing service members living in border forts. Special focus is placed on examining the socio-economic differences between officers and enlisted personnel, as well as the recording of deaths on the frontier. As a case study, the condition of the proposed location of the Fort Gates cemetery is explored and brief analysis of data gathered from the …

Nebraska Invasive Plants Field Guide, Nebraska Invasive Species Program

Nebraska Invasive Species Program

Invasive species are plants, animals or pathogens that are non-native to an ecosystem. They cause harm to the economy, environment or human health. They negatively affect native species and ecosystems and interfere with outdoor recreation opportunities. This guide identifies federal and state-listed noxious weeds. Federal noxious weeds are regulated by the U.S. Department of Agriculture; State noxious weeds are regulated by the Nebraska Department of Agriculture, Animal and Plant Health Protection, Noxious Weed Program. Aquatic invasive species are listed and regulated by Nebraska Game and Parks Commission.

ABSINTH WORMWOOD • AMUR HONEYSUCKLE • AUTUMN OLIVE • BRITTLE NAIAD • CALLERY …

Lehigh Valley Hospital: Statistical Report 2018, Lehigh Valley Health Network

Lehigh Valley Topper Cancer Institute

No abstract provided.

Health In All Policies: Working Across Sectors In Cooperative Extension To Promote Health For All, Michele Walsh, Deborah John, Nicole Peritore, Andrea Morris, Carolyn Bird, Marion Ceraso, Sarah Eichberger, Rachel Novotny, Laura Stephenson, Suzanne Stluka, Roberta Riportella

Health and Nutritional Sciences Faculty Publications

A Health in All Policies approach engages cross-sector stakeholders to collaboratively improve systems that drive population health. We, the members of the Extension Committee on Organization and Policy (ECOP)’s Health in All Policies Action Team, propose that adopting a Health in All Policies approach within the national Cooperative Extension System will better prepare us to contribute meaningfully to improving the nation’s health. We first explain the Health in All Policies approach and argue for why and how it is relevant for Extension. We then present insights gathered from Extension Family and Consumer Sciences program leaders and state specialists to assess …

Thomas A. Daschle Papers: U.S. Senate Papers, Sdsu Archives And Special Collections, Hilton M. Briggs Library

Thomas A. Daschle Papers

Composed of records created by Tom Daschle and his staff during his tenure in the U.S. Senate. Included are trip schedules, speeches, sponsored and cosponsored legislation, and administrative files including financial disclosures, appointments and schedules. This series does not contain much material related to Daschle's campaigns for voting records during this time. Also included are files on the Whitewater issue during the Clinton administration, veterans’ issues, Ellsworth Air Force Base, South Dakota Water Projects, the accident of South Dakota Governor Mickelson, and aviation issues.

Serving Fruits And Vegetables In Kid-Friendly Shapes Increased Fruit And Vegetable Consumption In Preschool Children Aged 2-5 Years, Sarah Millard, Sara Stevenson, Magda Cojocaru

Research Reports - Nutrition & Dietetics

Background. With childhood obesity rising, and taste preferences being influenced at an early age, it’s more important now than ever to encourage children to eat right.

Objective. To find whether shaping fruits and vegetables (F&Vs) into kid-friendly designs would increase consumption in preschool aged children.

Design. The four week long observational study took place at Loma Linda Children Academy in two stages during their normal lunch time hour. Baseline data was recorded during the first two weeks, and a month later intervention data was collected during the last two weeks. The menus served remained exactly the same except for the …

The Effects Of Daily Ginger Tea Consumption In Reducing Period Discomfort, Sherllie Kartika, Kristy Valencia

Research Reports - Nutrition & Dietetics

Background

For many years ginger has been known for its medicinal purposes and has been used as an herbal supplement to treat inflammation.⁶ Several studies have observed the effects of ginger supplementation in a capsulated form to alleviate the severity of dysmenorrhea, but very few studies have investigated the use of ginger tea.^6,7,9,10,11 Amutha and Kavuluru studied the effects of ginger tea on adolescent females and concluded that ginger has a positive effect in reducing menstrual discomfort.^1,2

Objective

The purpose of our graduate student research study is to observe the effects of daily ginger tea consumption in …

Oral Curcumin For Radiation Dermatitis: A Urcc Ncorp Study Of 686 Breast Cancer Patients, J. R. Wolf, C. E. Heckler, J. J. Guido, A. R. Peoples, J. S. Gewandter, M. Ling, V. P. Vinciguerra, T. Anderson, L. Evans, G. R. Morrow, +2 Additional Authors

Journal Articles

No abstract provided.

Hemoglobin Response To Ferric Citrate In Patients With Nondialysis-Dependent Chronic Kidney Disease And Iron Deficiency Anemia, P. E. Pergola, S. Fishbane, R. D. Lewinter, J. F. Neylan, K. Uhlig, G. A. Block, G. M. Chertow

Journal Articles

No abstract provided.

Practice Patterns In Transitioning Patients From Chronic Kidney Disease To Dialysis: A Survey Of United States Nephrologists, M. C. Mallappallil, S. Fishbane, R. Wanchoo, E. Lerma, A. Roche-Recinos, M. Salifu

Journal Articles

No abstract provided.

Development And Validation Of A Scoring System To Predict Outcomes Of Vedolizumab Treatment In Patients With Crohn's Disease, P. S. Dulai, B. S. Boland, S. Singh, K. Chaudrey, J. L. Koliani-Pace, G. Kochhar, M. P. Parikh, K. Sultan, A. Swaminath, C. Cao, +26 Additional Authors

Journal Articles

No abstract provided.

