Digital Commons Network^™

Microbiota-Sensitive Epigenetic Signature Predicts Inflammation In Crohn's Disease., D. Kelly, M. Kotliar, V. Woo, S. Jagannathan, J. Whitt, J. Moncivaiz, B. J. Aronow, M. C. Dubinsky, J. F. Markowitz, T. Alenghat, +12 Additional Authors

Journal Articles

Altered response to the intestinal microbiota strongly associates with inflammatory bowel disease (IBD); however, how commensal microbial cues are integrated by the host during the pathogenesis of IBD is not understood. Epigenetics represents a potential mechanism that could enable intestinal microbes to modulate transcriptional output during the development of IBD. Here, we reveal a histone methylation signature of intestinal epithelial cells isolated from the terminal ilea of newly diagnosed pediatric IBD patients. Genes characterized by significant alterations in histone H3-lysine 4 trimethylation (H3K4me3) showed differential enrichment in pathways involving immunoregulation, cell survival and signaling, and metabolism. Interestingly, a large subset …

Realizing Effectiveness Across Continents With Hydroxyurea: Enrollment And Baseline Characteristics Of The Multicenter Reach Study In Sub-Saharan Africa., P. T. Mcgann, T. N. Williams, P. Olupot-Olupot, G. A. Tomlinson, A. Lane, J. Luís Reis Da Fonseca, R. Kitenge, G. Mochamah, B. Aygun, R. E. Ware, +7 Additional Authors

Journal Articles

Despite its well-described safety and efficacy in the treatment of sickle cell anemia (SCA) in high-income settings, hydroxyurea remains largely unavailable in sub-Saharan Africa, where more than 75% of annual SCA births occur and many comorbidities exist. Realizing Effectiveness Across Continents with Hydroxyurea (REACH, ClinicalTrials.gov NCT01966731) is a prospective, Phase I/II open-label trial of hydroxyurea designed to evaluate the feasibility, safety, and benefits of hydroxyurea treatment for children with SCA in four sub-Saharan African countries. Following comprehensive training of local research teams, REACH was approved by local Ethics Committees and achieved full enrollment ahead of projections with 635 participants enrolled …

Management Of Acute Pancreatitis In The Pediatric Population: A Clinical Report From The North American Society For Pediatric Gastroenterology, Hepatology And Nutrition Pancreas Committee., M. Abu-El-Haija, S. Kumar, J. A. Quiros, K. Balakrishnan, B. Barth, S. Bitton, J. F. Eisses, E. J. Foglio, V. Fox, V. D. Morinville, +10 Additional Authors

Journal Articles

BACKGROUND:Although the incidence of acute pancreatitis (AP) in children is increasing, management recommendations rely on adult published guidelines. Pediatric-specific recommendations are needed. METHODS:The North American Society for Pediatric Gastroenterology, Hepatology and Nutrition Pancreas committee performed a MEDLINE review using several preselected key terms relating to management considerations in adult and pediatric AP. The literature was summarized, quality of evidence reviewed, and statements of recommendations developed. The authorship met to discuss the evidence, statements, and voted on recommendations. A consensus of at least 75% was required to approve a recommendation. RESULTS:The diagnosis of pediatric AP should follow the published INternational Study …

Metabolic Obesity Phenotypes And Risk Of Colorectal Cancer In Postmenopausal Women., G. C. Kabat, M. Y. Kim, M. Stefanick, G. Y. F. Ho, D. S. Lane, A. O. Odegaard, M. S. Simon, J. W. Bea, J. Luo, T. E. Wassertheil-Smoller

Journal Articles

Obesity has been postulated to increase the risk of colorectal cancer by mechanisms involving insulin resistance and the metabolic syndrome. We examined the associations of body mass index (BMI), waist circumference, the metabolic syndrome, metabolic obesity phenotypes and homeostasis model-insulin resistance (HOMA-IR-a marker of insulin resistance) with risk of colorectal cancer in over 21,000 women in the Women's Health Initiative CVD Biomarkers subcohort. Women were cross-classified by BMI (18.5-

Dynamic Hydrostatic Pressure Regulates Nucleus Pulposus Phenotypic Expression And Metabolism In A Cell Density-Dependent Manner, B. S. Shah, N. O. Chahine

Journal Articles

© 2018 by ASME. Dynamic hydrostatic pressure (HP) loading can modulate nucleus pulposus (NP) cell metabolism, extracellular matrix (ECM) composition, and induce transformation of notochordal NP cells into mature phenotype. However, the effects of varying cell density and dynamic HP magnitude on NP phenotype and metabolism are unknown. This study examined the effects of physiological magnitudes of HP loading applied to bovine NP cells encapsulated within three-dimensional (3D) alginate beads. Study 1: seeding density (1 M/mL versus 4 M/mL) was evaluated in unloaded and loaded (0.1 MPa, 0.1 Hz) conditions. Study 2: loading magnitude (0, 0.1, and 0.6 MPa) applied …

A Collaborative, Network-Based Approach To Advance Women's Depression Research In The United States: Preliminary Findings, H. A. Flynn, C. Spino, C. Guille, K. M. Deligiannidis, P. Maki, J. Jahnke, K. L. Rosenblum, C. N. Epperson, S. J. Weiss

Journal Articles

No abstract provided.

The Role Of Objectively Measured, Altered Physical Activity Patterns For Body Mass Index Change During Inpatient Treatment In Female Patients With Anorexia Nervosa, C. S. Lehmann, T. Hofmann, U. Elbelt, M. Rose, C. U. Correll, A. Stengel, V. Haas

Journal Articles

No abstract provided.

Successful Switching Of Patients With Acute Schizophrenia From Another Antipsychotic To Brexpiprazole: Comparison Of Clinicians' Choice Of Cross-Titration Schedules In A Post Hoc Analysis Of A Randomized, Double-Blind, Maintenance Treatment Study, C. U. Correll, L. Shi, C. Weiss, M. Hobart, A. Eramo, R. A. Duffy, E. Weiller, R. A. Baker

Journal Articles

© Cambridge University Press 2018. Objective To compare the tolerability and efficacy of different antipsychotic cross-titration schedules, using data from a brexpiprazole study (Equator; NCT01668797).MethodsPatients with schizophrenia were cross-titrated from other antipsychotics to brexpiprazole monotherapy in a 1-4 week open-label conversion phase, then entered a single-blind brexpiprazole treatment phase. Patients were stratified into four "conversion groups," according to the amount of time spent in the conversion phase. Discontinuation rates, treatment-emergent adverse events (TEAEs), and efficacy (Positive and Negative Syndrome Scale [PANSS]) were compared between conversion groups.ResultsOf the 404 patients treated with brexpiprazole, the majority (72.0%) spent 22-33 days in the …

Obesity In The Workplace: Impact, Outcomes, And Recommendations, C. M. Yarborough, S. Brethauer, W. N. Burton, R. J. Fabius, P. Hymel, S. Kothari, R. F. Kushner, J. M. Morton, M. S. Roslin, J. Ording, +8 Additional Authors

Journal Articles

Copyright © 2017 American College of Occupational and Environmental Medicine. Objective: To conduct a comprehensive literature review to develop recommendations for managing obesity among workers to improve health outcomes and to explore the impact of obesity on health costs to determine whether a case can be made for surgical interventions and insurance coverage. Methods: We searched PubMed from 2011 to 2016, and CINAHL, Scopus, and Cochrane Registry of Clinical Trials for interventions addressing obesity in the workplace. Results: A total of 1419 articles were screened, resulting in 275 articles being included. Several areas were identified that require more research and …

Prediction, Persuasion, And The Jurisprudence Of Behaviorism, Frank A. Pasquale, Glyn Cashwell

Faculty Scholarship

No abstract provided.