Baseline Characteristics Of The Vitamin D And Type 2 Diabetes (D2d) Study: A Contemporary Prediabetes Cohort That Will Inform Diabetes Prevention Efforts, E. S. Leblanc, R. E. Pratley, B. Dawson-Hughes, M. A. Staten, P. R. Sheehan, M. R. Lewis, A. Peters, S. H. Kim, E. P. Liao, A. G. Pittas, +16 Additional Authors

Journal Articles

© 2018 by the American Diabetes Association. OBJECTIVE: To describe baseline characteristics of the Vitamin D and Type 2 Diabetes (D2d) study, the first large U.S. diabetes prevention clinical trial to apply current American Diabetes Association (ADA) criteria for prediabetes.RESEARCH DESIGN AND METHODS: This is a multicenter (n = 22 sites), randomized, double-blind, placebo-controlled, primary prevention clinical trial testing effects of oral daily 4,000 IU cholecalciferol (D3) compared with placebo on incident diabetes in U.S. adults at risk for diabetes. Eligible participants were at risk for diabetes, defined as not meeting criteria for diabetes but meeting at least two 2010 …

Somatic Mutations And Clonal Hematopoiesis In Congenital Neutropenia, J. Xia, C. A. Miller, J. Baty, A. Ramesh, M. R. Jotte, R. S. Fulton, T. P. Vogel, M. A. Cooper, A. Vlachos, D. C. Link, +11 Additional Authors

Journal Articles

© 2018 by The American Society of Hematology. Severe congenital neutropenia (SCN) and Shwachman-Diamond syndrome (SDS) are congenital neutropenia syndromes with a high rate of leukemic transformation. Hematopoietic stressors may contribute to leukemic transformation by increasing the mutation rate in hematopoietic stem/progenitor cells (HSPCs) and/or by promoting clonal hematopoiesis. We sequenced the exome of individual hematopoietic colonies derived from 13 patients with congenital neutropenia to measure total mutation burden and performed error-corrected sequencing on a panel of 46 genes on 80 patients with congenital neutropenia to assess for clonal hematopoiesis. An average of 3.6 ± 1.2 somatic mutations per exome …

Long Ncrna Landscape In The Ileum Of Treatment-Naive Early-Onset Crohn Disease., Y. Haberman, M. Benshoshan, A. Di Segni, P. J. Dexheimer, T. Braun, B. Weiss, T. D. Walters, R. N. Baldassano, J. Markowitz, L. A. Denson, +27 Additional Authors

Journal Articles

Long noncoding RNAs (lncRNA) are key regulators of gene transcription and many show tissue-specific expression. We previously defined a novel inflammatory and metabolic ileal gene signature in treatment-naive pediatric Crohn disease (CD). We now extend our analyses to include potential regulatory lncRNA.Using RNAseq, we systematically profiled lncRNAs and protein-coding gene expression in 177 ileal biopsies. Co-expression analysis was used to identify functions and tissue-specific expression. RNA in situ hybridization was used to validate expression. Real-time polymerase chain reaction was used to test lncRNA regulation by IL-1β in Caco-2 enterocytes.We characterize widespread dysregulation of 459 lncRNAs in the ileum of CD …

Effects Of Soybean Lipid Infusion On Triglyceride And Unbound Free Fatty Acid Levels In Preterm Infants, T. Hegyi, A. Kleinfeld, A. Huber, B. Weinberger, N. Memon, W. Joe Shih, M. Carayannopoulos, W. Oh

Journal Articles

© 2018 Informa UK Limited, trading as Taylor & Francis Group Objective: To determine the plasma triglyceride (TG) and unbound free fatty acid (FFAu) levels in infants treated with increasing dosages of soybean lipid, intralipid (IL), infusion. Study design: TG and FFAu levels were measured in 78 preterm infants (BW 500–2000 g; GA 23–34 weeks) using the fluorescent probe ADIFAB2 and enzymatic method. Results: The infants’ BW was 1266.2 ± 440.7 g and GA 28.8 ± 3.1 weeks. TG levels were 77.4 ± 50 mg/dL, 140.2 ± 188 mg/dL (p < .04 compared to levels during low dose IL infusion) and 135.6 ± 118 mg/dL (p < .004), respectively during increased IL rates. FFAu levels were 17.7 ± 13 nM, 47.3 ± 102.8 nM (p = .07) and 98 ± 234 nM (p = .03). TG levels correlated with IL dose, the rate of IL administration, and FFAu levels. TG and FFAu levels were higher in infants below 28 weeks’ gestation Conclusions: Increasing dosage of IL is associated with increasing levels of TG and FFAu, especially in infants below 29 weeks of gestation. The increased level of FFAu suggests inefficient cellular utilization.

Free And Bioavailable 25-Hydroxyvitamin D Concentrations Are Associated With Disease Activity In Pediatric Patients With Newly Diagnosed Treatment Naive Ulcerative Colitis, C. G. Sauer, M. S. Loop, S. Venkateswaran, V. Tangpricha, T. R. Ziegler, A. Dhawan, C. Mccall, E. Bonkowski, J. Markowitz, L. A. Denson, +16 Additional Authors

Journal Articles

© 2018 Crohn's & Colitis Foundation. Published by Oxford University Press. All rights reserved. Background Vitamin D regulates intestinal epithelial and immune functions, and vitamin D receptor deficiency increases the severity of murine colitis. Bioavailable 25-hydroxyvitamin D (25(OH)D) is available to target tissues and may be a driver of immune function. The aim is to evaluate the relationship of bioavailable 25(OH)D to the clinical expression of treatment naive pediatric ulcerative colitis (UC). Methods The PROTECT (Predicting Response to Standardized Pediatric Colitis Therapy) study enrolled children ≤17 years newly diagnosed with UC. Free and total 25(OH)D were directly measured and 25(OH)D …