Development Of Normal And Cleft Palate: A Central Role For Connective Tissue Growth Factor (Ctgf)/Ccn2, J. T. Tarr, A. G. Lambi, J. P. Bradley, M. F. Barbe, S. N. Popoff

Journal Articles

© 2018 by the authors. Development of the palate is the result of an organized series of events that require exquisite spatial and temporal regulation at the cellular level. There are a myriad of growth factors, receptors and signaling pathways that have been shown to play an important role in growth, elevation and/or fusion of the palatal shelves. Altered expression or activation of a number of these factors, receptors and signaling pathways have been shown to cause cleft palate in humans or mice with varying degrees of penetrance. This review will focus on connective tissue growth factor (CTGF) or CCN2, …

The Relationship Of Physical Performance And Osteoporosis Prevention With Vitamin D In Older African Americans (Poda), R. Dhaliwal, M. Mikhail, G. Usera, A. Stolberg, S. Islam, L. Ragolia, J. F. Aloia

Journal Articles

© 2017 Elsevier Inc. Rationale Vitamin D deficiency is associated with bone loss, poor muscle strength, falls and fracture. This information in older African Americans (AAs) is sparse. Objective The study of the relationship of Physical performance, Osteoporosis prevention with vitamin D in older African Americans (PODA) is a randomized, double-blind, placebo-controlled 3-year trial examining the effect of vitamin D on bone loss and physical performance in older AA women. Methods 260 healthy AA women aged > 60 years were assigned to receive placebo or vitamin D3. Initial vitamin D3dose was determined by the baseline serum 25OHD level, and adjusted further …

Aerobic Physical Exercise Increases The Health-Related Quality Of Life In Older Adults, Patricia L. Parker

Doctor of Nursing Practice Projects

Abstract

Problem Description: Globally, the older adult population is expected to substantially increase in number throughout the next few decades. The aging process causes the body and mind to undergo many detrimental changes. Typically, older adults succumb to a more sedentary lifestyle due to factors such as decreased musculature and skeletal changes, chronic pain, socioeconomic and psychological stressors, and memory changes. Inevitably, health-related quality of life and overall independence dwindles in this population negating their perception of happiness and life satisfaction. There is significant research on preventing and/or managing cognitive disabilities in the older adult; however, Western medicine approaches, such …

Annual Report 2018: Community Benefit, Lehigh Valley Health Network

LVHN Annual & Statistical Reports

No abstract provided.

Lee Kong Chian School Of Business Year In Review 2016-2017, Singapore Management University

SMU Corporate Reports

The Lee Kong Chian School of Business (LKCSB) is the founding school of Singapore Management University (SMU), and is now in its 17th year. With nearly 4,000 students, the business school remains the largest school at SMU and also its flagship programme. It is the youngest business school to be featured in the Financial Times Global Top 50 for the quality of its teaching programmes. It is also the youngest to appear in the Global Top 50 for research productivity of its faculty in the University of Texas (UT) Dallas rankings. For a school founded in the new millennium, LKCSB …

Division Of Research And Economic Development Monthly Report For August 2018, Uri Division Of Research And Economic Development

Reports (Research and Economic Development)

The monthly reports include statistics for project proposals and awards received by individual academic and administrative departments at the University of Rhode Island.

Division Of Research And Economic Development Monthly Report For February 2018, Uri Division Of Research And Economic Development

Reports (Research and Economic Development)

The monthly reports include statistics for project proposals and awards received by individual academic and administrative departments at the University of Rhode Island.

Division Of Research And Economic Development Monthly Report For December 2018, Uri Division Of Research And Economic Development

Reports (Research and Economic Development)

The monthly reports include statistics for project proposals and awards received by individual academic and administrative departments at the University of Rhode Island.

Division Of Research And Economic Development Monthly Report For January 2018, Uri Division Of Research And Economic Development

Reports (Research and Economic Development)

The monthly reports include statistics for project proposals and awards received by individual academic and administrative departments at the University of Rhode Island.

Division Of Research And Economic Development Monthly Report For March 2018, Uri Division Of Research And Economic Development

Reports (Research and Economic Development)

The monthly reports include statistics for project proposals and awards received by individual academic and administrative departments at the University of Rhode Island.

Division Of Research And Economic Development Monthly Report For July 2018, Uri Division Of Research And Economic Development

Reports (Research and Economic Development)

The monthly reports include statistics for project proposals and awards received by individual academic and administrative departments at the University of Rhode Island.

Division Of Research And Economic Development Monthly Report For October 2018, Uri Division Of Research And Economic Development

Reports (Research and Economic Development)

The monthly reports include statistics for project proposals and awards received by individual academic and administrative departments at the University of Rhode Island.

Division Of Research And Economic Development Monthly Report For September 2018, Uri Division Of Research And Economic Development

Reports (Research and Economic Development)

The monthly reports include statistics for project proposals and awards received by individual academic and administrative departments at the University of Rhode Island.

Division Of Research And Economic Development Monthly Report For April 2018, Uri Division Of Research And Economic Development

Reports (Research and Economic Development)

The monthly reports include statistics for project proposals and awards received by individual academic and administrative departments at the University of Rhode Island.

Feeding Island Dreams: Exploring The Relationship Between Food Security And Agritourism In The Caribbean, Adelle Thomas, Amelia Moore, Michael Edwards

Marine Affairs Faculty Publications

Caribbean islands have increasingly turned to tourism as a pathway for economic advancement, often to the detriment of other industries, particularly agriculture. The influx of millions of tourists to these island destinations increases food demand, escalates food importation, and oftentimes results in food insecurity. Agritourism, an alternative tourism form, has been proposed as a way to stimulate domestic food production and increase food security. This article provides a selective examination of the possibilities of relationships between agritourism and food security in the context of a specific Caribbean island: New Providence, Bahamas. Drawing from semi-structured interviews and site visits with over …

Momentum: Research & Innovation For Spring 2018, University Of Rhode Island

Publications (Research and Economic Development)

The Spring 2018 issue of Momentum: Research & Innovation, a periodical focused on research at the University of Rhode Island.

An Investigation Into The Decline In The Use Of Fresh Potatoes And The Increased Demand For Processed Potato Products In The Foodservice Sector In The Leinster Area, Emily Gray

Level 3

The aim of this article is to examine the decline in use of fresh potatoes and the increased demand for processed potato products in the foodservice sector in Leinster. The study focused on the consumption and use of potatoes by chefs, restauranteurs, hoteliers, and managers in the foodservice sector. This was achieved by a survey questionnaire of one hundred and ten establishments of which sixty-five responded. The research also involved examination of background information and past literature, investigating when the decline of the potato occurred and the cause of that decline, and comparing data from the retail sector to the …

Pharmacy Staff Perspectives On Alcohol And Medication Interaction Prevention Among Older Rural Adults, Faika Zanjani, Hannah Allen, Rachel Vickers Smith, Demetra Antimisiaris, Nancy Schoenberg, Catherine Martin, Richard Clayton

Gerontology Publications

Older adults are at high risk for alcohol and medication interactions (AMI). Pharmacies have the potential to act as ideal locations for AMI education, as pharmacy staff play an important role in the community. This study examined the perspectives of pharmacy staff on AMI prevention programming messaging, potential barriers to and facilitators of older adult participation in such programming, and dissemination methods for AMI prevention information. Flyers, telephone calls, and site visits were used to recruit 31 pharmacy staff members who participated in semistructured interviews. A content analysis of interview transcriptions was conducted to identify major themes, categories, and subcategories. …

Fighting Frailty With The Mediterranean Diet, Edward F. Ansello

Director's Editorials from Age in Action

It’s appropriate for each of us to examine our eating habits, not just our nutrition intake. The various aspects of the Mediterranean Diet hold potential benefits beyond the important feature of helping to reduce frailty.

Into The Elder Law Trenches At Wake Forest University School Of Law, Kate Mewhinney

Case Studies from Age in Action

Educational Objectives:

1. Examine the benefits of a medical-legal partnership for training law students how to represent older clients.

2. Review common legal issues in the field of elder law.

3. Explore broader policy concerns facing an aging population.